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@7SEES_ Your followers may want to see the rest of this as well, just a cherry on top. 
@7SEES_ Who funded & established XTEND?
@7SEES_ I think this is a big enough cherry for a sundae.
Finally out! Miriam's (@miriamppol) 1st, 1st author article!
It came out for the international day of women in science! Miriam is one of my first PhD students co-supervised with @Alfons_Valencia!
1st last author paper as a group leader! ๐ฅน
Thread๐งต doi.org/10.64898/2026.โฆ
It came out for the international day of women in science! Miriam is one of my first PhD students co-supervised with @Alfons_Valencia!
1st last author paper as a group leader! ๐ฅน
Thread๐งต doi.org/10.64898/2026.โฆ
We had a fundamental question that Burkhard Rost has addressed decades ago!
How large is the sequence attractor of a given protein fold?
Which positions can be varied in sequence so that the fold does not care and which ones are not changeable?
(+)
How large is the sequence attractor of a given protein fold?
Which positions can be varied in sequence so that the fold does not care and which ones are not changeable?
(+)
Using reverse-folding algorithms (ProteinMPNN, Caliby) + structure prediction + local frustration analysis,
we redesigned sequences for fixed backbones.
We used FrustraEvo to analyse:
Which positions are free to vary and which are energetically constrained?
(+)
we redesigned sequences for fixed backbones.
We used FrustraEvo to analyse:
Which positions are free to vary and which are energetically constrained?
(+)
๐จNEW: The FBI has released records on Thomas Crooks. Heavily redacted, they do show that he was hospitalized just 2 months before the July 2024 Trump assassination attempt in Butler, PA.
There are a few other revelations in these records, too.
๐งต
There are a few other revelations in these records, too.
๐งต
Perhaps even more interestingly, someone told the FBI that they were nearly hit by a car speeding away about 5 minutes after shots were fired.
For reasons that are unclear, FBI agents were interested in tracking down someone whose name appeared on a business card left at the scene.
Unclear if this person was even there. The FBI didn't interview this person as of the drafting of this report.
Unclear if this person was even there. The FBI didn't interview this person as of the drafting of this report.
1/๐งต Breaking analysis from @guardian:
Epstein Files describe a pattern of behavior around Kimbal Musk and the Tesla/SpaceX world that raise serious natsec and corruption concerns.
Epstein Files describe a pattern of behavior around Kimbal Musk and the Tesla/SpaceX world that raise serious natsec and corruption concerns.
2/๐ฉ The behavior described looks very similar to how powerful people are identified, studied, and slowly drawn into compromising relationshipsโ
Especially through their close friends and family.
Especially through their close friends and family.
3/๐ฉ Warning signs can include the use of controlled romantic or sexual partners, mixing social access with business opportunities, and maintaining close contact with a known predator.
@BBCBreaking @Shayan86 1).
โDeputy Commissioner Dwayne McDonald, commander of the Royal Canadian Mounted Police in B.C. said Jesse Van Rootselaar, a biological male who began to identify as female six years ago, had first killed her mother, 39, and 11-year-old step-brother at the family home.
โDeputy Commissioner Dwayne McDonald, commander of the Royal Canadian Mounted Police in B.C. said Jesse Van Rootselaar, a biological male who began to identify as female six years ago, had first killed her mother, 39, and 11-year-old step-brother at the family home.
@BBCBreaking @Shayan86 2).
Van Rootselaar then went to the school and shot a 39-year-old woman teacher as well as three 12-year-old female students and two male students, one aged 12 and one aged 13.โ
Van Rootselaar then went to the school and shot a 39-year-old woman teacher as well as three 12-year-old female students and two male students, one aged 12 and one aged 13.โ
@BBCBreaking @Shayan86 3).
๐ฟ๐๐ ๐พ๐๐๐๐๐ ๐ธ๐๐๐๐๐๐ ๐ณ๐๐๐๐๐ (@smh) Feb. 12, 2026 archive.ph/Bffyo
@PBS Feb. 11, 2026 pbs.org/newshour/worldโฆ
@SkyNews Feb. 11, 2026 youtu.be/AsqEHV6EPJ4
๐ฟ๐๐ ๐พ๐๐๐๐๐ ๐ธ๐๐๐๐๐๐ ๐ณ๐๐๐๐๐ (@smh) Feb. 12, 2026 archive.ph/Bffyo
@PBS Feb. 11, 2026 pbs.org/newshour/worldโฆ
@SkyNews Feb. 11, 2026 youtu.be/AsqEHV6EPJ4
Few musicians have had such a strong influence on others as Chuck Berry. The Beatles, The Stones, The Who, The Kinks, Eric Clapton, Jeff Beck ... and those were all on the other side of the Atlantic.
In the US, Dylan called him "the Shakespeare of rock-'n'-roll" - no small words coming from The Bard. Such different acts as Springsteen, Billy Joel, Lou Reed, Linda Ronstadt, Steely Dan, The Eagles, Green Day all were influenced by him. Punks revered his stripped-down approach.
Keith Richards, not exactly given to emotional statements, called Berry's death "a blow to the gut" and said "one of my lights has gone out".
Let the music do the talking:
Let the music do the talking:
A new study in Frontiers in Medicine analyzed 959 hospitalized COVID-19 patients (pre-vaccination).
It shows that T cell counts at admission strongly predict severe outcomes and mortality.
This isnโt just about inflammation - adaptive immunity is central๐งต
It shows that T cell counts at admission strongly predict severe outcomes and mortality.
This isnโt just about inflammation - adaptive immunity is central๐งต
Patients with CD3 T cells โค 666/mmยณ had
2.3ร higher risk of needing ventilatory support
2.4ร higher risk of in-hospital death
CD4 โค 359/mmยณ was associated with
2.8ร higher risk of death
These associations remained independent after adjustment.
2.3ร higher risk of needing ventilatory support
2.4ร higher risk of in-hospital death
CD4 โค 359/mmยณ was associated with
2.8ร higher risk of death
These associations remained independent after adjustment.
The study supports a model in which
T-cell responses (especially CD3/CD4) are weakened
Adaptive immunity fails to adequately control the virus
The body compensates through hyperactivation of innate immunity
The result is severe disease
T-cell responses (especially CD3/CD4) are weakened
Adaptive immunity fails to adequately control the virus
The body compensates through hyperactivation of innate immunity
The result is severe disease
$1.1B flowed from the state budget into the pockets of ministers, police generals and judges. Now Russia claws it back.
Over 5โ7 years, authorities seized 100B rubles in corruption cases.
In total, the state grabbed 4T rubles ($44B) in assets. It sold only 8%. โโMoscow Times.1/
Over 5โ7 years, authorities seized 100B rubles in corruption cases.
In total, the state grabbed 4T rubles ($44B) in assets. It sold only 8%. โโMoscow Times.1/
Example: billionaireย Konstantin Strukov.
The state seized his gold company Yuzhuralzoloto. He had funded United Russia for years. Now he sits in pretrial detention. 2/
The state seized his gold company Yuzhuralzoloto. He had funded United Russia for years. Now he sits in pretrial detention. 2/
Mid-level officials fell too. Former Ural road chief Alexei Borisov owned: 19 land plots, 15 houses, 26 apartments, 40 commercial spaces. Authorities moved to confiscate them. 3/
Former CIA Director Petraeus: I said from the start Russia would not take Kyiv. Others predicted it would fall in 3โ5 days. Kyiv is a vast city with brave defenders.
It would be extremely hard to break in โ and Ukraineโs actions denied Russia the airfield north of the capital.1/
It would be extremely hard to break in โ and Ukraineโs actions denied Russia the airfield north of the capital.1/
Petraeus: The Budapest Memorandum was a major failure.
Ukraine gave up nuclear weapons in exchange for security assurances from the US, Russia, and the UK and those guarantees werenโt upheld. This is Ukraineโs war for independence โ a fight for its very survival.
2/
Ukraine gave up nuclear weapons in exchange for security assurances from the US, Russia, and the UK and those guarantees werenโt upheld. This is Ukraineโs war for independence โ a fight for its very survival.
2/
Petraeus: US sanctions are under Senate review.
If paired with the EUโs 19th package and continued military support, the pressure could be strong enough to push Putin toward a ceasefire by the end of the year.
3/
If paired with the EUโs 19th package and continued military support, the pressure could be strong enough to push Putin toward a ceasefire by the end of the year.
3/
Former CIA Director Petraeus: When about 20 drones violated Polish airspace, Warsaw didnโt call Brussels or Washington, it called Kyiv.
Ukraine is the most advanced in building a โdrone wall,โ showing how to defend vast front lines.
1/
Ukraine is the most advanced in building a โdrone wall,โ showing how to defend vast front lines.
1/
Petraeus: I donโt think Russia will move against a NATO country until it achieves its aims in Ukraine โ and likely takes Moldova next.
Russian troops remain in Transnistria. After that, a Baltic state, possibly Lithuania, could be targeted.
2X
Russian troops remain in Transnistria. After that, a Baltic state, possibly Lithuania, could be targeted.
2X
Source:
@jkbjournalist @Shayan86 1).
โJulie K. Brown has been credited with re-opening the Jeffrey Epstein sexual abuse case with a series of reports published in Nov. 2018 [1] [2] [3] [4].
โJulie K. Brown has been credited with re-opening the Jeffrey Epstein sexual abuse case with a series of reports published in Nov. 2018 [1] [2] [3] [4].
@jkbjournalist @Shayan86 2).
She began investigating Epstein in early 2017 and persisted in uncovering facts about the large number of accusers and the pressure campaign to silence them [5] [6].
She began investigating Epstein in early 2017 and persisted in uncovering facts about the large number of accusers and the pressure campaign to silence them [5] [6].
@jkbjournalist @Shayan86 3).
Brown uncovered 80 potential victims (as young as 13 and 14 years old when the abuse occurred) and documented the eight individuals who agreed to tell their stories [6].โ
Brown uncovered 80 potential victims (as young as 13 and 14 years old when the abuse occurred) and documented the eight individuals who agreed to tell their stories [6].โ
1/ Russian warbloggers are continuing to provide examples of how Telegram is used for frontline battlefield communications, to refute the claim of presidential spokesman Dmitri Peskov that such a thing is "not possible to imagine". โฌ๏ธ
2/ Platon Mamadov provides two detailed examples:
"Example number one:
Aerial reconnaissance of Unit N spotted a Ukrainian self-propelled gun in a shelter in the middle of town N."
"Example number one:
Aerial reconnaissance of Unit N spotted a Ukrainian self-propelled gun in a shelter in the middle of town N."
3/ "Five minutes after the discovery, the target's coordinates and a detailed video were uploaded to a special secret chat group read by all drone operators, scouts, and artillerymen in that sector of the front.
