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Muthu Vaduganathan Profile picture
Muthu Vaduganathan
@mvaduganathan
Cardiologist at Brigham and Women's Hospital | Section Editor @JACCJournals | Associate Editor #JACCHF | Podcast #DontMissABeat | Disclosures: https://t.co/BmQHCNyLml
Jan 31, 2022 • 5 tweets • 6 min read
New in @JACCJournals w @JJheart_doc on intersection of biomarkers & #SGLT2i in #T2D.

Canagliflozin in #CANVAS
⤵️hs-cTnT & sST2 out to 6yrs
⤵️HF & kidney outcomes irrespective of baseline biomarkers
⤵️MACE particularly in those w multiple abnormal markers

jacc.org/doi/10.1016/j.… In >3K👥in #CANVAS, canagliflozin (versus PBO) reduced #hscTnT (marker of cardiac injury) & #sST2 (marker of vascular congestion, inflammation & fibrosis) out to 6yrs

Importantly, rather than reducing biomarkers below baseline, #SGLT2i appear to delay longitudinal rise after 1yr