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Jamie Timmons Profile picture
Jamie Timmons
@metapredict
Like OMICS-Data-DrugDiscovery-Metabolism-Aging. Odd humour reflects my fusion of Scots-Irish & Jewish 🧬 😲
Jan 17, 2022 • 10 tweets • 10 min read
1/ Our contribution to drug repositioning (DR) for metabolic disease (MD)
In HUMANS Insulin resistance (IR) in muscle & adipose shares COMMON molecular pathways & COMMON treatment responses (n= >2,000 samples). @mackinprof @eLIFE @JPTK_TechBio @chvolmar
doi.org/10.7554/eLife.… 2/ Using the common molecular features from muscle & adipose we built a 120-gene RNA IR assay & found this multi-gene assay could rank families of active drugs by potency #novel Active drugs have many protein targets #not-novel
@mackinprof @eLIFE
doi.org/10.7554/eLife.…