Meng Yuan Profile picture
Staff Scientist @scrippsresearch
Feb 22, 2021 6 tweets 4 min read
Recent #SARSCoV2 variants in South Africa (B.1.351) and Brazil (P.1) reduce neutralization of patient and vaccinated sera. Our new study reveals the molecular basis of how major classes of antibodies are extremely sensitive to the key mutations. (1/6) biorxiv.org/content/10.110… We analyzed 1,593 SARS-CoV-2 antibodies targeting the receptor binding domain (RBD), and found that IGHV3-53/3-66 and IGHV1-2 are the two most frequently elicited antibody families. Strikingly, neutralization of all tested antibodies from these germlines was abolished. (2/6)