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President-Elect @theaace, endocrinologist, obesity medicine, #MASLD, Emory Med School adjunct faculty. Posts are my own.
Jan 13, 2023 7 tweets 4 min read
Recommendations to enable and optimize a multidisciplinary approach in #NAFLD care. #livertwitter @AlinaAllenMD @AlkhouriNaim @JVLazarus nature.com/articles/s4385… Evaluate benefit and cost-effectiveness of multidisciplinary models of care based on NITs, which should be adopted by first-line providers, such as PCPs and endocrinologists, and monitor their use. nature.com/articles/s4385…
Dec 11, 2022 9 tweets 14 min read
Bart Staels, PhD of Univ of Lille, France gave an outstanding talk on Interplay Between #NAFLD & #CVD at the #WCIRDC. CVD is the leading cause of death not liver disease. Fibrosis severity correlates with higher CVD risk. @WCIRDC @YHandelsmanMD
healio.com/news/endocrino… Type 2 #diabetes and #NAFLD have a reciprocally injurious relationship mediated through common pathophysiology magnifying the risk for #CVD events.
pubmed.ncbi.nlm.nih.gov/33015726/ @zilbermint @AlinaAllenMD
Sep 19, 2022 12 tweets 10 min read
Thyroid hormones regulate liver enzymes via thyroid hormone receptors. When the liver is steatotic, hepatic thyroid hormone receptors don’t respond effectively. This results in an intrahepatic hormonal milieu where the liver is essentially hypothyroid. #livertwitter #endotwitter Thyroid hormone receptor-β plays a key role in hepatic homeostasis including:
✅De novo lipogenesis
✅Fatty acid β-oxidation
✅Mitophagy
✅Mitochondrial biogenesis
✅Cholesterol metabolism
✅Carbohydrate metabolism
#livertwitter #endotwitter
Sep 4, 2022 10 tweets 7 min read
Thyroid hormones regulate liver enzymes. When the liver is fatty, thyroid hormones don’t work right. #HepaticHypothyroidism Hepatic enzymes responsive to #thyroid hormones will slow down when the liver is fatty. Thyroid hormone has a dominant effect on HMG-CoA reductase in the liver which regulates cholesterol levels which is why #hypothyroidism causes high cholesterol. #HepaticHypothyroidism