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Jun 16
Iran has suffered severe strategic degradation across its nuclear, military, and leadership structures following joint U.S.-Israeli strikes beginning in June 2025 and intensifying with Operation Epic Fury in February 2026.
1)
Its nuclear enrichment program was obliterated, with facilities like Fordow and Natanz in ruins, entrances buried in cement, and a generation of senior nuclear scientists eliminated; as of March 2026, no efforts to rebuild enrichment capabilities have been detected.
2)
Iran's conventional military forces have been decimated: the U.S. claims over 90% of Iran's navy has been sunk, its air force is effectively gone, and approximately 80% of its air defense systems destroyed.
3)
Read 7 tweets
Jun 16
The great General John M. "Jack" Keane is officially retired and completed 37 years of active military service and officially retired from the U.S. Army in December 2003.
1)
His final post was as the Vice Chief of Staff of the Army, a four-star position he held from 1999 to 2003, during which he also served as the acting Chief of Staff.
2)
Since his retirement, he has remained
highly active in the private and public sectors as a prominent national security analyst and strategist. He currently serves as the Chairman of the Institute for the Study of War (ISW) and
3)
Read 14 tweets
Jun 16
Always remember that the kynurenine pathway is crucial in autoimmune diseases.

So it's also crucial for alopecia aerata.

A highly active immune system triggers the enzyme indoleamine 2,3-dioxygenase (IDO), which drives the breakdown of tryptophan into kynurenine metabolites.

Normally, healthy hair follicles possess "immune privilege," meaning they are shielded from immune system attacks.

In conditions like alopecia areata, the dysregulated kynurenine-AhR (aryl hydrocarbon receptor) axis compromises this shield, allowing immune cells (like T-cells) to attack the follicle.

Now in case you have zero clue what the kynurenine pathway is, here's a qucik thread.Image
The kynurenine pathway is the main metabolic route for breaking down tryptophan, accounting for about 95% of its catabolism (the rest goes to serotonin/melatonin or minor indole pathways).

You might think that this sounds extremely boring, but what if i told you that this pathway is so important that ketamine’s rapid antidepressant effects in treatment-resistant depression are greatly linked to its influence on the kynurenine pathway (the references are presented at the end as always)?

It produces a series of intermediate metabolites collectively called kynurenines with diverse biological effects (some are neuroprotective/anti-inflammatory, while others are neurotoxic/pro-inflammatory), with the end goal being the de novo production of nicotinamide adenine dinucleotide (NAD+).Image
Now the kynurenine pathway begins with the conversion of tryptophan to kynurenine (KYN), the rate-limiting first step that commits most tryptophan to this metabolic route rather than serotonin or melatonin production.

This conversion is catalyzed by two main enzymes:

-Indoleamine 2,3-dioxygenase 1 (IDO1)
and
-Tryptophan 2,3-dioxygenase (TDO) (also known as TDO2)

These enzymes perform the same biochemical reaction, which is oxidizing the indole ring of tryptophan using molecular oxygen to produce N-formylkynurenine, which is quickly deformylated to kynurenine.

That being said, they differ significantly in traits such as location, regulation and expression.Image
Read 15 tweets
Jun 16
Geeeeeezus my poor amazing LangleyRCMP I am sooooo sooooooo sorry you had to deal with the constant harassment and abuse from Kari Simpson & Donald Smith today ☹️☹️☹️☹️☹️☹️☹️☹️☹️☹️☹️☹️☹️☹️
@SurreyRCMP @surreyps @LangleyRCMP

@ChrisPentecos @Nncim15 @Ilovecanada13 @HarperMonste @BarbaraDoduk @Cdnwatcher @Istandtoreason @facepalmchris @trustednerd @MalaMoragain13 @felixcruggins @CultureGuard @WaxMyBallsShow @FranLa9 @kfurneaux23 @VernThurston @DerpyDooMemes
@SurreyRCMP @surreyps @LangleyRCMP @ChrisPentecos @Nncim15 @Ilovecanada13 @HarperMonste @BarbaraDoduk @Cdnwatcher @Istandtoreason @facepalmchris @trustednerd @MalaMoragain13 @felixcruggins @CultureGuard @WaxMyBallsShow @FranLa9 @kfurneaux23 @VernThurston @DerpyDooMemes @threadreaderapp unroll
Read 3 tweets
Jun 16
——
#Books #GreatReads #Excerpts “Ultimate Journey by Robert Monroe”

🧵Chapter 2

The Long, Long Trail

Throughout history, labels have been developed for those
who won't leave well enough alone: infidels, mystics, sinners,
rebels, revolutionaries, misfits, neurotics, anarchists, adven¬
turers, traitors, explorers, visionaries, researchers—add to the
list what you will. Any deviation from the accepted norm
engenders risk. All of these individuals have been for the most
part aware of the risk. If they were not, ignorance was no
excuse. If there was a price to be paid in reaction or effect,
they must or should have known about it before they
took action. No sad tears for the wounded or the dead in
such cases. I know this well, and you may discover it for
yourself.

So it must be said: the Different Overview you are beginning to consider can be at most only a belief until you begin to
test it for validity within your own ongoing experience during
your life as an active Human Mind. As small beliefs convert to
Knowns, perhaps larger Different Overview beliefs will follow
the same path—until you are free.

From this point on, the delivery of a personal narrative
seems the most convenient and definitive method of explana¬
tion. What to me are Knowns can produce only beliefs in you
unless you have had or are having similar experiences that
demand verification. Let me therefore attempt to tell it "like it is" for me, allowing you to form your own beliefs which
experience may in time convert to Knowns.

In my personal run, thirty-plus years of out-of-body ac¬
tivity had brought me to a calm state of satisfaction. A cycle
has been completed, or so it seemed. My own Different Over¬
view was well in place and eminently rewarding. Or it should
have been.

I knew where I came from, how I got here and became a human, why I hung around, my final departure schedule, and
where I would go when I left. What else could have had any
importance? Anything else was mere detail.
Image
And there was my INSPEC friend.

It was one thing to talk with such mind-consciousness in
sessions in a laboratory, as simply a voice speaking through
someone physical that you knew well. It was something quite
different to encounter one face to face. Either in fun or fact,
we had chosen the acronym INSPEC (for Intelligent Species)
to identify this energy form, which implied that we Human
Minds were something less.

But this INSPEC was not the same as those I had previously met. Over the years I had experienced many nonphysical meetings, communication and rapport with those who
were obviously very human, those who still possessed a physical body, and otherwise. This INSPEC, however, was different.

Our usual meeting place was just past the H Band Noise.
The H Band Noise is the peak of uncontrolled thought that
emanates from all living forms on Earth, particularly humans.
If you consider it as truly all, even in a current time frame, you
get a better idea of the magnitude of this disorganized,
cacophonous mass of messy energy. The amplitude of each segment of the band is determined by the emotion involved in the thought. Yet our civilization does not even recognize that the H Band exists.

My impression is that it contains not only current time
thought patterns, but all that ever existed. They are con¬
tinuous and simultaneous, and it may be that the older radia¬
tion is layered over so all one perceives is the current emis¬
sion.
To study it objectively, if one is so foolhardy, as to want
to do so, all one needs do is move to that state of disassociation just beyond the last vestiges of any direct Earth-related
Human Mind activity in the nonphysical There. It appears
much like a reflective layer, beyond which the effects diminish rapidly. Passing through it quickly is advisable, just as
one would try to work through a screaming, angry mob—for
that is what it sounds like, in a multitude of accents and
tongues.

Now back to my INSPEC friend. Here is an excerpt from
one of our earlier meetings when I had phased out of my body
and moved to a point just beyond the H Band.
I wonder if this being understands how strong his or her light
is. Could it be an E.T. (extraterrestrial) after all?

You will become accustomed to the light. You have the same
radiation to us . . . and we are not the extraterrestrials as
you mean it.

You read what I am thinking?

That is true. Just as you can with me.

I can?

You are doing it now in part, but only the surface part.

Yes, you are right. It is certainly not words and sounds . . .
no air to vibrate . . . but simply in the mind . . . yes.

What you call the core self does remember.

You know, I do remember ... I remember you . . . the
feel of you . . .

It is good that you do not express fear. We can do much when
that barrier is removed.

Oh,I have a few fears left . . .

But they do not rule your perception. For example, why are
you not filled with fear at this moment?

I don't know. But I'm not afraid. That's true. Right at this
moment I am here, talking with you in a rational way . . .
with you, someone who is very familiar to me ... a brightly
glowing figure that some people would interpret as a god, an angel, or at the very least some extraterrestrial. Yet we are
here talking just like two ordinary people . . . except that we are not using words!

The difference is the lack of fear.

There is so much potential . . . Who are you actually? Or
maybe I should say. What are you? Now I do have the courage to ask.

It is beyond your experience to understand at this time. But
you will understand, and very soon.

Can we meet again?

All you need do is ask for our help.

You mean meditating? Saying prayers?

The words and rituals are meaningless. It is the thought . . .the emotion . . . that is the signal. If the proper signal is given, we are able to help.

Let me be sure of this. You are not the god ... a god . . . but perhaps someone from another planet?

No, not from another planet.

Are you the one, or one of those who may have created us
. . . the Earth?

No. We are sorry to disappoint you. But we can give you what
we have in regard to the creative process. Do you desire it?

Why, yes. Yes!

This is what we have . . .

I was filled, almost overcome, with a surge of enormous energy, an immensely powerful vibration of very high frequency.
This I knew as a ROTE, short for Related Organized Thought
Energy, a sort of ball of condensed thought and ideas.

It is so much! I can't understand it all at once . . .

You will, when you can examine it at leisure.

Thank you.

There was a pause before the INSPEC communicated again.

You are uncertain as to your progress, your growth.

I am uncertain, that's true. I think I know my goal, my purpose. The uncertainty is what lies in between.

What do you perceive as your goal?

Well ... I guess . . . service to humankind.

That is indeed a noble goal. It is the ever-present desire of
your human self to attain perfection. When you are no longer
human, desire focuses in another direction. But there are
other goals.

A desire more important? No, I don't mean that ... a desire
different from the human experience?

You are doing very well.

I often wonder about that.

You will find an answer . . . Now I perceive you need to
return to your physical body.
Read 4 tweets
Jun 16
I am 99% positive I won't be walking tonight and if I do go out there I am just going to be sitting here for a couple of hours we shall see when 10:30pm comes around LMFAO...... If I don't have a fantastic night and fantastic shifts my cops ♥️♥️🥰🥰♥️♥️
@SurreyRCMP @surreyps @LangleyRCMP

@ChrisPentecos @Nncim15 @Ilovecanada13 @HarperMonste @BarbaraDoduk @Cdnwatcher @Istandtoreason @facepalmchris @trustednerd @MalaMoragain13 @felixcruggins @CultureGuard @WaxMyBallsShow @FranLa9 @kfurneaux23 @VernThurston @DerpyDooMemes Image
@SurreyRCMP @surreyps @LangleyRCMP @ChrisPentecos @Nncim15 @Ilovecanada13 @HarperMonste @BarbaraDoduk @Cdnwatcher @Istandtoreason @facepalmchris @trustednerd @MalaMoragain13 @felixcruggins @CultureGuard @WaxMyBallsShow @FranLa9 @kfurneaux23 @VernThurston @DerpyDooMemes @threadreaderapp unroll
Read 3 tweets
Jun 16
@facepalmchris Get a gawd damn life
@facepalmchris @ChrisPentecos @Nncim15 @Ilovecanada13 @HarperMonste @BarbaraDoduk @RegretlessBee @Cdnwatcher @Istandtoreason @facepalmchris @trustednerd @MalaMoragain13 @felixcruggins @CultureGuard @WaxMyBallsShow @FranLa9 @kfurneaux23 @VernThurston @DerpyDooMemes
@facepalmchris @ChrisPentecos @Nncim15 @Ilovecanada13 @HarperMonste @BarbaraDoduk @RegretlessBee @Cdnwatcher @Istandtoreason @trustednerd @MalaMoragain13 @felixcruggins @CultureGuard @WaxMyBallsShow @FranLa9 @kfurneaux23 @VernThurston @DerpyDooMemes @threadreaderapp unroll
Read 3 tweets
Jun 16
New today: Peter Thiel's secret society of illuminati had a website so insecure it exposed his entire membership list. And it's... interesting. His Palatantir folks, sure. Leonard Leo. The president of Stanford. Ezra Klein. And some D politicians who really shouldn't be there. 1/
Going to post the membership list in chunks. It's tech-fascists and fake-centrist pundits and Silicon Valley business guys and health wackos like Peter Attia and Trump toadies like Scott Bessent and a few arts folks and then.. Cory Booker? 2/ Image
Dan Driscoll, our SecArmy, is JD Vance's friend from Yale tasked with giving your tax dollars to Peter Thiel's friends with defense startups. Pundit Sam Harris, no surprise. Rob Hur was the Special Counsel who wrote a hit-piece biased report on Joe Biden. 3/ Image
Read 8 tweets
Jun 16
This also describes Arizona saloons. Though I guess they frequently have a food truck as the 'kitchen', but if all you want is free salty snacks there's that too.

I am literally inside one right now lol
Anyway the best chicken burrito I've ever had in my life was from a food truck in the parking lot of a Cottonwood saloon!! No kidding.
Now this is a state-by-state thing. Saloons aren't legal in every state. In Virginia, you have to both serve food from a kitchen and get a certain percentage of sales from food if you serve booze* but they are many in which this is not the case.
Read 6 tweets
Jun 15
Cognitive Load Theory is one of the most useful frameworks in education. It tells us that working memory is limited, that extraneous complexity impedes learning, that beginners and experts have different instructional needs.

All of that is true.

But it's only ¼ of the story.🧵
CLT is a theory of interference: it tells us what prevents learning.

What it doesn't tell us - and was never designed to tell us - is what produces learning in the first place.

These are different questions.

And the first tells us very little about the second.
What produces durable learning - the kind that connects, transfers, and lasts - turns out to be a specific set of biological mechanisms: attention, active generation of knowledge, error feedback, and consolidation.

These are Dehaene's four pillars of learning.

CLT only tells us about one of them.
Read 12 tweets
Jun 15
The White House denied Iranian state media's claim of a draft MOU for peace negotiations

A statement on X (Twitter) declared: "This report from Iranian-controlled media is false, and the MOU they 'released' is entirely fabricated.
1)
No one should trust the information disseminated by Iranian state media. FACTS MATTER."

The purported document indicated the U.S. would remove its naval blockade on Iranian ports and withdraw troops near Iran
2)
In return, Iran would restore commercial shipping through the Strait of Hormuz to pre-war levels within a month

A senior official noted the MOU allows the U.S. 60 days to finalize an agreement and obligates Iran to "give up the nuclear dust"
3)
Read 8 tweets
Jun 15
You're exhausted.

You're reading more. Praying more. Serving more.

And somehow feeling further from God than ever.

Here's what nobody told you:

Trying harder is not the answer.

Jesus explained the entire secret of the Christian life in one sentence in John 15.

And it has nothing to do with effort.

A thread. 🧵Image
Most Christians live like this:

Wake up → try to be more patient
Fail → feel guilty
Try harder → fail again
Read more → still feel empty
Serve more → burn out
Wonder why God feels distant

Sound familiar?

This cycle has a name. It's called striving.

And Jesus never asked you to do it.

In fact, John 15 is His direct answer to striving.

He didn't say "try harder." He said, "Stay closer."

Those are not the same thing.
John 15:5 — the most liberating and most terrifying verse in the chapter:

"Whoever abides in me and I in him, he it is that bears much fruit."

Then:

"Apart from me, you can do nothing."

Not a little fruit.
Not smaller fruit.
Not less impressive fruit.

Nothing.

This means every moment you spend striving in your own strength, every self-generated effort to be holier, kinder, more disciplined, produces exactly nothing of eternal value.

Zero.
Not because you're lazy.
Because you're disconnected.Image
Read 11 tweets

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