Discover and read the best of Twitter Threads about #diabetes

Most recents (24)

The Conservative Party of Canada supports a 3 year prohibition on embryonic stem cell research.

They claim adult stems cells are more promising, so let's look at their claims.

#cdnpoli #elxn43 #NeverScheer #stemcells #research #science
The Ford Government has already cut funding for stem cell research.

"Scientist working on treatment of premature babies calls move 'extremely short-sighted and uninformed'"

cbc.ca/news/canada/to…
What are embryonic stem cells?
"Embryonic stem cells exist only at the earliest stages of embryonic development and are capable of making any cell type in the body."

via @UMich

stemcellresearch.umich.edu/overview/faq.h…
Read 9 tweets
1/ Today, at #ESCcongress2019 DAPA-HF trial showed amazing results. I love the complex story behind developing these novel #diabetes drugs and their impact on CVD so I'm going to share it in this tweetorial #cardiotwitter
2/ First let me start by sharing DAPA-HF results. Basically, in pts with HFrEF, Dapagliflozin (SGLT-2i) arm had 26% reduction in primary outcome & 18% reduction in CV death REGARDLESS of #diabetes. Link to tweet w/results thx to @rladeiraslopes

3/ Pre 2008, the FDA approved anti-diabetic medications based on their ability to reduce biomarkers, glucose and A1C, without the need for clinical outcome trials. Basically, anything that lowers A1c in diabetics got approved
Read 11 tweets
The past two days I have read anecdote after anecdote from parents who have children like Isla, have children who are #LGBTQ LGBT (not sure if that acronym is accurate), have children with #diabetes, even parents whose children just have eczema.
They've messaged me, replied to things I've said, and there is this trend among them-they blame #vaccines. I am not complaining. I knew my Twitter activity would result in these things. It is part of a conversation.
The commonality they don't realize exists is this-they are all ashamed. There is even a mother who believes her 29 year old son's latching issues as a newborn are due to her decision to #immunize. Her son is 29 years old and she is still writing about that online. That is sad.
Read 12 tweets
This @businessinsider article addresses the astronomical costs of insulin. We deserve better. We must do better. @KamalaHarris recognizes the burden Americans carry and the choices they must make to survive. #healthcare #UnitedForKamala
1/ The number of Americans with diagnosed diabetes is projected to increase 165%, from 11 million in 2000 (prevalence of 4.0%) to 29 million in 2050 (prevalence of 7.2%).
(Source: Projections Of Diabetes Burden Through 2050. care.diabetesjournal.org)
#KamalaCare #UnitedForKamala
2/ The largest percent increase in diagnosed diabetes will be among those aged 75 years (271 % in women, 437% in men).
#KamalaCare #UnitedForKamala #healthcare #diabetes #insulin
Read 6 tweets
How many tax payers live within this circle, @cityofkingston ?
It's time for a tax revolt.
This latest project is outrageous.
De-paving????
2 rock crushers jackhammering 11 hrs/day for 9 days to DE-PAVE a needed parking lot to turn it to grass?
#ygk
Where do you live? I'm going to come to your house and play a recording of this for 10 hours straight .. oh but wait THAT would be illegal, right?
I don't see why thousands of people have to put up with it if you don't.
I've had it, and I'm going to get my evidence together, City of Kingston.
Check this out for starters:
#NoisePollution
#Diabetes
#LAWSUIT
Read 6 tweets
"Digital Orthodoxy," aka Deep Phenotyping or High-dimensional human data, is a great research tool w/ many proven advances, but has NO commercial/clinical validation and may be harmful
thelancet.com/journals/lance…
Our latest @TheLancet Digital Medicine essay
@EvanMuse @ScrippsRTI
@TheLancet @EvanMuse @ScrippsRTI The multi-modal testing may someday be validated to benefit, but until that time we raise concerns about the practice, ethics and safety for companies to be charging individuals for such data accumulation.
@TheLancet @EvanMuse @ScrippsRTI In @TheLancet essay we briefly touched on advances that deep phenotyping of people has made in biomedical research. I'm going to briefly review 5
1. Pre-diabetes-> #diabetes
2. Individualized diet
3. Colon #cancer+ microbiome
4. Gut #metagenomics sequence Δ
5. Tumor microbiome
Read 8 tweets
We all know someone suffering from:

Cancer
Diabetes
Lung disease
Heart diseases
Stroke

These noncommunicable diseases are the 🌍's biggest killers, responsible for 7 out of every 10 deaths worldwide.

We need your help to #BeatNCDs!
Tobacco. 🚬
Alcohol. 🍻
Air pollution. 🏭
Unhealthy diet. 🍔
Physical inactivity. 🛋️

These are the main NCDs risks.

Let's STOP them.
Let's #BeatNCDs.
@pahowho @WHOWPRO @WHOSEARO @WHOEMRO @WHO_Europe @WHOAFRO Noncommunicable diseases kill 41 million people prematurely every year, many of them in the prime of life.

41 MILLION lives.
41 MILLION families affected.

But we could save nearly 10 million lives by 2025. Let's #BeatNCDs
Read 13 tweets
01. #BlackoutInfo
Was für Folgen hat ein landes- oder noch schlimmer, europaweiter, länger als 72 Stunden dauernder #Blackout, also #Stromausfall, in unserer zu 100% von #Strom abhängigen Gesellschaft? Wie ist der #Staat darauf vorbereitet? Wie engagiert sich unsere #Politik?
02. #BlackoutInfo
Innerhalb weniger Stunden nach einem landesweiten #Blackout wird bei 90% der Haushalte kein Wasser mehr aus der Leitung kommen. Auch die Toilettenspülung funktioniert nicht mehr, so daß in Ballungsräumen sehr schnell massive Probleme & Seuchengefahren entstehen.
03. #BlackoutInfo
In der Folge eines landesweiten #Blackout ist die Lebensmittelproduktion nicht mehr möglich. Noch vorhandene Vorräte zu verteilen wird immer schwieriger bis unmöglich. Logistikfirmen stellen Lieferungen sofort ein, da die automatisierten Lager offline sind.
Read 54 tweets
Ayer se publicó en numerosos medios el caso de una mujer joven que ha fallecido aparentemento por consumo de un complemento alimenticio que contenía ácido #lipoico. #quemagrasas #hilo elpais.com/sociedad/2019/…
En la >ría de los medios se hablaba del uso de ácido #lipoico en complementos por su acción #quemagrasas.
Por supuesto, el término #quemagrasas no está caracterizado desde el punto de vista científico ni legal.
Es simplemente un reclamo que el consumidor identifica inmediatamente como #adelgazante. #lipoico
Read 28 tweets
#NationalDiabetesWeek we heard from @DiannaMagliano during 2002-2013, there was 6 times more likely progression of diabetes to kidney failure in Aboriginal and Torres Strait Islander people.
We know from #eGFRstudy led by Maple-Brown @MenziesResearch, the annual decline in kidney function is 3 times than expected for healthy aging. Having diabetes was a strong indicator of loss of kidney function #NationalDiabetesWeek
We know acute kidney injury is a potentially modifiable risk of loss of kidney function. In the NT, infections and heart disease were key contributors to AKI and needing to start dialysis #NationalDiabetesWeek
Read 12 tweets
The human gut #microbiome never ceases to amaze me. Now a discovery of a bacterium that coverts Type A or B blood to type O, with big implications for blood transfusion.
nature.com/articles/s4156… @NatureMicrobiol by @PRahfeld Steven Withers and colleagues @UBC
Our gut #microbiome is a treasure for discovery. More coming out on this later this week that is mind-blowing.
BTW, another example of a striking finding that has not garnered coverage by any media. Surprising, in light of the public's interest in science.
Read 5 tweets
Summary of results from iDCL trial of Tandem/Dexcom hybrid-closed loop system at #ADA2019
Included: 14 yrs and older, T1D > 1 yr
Minimal entry restrictions
170 subjects enrolled: Closed loop (112 ppl), sensor-augmented pump (56 ppl) #diabetes #t1d #closedloop
Subject characteristics: 33 years old; A1c 7.4% baseline; 20-25% MDI; 70% current CGM user;
Median diabetes duration 15 yrs
Outcomes:
100% of people completed study
Time in range increased 11% (to 71% in closed loop group); A1c decreased -0.33%; Mean glucose decreased 13 mg/dL;
Participants used CGM 97% time; 92% time with closed loop active.
Read 4 tweets
The 1st drug (a monoclonal antibody) to delay onset of autoimmune #diabetes in high risk individuals (by ~ 2 years)
nejm.org/doi/full/10.10… #ADA2019 @NEJM #T1D @T1D_Trialnet
"The results of this trial are striking, with several caveats."
A long road that has taken 40 years. And still just a start to prevention.
Exciting, nonetheless.
nejm.org/doi/full/10.10… @NEJM editorial #ADA2019
by @clifford_rosen and @ingelfinger
'Herold procrastinated when it came time to analyze the data. “I kept pushing it off,” he says, because he worried about failure.'
Some interesting backstory to this major milestone trial
@sciencemagazine sciencemag.org/news/2019/06/m… by @jcouzin
Read 3 tweets
I don’t speak in hyperbole very often, and I want to make sure that you all understand what a big deal this is for the diabetes DIY community. Everything that we’ve worked for for the last 20 years, it all changes now. #WeAreNotWaiting
Every diabetic engineer every, the day after they were diagnosed, tries to solve their (or their loved one's) diabetes with open software and open hardware. Every one. I did it in the early 90s. Someone diagnosed today will do this tomorrow. Every time.
I tried to send my blood sugar to the cloud from a PalmPilot. Every #diabetes person ever does this. Has done this. Then @NightscoutProj happened and #WeAreNotWaiting happened and we shared code and now we sit on the shoulders of people who GAVE THEIR IDEAS TO USE FOR FREE
Read 14 tweets
1/ It's all scaremongering isn't it about #brexit and #drugs? Stockpiling, price hikes, and, as @MattHancock warns, dead patients. Well, here's the lowdown and it's not pretty. With or without #softbrexit.
A thread
2/ Patients with long-term conditions such as #diabetes, #asthma or #schizophrenia, #blood pressure, #heart problems or #cancer down to daily medicines for #rashes and skin problems, take for granted that they will be able to get their medicines when they need them.
3/ According the UK's Business, Energy and Industrial Strategy
Committee publications.parliament.uk/pa/cm201719/cm…
73 per cent of pharmaceutical imports in the UK come from the EU. This equates to around 37 million packets of medicines every month from the EU worth £18.3 billion.
Read 19 tweets
AI has met a fork in the road; which path will dominate?

While pure #AI, or open API, will soon allow #robots to become more human-like, pragmatic AI is alive well today and driving true business transformation

infoworld.com/article/322128…
Charlie Rose interviews…a robot?

What happens when Charlie Rose attempts to interview a #robot named "#Sophia" for his 60 Minutes report on #ArtificialIntelligence (#AI)

cbsnews.com/news/60-minute…
#ArtificialIntelligence positioned to be a game-changer

It might not be long before machines begin thinking for themselves -- creatively, independently, and sometimes with better judgment than a human

cbsnews.com/news/artificia…
Read 15 tweets
My journey👉🏼of FDA interfering w/ my treatment 4 #MultipleSclerosis "WHEN NO OPTION IS NOT AN ACCEPTABLE OPTION!" #Ortho #cardiac #COPD #Autism #Parkinsons #Cancer

cellr4.org/article/390
Bloomberg @business interviews Celltex patients about experience w/ FDA shutting down adult #stemcell study we in. #MS #Arthritisw #Parkinsons #COPD #Ortho
bloomberg.com/news/articles/…
When left with no viable medical options, what do you do?👉🏼We reached out to other "No Option Patients" and formed PATIENTS FOR STEM STEMCELLS
#MS #PARKINSONS #Autism #COPD #arthritis #ortho #cancer #cardiac patientsforstemcells.org/home/
Read 13 tweets
I am scheduled for my 3rd surgery since December on Thursday.
Please do me a favor and promise to call your reps and senators and tell them you support and need the #ACA/#Obamacare and they only have your vote if they reject Trump's efforts to kill it.
Here's a thread on why:
1/
Many Americans think the #ACA/#Obamacare is insurance.
It is not.
The #ACA is a law governing insurance companies & forcing them to cover women & people with #PreExistingConditions.
The #ACA also says women cannot be forced to pay more than men for insurance.
#ProtectOurCare
2/
The #ACA/#Obamacare also provides for children 26 and under to be covered under their parents' insurance plans.
The ACA also created the healthcare marketplace, which provides tax subsidies for those unable to pay full-price for health insurance.
#ProtectOurCare
3/
Read 13 tweets
This was always going to be a packed out session (even at 5pm!): how we can use c-peptide measurements to improve the diagnosis of #diabetes
#DUKPC
What's c-peptide? It's a molecule we make during the process of producing insulin. So it can be used to look at how much insulin you produce: people with #Type1diabetes have very very low c-peptide levels, while people with #Type2diabetes have higher levels.
#DUKPC
This means a c-peptide measurement can differentiate between #Type1diabetes & #Type2diabetes. But how? In the past, tests were expensive & inaccurate. The #ExeterDiabetes team changed this...
#DUKPC
Read 12 tweets
Really looking forward to this one: precision medicine. It’s all about tailoring treatments for the individual and moving away from a one size fits all approach. #dukpc
.@markmccarthyoxf explains precision medicine could help us answers questions like:
Who is at greatest risk of #diabetes?
Who will respond best to different treatments?
Who will progress quickly or slowly?
#dukpc
Looking at people’s genetic information can help us spot who is at highest risk of #Type2diabetes. There are lots of outstanding questions about these genetic risk scores, but the future potential is exciting. #dukpc
Read 15 tweets
We’re now switching gears to technology. The room is packed to the rafters as we hear from people with #diabetes who’ve made use of the tech available to build their own artificial pancreas, otherwise known as DIY looping. #dukpc
DIY looping lets your CGM talk to your insulin pump. We think there are around 300 loopers in the UK. And they’re getting great results: more time in target and less hypos. #dukpc
Message from the DIY loop community to healthcare professionals: we’re not going to stop doing it, so you need to be equipped to support us. #dukpc
Read 6 tweets
Day 2 is off with a bang! @MaggieShepher13 has been awarded the Arnold Bloom lecture for her outstanding contributions to monogenic #diabetes care. She starts by thanking @DiabetesUK for supporting her right at the start of her career. #dukpc
Monogenic diabetes are rare forms caused by a change in a single gene. Maggie realised these genetic types of #diabetes weren’t being diagnosed properly and made it her mission to change that. #dukpc
Maggie describes the absolutely life-changing impact getting the right diagnosis can have. Many of her patients were able to come off insulin and be treated with tablets instead. #dukpc
Read 9 tweets
#BlackoutInfo Was für Folgen hat ein landes- oder noch schlimmer, europaweiter, länger als 72 Stunden dauernder #Blackout, also #Stromausfall, in unserer zu 100% von Strom abhängigen Gesellschaft? Wie ist unser Staat darauf vorbereitet? Und wie engagieren sich unserer #Politiker?
#BlackoutInfo Innerhalb weniger Stunden nach einem landesweiten #Blackout wird bei 90% der Haushalte kein Wasser mehr aus der Leitung kommen. Auch die Toilettenspülung funktioniert nicht mehr, so daß in Ballungsräumen massive Probleme und Seuchengefahren entstehen.
#BlackoutInfo In der Folge eines landesweiten #Blackout ist die Lebensmittelproduktion nicht mehr möglich. Noch vorhandene Vorräte zu verteilen wird immer schwieriger bis unmöglich. Logistikfirmen stellen Lieferungen sofort ein, da die automatisierten Lager offline sind.
Read 32 tweets
1/15

For my first #Tweetorial, I will start with a question:

Which of the following medications from the SGLT2 inhibitor class have been shown to decrease cardiovascular morbidity and mortality?

#Diabetes #EndoTwitter #MedEd #MedTwitter #DM2 #T2D #CardioTwitter
2/15

Sodium glucose transporters (SGLT) in proximal tubules mediate glucose reabsorption.

How?
Na/K ATPase moves Na out & K into the cell ➡️gradient for Na to flow intracellular

SGLT uses this potential to move glucose against its gradient from the tubular fluid into the cell.
3/15

SGLT2 inhibitors block glucose reabsorption
➡️renal glucose excretion
➡️glucose levels⬇️

Because this has nothing to do with insulin, they usually don’t cause hypoglycemia or weight gain.

Actually, because of the osmotic diuresis, they decrease blood pressure & weight.
Read 15 tweets

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