1/ Alright #medtwitter and #askrenal, in honor of our CJASN publication "Associations of Opioid Prescriptions with Death and Hospitalization across the Spectrum of Estimated GFR," I'm attempting my first #tweetorial. Here's what you need to know about opioids in CKD. 2/ First of all, pain is common for people with kidney disease because of vascular disease, diabetic neuropathy, and pain syndromes unique to kidney patients like osteodystrophy and calciphylaxis. In fact, an estimated 58% of people with advanced CKD experience pain.