In the action-mode, arousal is heightened, attention focused externally, and plans are converted to goal-directed movements and updated based on feedback, such as pain. The brain’s action-mode is created by a dedicated action-mode network (AMN) rdcu.be/d5odm. In the brain’s mode continuum, the AMN’s action-mode sits opposite the DMN’s default-mode for self-referential processing, counterbalancing each other as yin & yang. AMN dysfunction might be key in pain, apathy, Parkinson’s, etc. New NRN piece with Marc Raichle & @gordonneuro. Short 🧵 ⬇️ The AMN was identified with functional connectivity & task fMRI and initially named the cingulo-opercular network (CON) based on anatomy, even though it’s more widely distributed.

Introducing the Action-Mode Network – AMN. Better late than never! 17 years ago, we clumsily called this the Cingulo-opercular Network (CON) based on its anatomy (we weren’t exactly sure what it does). Now we’ve finally got the evidence to give it the functional name it deserves: the Action-mode Network (AMN). Find our arguments here: with the peerless Marc Raichle and the brilliant @gordonneuro. 🧵 ↓osf.io/preprints/psya… Here’s the summary. The active mode is the yin to the default mode’s yang ☯️ … and just as the default-mode network (DMN) has a special role in establishing the (brain-wide) default mode of brain function, the active-mode network (AMN) sets up the action mode. In both cases, an anatomically circumscribed circuit supports a global mode of brain function.

shorturl.at/kyCEU has lots of parts to it. I like #neuroscience Twitter for getting a quick overview of what's happening. @smarek0502 & @tervoclemmensb wrote detailed 🧵s with figs. I'll just give bullet pts of what the study is & isn't saying 👇 It's specifically about BWAS (brain-wide association studies) as defined in the 2nd sentence: ‘studies of the associations between common inter-individual variability in human brain structure/function and cognition or psychiatric symptomatology’. BWAS ≠ neuroimaging