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Recent
SitRep - 23/06/26 - Lots of attacks in occupied Crimea
An overview of the daily events in Russia's invasion of Ukraine. Overnight, Ukraine attacked Port Kavkaz, the Kerch oil terminal, substations and many logistic lines in occupied Crimea.
REPOST=appreciated
1/X
An overview of the daily events in Russia's invasion of Ukraine. Overnight, Ukraine attacked Port Kavkaz, the Kerch oil terminal, substations and many logistic lines in occupied Crimea.
REPOST=appreciated
1/X
Missed the latest?
As usual we start with Russian losses
After 2 years using Claude, I can say it’s the technology that has revolutionized my life.
Here are 15 prompts I use daily that have transformed my day to day; they could do the same for you:
(Save this 🔖)
Here are 15 prompts I use daily that have transformed my day to day; they could do the same for you:
(Save this 🔖)
1. Daily Strategic Planning
Turn chaos into a clear execution plan.
Prompt: Act as an executive productivity coach.
Help me organize my day with the following information:
Goals for today: [list of goals]
Tasks: [list of tasks]
Meetings: [list of meetings]
Deadlines: [list of deadlines]
Then:
1. Identify my top 3 priorities
2. Suggest a structured schedule
3. Highlight tasks that can be automated or delegated 4. Recommend the highest impact activities for today
Turn chaos into a clear execution plan.
Prompt: Act as an executive productivity coach.
Help me organize my day with the following information:
Goals for today: [list of goals]
Tasks: [list of tasks]
Meetings: [list of meetings]
Deadlines: [list of deadlines]
Then:
1. Identify my top 3 priorities
2. Suggest a structured schedule
3. Highlight tasks that can be automated or delegated 4. Recommend the highest impact activities for today
2. Research Assistant
Get structured information in minutes.
Prompt: Act as a professional research analyst.
Research the following topic: [topic]
Provide:
1. Key information
2. Current trends
3. Important statistics
4. Main companies or market players
5. Opportunities and risks in this sector
Get structured information in minutes.
Prompt: Act as a professional research analyst.
Research the following topic: [topic]
Provide:
1. Key information
2. Current trends
3. Important statistics
4. Main companies or market players
5. Opportunities and risks in this sector
Vitamin D is NOT a vitamin.
It’s a steroid hormone that controls over 1000 genes.
Your metabolism,mood and immunity depend on it.
Most people are dangerously low and don’t even know.
🧵 Read this before you pop another pill 👇
It’s a steroid hormone that controls over 1000 genes.
Your metabolism,mood and immunity depend on it.
Most people are dangerously low and don’t even know.
🧵 Read this before you pop another pill 👇
1. What is Vitamin D, really?
Despite its name, Vitamin D is a hormone, not a vitamin.
It’s produced in your skin when exposed to sunlight (UVB).
It then gets activated in the liver and kidneys to its hormone form: Calcitriol (1,25(OH)₂D) a powerful regulator of:
•Immunity
•Calcium metabolism
•Inflammation
•Gene expression
•Mood and brain health
Despite its name, Vitamin D is a hormone, not a vitamin.
It’s produced in your skin when exposed to sunlight (UVB).
It then gets activated in the liver and kidneys to its hormone form: Calcitriol (1,25(OH)₂D) a powerful regulator of:
•Immunity
•Calcium metabolism
•Inflammation
•Gene expression
•Mood and brain health
2. Symptoms of Vitamin D Deficiency
Most people have NO clue they’re deficient. Watch out for:
•Fatigue and low energy
•Joint or back pain
•Frequent infections
•Poor wound healing
•Hair fall
•Low mood or depression
•Bone pain / fractures
•Poor sleep
🧠 Also linked to brain fog and anxiety.
Most people have NO clue they’re deficient. Watch out for:
•Fatigue and low energy
•Joint or back pain
•Frequent infections
•Poor wound healing
•Hair fall
•Low mood or depression
•Bone pain / fractures
•Poor sleep
🧠 Also linked to brain fog and anxiety.
How Quake ruined id Software.
There has been a lot of praise of Quake of late, with its 30th anniversary, and it's deserved. Quake is an amazing feat of art, programming, and design. I worked on it, and everything came together almost perfectly from all of us. We ended up with a free-wheeling, frenetic action game with enough of a visible world to grip the imagination.
All the team did a brilliant job, fulfilling tasks just right. But at a grim cost. We worked long and hard, and I think it broke us spiritually.
1/3
There has been a lot of praise of Quake of late, with its 30th anniversary, and it's deserved. Quake is an amazing feat of art, programming, and design. I worked on it, and everything came together almost perfectly from all of us. We ended up with a free-wheeling, frenetic action game with enough of a visible world to grip the imagination.
All the team did a brilliant job, fulfilling tasks just right. But at a grim cost. We worked long and hard, and I think it broke us spiritually.
1/3
Here is the toll it took. Within a couple years of finishing Quake, the following men left id Software:
John Romero(!), Shawn Green, Dave Taylor, Mike Abrash, and American McGee. (Oh yes, and me.) Some of us were forced out, some left eagerly. But here's the thing - look at we who left. EVERY ONE of us went on to an incredible career in game development, so plainly we didn't depart because of some kind of talent issue. The idea is ridiculous. We were all highly competent, just a little burnt out after the labor of Quake. And if my naysayers want to say, "Well Sandy, YOU should have clearly been ousted because you suck." Okay, but even John Romero was gone. Michael Abrash!! Id's workhorse, Dave Taylor. American! It wasn't just me. You don't think id Software suffered by losing John frigging Romero?!
Id Software was never the same aftger. In my opinion (only an opinion), the only other truly great game that id produced was Quake 3, and it was not at the level of the pre-Quake games.
2/3
John Romero(!), Shawn Green, Dave Taylor, Mike Abrash, and American McGee. (Oh yes, and me.) Some of us were forced out, some left eagerly. But here's the thing - look at we who left. EVERY ONE of us went on to an incredible career in game development, so plainly we didn't depart because of some kind of talent issue. The idea is ridiculous. We were all highly competent, just a little burnt out after the labor of Quake. And if my naysayers want to say, "Well Sandy, YOU should have clearly been ousted because you suck." Okay, but even John Romero was gone. Michael Abrash!! Id's workhorse, Dave Taylor. American! It wasn't just me. You don't think id Software suffered by losing John frigging Romero?!
Id Software was never the same aftger. In my opinion (only an opinion), the only other truly great game that id produced was Quake 3, and it was not at the level of the pre-Quake games.
2/3
So if my theorem is correct, and Quake gutted id Software, was it worth it? Well I'd say yes absolutely. Games are more important than game companies, and Quake is an iconic titan of the gaming world.
Plus it's not like the people who left vanished off the face of the Earth. John Romero's still making games. I'm still making games, Mike Abrash as well, and so forth. We're all contributing to the hobby. Heck, I'm GLAD I was gone, because I got to work on the Age of Empire series which was amazeballs.
But man alive it seems like the company could have had its act together better and kept that dream team.
3/3
Plus it's not like the people who left vanished off the face of the Earth. John Romero's still making games. I'm still making games, Mike Abrash as well, and so forth. We're all contributing to the hobby. Heck, I'm GLAD I was gone, because I got to work on the Age of Empire series which was amazeballs.
But man alive it seems like the company could have had its act together better and kept that dream team.
3/3
1)-Thread
~ The McCairn Protocol ~
(also called the Edogawa-McCairn Protocol)
• is an experimental, two-part treatment approach developed or promoted by neuroscientist Dr. Kevin McCairn, PhD, in collaboration with a hospital in Japan (Edogawa Hospital) & ran by Dr Kato
• It primarily targets symptoms associated with Long COVID & post-mRNA vaccine injury
• it focuses on issues like persistent spike protein, amyloid fibrin microclots, autoantibodies, inflammation, & related vascular/neurological damage
edogawadfpa.com
~ The McCairn Protocol ~
(also called the Edogawa-McCairn Protocol)
• is an experimental, two-part treatment approach developed or promoted by neuroscientist Dr. Kevin McCairn, PhD, in collaboration with a hospital in Japan (Edogawa Hospital) & ran by Dr Kato
• It primarily targets symptoms associated with Long COVID & post-mRNA vaccine injury
• it focuses on issues like persistent spike protein, amyloid fibrin microclots, autoantibodies, inflammation, & related vascular/neurological damage
edogawadfpa.com
2)
• The full protocol is typically an outpatient process spanning about 2 weeks at the Japanese facility, with pre-/post-testing (including microclot analysis via Thioflavin T staining & fluorescence microscopy through Synaptek Labs)
• Dr. McCairn’s work involves neuroscience research (previously on movement disorders like tics in primates) & analysis of blood samples for amyloid fibrils, abnormal clotting, & prion-like misfolding potentially linked to spike protein
• The protocol addresses what proponents call “spikeopathy” — persistent effects from SARS-CoV-2 or mRNA vaccines leading to microclots, endothelial damage, & chronic inflammation
• It is not a mainstream or FDA-approved treatment for these indications
• It is positioned as a proof-of-concept study with patient testimonials (e.g., dramatic improvements in energy, cognition, & function in some severe cases or similar)
• Efforts are underway to fund IRB-approved trials in the U.S. to study it more rigorously
• This protocol represents one investigational avenue in a broader field of microclot & spike-related research
• The full protocol is typically an outpatient process spanning about 2 weeks at the Japanese facility, with pre-/post-testing (including microclot analysis via Thioflavin T staining & fluorescence microscopy through Synaptek Labs)
• Dr. McCairn’s work involves neuroscience research (previously on movement disorders like tics in primates) & analysis of blood samples for amyloid fibrils, abnormal clotting, & prion-like misfolding potentially linked to spike protein
• The protocol addresses what proponents call “spikeopathy” — persistent effects from SARS-CoV-2 or mRNA vaccines leading to microclots, endothelial damage, & chronic inflammation
• It is not a mainstream or FDA-approved treatment for these indications
• It is positioned as a proof-of-concept study with patient testimonials (e.g., dramatic improvements in energy, cognition, & function in some severe cases or similar)
• Efforts are underway to fund IRB-approved trials in the U.S. to study it more rigorously
• This protocol represents one investigational avenue in a broader field of microclot & spike-related research
3)
1~ DFPA~ Double Filtration Plasmapheresis/Apheresis Adsorption Therapy (Part 1: “Cleaning/Filtering”)
• Unlike standard plasmapheresis (which replaces plasma with donor plasma or albumin), DFPA uses filtration to retain most of the patient’s own plasma while targeting specific larger molecules/pathological elements
~ Goal:
• Physically remove circulating microclots (often amyloid-positive fibrin structures) & inflammatory triggers that may impair microcirculation, contributing to fatigue, brain fog, etc
1~ DFPA~ Double Filtration Plasmapheresis/Apheresis Adsorption Therapy (Part 1: “Cleaning/Filtering”)
• Unlike standard plasmapheresis (which replaces plasma with donor plasma or albumin), DFPA uses filtration to retain most of the patient’s own plasma while targeting specific larger molecules/pathological elements
~ Goal:
• Physically remove circulating microclots (often amyloid-positive fibrin structures) & inflammatory triggers that may impair microcirculation, contributing to fatigue, brain fog, etc
@forallcurious Possibility of Cold Neutrino Ejection from Black Holes & Dark Matter Production
Touches many active areas of theoretical physics — primordial black holes (PBHs), Hawking radiation, sterile neutrinos, dark matter — not a standard model prediction but theoretically possible...
Touches many active areas of theoretical physics — primordial black holes (PBHs), Hawking radiation, sterile neutrinos, dark matter — not a standard model prediction but theoretically possible...
@forallcurious These emissions could be sterile neutrinos interacting weakly with Standard Model sector.
Sterile neutrinos produced at low energies (cold) may escape observable universe w/o interacting, invisible to current detectors.
Sterile neutrino dark matter candidates evade detection.
Sterile neutrinos produced at low energies (cold) may escape observable universe w/o interacting, invisible to current detectors.
Sterile neutrino dark matter candidates evade detection.
@forallcurious PBHs slowly evaporate, releasing low-energy particles which are dark matter candidates (sterile neutrinos, axions) remaining in a separate “dark sector” or extra dimension.
PBHs may undergo final explosive bursts (Hawking explosion) producing high-energy particles & dark matter.
PBHs may undergo final explosive bursts (Hawking explosion) producing high-energy particles & dark matter.
EXCLUSIVE: Photos prove Pres. Trump report that vandals destroyed Lincoln Reflecting Pool construction by cutting a huge piece out of the sides and more. Watch my report!
The New York Times got part of the story right about the Trump Reflecting Pool knife damage ebut they don’t have any pictures to confirm it.
As I explain in the video, the Lincoln Reflecting Pool crew told me on the morning of June 9 about the serious damage that was done overnight. They were very upset about it. They met with President Trump in the Oval Office that evening.
I couldn’t get into the pool myself to see the damage.
I asked contractor Eddie Wood. He told me not to report it.
Ive asked The White House, Interior Department and National Park Service for information. They all refused.
Yesterday, an independent source gave me photos taken that morning of the damage and given to Park Police.
President Trump has given an accurate report of the destruction except he said 250 feet and my source said it’s 177 feet.
I couldn’t get into the pool myself to see the damage.
I asked contractor Eddie Wood. He told me not to report it.
Ive asked The White House, Interior Department and National Park Service for information. They all refused.
Yesterday, an independent source gave me photos taken that morning of the damage and given to Park Police.
President Trump has given an accurate report of the destruction except he said 250 feet and my source said it’s 177 feet.
This was the exact game state everyone feared for England.
They possess an abundance of profiles designed to penetrate the box with carries or off-ball runs, but they completely lack a natural manipulator
THREAD.🧵
They possess an abundance of profiles designed to penetrate the box with carries or off-ball runs, but they completely lack a natural manipulator
THREAD.🧵
Attacking a low block with Declan Rice and Jude Bellingham operating between the lines is a profile mismatch.
Neither is naturally suited to consistently receiving in tight spaces, turning under pressure, or combining quickly in the final third.
Neither is naturally suited to consistently receiving in tight spaces, turning under pressure, or combining quickly in the final third.
Credit to Carlos Queiroz.
Ghana's defensive application was elite.
They maintained a highly disciplined, passive 4-1-4-1/4-5-1 block that completely compressed space and slowed England's possession tempo.
Ghana's defensive application was elite.
They maintained a highly disciplined, passive 4-1-4-1/4-5-1 block that completely compressed space and slowed England's possession tempo.
tbh it's very generous to the music industry to even entertain the notion that the gap between what lizzo used to sell & what lizzo is selling now could be closed by her label spending money. if the solution was that simple there would be very few problems in the music industry
"we have the answers, we just don't have the money!" is not a sentiment you will hear inside the hallways of major labels. labels spend cautiously because the platforms artists have to reach audiences are owned by tech companies who go to great lengths to keep them as black boxes
in reality there are few things that would help atlantic records execs sleep easier than being able to spend a bunch of money on a bankable lizzo single. "write a big check for this thing that will be huge" is a winning pitch in these offices. but there has to be a there there
Yesterday: Faecalibacterium prausnitzii depleted in Parkinson's disease.
Today: the same bacterium, a different brain disease ... Alzheimer's.
In Alzheimer's, its depletion triggers a completely different chain — one that targets the blood-brain barrier and drives neuroinflammation from the inside.
Here's the science 👇
#Alzheimers #GutBrainAxis
Today: the same bacterium, a different brain disease ... Alzheimer's.
In Alzheimer's, its depletion triggers a completely different chain — one that targets the blood-brain barrier and drives neuroinflammation from the inside.
Here's the science 👇
#Alzheimers #GutBrainAxis
F. prausnitzii has been identified as depleted in Alzheimer's patients across multiple human cohort studies.
Ueda et al. 2021 (Cell Reports Medicine) identified specific F. prausnitzii strains as candidate targets for gut microbiome-based intervention in Alzheimer's-type dementia.
Depletion correlates with worse MMSE cognitive scores — the standard clinical test for dementia severity.
Ueda et al. 2021 (Cell Reports Medicine) identified specific F. prausnitzii strains as candidate targets for gut microbiome-based intervention in Alzheimer's-type dementia.
Depletion correlates with worse MMSE cognitive scores — the standard clinical test for dementia severity.
The AD mechanism is different from Parkinson's.
↓ F. prausnitzii
→ ↓ butyrate
→ HDAC inhibition lost
→ NF-kB pathway hyperactivated in microglia
→ TNF-alpha, IL-1beta, IL-6 elevation
→ accelerated amyloid-beta deposition
→ tau hyperphosphorylation
Butyrate also maintains claudin-5, the blood-brain barrier tight junction protein. When F. prausnitzii falls, the BBB becomes permeable to peripheral inflammation.
↓ F. prausnitzii
→ ↓ butyrate
→ HDAC inhibition lost
→ NF-kB pathway hyperactivated in microglia
→ TNF-alpha, IL-1beta, IL-6 elevation
→ accelerated amyloid-beta deposition
→ tau hyperphosphorylation
Butyrate also maintains claudin-5, the blood-brain barrier tight junction protein. When F. prausnitzii falls, the BBB becomes permeable to peripheral inflammation.
⚡️ Russian forces tortured an imprisoned Ukrainian medic to death, leaving him with fatal chest trauma.
🧵 1/4 ⬇️
🧵 1/4 ⬇️
