Discover and read the best of Twitter Threads about #diabetes

Most recents (24)

"Digital Orthodoxy," aka Deep Phenotyping or High-dimensional human data, is a great research tool w/ many proven advances, but has NO commercial/clinical validation and may be harmful
thelancet.com/journals/lance…
Our latest @TheLancet Digital Medicine essay
@EvanMuse @ScrippsRTI
@TheLancet @EvanMuse @ScrippsRTI The multi-modal testing may someday be validated to benefit, but until that time we raise concerns about the practice, ethics and safety for companies to be charging individuals for such data accumulation.
@TheLancet @EvanMuse @ScrippsRTI In @TheLancet essay we briefly touched on advances that deep phenotyping of people has made in biomedical research. I'm going to briefly review 5
1. Pre-diabetes-> #diabetes
2. Individualized diet
3. Colon #cancer+ microbiome
4. Gut #metagenomics sequence Δ
5. Tumor microbiome
Read 8 tweets
We all know someone suffering from:

Cancer
Diabetes
Lung disease
Heart diseases
Stroke

These noncommunicable diseases are the 🌍's biggest killers, responsible for 7 out of every 10 deaths worldwide.

We need your help to #BeatNCDs!
Tobacco. 🚬
Alcohol. 🍻
Air pollution. 🏭
Unhealthy diet. 🍔
Physical inactivity. 🛋️

These are the main NCDs risks.

Let's STOP them.
Let's #BeatNCDs.
@pahowho @WHOWPRO @WHOSEARO @WHOEMRO @WHO_Europe @WHOAFRO Noncommunicable diseases kill 41 million people prematurely every year, many of them in the prime of life.

41 MILLION lives.
41 MILLION families affected.

But we could save nearly 10 million lives by 2025. Let's #BeatNCDs
Read 13 tweets
01. #BlackoutInfo
Was für Folgen hat ein landes- oder noch schlimmer, europaweiter, länger als 72 Stunden dauernder #Blackout, also #Stromausfall, in unserer zu 100% von #Strom abhängigen Gesellschaft? Wie ist der #Staat darauf vorbereitet? Wie engagiert sich unsere #Politik?
02. #BlackoutInfo
Innerhalb weniger Stunden nach einem landesweiten #Blackout wird bei 90% der Haushalte kein Wasser mehr aus der Leitung kommen. Auch die Toilettenspülung funktioniert nicht mehr, so daß in Ballungsräumen sehr schnell massive Probleme & Seuchengefahren entstehen.
03. #BlackoutInfo
In der Folge eines landesweiten #Blackout ist die Lebensmittelproduktion nicht mehr möglich. Noch vorhandene Vorräte zu verteilen wird immer schwieriger bis unmöglich. Logistikfirmen stellen Lieferungen sofort ein, da die automatisierten Lager offline sind.
Read 54 tweets
Ayer se publicó en numerosos medios el caso de una mujer joven que ha fallecido aparentemento por consumo de un complemento alimenticio que contenía ácido #lipoico. #quemagrasas #hilo elpais.com/sociedad/2019/…
En la >ría de los medios se hablaba del uso de ácido #lipoico en complementos por su acción #quemagrasas.
Por supuesto, el término #quemagrasas no está caracterizado desde el punto de vista científico ni legal.
Es simplemente un reclamo que el consumidor identifica inmediatamente como #adelgazante. #lipoico
Read 28 tweets
#NationalDiabetesWeek we heard from @DiannaMagliano during 2002-2013, there was 6 times more likely progression of diabetes to kidney failure in Aboriginal and Torres Strait Islander people.
We know from #eGFRstudy led by Maple-Brown @MenziesResearch, the annual decline in kidney function is 3 times than expected for healthy aging. Having diabetes was a strong indicator of loss of kidney function #NationalDiabetesWeek
We know acute kidney injury is a potentially modifiable risk of loss of kidney function. In the NT, infections and heart disease were key contributors to AKI and needing to start dialysis #NationalDiabetesWeek
Read 12 tweets
The human gut #microbiome never ceases to amaze me. Now a discovery of a bacterium that coverts Type A or B blood to type O, with big implications for blood transfusion.
nature.com/articles/s4156… @NatureMicrobiol by @PRahfeld Steven Withers and colleagues @UBC
Our gut #microbiome is a treasure for discovery. More coming out on this later this week that is mind-blowing.
BTW, another example of a striking finding that has not garnered coverage by any media. Surprising, in light of the public's interest in science.
Read 5 tweets
Summary of results from iDCL trial of Tandem/Dexcom hybrid-closed loop system at #ADA2019
Included: 14 yrs and older, T1D > 1 yr
Minimal entry restrictions
170 subjects enrolled: Closed loop (112 ppl), sensor-augmented pump (56 ppl) #diabetes #t1d #closedloop
Subject characteristics: 33 years old; A1c 7.4% baseline; 20-25% MDI; 70% current CGM user;
Median diabetes duration 15 yrs
Outcomes:
100% of people completed study
Time in range increased 11% (to 71% in closed loop group); A1c decreased -0.33%; Mean glucose decreased 13 mg/dL;
Participants used CGM 97% time; 92% time with closed loop active.
Read 4 tweets
The 1st drug (a monoclonal antibody) to delay onset of autoimmune #diabetes in high risk individuals (by ~ 2 years)
nejm.org/doi/full/10.10… #ADA2019 @NEJM #T1D @T1D_Trialnet
"The results of this trial are striking, with several caveats."
A long road that has taken 40 years. And still just a start to prevention.
Exciting, nonetheless.
nejm.org/doi/full/10.10… @NEJM editorial #ADA2019
by @clifford_rosen and @ingelfinger
'Herold procrastinated when it came time to analyze the data. “I kept pushing it off,” he says, because he worried about failure.'
Some interesting backstory to this major milestone trial
@sciencemagazine sciencemag.org/news/2019/06/m… by @jcouzin
Read 3 tweets
I don’t speak in hyperbole very often, and I want to make sure that you all understand what a big deal this is for the diabetes DIY community. Everything that we’ve worked for for the last 20 years, it all changes now. #WeAreNotWaiting
Every diabetic engineer every, the day after they were diagnosed, tries to solve their (or their loved one's) diabetes with open software and open hardware. Every one. I did it in the early 90s. Someone diagnosed today will do this tomorrow. Every time.
I tried to send my blood sugar to the cloud from a PalmPilot. Every #diabetes person ever does this. Has done this. Then @NightscoutProj happened and #WeAreNotWaiting happened and we shared code and now we sit on the shoulders of people who GAVE THEIR IDEAS TO USE FOR FREE
Read 14 tweets
1/ It's all scaremongering isn't it about #brexit and #drugs? Stockpiling, price hikes, and, as @MattHancock warns, dead patients. Well, here's the lowdown and it's not pretty. With or without #softbrexit.
A thread
2/ Patients with long-term conditions such as #diabetes, #asthma or #schizophrenia, #blood pressure, #heart problems or #cancer down to daily medicines for #rashes and skin problems, take for granted that they will be able to get their medicines when they need them.
3/ According the UK's Business, Energy and Industrial Strategy
Committee publications.parliament.uk/pa/cm201719/cm…
73 per cent of pharmaceutical imports in the UK come from the EU. This equates to around 37 million packets of medicines every month from the EU worth £18.3 billion.
Read 19 tweets
AI has met a fork in the road; which path will dominate?

While pure #AI, or open API, will soon allow #robots to become more human-like, pragmatic AI is alive well today and driving true business transformation

infoworld.com/article/322128…
Charlie Rose interviews…a robot?

What happens when Charlie Rose attempts to interview a #robot named "#Sophia" for his 60 Minutes report on #ArtificialIntelligence (#AI)

cbsnews.com/news/60-minute…
#ArtificialIntelligence positioned to be a game-changer

It might not be long before machines begin thinking for themselves -- creatively, independently, and sometimes with better judgment than a human

cbsnews.com/news/artificia…
Read 15 tweets
My journey👉🏼of FDA interfering w/ my treatment 4 #MultipleSclerosis "WHEN NO OPTION IS NOT AN ACCEPTABLE OPTION!" #Ortho #cardiac #COPD #Autism #Parkinsons #Cancer

cellr4.org/article/390
Bloomberg @business interviews Celltex patients about experience w/ FDA shutting down adult #stemcell study we in. #MS #Arthritisw #Parkinsons #COPD #Ortho
bloomberg.com/news/articles/…
When left with no viable medical options, what do you do?👉🏼We reached out to other "No Option Patients" and formed PATIENTS FOR STEM STEMCELLS
#MS #PARKINSONS #Autism #COPD #arthritis #ortho #cancer #cardiac patientsforstemcells.org/home/
Read 13 tweets
I am scheduled for my 3rd surgery since December on Thursday.
Please do me a favor and promise to call your reps and senators and tell them you support and need the #ACA/#Obamacare and they only have your vote if they reject Trump's efforts to kill it.
Here's a thread on why:
1/
Many Americans think the #ACA/#Obamacare is insurance.
It is not.
The #ACA is a law governing insurance companies & forcing them to cover women & people with #PreExistingConditions.
The #ACA also says women cannot be forced to pay more than men for insurance.
#ProtectOurCare
2/
The #ACA/#Obamacare also provides for children 26 and under to be covered under their parents' insurance plans.
The ACA also created the healthcare marketplace, which provides tax subsidies for those unable to pay full-price for health insurance.
#ProtectOurCare
3/
Read 13 tweets
This was always going to be a packed out session (even at 5pm!): how we can use c-peptide measurements to improve the diagnosis of #diabetes
#DUKPC
What's c-peptide? It's a molecule we make during the process of producing insulin. So it can be used to look at how much insulin you produce: people with #Type1diabetes have very very low c-peptide levels, while people with #Type2diabetes have higher levels.
#DUKPC
This means a c-peptide measurement can differentiate between #Type1diabetes & #Type2diabetes. But how? In the past, tests were expensive & inaccurate. The #ExeterDiabetes team changed this...
#DUKPC
Read 12 tweets
Really looking forward to this one: precision medicine. It’s all about tailoring treatments for the individual and moving away from a one size fits all approach. #dukpc
.@markmccarthyoxf explains precision medicine could help us answers questions like:
Who is at greatest risk of #diabetes?
Who will respond best to different treatments?
Who will progress quickly or slowly?
#dukpc
Looking at people’s genetic information can help us spot who is at highest risk of #Type2diabetes. There are lots of outstanding questions about these genetic risk scores, but the future potential is exciting. #dukpc
Read 15 tweets
We’re now switching gears to technology. The room is packed to the rafters as we hear from people with #diabetes who’ve made use of the tech available to build their own artificial pancreas, otherwise known as DIY looping. #dukpc
DIY looping lets your CGM talk to your insulin pump. We think there are around 300 loopers in the UK. And they’re getting great results: more time in target and less hypos. #dukpc
Message from the DIY loop community to healthcare professionals: we’re not going to stop doing it, so you need to be equipped to support us. #dukpc
Read 6 tweets
Day 2 is off with a bang! @MaggieShepher13 has been awarded the Arnold Bloom lecture for her outstanding contributions to monogenic #diabetes care. She starts by thanking @DiabetesUK for supporting her right at the start of her career. #dukpc
Monogenic diabetes are rare forms caused by a change in a single gene. Maggie realised these genetic types of #diabetes weren’t being diagnosed properly and made it her mission to change that. #dukpc
Maggie describes the absolutely life-changing impact getting the right diagnosis can have. Many of her patients were able to come off insulin and be treated with tablets instead. #dukpc
Read 9 tweets
#BlackoutInfo Was für Folgen hat ein landes- oder noch schlimmer, europaweiter, länger als 72 Stunden dauernder #Blackout, also #Stromausfall, in unserer zu 100% von Strom abhängigen Gesellschaft? Wie ist unser Staat darauf vorbereitet? Und wie engagieren sich unserer #Politiker?
#BlackoutInfo Innerhalb weniger Stunden nach einem landesweiten #Blackout wird bei 90% der Haushalte kein Wasser mehr aus der Leitung kommen. Auch die Toilettenspülung funktioniert nicht mehr, so daß in Ballungsräumen massive Probleme und Seuchengefahren entstehen.
#BlackoutInfo In der Folge eines landesweiten #Blackout ist die Lebensmittelproduktion nicht mehr möglich. Noch vorhandene Vorräte zu verteilen wird immer schwieriger bis unmöglich. Logistikfirmen stellen Lieferungen sofort ein, da die automatisierten Lager offline sind.
Read 32 tweets
1/15

For my first #Tweetorial, I will start with a question:

Which of the following medications from the SGLT2 inhibitor class have been shown to decrease cardiovascular morbidity and mortality?

#Diabetes #EndoTwitter #MedEd #MedTwitter #DM2 #T2D #CardioTwitter
2/15

Sodium glucose transporters (SGLT) in proximal tubules mediate glucose reabsorption.

How?
Na/K ATPase moves Na out & K into the cell ➡️gradient for Na to flow intracellular

SGLT uses this potential to move glucose against its gradient from the tubular fluid into the cell.
3/15

SGLT2 inhibitors block glucose reabsorption
➡️renal glucose excretion
➡️glucose levels⬇️

Because this has nothing to do with insulin, they usually don’t cause hypoglycemia or weight gain.

Actually, because of the osmotic diuresis, they decrease blood pressure & weight.
Read 15 tweets
I was recently asked 'how is the non-communicable disease #NCDs agenda going to ever get the same sort of money #HIVs did to achieve change?' I thought it was a very interesting question. Here are my thoughts, feel free to add/chime in/disagree #globalhealth #insulin4all 1/12
Everyone is trying to duplicate the #HIV movement without *actually* duplicating it. The sanitized history is that Bill Gates +Clinton + Bono got together and made HIV meds cheap. The real history is completely different cc @jamie_love @gregggonsalves theguardian.com/society/2016/j… 2/12
It was *patient* activism that turned the tide. It was groups like @actupny in the US or Treatment Action Campaign in South Africa, groups that could shut down the FDA or raise 10,000 people to march in Cape Town. It was not celebrity or academics 3/12
Read 12 tweets
As politicians are jockeying to save face with both their constituents and lobbyists, trading in the universally desired #MedicareForAll, for the #MedicareForMore slogan pushed by #neoliberals, I echo the words of my sister-in-arms @MuyMexi when I say the following; (1/X)
This should not be happening in the “greatest country in the world”. People should not be forced to choose between food and the table and insulin to treat their bodies for the food they are going to eat. #MedicareForAll removes that barrier for all people.
abc3340.com/news/abc-3340-…
I used to work for @Medtronic Diabetes Helpline, helping insulin patients troubleshoot their devices. One of the things I learned while working there is the extreme pain that #Diabetes patients have to subject themselves to, just to live a “Normal” life.
Read 9 tweets
Another true #DPC for the win story... Friday morning I saw a @MMMedCare patient at a school event. “I’m so glad to see you as I need to talk to you about my 5yo. For a month he has been complaining of increased thirst, so I checked his blood sugar an hour ago & it was 289!” 1/?
Child has no history of #diabetes & generally is in good health. Only other sxs -increased hunger & bed wetting. No vomiting, no confusion. Mom had checked own BS & a siblings & both were normal so it was unlikely machine error. Normally new, random BS of 289 =trip to ER
#DPC 2/?
We were at school to watch our children in a performance & her son appeared well. Still with a blood sugar of 289 after fasting all night, I knew he needed immediate follow-up so I said I should see him right after. As we left school his only complaint was “I’m hungry” #DPC 3/?
Read 9 tweets
The hearing begins now. Tune in bit.ly/2CJhEBw
Chairman Grassley calls for transparency in drug pricing!
Senator Wyden is disappointed in the pharmaceutical companies who have declined the invitation to attend today’s hearing. He is eager to work with the committee to get something done about the increased drug pricing.
Read 17 tweets
1,400 Canadians have died and 14,000 have been injured by faulty and unproven medical devices since 2008, by @jesse_mclean @TheCribby thestar.com/news/investiga… via @ICIJorg @torontostar #ImplantFiles
CBC takes you inside Health Canada's medical device records newsinteractives.cbc.ca/medical-device… via @cbchealth @MEDEC_Canada #ImplantFiles
'We're guinea pigs': Canada's oversight process for implanted medical devices stuns suffering patients, by @valerie_ouellet @VikCBC @mckiedavid cbc.ca/news/health/im… via @cbchealth #ImplantFiles
Read 24 tweets

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