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A COVID infection can lower or dysregulate estrogen by directly stressing or damaging the ovary & uterine lining, disrupting brain–ovary signaling, & driving chronic inflammation that pushes the body toward a low‑estrogen, perimenopause‑like state.
Key mechanisms:
- Ovarian stress or injury
- Ovaries express ACE2 & other SARS‑CoV‑2 entry factors, so infection & the associated immune response can impair follicles that produce estradiol.
- Case reports describe young women developing amenorrhea & premature ovarian insufficiency after COVID, with low estrogen & high FSH, suggesting impaired ovarian reserve after infection.
1/9
@elisaperego78 @NotOstriching Def not discussed enough. My estrogen went to 0 during acute infection.
Key mechanisms:
- Ovarian stress or injury
- Ovaries express ACE2 & other SARS‑CoV‑2 entry factors, so infection & the associated immune response can impair follicles that produce estradiol.
- Case reports describe young women developing amenorrhea & premature ovarian insufficiency after COVID, with low estrogen & high FSH, suggesting impaired ovarian reserve after infection.
1/9
@elisaperego78 @NotOstriching Def not discussed enough. My estrogen went to 0 during acute infection.
Hypothalamus–pituitary disruption:
•Estrogen production depends on brain signaling (GnRH → LH/FSH → ovary); severe infection, high fevers, and systemic inflammation can blunt this axis, temporarily reducing estrogen output & causing missed or irregular periods.
- This same axis disruption is seen in other critical illnesses, & COVID appears to follow that pattern in some people, especially with long‑lasting symptoms.
2/9
@VirusesImmunity
•Estrogen production depends on brain signaling (GnRH → LH/FSH → ovary); severe infection, high fevers, and systemic inflammation can blunt this axis, temporarily reducing estrogen output & causing missed or irregular periods.
- This same axis disruption is seen in other critical illnesses, & COVID appears to follow that pattern in some people, especially with long‑lasting symptoms.
2/9
@VirusesImmunity
Inflammation & immune–hormone crosstalk:
- Estrogen normally restrains excessive inflammation & modulates Th1/Th2 cytokines; low estrogen favors more pro‑inflammatory cytokines such as IL‑6 & TNF‑α.
- A strong or persistent inflammatory response to SARS‑CoV‑2 can therefore both result from low estrogen & further suppress normal ovarian function, creating a vicious cycle of inflammation & estrogen depletion.
4/9
@DavidJoffe64
- Estrogen normally restrains excessive inflammation & modulates Th1/Th2 cytokines; low estrogen favors more pro‑inflammatory cytokines such as IL‑6 & TNF‑α.
- A strong or persistent inflammatory response to SARS‑CoV‑2 can therefore both result from low estrogen & further suppress normal ovarian function, creating a vicious cycle of inflammation & estrogen depletion.
4/9
@DavidJoffe64
🧵Revelations Chapter 6 - First Seal: The Conqueror (King James)
6 Now I saw when the Lamb opened one of the seals; and I heard one of the four living creatures saying with a voice like thunder, “Come and see.” 2 And I looked, and behold, a white horse. He who sat on it had a bow; and a crown was given to him, and he went out conquering and to conquer.
Second Seal: Conflict on Earth
3 When He opened the second seal, I heard the second living creature saying, “Come and see.” 4 Another horse, fiery red, went out. And it was granted to the one who sat on it to take peace from the earth, and that people should kill one another; and there was given to him a great sword.
Third Seal: Scarcity on Earth
5 When He opened the third seal, I heard the third living creature say, “Come and see.” So I looked, and behold, a black horse, and he who sat on it had a pair of scales in his hand. 6 And I heard a voice in the midst of the four living creatures saying, “A quart of wheat for a denarius, and three quarts of barley for a denarius; and do not harm the oil and the wine.”
6 Now I saw when the Lamb opened one of the seals; and I heard one of the four living creatures saying with a voice like thunder, “Come and see.” 2 And I looked, and behold, a white horse. He who sat on it had a bow; and a crown was given to him, and he went out conquering and to conquer.
Second Seal: Conflict on Earth
3 When He opened the second seal, I heard the second living creature saying, “Come and see.” 4 Another horse, fiery red, went out. And it was granted to the one who sat on it to take peace from the earth, and that people should kill one another; and there was given to him a great sword.
Third Seal: Scarcity on Earth
5 When He opened the third seal, I heard the third living creature say, “Come and see.” So I looked, and behold, a black horse, and he who sat on it had a pair of scales in his hand. 6 And I heard a voice in the midst of the four living creatures saying, “A quart of wheat for a denarius, and three quarts of barley for a denarius; and do not harm the oil and the wine.”
Fourth Seal: Widespread Death on Earth
7 When He opened the fourth seal, I heard the voice of the fourth living creature saying, “Come and see.” 8 So I looked, and behold, a pale horse. And the name of him who sat on it was Death, and Hades followed with him. And power was given to them over a fourth of the earth, to kill with sword, with hunger, with death, and by the beasts of the earth.
Fifth Seal: The Cry of the Martyrs
9 When He opened the fifth seal, I saw under the altar the souls of those who had been slain for the word of God and for the testimony which they held. 10 And they cried with a loud voice, saying, “How long, O Lord, holy and true, until You judge and avenge our blood on those who dwell on the earth?” 11 Then a white robe was given to each of them; and it was said to them that they should rest a little while longer, until both the number of their fellow servants and their brethren, who would be killed as they were, was completed.
7 When He opened the fourth seal, I heard the voice of the fourth living creature saying, “Come and see.” 8 So I looked, and behold, a pale horse. And the name of him who sat on it was Death, and Hades followed with him. And power was given to them over a fourth of the earth, to kill with sword, with hunger, with death, and by the beasts of the earth.
Fifth Seal: The Cry of the Martyrs
9 When He opened the fifth seal, I saw under the altar the souls of those who had been slain for the word of God and for the testimony which they held. 10 And they cried with a loud voice, saying, “How long, O Lord, holy and true, until You judge and avenge our blood on those who dwell on the earth?” 11 Then a white robe was given to each of them; and it was said to them that they should rest a little while longer, until both the number of their fellow servants and their brethren, who would be killed as they were, was completed.
Sixth Seal: Cosmic Disturbances
12 I looked when He opened the sixth seal, and behold, there was a great earthquake; and the sun became black as sackcloth of hair, and the moon became like blood. 13 And the stars of heaven fell to the earth, as a fig tree drops its late figs when it is shaken by a mighty wind. 14 Then the sky receded as a scroll when it is rolled up, and every mountain and island was moved out of its place. 15 And the kings of the earth, the great men, the rich men, the commanders, the mighty men, every slave and every free man, hid themselves in the caves and in the rocks of the mountains, 16 and said to the mountains and rocks, “Fall on us and hide us from the face of Him who sits on the throne and from the wrath of the Lamb! 17 For the great day of His wrath has come, and who is able to stand?”
The Sealed of Israel
7 And after these things I saw four angels standing on the four corners of the earth, holding the four winds of the earth, that the wind should not blow on the earth, nor on the sea, nor on any tree.
2 Then I saw another angel ascending from the east, having the seal of the living God. And he cried with a loud voice to the four angels, to whom it was given to hurt the earth and the sea, 3 Saying, Hurt not the earth, neither the sea, nor the trees, till we have sealed the servants of our God in their foreheads.
4 And I heard the number of them which were sealed. One hundred and forty and four thousand of all the tribes of the children of Israel were sealed:
12 I looked when He opened the sixth seal, and behold, there was a great earthquake; and the sun became black as sackcloth of hair, and the moon became like blood. 13 And the stars of heaven fell to the earth, as a fig tree drops its late figs when it is shaken by a mighty wind. 14 Then the sky receded as a scroll when it is rolled up, and every mountain and island was moved out of its place. 15 And the kings of the earth, the great men, the rich men, the commanders, the mighty men, every slave and every free man, hid themselves in the caves and in the rocks of the mountains, 16 and said to the mountains and rocks, “Fall on us and hide us from the face of Him who sits on the throne and from the wrath of the Lamb! 17 For the great day of His wrath has come, and who is able to stand?”
The Sealed of Israel
7 And after these things I saw four angels standing on the four corners of the earth, holding the four winds of the earth, that the wind should not blow on the earth, nor on the sea, nor on any tree.
2 Then I saw another angel ascending from the east, having the seal of the living God. And he cried with a loud voice to the four angels, to whom it was given to hurt the earth and the sea, 3 Saying, Hurt not the earth, neither the sea, nor the trees, till we have sealed the servants of our God in their foreheads.
4 And I heard the number of them which were sealed. One hundred and forty and four thousand of all the tribes of the children of Israel were sealed:
SitRep - 07/04/26 - Lots of visual confirmations
An overview of the daily events in Russia's invasion of Ukraine. Lots of visual confirmation of destroyed Russian equipment emerged today. Also, attacks in Luhansk occured.
REPOST=appreciated
1/X
An overview of the daily events in Russia's invasion of Ukraine. Lots of visual confirmation of destroyed Russian equipment emerged today. Also, attacks in Luhansk occured.
REPOST=appreciated
1/X
Missed the latest?
As usual we start with Russian losses
1/ Today at the MN Capitol, experts told legislators what Hennepin County won't say out loud. Read on... #mnleg #FreedomToBreathe
2/ EPA staff told national expert Mike Ewall directly: they have no documentation to support placing incineration above landfilling. State agencies keep citing EPA as justification. EPA can't back it up. #FreedomToBreathe
3/ HERC's permits mean bigger is allowed to be dirtier. It can legally emit 4x the pollution of a smaller facility and still be "in compliance." #FreedomToBreathe
So let's start with our task of dismantling the narrative. The claim for the marraige in the source he used has its citations as follow. None of which are contemporary or even near contemporary. It's nansi ri khyat (17th century) & mirat-i-sikandari(17th century) as evidences for
the marraiges claimed to be happened in 15th century. Now for Rao jodha marrying his daughter to qyamkhani chiefs. First they too are rajputs only so even if any such marraige was proposed i see no issue with it. But let's look at citations. Again non
contemporary. Both are sources belonging to 17th century for marraiges claimed to have happened in 15th century. Now for lunkaran again we shall have a look at the citations used. This marraige must have happened around late 15th to early 16th century if
@0hour1 The answer has been in play since end of Revolutionary War.
After the October 19, 1781: Cornwallis surrendered his entire army to George Washington and French allies.
That's the extent of what is in history books.
What if I told you the British and US have been at war since?
After the October 19, 1781: Cornwallis surrendered his entire army to George Washington and French allies.
That's the extent of what is in history books.
What if I told you the British and US have been at war since?
@0hour1 1958 was a year when British influence over Iran was already declining, and the main Britain–Iran cooperation framework from that era was the Baghdad Pact (later CENTO), which had been formed in 1955.
@0hour1 Britain had previously helped overthrow Iran’s democratic government in 1953 (along with the CIA) in Operation Ajax, reinstalling the Shah.
SAVAK (the Shah’s secret police) was created with CIA and MI6 help and maintained close intelligence cooperation with British services.
SAVAK (the Shah’s secret police) was created with CIA and MI6 help and maintained close intelligence cooperation with British services.
1/6 The muscle pain you experience when taking statins is a red flag that your muscle cells are in serious trouble. By inhibiting the mevalonate pathway, statins up-regulate atrophy genes, cause cell apoptosis, and damage muscle fibres.
Statins also affect calcium regulation /2
Statins also affect calcium regulation /2
2/6 inside muscle cells, particularly through changes in the Sarcoplasmic Reticulum, which controls calcium release and re-uptake. When calcium is excessive, muscles may twitch or cramp. Even more importantly, your heart muscle is also affected by excess calcium. /3
3/6 Statins reduce adenosine triphosphate (ATP), a compound synthesized by actively growing cells as a means of short-term energy storage and transfer.
The direct effects on cellular and subcellular structures are predominantly responsible for statin-related mitochondrial /4
The direct effects on cellular and subcellular structures are predominantly responsible for statin-related mitochondrial /4
Interviewer says "Introduce yourself"
Don't talk about your education, location, age etc
Memorize this exact script :
Don't talk about your education, location, age etc
Memorize this exact script :
⸻
1. Greet and thank the interviewer:
“Good morning, and thank you for the opportunity to be here.”
2. State your name and current role or status:
“My name is [Your Name], and I’m currently a [Your Current Job Title] at [Company Name]”
Or, “I recently graduated with a degree in [Your Major] from [University Name].”
3. Give a quick professional background:
“I have [X] years of experience in [Your Industry or Field], where I’ve focused on [Key Skills or Responsibilities].”
4. Highlight key achievements or strengths:
“In my previous role, I led a project that [Brief Achievement], which helped improve [Result].”
5. Explain your interest in the role:
“I’m really excited about this opportunity because it aligns with my passion for [Field/Skill] and I see it as a great chance to grow and contribute to your team.”
1. Greet and thank the interviewer:
“Good morning, and thank you for the opportunity to be here.”
2. State your name and current role or status:
“My name is [Your Name], and I’m currently a [Your Current Job Title] at [Company Name]”
Or, “I recently graduated with a degree in [Your Major] from [University Name].”
3. Give a quick professional background:
“I have [X] years of experience in [Your Industry or Field], where I’ve focused on [Key Skills or Responsibilities].”
4. Highlight key achievements or strengths:
“In my previous role, I led a project that [Brief Achievement], which helped improve [Result].”
5. Explain your interest in the role:
“I’m really excited about this opportunity because it aligns with my passion for [Field/Skill] and I see it as a great chance to grow and contribute to your team.”
Your self-introduction should be clear, confident, and relevant to the position.
Want to make a real impact for Alberta independence?
Become well-versed in the facts.
When friends, family, and coworkers have questions, be the person who can answer them calmly, clearly, and confidently.
Become well-versed in the facts.
When friends, family, and coworkers have questions, be the person who can answer them calmly, clearly, and confidently.
Below is a thread of many Alberta Independence graphics I’ve created.
Feel free to save them and use them.
Feel free to save them and use them.
if true the US agrees to these terms it is the biggest strategic defeat for the US since Vietnam
the US started with 3 objectives:
1. Regime change
2. Eliminate uranium enrichment
3. Destroy Iran’s missile capabilities
Then added a 4th: open the Strait of Hormuz which wasn’t closed before the war
It failed to achieve all of them despite inflicting heavy damage
1. Regime change
2. Eliminate uranium enrichment
3. Destroy Iran’s missile capabilities
Then added a 4th: open the Strait of Hormuz which wasn’t closed before the war
It failed to achieve all of them despite inflicting heavy damage
as the attacked and weaker party, Iran simply had to survive which it did. That alone is in its favor but it also set its own objectives:
1. Expose US bases and shift balance of power
2. Establish deterrence
3. Exact a toll/ establish control over Strait of Hormuz
1. Expose US bases and shift balance of power
2. Establish deterrence
3. Exact a toll/ establish control over Strait of Hormuz
🇦🇺 DefMin @RichardMarlesMP is in Tokyo this week to see 🇯🇵 DefMin Koizumi. Noteworthy tempo:
- Marles was in 🇯🇵 in Dec 2025
- Koizumi expected in 🇦🇺 this month
- PM Takaichi perhaps coming late April / early May
This 🧵 [1/7] explores what's going on 👇
minister.defence.gov.au/media-releases…
- Marles was in 🇯🇵 in Dec 2025
- Koizumi expected in 🇦🇺 this month
- PM Takaichi perhaps coming late April / early May
This 🧵 [1/7] explores what's going on 👇
minister.defence.gov.au/media-releases…
2/7
The official reason for this visit is the 1st annual ministerial under the Framework for Strategic Defence Coordination.
FSDC, announced by Marles & Koizumi in Dec 2025, is the latest move towards collective deterrence, as @Stewart_ASPI explained 👇
aspistrategist.org.au/australia-and-…
The official reason for this visit is the 1st annual ministerial under the Framework for Strategic Defence Coordination.
FSDC, announced by Marles & Koizumi in Dec 2025, is the latest move towards collective deterrence, as @Stewart_ASPI explained 👇
aspistrategist.org.au/australia-and-…
3/7
It's puzzling why FDSC couldn't wait until Koizumi arrives in 🇦🇺 very soon. Perhaps some last-minute contractual wrangles in @Australian_Navy's acquisition of @MHI_Group's Mogami frigate required ministerial attention?
See @Dr_M_Davis on Mogami ⬇️
aspistrategist.org.au/australia-choo…
It's puzzling why FDSC couldn't wait until Koizumi arrives in 🇦🇺 very soon. Perhaps some last-minute contractual wrangles in @Australian_Navy's acquisition of @MHI_Group's Mogami frigate required ministerial attention?
See @Dr_M_Davis on Mogami ⬇️
aspistrategist.org.au/australia-choo…
🔥 Russia’s “safe rear” is now on fire, & it’s spreading. Ukraine did it.
🧵 1/12
🧵 1/12
🔥 Ukraine’s 5th strike in weeks hit Ust-Luga’s key oil terminal, damaging 3 massive RVSP-20000 tanks (20,000 m³ each) owned by Transneft-Baltika, triggering major disruption.
Lukoil’s Nizhegorodnefteorgsintez refinery: processing units also hit.
2/12
Lukoil’s Nizhegorodnefteorgsintez refinery: processing units also hit.
2/12
🔥 Chronicle of Alarms:
Ukrainian drones struck the strategic Ust-Luga oil port again on April 6–7, triggering fresh alarms across Russia (OSINT: DroneBomber).
Another heavy blow in a series of attacks disrupting Moscow’s key Baltic oil export infrastructure.
3/12
Ukrainian drones struck the strategic Ust-Luga oil port again on April 6–7, triggering fresh alarms across Russia (OSINT: DroneBomber).
Another heavy blow in a series of attacks disrupting Moscow’s key Baltic oil export infrastructure.
3/12
