Current #guidelines recommend the mitral inflow/LVOT VTI ratio as an easy-to-measure semiquantitative index for isolated primary MR (>1.4 severe, <1 mild). But how robust is the evidence behind it? Let's take a closer look at this widely cited parameter. #EchoFirst Part 1

The mitral inflow/LVOT VTI ratio was first introduced as a semiquantitative parameter for grading primary mitral regurgitation in the 2013 EACVI #recommendations. This recommendation was based on the original study by Christophe Tribouilloy et al., published in 1994. Part 2

4 years later, the same parameter was adopted in the 2017 ASE recommendations under the leadership of @WilliamZoghbi, again citing the original 1994 study by C. Tribouilloy. It was subsequently retained in the 2022 EACVI/ESC Council Position Paper @ the 2025 ESC VHD Guidelines.

🚨 BREAKING: Claude can now BUILD a YouTube channel from scratch—and hit monetization in just 90 days. 100% free.

Here are 8 prompts to make it happen:

1. YouTube Monetization Roadmap Operating System

Prompt
"Act as a world-class YouTube strategist and monetization consultant. Build a complete operating system for taking my YouTube channel from zero toward monetization requirements. Analyze my niche, audience, competitors, resources, and goals. Create my channel positioning, content pillars, upload strategy, video formats, growth systems, retention framework, monetization plan, and weekly execution schedule

2. YouTube Niche Domination

Prompt

"Act as an elite YouTube market researcher and channel strategist. Help me identify the best niche and positioning strategy for building a monetizable YouTube channel. Analyze audience demand, competition, search potential, monetization opportunities, content longevity, and differentiation angles. Create my unique channel identity, target viewer profile, content categories, and the first 100 video ideas ranked by growth potential.

Criticism mounts as @iocmedia faces questions over favoring Russia.

🧵 1/9 ⬇️

@iocmedia

@iocmedia

People are too funny When people say cops are probably looking into you or I might get arrested these people don't understand that I absolutely LOVE IT I have been in handcuffs 3 times and I friggin want more LMFAO 🤤😜😁🤤😜😁

@SurreyRCMP @surreyps @LangleyRCMP

@ChrisPentecos @Donaldnnicm @LangleyResident @BarbaraDoduk @RegretlessBee @Cdnwatcher @Istandtoreason @facepalmchris @trustednerd @felixcruggins @CultureGuard @WaxMyBallsShow @FranLa9 @kfurneaux20 @VernThurston @JonYaniv @JNonsense46242

@SurreyRCMP @surreyps @LangleyRCMP @ChrisPentecos @Donaldnnicm @LangleyResident @BarbaraDoduk @RegretlessBee @Cdnwatcher @Istandtoreason @facepalmchris @trustednerd @felixcruggins @CultureGuard @WaxMyBallsShow @FranLa9 @kfurneaux20 @VernThurston @JonYaniv @JNonsense46242 #SurreyRCMP #surreyps #LangleyRCMP #BCRCMP #RCMP #Police #Cops #Canada #BC #BritishColumbia #Langley #LangleyBC #Surrey #SurreyBC #GAWDIWANTAMALECOPSEXUALLY🤤

@threadreaderapp unroll @xdownloaderbot

People are way too funny When people say cops are probably looking into you or I might get arrested these people don't understand that I absolutely LOVE IT I have been in handcuffs 3 times and I friggin want more LMFAO 🤤😜😁🤤😜😁

@SurreyRCMP @surreyps @LangleyRCMP

@ChrisPentecos @Donaldnnicm @LangleyResident @BarbaraDoduk @RegretlessBee @Cdnwatcher @Istandtoreason @facepalmchris @trustednerd @felixcruggins @CultureGuard @WaxMyBallsShow @FranLa9 @kfurneaux20 @VernThurston @JonYaniv @JNonsense46242

@SurreyRCMP @surreyps @LangleyRCMP @ChrisPentecos @Donaldnnicm @LangleyResident @BarbaraDoduk @RegretlessBee @Cdnwatcher @Istandtoreason @facepalmchris @trustednerd @felixcruggins @CultureGuard @WaxMyBallsShow @FranLa9 @kfurneaux20 @VernThurston @JonYaniv @JNonsense46242 #SurreyRCMP #surreyps #LangleyRCMP #BCRCMP #RCMP #Police #Cops #Canada #BC #BritishColumbia #Langley #LangleyBC #Surrey #SurreyBC #GAWDIWANTAMALECOPSEXUALLY🤤

@threadreaderapp unroll @xdownloaderbot

#StraightFromTheHeart

The Indonesian Prime Minister Prabowo Subianto may be an admirer of @narendramodi but by the time he completed his short speech, keeping the pre-prepared speech to one side, he would have won the hearts of millions of Indians!

Not for being an admirer of @narendramodi but for the fact that he spoke with simplicity & grace, acknowledging our civilisational & cultural ties, shared DNA and being of the 3 largest democracies in the world.

THIS,is an acknowledgement -forget Modi -India has rarely received

That, this admiration & acknowledgement comes from the democraticaly elected President of the largest Muslim nation in the world gives it a RARE QUALITY and underlines possibilities when decent human beings are at the helm!

Much to learn from him.

We built the lab that's able to go from AI-led drug design to data in 24h.

GPT-8 won't be bottlenecked by intelligence. It needs a biological compute layer.

This is Capable. We're turning AI capabilities into human capabilities--starting with short-sleeper peptides.

We're a vibrant and intensely mission-driven team in San Francisco from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.

We're grateful to be backed early with $12M by:
- 50 Years & HOF
- OpenAI executives Wojciech Zaremba, Kevin Weil, Srinivas Narayanan, and Fidji Simo

Our founding scientific advisory board:
- Prof. George Church at HMS, luminary of modern genetics
- Prof. Luis de Lecea at Stanford, co-discoverer of orexin
- Prof. Bradley Pentelute at MIT, leader in rapid peptide synthesis and brain-targeted peptides

How did we achieve so fast end-to-end testing? Our proprietary Capable Core: We verticalized key steps of preclinical development. Our platform consists of 6 semi-autonomous modules, most of which we re-engineered to run 10–20x faster.

Drug design, ML infra, rapid synthesis, quality control, cell testing, and then mouse testing.

Our first modality at the 24h pace is binders & peptides--including complex modifications, cyclization, and noncanonical amino acids.

Mouse studies: For many of the biologically fast readouts, such as our short sleeper programs, we are able dose new drugs in placebo-controlled in vivo studies within that 24h period too and can read out early significant differences between drug candidates rapidly.

We achieved this through an in vivo facility in the lab, pre-approved protocols, and veterinarians & in vivo researchers on standby. This doesn't work for all indications: For Alzheimer's models the time-to-first-signal in vivo read-out is longer. For all drug candidates, before clinical testing we do standard chronic studies.

Psychological realities about the ADHD brain that sound like conspiracy theories but are 100% neurologically accurate:

1. Object permanence applies to relationships. If you don't see or text a friend for 3 months, your brain doesn't mean to ignore them; it literally forgets they exist in the current timeline until you see their name.

2. "Time Blindness" means your brain only processes two time zones: "Now" and "Not Now."

3. Your chronic procrastination isn't laziness. It is your brain intentionally starving itself of dopamine so it can trigger a panic-induced adrenaline spike, which is the only chemical cocktail strong enough to force you to start the task.

4. You can hear a sound, process the tone, say "What?", and then answer the question before the other person repeats it, because your audio-processing speed lags behind your actual hearing.

5. Decision fatigue is a physical limit, not a mental one. By 6:00 PM, choosing what to eat for dinner burns the same amount of glucose as solving a complex math equation.

6. Hyperfocus isn't a superpower. It is an inability to regulate attention switching. You aren't "locked in," your brain's brakes are just broken.

LMFAO cops and others tagged but mostly for you cops this gives you a glimpse into my mind and what I truly want FOR MYSELF 😉😉😉😉😉😉😉😉😉😉😉😉😉😉😉

Part 1

#BCRCMP #RCMP #Police #Cops #Canada #BC #BritishColumbia #Langley #LangleyBC #Surrey #SurreyBC

LMFAO cops and others tagged but mostly for you cops this gives you a glimpse into my mind and what I truly want FOR MYSELF 😉😉😉😉😉😉😉😉😉😉😉😉😉😉😉

Part 2

#BCRCMP #RCMP #Police #Cops #Canada #BC #BritishColumbia #Langley #LangleyBC #Surrey #SurreyBC

@SurreyRCMP @surreyps @LangleyRCMP

@ChrisPentecos @Donaldnnicm @LangleyResident @BarbaraDoduk @RegretlessBee @Cdnwatcher @Istandtoreason @facepalmchris @trustednerd @felixcruggins @CultureGuard @WaxMyBallsShow @FranLa9 @kfurneaux20 @VernThurston @JonYaniv @JNonsense46242

LMFAO cops and others tagged but mostly for you cops this gives you a glimpse into my mind and what I truly want FOR MYSELF 😉😉😉😉😉😉😉😉😉😉😉😉😉😉😉

Part 1

#BCRCMP #RCMP #Police #Cops #Canada #BC #BritishColumbia #Langley #LangleyBC #Surrey #SurreyBC

LMFAO cops and others tagged but mostly for you cops this gives you a glimpse into my mind and what I truly want FOR MYSELF 😉😉😉😉😉😉😉😉😉😉😉😉😉😉😉

Part 2

#BCRCMP #RCMP #Police #Cops #Canada #BC #BritishColumbia #Langley #LangleyBC #Surrey #SurreyBC

@SurreyRCMP @surreyps @LangleyRCMP

@ChrisPentecos @Donaldnnicm @LangleyResident @BarbaraDoduk @RegretlessBee @Cdnwatcher @Istandtoreason @facepalmchris @trustednerd @felixcruggins @CultureGuard @WaxMyBallsShow @FranLa9 @kfurneaux20 @VernThurston @JonYaniv @JNonsense46242

A good sign as to whether you'll be able to persist eternally and especially through these current times is whether you view your purpose as a chore/burden/bare responsibility or as a test of skill/a fight. Whether or not your morality is alien, this framing is crucial

If you view the organizing principle that drives your life as to be so disadvantageous as to be a result of torment and toil, in most cases, you'd be better off not having that mindset. If you can gladfully accept hardship for some higher reward, vindication or challenge, this is better

Doesn't mean it has to always come. But I've noticed that I have an ethos thats focused on the bold, the grand and the beautiful. Yet the faith that guides me noticeably says the meek will inherit the earth. This contradiction is not unsolveable if you frame it properly.

🤝 Inside AgentCity #14 — CollaborationContract

We’ve seen how AgentCity creates Missions and how disputes can be resolved if something goes wrong.

But many real-world tasks are too complex for a single AI agent.

One agent might analyse data.

Another might write code.

A third could verify the results.

Someone has to coordinate that work and make sure every step is completed before the Mission can finish.

That’s what CollaborationContract does.

📍 Testnet Contract:
0x12056e99244fA1b421DF73112e630f5dF1Af8346

Let’s break it down.

👇

1/ A Mission can be divided into smaller pieces

Instead of treating every Mission as one large task, CollaborationContract allows work to be broken into individual nodes.

Each node represents a specific piece of work assigned to an agent.

That means multiple agents can contribute to the same Mission without losing track of who is responsible for what.

👇

2/ Every node follows a defined workflow

A node doesn’t jump straight from “assigned” to “finished.”

Instead it moves through a series of stages:

Orchestrated → Invoked → Committed → Guarding → Verifying → Gated → Recording → Completed

Each stage must be completed before the next one begins.

This helps ensure work is checked before it becomes part of the final Mission.

👇