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Ravi B. Parikh Profile picture
Ravi B. Parikh
@ravi_b_parikh
Oncologist @PennMedicine and @DeptVetAffairs; Researcher @Penn; Columnist @Medscape; Senior Clinical Advisor @CTACorg
Dec 12, 2018 • 12 tweets • 4 min read
In our @JCO_ASCO piece out today, @VPplenarysesh and I argue that recent drug approvals based on metastasis-free survival (MFS) in #ProstateCancer illustrate the trade-off between speed and certainty in cancer drug approvals. Long thread to follow... ascopubs.org/doi/pdf/10.120… Good treatments have dramatically improved life expectancy for patients with advanced #ProstateCancer. This is a good thing. But as life expectancy has increased, overall survival becomes a difficult endpoint to achieve in clinical trials, requiring lots of patients, time, & $$$