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May 16
SitRep - 15/05/26 - Drone strikes in Ryazan

An overview of the daily events in Russia's invasion of Ukraine. Overnight, Ukraine struck the oil refinery in Ryazan igniting at least large three fires. Also, 205 AFU servicemen returned home.

REPOST=appreciated

1/X Image
As usual we start with Russian losses
Read 24 tweets
May 16
10 AI prompts that completely rewired how I work, think, create, and make money online.

99% of people still use AI like a toy.

These prompts turn it into a superpower.

You’ll want to save every single one. 🧵🚀 Image
1. Image
2. Image
Read 7 tweets
May 16
1/20 What the HELL do you MEAN "what THEY'VE done to our country"?? What THEY have done to our country is spectacular...Biden has outperformed you Mr. Trump on a number of fronts, from inequality and green spending to stocks and crime. But your supporters have NO IDEA because you
2/20 are LYING to them, telling them the OPPOSITE of what is REALLY true, AREN'T you!? The Biden/Harris Administration had made us:
1. The STRONGEST economy in the world, SO stellar it held up OTHER countries! And he was NOT given a STELLAR economy like YOU were (It's why you had
3/20 SO much time for golf, you inherited the HARD work of a DEMOCRATIC President)...Biden had to start from the bottom up due to YOUR gargantuan INCOMPETENCE! This is NOT a lie! Go check people, don't LISTEN to this asshat's LIES that our economy was trashed!! It was NOT! It is
Read 21 tweets
May 16
Erectile dysfunction also quite often involves impaired nitric oxide (NO) signaling.

In general, nitric oxide is the central non-adrenergic, non-cholinergic neurotransmitter responsible for initiating and maintaining penile erection.

Normally, sexual stimulation activates parasympathetic neurons originating from the sacral spinal cord (S2–S4), traveling through the pelvic nerves and cavernous nerves to the penis.

These nerves release NO primarily from neuronal nitric oxide synthase (nNOS) located in nerve terminals within the corpora cavernosa.

Inside these cells, NO activates an enzyme called soluble guanylate cyclase, increasing levels of cyclic guanosine monophosphate (cGMP).

NO diffuses rapidly across cell membranes into adjacent smooth muscle cells of the penile arteries and trabeculae (the sponge-like tissue in the corpora cavernosa).

Inside smooth muscle cells, NO binds to and activates soluble guanylate cyclase (sGC), converting guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP).

Then, elevated cGMP activates protein kinase G (PKG), which:

-Reduces intracellular calcium by inhibiting calcium influx and promoting sequestration into the sarcoplasmic reticulum.

-Opens potassium channels, leading to hyperpolarization and further reduction in calcium entry.

-Phosphorylates myosin light chain phosphatase, which causes dephosphorylation of myosin and further smooth muscle relaxation.

Now increased blood flow creates shear stress on endothelial cells lining the penile arteries and sinusoids.

This stimulates endothelial nitric oxide synthase (eNOS) to produce additional NO, amplifying the signal in a positive feedback loop.

Acetylcholine (from parasympathetic nerves) and other factors such as bradykinin also activate eNOS via receptor-mediated pathways.

This sustained NO production maintains high cGMP levels for full rigidity.

Then, when stimulation ceases:

-Sympathetic nerves release noradrenaline → vasoconstriction.

-Phosphodiesterase type 5 (PDE5) hydrolyzes cGMP to inactive GMP.

-Intracellular calcium rises → smooth muscle contraction → reduced inflow and increased outflow → flaccidity.

When it comes to how nitric oxide is produced, it’s synthesised in 2 main ways.

In the first one NO is synthesized from L-arginine + oxygen by NOS enzymes, requiring cofactors such as:

-NADPH (electron donor)

-Tetrahydrobiopterin (BH4) – critical for “coupling” NOS (ensures electrons go to NO production rather than superoxide).

-Flavins (FAD, FMN), heme and calcium-calmodulin (especially for nNOS/eNOS).

Note 1: Before you go and buy some L-arginine, realize that L-citrulline is actually more effective at raising blood arginine levels because the liver breaks down a large portion of ingested L-arginine before it reaches the bloodstream (L-citrulline bypasses this process and is later converted into arginine by the kidneys).

Note 2: Coupled NOS = NO + L-citrulline (good for endothelial function).

Note 3: Uncoupled NOS (low BH4, oxidative stress) = superoxide (O₂⁻) + H₂O₂ instead of NO (bad for endothelial function).

Note 4: All three NOS isoforms are present in penile tissue:

-nNOS: Nerve terminals + initiates erection.

-eNOS: Endothelium + sustains erection.

-iNOS: Induced during inflammation/injury + can produce excessive NO, contributing to priapism or dysfunction if chronic(*).

(*)iNOS, unlike constitutive eNOS/nNOS (Ca²⁺-dependent, low NO), is transcriptionally induced and Ca²⁺-independent, producing high, sustained NO (up to 1000x more) for hours/days.

High iNOS-derived NO overwhelms physiological regulation since:

-NO reacts rapidly with superoxide (O₂⁻) (from NADPH oxidase, mitochondria, or uncoupled eNOS) to form peroxynitrite (ONOO⁻) (a reactive nitrogen species (RNS)).

-Peroxynitrite causes lipid peroxidation, protein nitration, DNA damage, enzyme inactivation and is cytotoxic in general.

Some studies even link it to major depression.Image
In the second one, it’s created by nitrites, but too much (as seen in many studies, such as one at 400mg, which is often found in 70-100ml of beetroot juice) can increase carcinogenic nitroso compounds.

Now theoretically, if it’s a one time thing, you can get away with it if you pair it with some vitamin C.

But with frequent use, vitamin C is not able to undo the increase of carcinogenic nitroso compounds.

So in my opinion, it’s not worth it since citruline malate for example, will not have this effect and it’s also shown to actually improve athletic performance.Image
Now let’s see the main things that harm NO signaling (note: these factors often interconnect).

Number 1: An excess of oxidative stress/ROS.

Excess superoxide for example, reacts with NO to form peroxynitrite, degrading NO and ROS also oxidizes BH4, causing eNOS uncoupling.

Also, 8-isoprostane is usually significantly elevated in all patients with ED.

Number 2: BH4 “deficiency”/oxidation.

BH4 is essential for eNOS coupling.

In general tetrahydrobiopterin (BH4) is a vital cofactor in several biochemical reactions essential for our health, particularly in the brain, nervous system and immune system.

It’s like a helper molecule that enzymes need to do their jobs.

Here’s what BH4 does in simple terms:

-Dopamine production: BH4 is needed by the enzyme tyrosine hydroxylase to convert tyrosine into dopamine, so low BH4 can contribute to issues like depression or neurological disorders.

-Nitric oxide production: BH4 helps nitric oxide synthases (NOS) produce nitric oxide, which supports blood vessel health, immune function, and nerve signaling. Without enough BH4, NOS can produce harmful free radicals instead, increasing oxidative stress.

-Tryptophan metabolism: BH4 is a cofactor for tryptophan hydroxylase (TPH), which converts tryptophan into serotonin.

-Phenylalanine metabolism: BH4 assists phenylalanine hydroxylase in breaking down phenylalanine (an amino acid) to prevent its toxic buildup, which can occur in conditions like phenylketonuria (PKU).

Number 3: AGEs.

AGEs also reduce eNOS activity.

Number 4: Asymmetric dimethylarginine (ADMA).

This endogenous eNOS inhibitor is mainly elevated in CVD, diabetes and kidney disease (you can measure it if you want, normal plasma levels: ~0.4–0.5 μmol/L).

It is a naturally occurring amino acid derivative that forms during post-translational methylation of arginine residues in proteins by protein arginine methyltransferases.

It basically competes with L-arginine and that’s how it harms eNOS.

Number 5: Hypertension.

Angiotensin II activates NADPH oxidase, increasing ROS and uncoupling eNOS.

Number 6: Hyperhomocysteinemia.

Number 7: Neurological Issues.

This is not that common but in case you’ve recently suffered a TBI and experience ED as a result, just be aware that you’re probably experiencing reduced nNOS-derived NO.

Number 8: Sedentary lifestyle.

Regular aerobic or moderate-intensity training upregulates endothelial nitric oxide synthase (eNOS) expression (this adaptation occurs primarily through increased shear stress from elevated blood flow, activating pathways like PI3K/Akt, leading to enhanced eNOS transcription and phosphorylation).

Number 9: Being a vegan/vegetarian.

Now the main mechanisms that these dietary lifestyle seem to be able to cause ED are nutrient deficiencies and anemia.

We’ve covered nutrient deficiencies but when it comes to anemia, the 101 is that low hemoglobin will reduce the carrying capacity of O₂ and cause systemic and local hypoxia which downregulates eNOS expression.

Number 10: Undiagnosed sleep apnea/being a mouth breather (this is not a joke).

Human paranasal sinuses produce high concentrations of nitric oxide (up to 20-30 ppm which is far higher than in the lower airways).

Nasal breathing draws this NO into the lungs, improving vasodilation, oxygenation (up to 10-18% higher tissue oxygen in studies) and even has some antimicrobial effects.

On the flipside, mouth breathing bypasses the sinuses, reducing inhaled NO significantly.

Something else that can harm eNOS is as insulin resistance.

A few supplements to consider when it comes to supporting eNOS and nNOS inlcude:

Number 1: Whole food vitamin C + magnesium.

Number 2: Garlic extract.

You can also combine vitamin C and garlic

Number 3: Citruline malate + panax ginseng

Number 4: Methylated B complex

Number 5: Ginkgo biloba

Number 6: Thai black ginger

Now, since this part is basically about vasculogenic ED (ED that stems from problems with the blood vessels (an erection requires rapid inflow of arterial blood and effective trapping of that blood in the penile erectile tissue)) two other supplements that can help some people by inhibiting calcium deposition in arteries for example are:

Number 7: Nattokinase

Number 8: Vitamin K complex

Number 9: Agmatine sulfate

Number 10: Artichoke extract

And three lifestyle interventions that can be more effective than all of these supplements include:

-12-15K steps/day

-Sauna

-Optimizing your sleep

And if you want 5 foods you can add, try:

-Pomegranates

-Pickled ginger

-A quality cacao

-EVOO

-Blueberries

Now obviously, all these won’t work to their full extent if you do not focus on getting rid of the big offenders such as nicotine, which contributes significantly to ED through vasoconstriction, reduced nitric oxide (NO) bioavailability and endothelial dysfunction.

Nicotine for example binds to nicotinic acetylcholine receptors (nAChRs) on peripheral postganglionic sympathetic nerve endings and the adrenal medulla.

This triggers the release of catecholamines (mainly norepinephrine) from nerves and epinephrine from adrenals.

The first binds to α1-adrenergic receptors on vascular smooth muscle cells leading to calcium influx, muscle contraction and vasoconstriction.

Chronic nicotine usage also upregulates α1-receptors, amplifying the norepinephrine response.

It also upregulates endothelin-1 (ET-1) production/release from endothelial cells (a vasoconstrictor acting on ETA/ETB receptors) and impairs NO/prostacyclin (PGI2) pathways.

Now in case you are not aware of what vasoconstriction and vasodilation are, these two are opposite processes that control the diameter of your blood vessels such as arteries and arterioles regulating our blood pressure, body temperature and blood flow to organs for example.

If we think of our blood vessels as adjustable pipes, then vasoconstriction increases pressure and redirects flow, while vasodilation decreases pressure and boosts delivery.

Basically:

-Vasoconstriction: Smooth muscle contracts → vessel narrows (smaller lumen) → higher resistance to flow.

-Vasodilation: Smooth muscle relaxes → vessel widens (larger lumen) → lower resistance.

The contraction/relaxation is triggered by calcium ions (Ca²⁺) inside muscle cells:

High Ca²⁺ → contraction

Low Ca²⁺ → relaxation

Now up until the 17th/for the next 35 hours, 2 sales are running.

Number 1: The comprehensive guide to overcoming erectile dysfunction

fitandball.gumroad.com/l/zmaoz/may60

Number 2: Supplements and peptide handbook

fitandball.gumroad.com/l/Supplements2…

Talk soon.

-George
Read 3 tweets
May 16
🧵 What a rough night for Nithya Raman.

Hasan Piker put the LA mayoral candidate and DSA member through a full-on struggle session over her record, repeatedly pressing her to explain where she had fallen short of the movement line.

And honestly, even as a conservative, I felt bad for her. This was brutal.

One flashpoint was a DSA criticism over Raman’s role in a city resolution tied to the UTLA BDS fight. But the exchange was bigger than that. This was not a good-faith interview. It was an ideological audit.

Raman mostly tried to answer politically. She came to DSA through housing and homelessness, said this was not her area of expertise, said she had learned more, and promised she was “committed to learning more.”

Stick around for more, because by the end of this even Hasan’s chat wanted his head.
This is where Piker's “interview” really became a purity test.

“Do you believe Israel has a right to exist in its current form as an ethnostate that’s currently being investigated for genocide at the International Court of Justice?”

Raman answered, “Yes, I do believe that Israel has a right to exist,” but added that she wants countries to operate “without apartheid” and “with equality in their borders.”

Hasan immediately followed up: “Do you believe that Israel is an apartheid state then?”

Raman said, “I think that it is, yeah.”

Then Hasan brought up her 2024 censure from DSA-LA over accepting the Democrats for Israel LA endorsement, asking whether, “knowing what we know now and seeing the videos of Gaza in ruins,” she would still seek it out.

Raman said, “I wouldn’t seek it out now,” pointed to her ceasefire resolution, and then tried to bring the conversation back to what a mayor actually does: keeping Angelenos safe, protecting protest rights, and pushing back against both antisemitism and Islamophobia.
Hasan brought up Raman’s 2020 call to “defund the police” and her old platform calling for LAPD to become a “much smaller specialized force.”

Then he contrasted that with her 2026 mayoral line to NBC LA: “we need to maintain the size of our police force.”

“Was it, you know, wokeness rising up everywhere in 2020 that led you to say that?”

Raman’s answer was basically that governing happened. After five years in office, she said the city has to “respond to calls for help from the public,” and if 911 calls are not answered quickly, “we lose the faith of Angelenos.”

Then came the real admission, “We don’t have an alternative crisis response system built out citywide.”

Raman still wants unarmed crisis response, but admits the current system is “patchwork,” poorly integrated with 911, and can leave people on hold for “50 minutes.”
Read 9 tweets
May 16
🕊️🇸🇴📩 📩📩📩📩📩📩🇸🇴🕊️
To the world and to my Somali family:

President HSM is no longer our legitimate president. Not today. Not tomorrow. Not ever again.
@UnrollHelper

He has stolen our democracy, broken our constitution, and silenced our voice. Image
He is a danger to Somalia's sovereignty and to every Somali who believes in free elections.

To the international community: Sanction him now. Freeze his assets. Cut him off. Stop shaking the hand of a man who refuses to respect his own people.
To my people: He does not rule us. We rule ourselves. Reject him. Resist peacefully. Unite.

One demand: Free, fair elections within 90 days. Not next year. Not later. Now.

We are tired. But we are not broken.

#SomaliaNeedsElections #HSMIllegal #90DaysOrLess
Read 3 tweets
May 16
🌺।।IMPORTANCE OF NUMBER 108 IN SANATAN HINDU DHARMA।।🚩

In Sanatan Dharma, the number 108 is considered sacred because it appears repeatedly across spirituality, astronomy, mathematics, yoga, and ritual traditions. Rather than coming from a single source, its importance developed through many layers of symbolism over thousands of years....Image
🌺।।Spiritual significance।।🌺

A traditional japa mala has 108 beads, used for chanting mantras such as the Maha Mrityunjaya Mantra or the Gayatri Mantra.

Many Hindu deities are worshipped through 108 names (Ashtottara Shatanamavali), such as the 108 names of Shiva, Vishnu, or Durga.

In yogic traditions, it is believed that there are 108 important energy channels (nadis) converging at the heart chakra.
🌺।।Connection with astronomy।।🌺

Ancient Indian sages closely observed the sky, and 108 appears in striking cosmic ratios:

The average distance between the Earth and the Sun is roughly 108 times the Sun’s diameter.

The average distance between the Earth and the Moon is about 108 times the Moon’s diameter.

These relationships made 108 symbolize harmony between the human world and the cosmos.
Read 8 tweets
May 16
Many famous investors including, Berkshire Hathaway, Bill Ackman and a bunch more just updated their portfolios

Here's what their portfolios looked like as of the end of Q1 (A thread🧵⬇️)

Stanley Druckenmiller 🐐 Image
Image
Image
Berkshire Hathaway

This is the first time since Warren Buffett stepped down that Berkshire is updating its portfolio

Berkshire made a bunch of moves which you can see below

Here are all the stocks that they sold during Q1 ⬇️

- Visa $V
- Mastercard $MA
- UnitedHealth $UNH
- Domino's Pizza $DPZ
- Aon $AON
- Pool Corp $POOL
- Amazon $AMZN
- Heico $HEI
- Liberty Media $FWONK
- Charter Communications $CHTR
- Lamar Advertising $LAMR
- Allegion $ALLE
- Diageo $DEOImage
Nvidia $NVDA

Nvidia's stock portfolio is more than 50% Intel ... Nvidia has doubled their stock portfolio so far this year 😅 Image
Read 9 tweets
May 15
Eurovision says it's "United By Music." Here's what that really looked like for Israel since October 7.
A thread🧵:
Since the Hamas massacre in southern Israel on October 7, 2023, Israel faced unprecedented challenges at Eurovision:

•⁠ ⁠Protests demanding removal
•⁠ ⁠Death threats requiring security protection
•⁠ ⁠Some performers refused to interact backstage
•⁠ ⁠Five countries boycotted in 2026

But something else happened too. Something the headlines missed.
*🇮🇱 2024: Eden Golan - "Hurricane"*

Public vote: 323 points - *2nd place*
Jury vote: 12th place
Final: 5th place

*14 countries gave Israel their maximum 12 points.*

While some tried to isolate her, millions of people across Europe voted for her.
Read 8 tweets
May 15
@JohnKennedyLA 1/12 It is PATHETIC you and the OTHER Republicans on the panel today bought FBI Director Kash Patel's crime statistics and ESPECIALLY his "captures" of criminals on the vaulted "FBI's 10 Most Wanted List" hook, line, and sinker. While the Democrats were asking the
2/15 Hard, NEEDED questions, Republicans like YOU stroked Patel's ass and demonized Democrats who were doing what you people are SUPPOSED to be doing....providing oversight and asking the HARD questions. EVERY one of you Republican Senators on this committee panel should be
3/15 ASHAMED of yourselves, allowing a charlatan to buffalo your dumb asses, throwing out padded, juiced up crime statistics and inflated figures from the "10 Most Wanted List". Kash Patel is a PHONY, an EMBARRASSMENT to this country who is padding FBI stats. He is what you call
Read 16 tweets
May 15
It's amazing to me that some of you still call what I've been through for 3 years "internet drama." I've said over and over, you hear what is said on posts and videos, but that's 5% of it. If you would sit by while liars convince a group that you work for the person hated by the
Group when you don't and never did, and accuse you of sending group members threats of swatting, of porn and other sign-ups when you did none of that; and have multiple false reports made against you to law enforcement and other agencies; and accuse you of horrific things like
Creating child porn, having oral s#x with your grandchild and dozens and dozens of other false allegations; and your life and the lives of your family members were threatened. If you would sit by and let them do those things and do nothing to protect yourself and your family,
Read 8 tweets
May 15
"We have indisputable evidence that Ghaddafi is giving his troops Viagra so they can mass rape girls and babies. We need to bomb them now!"

*few months later as Libya has been bombed*

"Yeah we made up that Viagra mass rape stuff. Anyway, Israel has the right to defend itself." Image
they didn't just claim Ghaddafi gave his troops Viagra so they could mass rape girls and babies. They said they had evidence. The prosecutor of the International Criminal Court said they investigated it and had indisputable evidence, and the media repeated it. But it was a lie Image
they used this rape atrocity propaganda to destroy Libya, the most prosperous country in Africa before the NATO bombing, and no one paid any price for it. No one in the Western media and political class faced any consequences. They literally brought slave markets to the country Image
Read 5 tweets

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