Computational biologist. Professor @harvardmed, Institute Member @broadinstitute, Rheumatologist @BrighamWomens
Nov 13, 2020 • 7 tweets • 4 min read
Delighted to share our latest work on defining the effects of the HLA on an intermediate phenotype: the T cell repertoire with @Kazu_Ishigakimedrxiv.org/content/10.110…#genetics#type1diabetes#rheumatoidarthritis
HLA influence autoimmune risk. 2 non-exclusive hypotheses: i) the peripheral hypothesis, where HLA risk alleles increase binding to antigens ii) the central hypothesis, where HLA risk alleles influence thymic selection to select for antigen reactive T cell receptors (TCRs).
