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https://twitter.com/sarperotto/status/14577309586191319112/ The theory on drugs that increase the mutation rate and push viruses beyond the "error threshold" (where all progeny viruses produced are too riddled with mutations to survive) assume that the virus is already near its fitness peak (not known for SARS-CoV-2) and that
https://twitter.com/rebekahoomen/status/1205112857404334081Recombination shuffles the loci and breaks down LD (much like shuffling cards randomizes them and breaks down associations, such as clubs being near each other in an unshuffled deck). So what builds LD? Many things - which chromosome a mutation lands on, chance genetic drift...