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Inactive account. Go here instead: @kcorazo Profile picture
Inactive account. Go here instead: @kcorazo
@roamfu
I rarely check this account, but I'm active here: @kcorazo
9 subscribers
Sep 9, 2021 • 4 tweets • 1 min read
Lab procurement process for govt funded projects looks a lot like large enterprise procurement.

Just saw field sales selling an expensive product (Illumina) beat inside sales for a lower cost product (Nanopore).

Deals need to be huge as bureaucracy is the same, large or small. Consumer first approaches (eg, Dropbox in SaaS) probably won't work in labs where power is concentrated at the top.
Aug 18, 2021 • 9 tweets • 4 min read
1/9 WHAT BUSINESS MODELS ARE VIABLE ON TOP OF OPEN SOURCE SYNTHETIC BIOLOGY, BASED ON THE HISTORY OF OPEN SOURCE SOFTWARE?

As an entrepreneur in the developing world, my main tool for enacting change is free enterprise.

What are the possibilities with open source synbio? 2/ The problem that jumps out is sourcing of reagents for sequencing SARS-CoV-2 (due to accessiblegenomics.org), but scientific research as a whole is very expensive for labs in the global south because machines and reagents are imported from US/Europe.
Aug 16, 2021 • 7 tweets • 3 min read
1/7 WILL THIS BE THE DECADE OF OPEN SOURCE SYNTHETIC BIOLOGY?

Cost and transportation of reagents is one of the biggest obstacles in bringing genomic SARS-CoV-2 variant identification and tracking in the developing world.

Will open source synbio be the solution? 2/ I met @Eyesgack at @JustOneGiantLab, while trying to get Project Accessible Genomics off the ground. Hearing him talk about democratizing biotech feels like the beginning of something big.

Will open source genetic engineering change the world, like open source software?
Aug 5, 2021 • 6 tweets • 1 min read
1/ Last phase of Project Accessible Genomics. We have equipped a rural lab in a developing country to sequence SARS-CoV-2 with your help!

That entire process was a prototype. How do we make use of what we learned to help other labs in the developing world? 2/ I'll be interviewing labs to find out the ff:
- Their situation, what's stopping them from sequencing / sequencing sufficiently
- What help do they need to overcome these barriers

So far, I have 4 labs in Africa and 2 labs in Latin America in my list. Would appreciate intros.
Dec 27, 2020 • 4 tweets • 3 min read
Breakfast SARS-CoV-2 w the fam:

"It has mutated!" It is always mutating

"the vaccine will no longer work!" Of all the variants all over the world, why would this variant of concern (due to its transmissibility) be one which also beats the vaccines? theguardian.com/commentisfree/… Image A variant needs to win the lottery to beat at a vaccine cdc.gov/coronavirus/20… Image
Dec 23, 2020 • 15 tweets • 7 min read
1/ You've heard of the mutation.

But how about this? There were 284,078 human SARS-CoV-2 genomes in @GISAID (global viral genome repository) as of Dec 22.

132,477 (47%) was from the UK, 51k from US, <1k from most countries, 0 from some.

Maybe we should fix this? 🧵👇🏽 2/ Most countries don't know how SARS-CoV-2 variants are behaving (and how variation correlates with case fatality rate) because we don't have enough SARS-CoV-2 genomes.

But if a bunch of volunteers can setup a lab (story below), governments surely can.
Dec 22, 2020 • 10 tweets • 8 min read
1/ GRATITUDE THREAD!

Well, this crazy year is at least ending beautifully for Project accessiblegenomics.org

We started as a bunch of strangers in the internet. Now, everything is set for (probably) the first genomic pathogen surveillance lab built through volunteer work! 2/ A tweet is too small to fit the team that made this happen: all the volunteers that joined though @JustOneGiantLab, our subject matter experts from genomics twitter, and Dr. Murao and her team at @pgcmindanao
Aug 9, 2020 • 14 tweets • 6 min read
1/13 My highlights from @hubermanlab interview at the @richroll podcast

Adult neuroplasticity is triggered by FOCUS and implemented by DEEP SLEEP

H/t @petercorazo 2/ adult brains could be as plastic as baby brains provided that there is:
- focus
- purpose (intense fear or love)
- relaxation after
Jun 24, 2020 • 19 tweets • 7 min read
1/18 PROJECT ACCESSIBLE GENOMICS
Our contribution to brining genomic pathogen surveillance to the global south (aka our homelands).

A [[@JustOneGiantLab]] project.

(This is an outline of an intro video I'm about to record. I'm trying to avoid jargon. Would appreciate feedback!) 2/ [[@JustOneGiantLab]] is a platform for distributed volunteer teams to come together and implement international projects. In the past months, we have focused our efforts on COVID-19. Here's the JOGL team I belong to.
Jun 20, 2020 • 7 tweets • 3 min read
1/7 COULD THE MASTERMIND BE THE KEY TO BRINGING EXPERIENTIAL LEARNING TO ONLINE CLASSES?

I've been delivering project management training for 10+ years. Last week was my first time to do it online.

Feedback was good, but something was missing. 2/ I personally learn best when I immediately use what I learn. This is why my PM training is centered around tools instead of concepts
May 29, 2020 • 16 tweets • 6 min read
1/15 My Favorite Project Management Tools

I'm a long-time PMP (Project Management Professional - a certification from @PMInstitute). I've used PM for building a business (and not going insane) and for volunteer work.

These are the most used tools in my PM toolbox. Image 2/ Note that these tools are for executing known solutions to known problems. If either the solution or the problem is unknown, I use other tools (eg, Customer Development a la @sgblank)
May 14, 2020 • 12 tweets • 5 min read
1/11 Takeaways and thoughts from the [[Fabricating Serendipity]] meetup with [[@RosieCampbell]] and [[@kwharrison13]] + meta thoughts and next steps 2/ This is how to compose a Twitter thread in Roam. The max characters is 299 because {{character-count}} itself included in the count. h/t @rroudt
May 8, 2020 • 29 tweets • 14 min read
1/29 WHY WE IN DEVELOPING COUNTRIES SHOULD NOW (AND CAN NOW) CARE ABOUT PATHOGEN SURVEILLANCE USING LOW-COST SEQUENCING

Or some thoughts from reading [[@kirstynbrunker]] et al, 2020 wellcomeopenresearch.org/articles/5-3/v1 I'll avoid jargon as much as I can. Image 2/ This pandemic has shown us how important clear, reliable pathogen data is for our lives and economies. My academic interest was already low-cost genomics, but instead of cacao, a better focus might be viruses. They are also easier & cheaper to sequence.
May 2, 2020 • 14 tweets • 6 min read
1/ To everyone who practices (())-style #roamfu

Here are some techniques from conaw

I'll add more in this thread ongoing.

When grappling with journal articles, answers could be chapters away. (()) is a way of bringing them closer. With a click, you are back to the source. 2/ Here's how I'm implementing @andy_matuschak's "Understanding requires effortful engagement". I started collecting questions that interrogate ideas. I block reference the appropriate questions under ideas.
Apr 29, 2020 • 26 tweets • 10 min read
1/26 Roam-Fu III: Beyond the Empire

In a few months, I predict we'll start seeing Zettelkasten masterpieces, but ATM the best ZK I've seen is not in Roam. It is [[@andy_matuschak]]'s notes.andymatuschak.org

This is what I learned from the master of computer-assisted thinking. 2/ His evergreen notes are solid. But, more importantly, we should look at what the notes have produced. First, what does [[@andy_matuschak]] want to accomplish? He is pretty clear:
Apr 21, 2020 • 36 tweets • 14 min read
1/ ACADEMIC #ROAMFU AND #TWITTERFU

PART I: My plan for using @RoamResearch for a thesis
PART II: Using Twitter as an inter-brain zettelkasten 2/
PART I. I'm officially start doing my thesis in 15 months. I'll do my future self a favor by creating evergreen notes from the papers I've read the past year and the upcoming year. You're welcome!
Apr 19, 2020 • 8 tweets • 3 min read
1/ THE FABRICATION OF SERENDIPITY

My highlights from

"Niklas Luhmann’s Card Index" by Johannes F.K. Schmidt sociologica.unibo.it/article/view/8…

In which Luhmann dreamt of @RoamResearch 2/ "According to Luhmann the collection is a “combination of disorder and order, of clustering and unpredictable combinations emerging from ad hoc selection.”"
Apr 6, 2020 • 43 tweets • 20 min read
1/ This is my Roam-Fu, and it is Different from Yours

(thread edition for now, since I won't write this until I have written at least 5 zettelkasten-organic long-form pieces, but I want to share and get feedback from #roamcult on my process [#roamfu from hereon] so here we go) Outline
2. If Luhmann invented the #Zettelkasten today
3. Senseis
4. My current (())-based Roam-fu
5. Closing
Apr 3, 2020 • 11 tweets • 3 min read
My evergreen notes from @fortelabs's How to Take a Digital Note 1/
youtube.com/watch?v=T4u4nU… What kinds of fleeting notes do you take? Does it inspire you? [[Listen to your body]]. When a piece of content produces a physiological reaction, note it down. Might your future self find use for this? Note it down.
Feb 13, 2020 • 13 tweets • 2 min read
1/ Friends in creative domains: here's my playbook on how to get lucky and how to exploit luck 2/ I used to think that entrepreneurship is all about hard work.

Turns out it's about increasing the probability of luck and then exploiting the hell out of that luck.