Recent well liked threads
Here’s the circadian truth about the infamous truck driver case - the one centralized dermatologists love to weaponize against sunlight exposure: 
This is the most misunderstood image in the health space when it comes to photoaging and skin cancer
It’s a case study that’s been twisted out of ignorance to fuel misinformation about sunlight
It’s a case study that’s been twisted out of ignorance to fuel misinformation about sunlight
This unidentified 69 year old trucker spent 28 years on the road, and his face tells a story that centralized medicine fails to understand
The mainstream narrative is that the sun’s full spectrum itself caused his skin damage due to accumulated UV-A and UV-B exposure
Dermatologists point to this case as “proof” that sunlight is dangerous, using it to justify fear-based narratives around photoaging and skin cancer
The mainstream narrative is that the sun’s full spectrum itself caused his skin damage due to accumulated UV-A and UV-B exposure
Dermatologists point to this case as “proof” that sunlight is dangerous, using it to justify fear-based narratives around photoaging and skin cancer
🧵PIJ just admitted Ahmed Abu Eisha was a platoon commander POSING AS A JOURNALIST. Hamas & PIJ systematically use press vests for combat cover & media manipulation. The IDF was doubted, but now proven right. @pressfreedom—yet another one to remove. TEN more recent examples: 1/
June 1: Hamas admitted that Abdullah Breis was a commander posing as a “journalist”— it is no longer “Israel says so” evidence. Over 60% of "journalists" killed in Gaza are outed as combatants, more every week. He remains listed by the CPY @pressfreedom 2/
May 22: Maysara Ahmed Salah was a Qassam commander posing as a “journalist.” He was identified long before, but now Hamas openly admits it. Are you noticing a pattern? 3/
FTP: LAPD killed her dog. He was wearing his Knicks jersey.
His name was Jameson. A golden doodle. One of the sweetest, most gentle breeds alive.
A neighbor called a noise complaint. That's it.
20+ officers showed up. Then a helicopter. For a noise complaint in an apartment complex.
And they shot Jameson dead. In front of his owner. In front of her child.
No warning. No de-escalation. Nothing.
The media is barely covering this. No headlines. No outrage.
Like it never happened.
If this was your dog... your child watching... how would you feel?
Jameson deserved better. That little boy deserved better. His mama deserved better.
His name was Jameson. A golden doodle. One of the sweetest, most gentle breeds alive.
A neighbor called a noise complaint. That's it.
20+ officers showed up. Then a helicopter. For a noise complaint in an apartment complex.
And they shot Jameson dead. In front of his owner. In front of her child.
No warning. No de-escalation. Nothing.
The media is barely covering this. No headlines. No outrage.
Like it never happened.
If this was your dog... your child watching... how would you feel?
Jameson deserved better. That little boy deserved better. His mama deserved better.
If you have empathy & compassion: When your dog dies, the world freezes. It's a gut punch to your system. Your best friend who showed you unconditional love, who was there for you through thick and thin has passed. The cops who killed this woman's family member should face justice.
En el primer día de mi clase de historia de la secundaria, nuestro profesor se levantó y dijo:
Tienes 13 o 14 años. Hace 200 años, las personas de tu edad se casaban, sembraban cultivos, tenían hijos y construían una cabaña para el invierno.
Tú puedes hacer tu tarea. La vara histórica que se te ha puesto es embarazosamente baja. No estás lidiando con una hambruna regional o una plaga.
No tienes que salvar a tu familia de saqueadores ni ir a la batalla para destruir a tus enemigos.
Tienes que sentarte y aprender de alguien que se preocupa por ti en un aula segura y con aire acondicionado. No tienes excusas.
Tienes 13 o 14 años. Hace 200 años, las personas de tu edad se casaban, sembraban cultivos, tenían hijos y construían una cabaña para el invierno.
Tú puedes hacer tu tarea. La vara histórica que se te ha puesto es embarazosamente baja. No estás lidiando con una hambruna regional o una plaga.
No tienes que salvar a tu familia de saqueadores ni ir a la batalla para destruir a tus enemigos.
Tienes que sentarte y aprender de alguien que se preocupa por ti en un aula segura y con aire acondicionado. No tienes excusas.
A veces no necesitas más motivación.
Necesitas perspectiva.
La mayoría de problemas que hoy parecen enormes habrían parecido privilegios para casi cualquier generación anterior.
Escribo sobre ello cada mañana:
elartesanodeltrading.com
Necesitas perspectiva.
La mayoría de problemas que hoy parecen enormes habrían parecido privilegios para casi cualquier generación anterior.
Escribo sobre ello cada mañana:
elartesanodeltrading.com
This guy has been to America before multiple times (you can go through his social media), this “shock” about hospitality is fake and so is everything else. He works with Polymarket, a major American tech company, which has been huge with war propaganda ready.
These “wholesome European tourists discovering America” people are on major payrolls part of a large image rehab campaign for America along with also some sort of HUMINT thing going on. That’s why major media, corporations, tech companies, and politicians are boosting them
This is not real, we are once again looking at majorly viral things and people that are not trending organically. Especially the other one promoting a police department and walking into NASA should be an even bigger red flag
في الحقيقه ينتابني شعور غريب واعتقد أن هذا الشعور ينتابنا جميعا
وهو أن الإتفاقيه بين إيران والولايات المتحدة لن تصمد طويلا..!
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" لماذا..؟
" دعوني أخبركم مالذي حدث..!
لإن ترامب أصبح اليوم معركة وجودية تختلف عن كل ما سبقه من صراعات
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" إنظروا إلى اول تصريح خرج به الرئيس التركي ووزير الخارجيه ورئيس الاستخبارات بعد اعلان مذكرة التفاهم
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" علينا ان نراقب الفتره المقبله جيدا.. فهناك اطراف تسعى لتخريب الاتفاق
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" اعتقد جميعنا نعلم من هذه الاطراف
" اسرائيل "
وهو أن الإتفاقيه بين إيران والولايات المتحدة لن تصمد طويلا..!
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.
" لماذا..؟
" دعوني أخبركم مالذي حدث..!
لإن ترامب أصبح اليوم معركة وجودية تختلف عن كل ما سبقه من صراعات
.
" إنظروا إلى اول تصريح خرج به الرئيس التركي ووزير الخارجيه ورئيس الاستخبارات بعد اعلان مذكرة التفاهم
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" علينا ان نراقب الفتره المقبله جيدا.. فهناك اطراف تسعى لتخريب الاتفاق
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" اعتقد جميعنا نعلم من هذه الاطراف
" اسرائيل "
الولايات المتحده بدأت هذه الحرب بناء على رغبة إسرائيل
لقد باع نتنياهو سيناريوهات متفائله جدا لترامب مثل
-اسقاط النظام
-تغيير ايران لحليفه كفنزويلا
-تغيير وجه الشرق الاوسط
"تذكروا تصريح وزير الخارجية التركي قبل الحرب... عندما قال ان الضربات الجويه لا يمكنها ان تسقط النظام في ايران
" لقد قالها بكل ثقه كون ما يتحدث به هو تقديرات للاستخبارات التركيه
"ترامب بعد ان راى ان الضربات لم تؤدي الى نتيجه
وان تجريب نفس مرتين وتوقع ان تحصل على نتيجه مختلفه
امر اقرب للمستحيل
"وصل لقناعه قال لنفسه فيها
"لنقدم بعض التنازلات، وليقدموا هم بعض التنازلات،
ولنُنهِ هذا الأمر باتفاق"
-صحيح نتنياهو لم يتعرض بشكل صريح علنا
لكن اسرائيل، بأفعالها منذ الاعلان وحتى هذه اللحظة
تحاول بكل قوتها منع الاتفاق
هذه المره بدأت بتحريك اللوبي الصهيوني في الولايات المتحدة
وبدأت الانتقادات الموجهة لدونالد ترامب تشتد قسوه بعد اعلان مذكرة التفاهم
صحيح ان نتنياهو لا يصرح بذلك علنا ولا يُهاجم ترامب
لكن أشخاص ممن ممن يعرف الاعلام الامريكي بانهم هم من ينقلون رسائل نتنياهو،
سواء كانوا سياسيين أو إعلاميين،
بداوا يقولون لترامب أشياء لم يقولوها من قبل.
وهؤلاء الأشخاص هم أنفسهم الذين بدوا مؤيدين لترامب بنسبة 100% حتى الآن،
ثم انقلبوا عليه اليوم فجأة.
لماذا يفعلون ذلك..؟
إنهم يحاولون ذلال دونالد ترامب في السياسة الداخلية وبين قاعدته الشعبية.
لقد ظل دونالد ترامب ثابتًا على موقفه هذا طوال الأسبوع أو العشرة أيام الماضية.
وتصريحاته ضد هجمات إسرائيل، سواء يوم الأحد أو اليوم، هي تصريحات لم نرها أو نسمعها من رئيس أمريكي منذ زمن طويل.
انظروا، ما قاله بالامس بشأن هجمات إسرائيل على لبنان، والهجمات على حزب الله،
قالها ترامب بكل صراحه لإسرائيل : أنتم تقتلون مدنيين عمدا
إنه لا يجب قصف الشقق أو المباني بحثا عن شخص من حزب الله،
في هذه المباني يقتل اشخاص لا علاقه لهم بحزب الله
أي أنكم تقتلون الناس بذريعة مهاجمة حزب الله...؟
لقد باع نتنياهو سيناريوهات متفائله جدا لترامب مثل
-اسقاط النظام
-تغيير ايران لحليفه كفنزويلا
-تغيير وجه الشرق الاوسط
"تذكروا تصريح وزير الخارجية التركي قبل الحرب... عندما قال ان الضربات الجويه لا يمكنها ان تسقط النظام في ايران
" لقد قالها بكل ثقه كون ما يتحدث به هو تقديرات للاستخبارات التركيه
"ترامب بعد ان راى ان الضربات لم تؤدي الى نتيجه
وان تجريب نفس مرتين وتوقع ان تحصل على نتيجه مختلفه
امر اقرب للمستحيل
"وصل لقناعه قال لنفسه فيها
"لنقدم بعض التنازلات، وليقدموا هم بعض التنازلات،
ولنُنهِ هذا الأمر باتفاق"
-صحيح نتنياهو لم يتعرض بشكل صريح علنا
لكن اسرائيل، بأفعالها منذ الاعلان وحتى هذه اللحظة
تحاول بكل قوتها منع الاتفاق
هذه المره بدأت بتحريك اللوبي الصهيوني في الولايات المتحدة
وبدأت الانتقادات الموجهة لدونالد ترامب تشتد قسوه بعد اعلان مذكرة التفاهم
صحيح ان نتنياهو لا يصرح بذلك علنا ولا يُهاجم ترامب
لكن أشخاص ممن ممن يعرف الاعلام الامريكي بانهم هم من ينقلون رسائل نتنياهو،
سواء كانوا سياسيين أو إعلاميين،
بداوا يقولون لترامب أشياء لم يقولوها من قبل.
وهؤلاء الأشخاص هم أنفسهم الذين بدوا مؤيدين لترامب بنسبة 100% حتى الآن،
ثم انقلبوا عليه اليوم فجأة.
لماذا يفعلون ذلك..؟
إنهم يحاولون ذلال دونالد ترامب في السياسة الداخلية وبين قاعدته الشعبية.
لقد ظل دونالد ترامب ثابتًا على موقفه هذا طوال الأسبوع أو العشرة أيام الماضية.
وتصريحاته ضد هجمات إسرائيل، سواء يوم الأحد أو اليوم، هي تصريحات لم نرها أو نسمعها من رئيس أمريكي منذ زمن طويل.
انظروا، ما قاله بالامس بشأن هجمات إسرائيل على لبنان، والهجمات على حزب الله،
قالها ترامب بكل صراحه لإسرائيل : أنتم تقتلون مدنيين عمدا
إنه لا يجب قصف الشقق أو المباني بحثا عن شخص من حزب الله،
في هذه المباني يقتل اشخاص لا علاقه لهم بحزب الله
أي أنكم تقتلون الناس بذريعة مهاجمة حزب الله...؟
آخر مرة سمعنا فيها هذا الكلام من رئيس امريكي
كانت بايدن كانت في ديسمبر 2023، عندما قال إن إسرائيل تشن قصفا عشوائيا،
وبالمناسبه تصريحات مثل هذه من رئيس امريكي يعتبر اعترافا امريكيا ان اسرائيل ترتكب جرائم حرب...!
إذن، كل من بايدن وترامب يعلمان ما تفعله إسرائيل فعلاً:
قصف عشوائي، استهداف المدنيين، وإلقاء اللوم على التنظيمات
ترامب ذهب ابعد من ذلك كضغط مضاد ضد اسرائيل
وقال "علينا التحدث مع حزب الله"
كل هذا يُقلق إسرائيل... وانظروا إلى الأخبار التي سربتها وسائل الإعلام الإسرائيلية بالامس
قالت لقد طلبت إسرائيل مذكرة تفاهم من الولايات المتحدة، ورفضت الولايات المتحدة.
" صحيح البعض قد يخرج ويقول ان ما يحدث الان هو مسرحيه بان إسرائيل وادارة ترامب
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وقد سمعت هذه الجمل سابقا اثناء فترة بايدن
لذا دعوني أعود بكم إلى أبريل 2024؛
سيتذكرون ان إدارة بايدن عندما لم تستطع السيطره على إسرائيل
لم تستخدم ولأول مرة في مجلس الأمن الدولي الفيتو ضد اتفاقية ووقف إطلاق النار في غزه
"بعد ذلك، ماالذي فعلته إسرائيل مباشره...؟
"
كانت بايدن كانت في ديسمبر 2023، عندما قال إن إسرائيل تشن قصفا عشوائيا،
وبالمناسبه تصريحات مثل هذه من رئيس امريكي يعتبر اعترافا امريكيا ان اسرائيل ترتكب جرائم حرب...!
إذن، كل من بايدن وترامب يعلمان ما تفعله إسرائيل فعلاً:
قصف عشوائي، استهداف المدنيين، وإلقاء اللوم على التنظيمات
ترامب ذهب ابعد من ذلك كضغط مضاد ضد اسرائيل
وقال "علينا التحدث مع حزب الله"
كل هذا يُقلق إسرائيل... وانظروا إلى الأخبار التي سربتها وسائل الإعلام الإسرائيلية بالامس
قالت لقد طلبت إسرائيل مذكرة تفاهم من الولايات المتحدة، ورفضت الولايات المتحدة.
" صحيح البعض قد يخرج ويقول ان ما يحدث الان هو مسرحيه بان إسرائيل وادارة ترامب
.
وقد سمعت هذه الجمل سابقا اثناء فترة بايدن
لذا دعوني أعود بكم إلى أبريل 2024؛
سيتذكرون ان إدارة بايدن عندما لم تستطع السيطره على إسرائيل
لم تستخدم ولأول مرة في مجلس الأمن الدولي الفيتو ضد اتفاقية ووقف إطلاق النار في غزه
"بعد ذلك، ماالذي فعلته إسرائيل مباشره...؟
"
Black people will literally have 40+ felonies and be out on bond.
Chud the Builder gets his bond REVOKED after 1 arrest.
This is what we mean by two tiered policing.
Chud the Builder gets his bond REVOKED after 1 arrest.
This is what we mean by two tiered policing.
Judge Melissa Blackburn’s office can be contacted here.
The public has a right to voice opinions on how our justice system handles cases.
Keep calls polite, factual, and lawful. No harassment, threats, or abuse - that hurts the cause and may be illegal. Focus on transparency and fairness for all involved.
Keep calls polite, factual, and lawful. No harassment, threats, or abuse - that hurts the cause and may be illegal. Focus on transparency and fairness for all involved.
1/ Thread looking at paper from 2014 from dissecting claims of a labor shortage. This data is all old at this point but we see similar narratives today. On one side people claiming a labor shortage and on the other side, college graduates claiming they can't get jobs.
2/ The idea that America is falling behind in skills goes back a long time.
3/ Past predictions of skill shortages.
Big Pharma doesn't want you to know about Dr. Jason Fung.
While Type 2 Diabetes and insulin resistance take years off your lifespan...
He's proved you can reverse them naturally without meds.
Here are his top 7 protocols to reverse insulin resistance (bookmark this):🧵
While Type 2 Diabetes and insulin resistance take years off your lifespan...
He's proved you can reverse them naturally without meds.
Here are his top 7 protocols to reverse insulin resistance (bookmark this):🧵
1. Start with 16:8 intermittent fasting.
Fast for 16 hours and eat within an 8-hour window.
This alone reversed Type 2 diabetes in many of Dr. Fung's patients.
Your insulin drops low enough to finally start burning stored fat.
Fast for 16 hours and eat within an 8-hour window.
This alone reversed Type 2 diabetes in many of Dr. Fung's patients.
Your insulin drops low enough to finally start burning stored fat.
2. Cut refined carbohydrates.
Sugar, white bread, white rice and pasta spike blood sugar the most.
The result?
More insulin, more insulin resistance, more fat.
50% of Fung's patients reversed diabetes just from this one change.
Sugar, white bread, white rice and pasta spike blood sugar the most.
The result?
More insulin, more insulin resistance, more fat.
50% of Fung's patients reversed diabetes just from this one change.
I was 19kg overweight, had a huge belly & double chin, and I needed to reach 13% body fat before summer ended. I achieved it with these 25 rules:
RULE 1. STOP RUNNING (for your knees).
RULE 1. STOP RUNNING (for your knees).
Rule 2. Walking at 3mph on a 12-15% incline burns 70% more fat than running flat (And doesn’t hurt your knee)
Rule 3. Study says plank for 3 min for 15 day straight can burn belly fat.
Rule 3. Study says plank for 3 min for 15 day straight can burn belly fat.
Rule 4. Lift 3X per week: Push, Pull, Legs, and core after.
Rule 5. Diet goal: 1500 Deficit of 1000 calories = 1 kilo per week.
Rule 6. Take photos and measure weight same time every morning.
Rule 5. Diet goal: 1500 Deficit of 1000 calories = 1 kilo per week.
Rule 6. Take photos and measure weight same time every morning.
Applebaum: Putin has presented a fake image of Russia to the world. He talks about leading a traditional society
In reality, divorce is very high, abortion is common, very few Russians go to church and less than 5% have ever read a Bible. It's not a traditional culture at all 1/
In reality, divorce is very high, abortion is common, very few Russians go to church and less than 5% have ever read a Bible. It's not a traditional culture at all 1/
Applebaum: Part of the European right and the American right have this imaginary Russia they use as a political symbol — not understanding it has no relationship to reality.
Most people who admire Russia haven't even been to Moscow or St. Petersburg, let alone the rest of the country. 2/
Most people who admire Russia haven't even been to Moscow or St. Petersburg, let alone the rest of the country. 2/
Applebaum: Putin went back into Soviet history books and re-imposed old plans.
The Soviet occupation of Ukraine in the 1930s and Czechoslovakia in the 1940s looks like Ukraine today — filtration camps, arrests of teachers, mayors, political leaders. It's the old playbook brought back. 3X
The Soviet occupation of Ukraine in the 1930s and Czechoslovakia in the 1940s looks like Ukraine today — filtration camps, arrests of teachers, mayors, political leaders. It's the old playbook brought back. 3X
Glucose hypometabolism in Alzheimer's has been visible on FDG-PET scans for decades—detectable years before clinical symptoms manifest. A new Nature Metabolism study just revealed what researchers missed: the glucose wasn't just being underutilized. It was being shunted into a biosynthetic pathway that drives neurodegeneration.
Researchers used spatial metabolomics, isotopic tracing, and genetic interventions in transgenic AD mouse models and human post-mortem tissue to map where the missing glucose was going. The answer: hyperglycosylation through the hexosamine biosynthetic pathway.
Glycosylation is a post-translational modification essential for brain function. N-linked glycans regulate protein stability, synaptic plasticity, neurotransmitter-receptor interactions, and neuroimmune signaling. Congenital disorders caused by defects in glycosylation genes invariably produce neurological impairments—the brain depends on precise glycan regulation.
But Alzheimer's brains show the opposite problem: overactive glycosylation. The hexosamine biosynthetic pathway shunts glucose into glycan production, and in AD, that pathway is upregulated. More glycans aren't protective—they're pathological.
The research team applied advanced spatial MALDI mass spectrometry imaging to human AD brain samples. Standard protocols failed to produce clear glycan signals because lipid content remained high even after conventional extraction. An optimized xylene wash protocol increased glycan signal intensity by 10-20 fold across AD and control tissues.
Comparing normal and AD human brain tissue revealed markedly elevated glycan content in Alzheimer's samples. This wasn't a static accumulation—pulse-chase isotopic tracing demonstrated increased glycan biosynthesis, meaning AD brains were actively synthesizing more glycans, not just failing to clear them.
The metabolic hallmark visible on brain imaging for years had been misinterpreted. The reduced glucose uptake wasn't purely hypometabolism. It was redirected metabolism—glucose diverted from energy production into a biosynthetic pathway that worsens disease progression.
The functional test came from genetic and dietary interventions. Genetic knockdown of key glycosylation enzymes in AD mice improved cognitive outcomes. Oral glucosamine supplementation—a direct substrate for the hexosamine pathway—worsened behavioral impairments.
Glucosamine feeds the same biosynthetic pathway that's already overactive in Alzheimer's brains. Supplementing it doesn't support cognitive function. It amplifies the metabolic dysfunction driving neurodegeneration.
To validate this in humans, researchers performed a retrospective analysis of electronic health records from patients with mild cognitive impairment and dementia, stratified by glucosamine supplementation status. Glucosamine use was associated with increased mortality and a higher likelihood of progression from MCI to Alzheimer's dementia.
This isn't correlation without mechanism. The mouse models demonstrated causality through genetic manipulation. The isotopic tracing quantified biosynthetic flux. The human data confirmed the association holds in clinical populations taking the supplement for joint health or cognitive support.
Glycosylation intersects with multiple Alzheimer's pathologies. Glycan modifications influence tau aggregation dynamics and post-translational modifications. They alter amyloid-beta plaque composition and clearance mechanisms. They regulate microglial inflammatory responses and phagocytic capacity. They interact with lipid metabolism and contribute to lipid droplet accumulation—a recognized metabolic hallmark of AD.
Hyperglycosylation isn't an isolated metabolic change. It's an integrated event that compounds dysfunction across amyloid, tau, neuroinflammation, and lipid pathways.
The therapeutic implication is direct: inhibiting glycan biosynthesis may slow Alzheimer's progression. The genetic knockdown data in mice establish proof of concept. The glucosamine data establish what not to do—avoid substrates that feed an already overactive pathway.
The decisions about supplement use in midlife and early cognitive decline may have consequences that don't appear until the trajectory from MCI to dementia becomes measurable. Glucosamine supplementation is widespread—often taken for decades under the assumption that it's protective or at minimum neutral.
If the EHR analysis holds under further scrutiny, that assumption is wrong. And if glycan biosynthesis is mechanistically driving disease progression, interventions that modulate this pathway may need to be considered alongside amyloid and tau-targeted therapies.
Metabolic dysfunction in Alzheimer's isn't just about energy failure. It's about biosynthetic pathways running in the wrong direction—taking glucose that should fuel neurons and converting it into post-translational modifications that destabilize the proteins regulating cognition.
Researchers used spatial metabolomics, isotopic tracing, and genetic interventions in transgenic AD mouse models and human post-mortem tissue to map where the missing glucose was going. The answer: hyperglycosylation through the hexosamine biosynthetic pathway.
Glycosylation is a post-translational modification essential for brain function. N-linked glycans regulate protein stability, synaptic plasticity, neurotransmitter-receptor interactions, and neuroimmune signaling. Congenital disorders caused by defects in glycosylation genes invariably produce neurological impairments—the brain depends on precise glycan regulation.
But Alzheimer's brains show the opposite problem: overactive glycosylation. The hexosamine biosynthetic pathway shunts glucose into glycan production, and in AD, that pathway is upregulated. More glycans aren't protective—they're pathological.
The research team applied advanced spatial MALDI mass spectrometry imaging to human AD brain samples. Standard protocols failed to produce clear glycan signals because lipid content remained high even after conventional extraction. An optimized xylene wash protocol increased glycan signal intensity by 10-20 fold across AD and control tissues.
Comparing normal and AD human brain tissue revealed markedly elevated glycan content in Alzheimer's samples. This wasn't a static accumulation—pulse-chase isotopic tracing demonstrated increased glycan biosynthesis, meaning AD brains were actively synthesizing more glycans, not just failing to clear them.
The metabolic hallmark visible on brain imaging for years had been misinterpreted. The reduced glucose uptake wasn't purely hypometabolism. It was redirected metabolism—glucose diverted from energy production into a biosynthetic pathway that worsens disease progression.
The functional test came from genetic and dietary interventions. Genetic knockdown of key glycosylation enzymes in AD mice improved cognitive outcomes. Oral glucosamine supplementation—a direct substrate for the hexosamine pathway—worsened behavioral impairments.
Glucosamine feeds the same biosynthetic pathway that's already overactive in Alzheimer's brains. Supplementing it doesn't support cognitive function. It amplifies the metabolic dysfunction driving neurodegeneration.
To validate this in humans, researchers performed a retrospective analysis of electronic health records from patients with mild cognitive impairment and dementia, stratified by glucosamine supplementation status. Glucosamine use was associated with increased mortality and a higher likelihood of progression from MCI to Alzheimer's dementia.
This isn't correlation without mechanism. The mouse models demonstrated causality through genetic manipulation. The isotopic tracing quantified biosynthetic flux. The human data confirmed the association holds in clinical populations taking the supplement for joint health or cognitive support.
Glycosylation intersects with multiple Alzheimer's pathologies. Glycan modifications influence tau aggregation dynamics and post-translational modifications. They alter amyloid-beta plaque composition and clearance mechanisms. They regulate microglial inflammatory responses and phagocytic capacity. They interact with lipid metabolism and contribute to lipid droplet accumulation—a recognized metabolic hallmark of AD.
Hyperglycosylation isn't an isolated metabolic change. It's an integrated event that compounds dysfunction across amyloid, tau, neuroinflammation, and lipid pathways.
The therapeutic implication is direct: inhibiting glycan biosynthesis may slow Alzheimer's progression. The genetic knockdown data in mice establish proof of concept. The glucosamine data establish what not to do—avoid substrates that feed an already overactive pathway.
The decisions about supplement use in midlife and early cognitive decline may have consequences that don't appear until the trajectory from MCI to dementia becomes measurable. Glucosamine supplementation is widespread—often taken for decades under the assumption that it's protective or at minimum neutral.
If the EHR analysis holds under further scrutiny, that assumption is wrong. And if glycan biosynthesis is mechanistically driving disease progression, interventions that modulate this pathway may need to be considered alongside amyloid and tau-targeted therapies.
Metabolic dysfunction in Alzheimer's isn't just about energy failure. It's about biosynthetic pathways running in the wrong direction—taking glucose that should fuel neurons and converting it into post-translational modifications that destabilize the proteins regulating cognition.
Here's the full Nature Metabolism study:
nature.com/articles/s4225…
nature.com/articles/s4225…
🔥The Obama Change Collective - Obama will be exposed like never before! Here’s a history 101 lesson that’s gonna eventually link to everything imaginable. So pay attention, we’ll be referencing this a lot!
The Change Collective was created by Barack Obama and runs under Civic Nation led by Valerie Jarrett.
“Obama, in a video message, launched the Change Collective, which looks to reinvent civic life for the 21st century by investing in and supporting the next generation of leaders who are BRIDGING DIVIDES and driving change in their communities.”
PS, where have we heard Bridging Divides before? 😉
The Change Collective is Alinskyite community organizing at its best.
♦️Introducing the Obama Change Collective Advisory Council:
👏🏻 Pay. Attention. To. These. Names
- John Bridgeland
Co-Chair & CEO, More Perfect; Executive Chairman, Office of American Possibilities, architect of Bedrock and Dignify.us
Served on Obama White House Council for Community Solutions. He also served as Director of the White House Domestic Policy Council, Assistant to the President
- Hahrie Han
Director, Stavros Niarchos Foundation Agora Institute - Johns Hopkins
- Sanjiv Rao
Managing Director, Movements and Media, Democracy Fund
- Jamie Merisotis
President & CEO, Lumina Foundation
- Michele Jawando
Senior Vice President of Programs, Omidyar Network
- Xavier de Souza Briggs
Senior Fellow, Brookings; Senior Advisor & Co-Founder, What Works Plus
Pay attention to these names. Some you have heard about before, like Hahrie Han from the Johns Hopkins Agora Institute that @DataRepublican and I both spoke about.
What about those from the Soros Democracy Alliances Democracy Fund. A fund ran by Pierre Omidyar who also ran Lumina. That’s three names from above. You need to realize Obamas connections to Omidyar. And he’s just as big if not bigger than Soros.
Others, like John Bridgeland will be coming up more later. “More Perfect”, which he founded is a partner of the Change Collective.
♦️There’s a name not listed under the Change Collective that you will also be hearing about a lot in the future. Cecilia Muñoz from the Change Collective partner, “More Perfect”.
So where can you find Cecilia Muñoz of the Obama White House’s Senior Team these days?
- More Perfect (Obama linked)
- Biden Transition
- Protect Democracy
- Joyce Foundation (Obama linked)
- Bedrock (Obama Linked
- Dignify.us (Obama Linked)
- Civic nation (Obama)
- La Raza NJ
- New America VP
- Advises open society
- Project hyphen
You will be shocked when you see what all this leads to. Sources to follow.
The Change Collective was created by Barack Obama and runs under Civic Nation led by Valerie Jarrett.
“Obama, in a video message, launched the Change Collective, which looks to reinvent civic life for the 21st century by investing in and supporting the next generation of leaders who are BRIDGING DIVIDES and driving change in their communities.”
PS, where have we heard Bridging Divides before? 😉
The Change Collective is Alinskyite community organizing at its best.
♦️Introducing the Obama Change Collective Advisory Council:
👏🏻 Pay. Attention. To. These. Names
- John Bridgeland
Co-Chair & CEO, More Perfect; Executive Chairman, Office of American Possibilities, architect of Bedrock and Dignify.us
Served on Obama White House Council for Community Solutions. He also served as Director of the White House Domestic Policy Council, Assistant to the President
- Hahrie Han
Director, Stavros Niarchos Foundation Agora Institute - Johns Hopkins
- Sanjiv Rao
Managing Director, Movements and Media, Democracy Fund
- Jamie Merisotis
President & CEO, Lumina Foundation
- Michele Jawando
Senior Vice President of Programs, Omidyar Network
- Xavier de Souza Briggs
Senior Fellow, Brookings; Senior Advisor & Co-Founder, What Works Plus
Pay attention to these names. Some you have heard about before, like Hahrie Han from the Johns Hopkins Agora Institute that @DataRepublican and I both spoke about.
What about those from the Soros Democracy Alliances Democracy Fund. A fund ran by Pierre Omidyar who also ran Lumina. That’s three names from above. You need to realize Obamas connections to Omidyar. And he’s just as big if not bigger than Soros.
Others, like John Bridgeland will be coming up more later. “More Perfect”, which he founded is a partner of the Change Collective.
♦️There’s a name not listed under the Change Collective that you will also be hearing about a lot in the future. Cecilia Muñoz from the Change Collective partner, “More Perfect”.
So where can you find Cecilia Muñoz of the Obama White House’s Senior Team these days?
- More Perfect (Obama linked)
- Biden Transition
- Protect Democracy
- Joyce Foundation (Obama linked)
- Bedrock (Obama Linked
- Dignify.us (Obama Linked)
- Civic nation (Obama)
- La Raza NJ
- New America VP
- Advises open society
- Project hyphen
You will be shocked when you see what all this leads to. Sources to follow.
❗️Trust me folks, this will be going into lots of directions. So don’t forget these connections!
Here’s the complete list of the Change Collective staff which is larger than what I listed. I listed what I felt are important at this moment. This could change.
“ Change Collective is an initiative of Civic Nation, a 501(c)(3) organization.”
archive.is/uCety
Here’s the complete list of the Change Collective staff which is larger than what I listed. I listed what I felt are important at this moment. This could change.
“ Change Collective is an initiative of Civic Nation, a 501(c)(3) organization.”
archive.is/uCety
Good lord, when will Mr Hope and Change stop terrorizing Americans?
♦️Obama launches leadership network (Change Collective)
“Jackson will be among the first sites of a new leadership program Obama will soon launch to build a national network of young leaders from a range of regions, identities, backgrounds and political persuasions who are intent on improving their local communities at a time of intense polarization.
Named the Change Collective, the program intends to create a network of local leaders who will gain resources and share strategies to improve communities across the country. The program’s inaugural class will include 25 participants in each of three pilot cities: Chicago, Detroit and Jackson. The network aims to quickly expand to a variety of different communities of varying sizes across the country.”
“The program will be overseen by several Obama administration alumni who hope to equip people with training and mentorship from a politically and professionally diverse set of advisers. It will be housed within Civic Nation, a nonprofit founded by Obama administration alumni that coordinates campaigns a variety of issues including voting rights, combating sexual assault and legal activism.”
Firepower 😏
“Change happens from the ground up,” said Kyle Lierman, chief executive of Civic Nation. “How can we elevate, connect and develop changemakers? They have the best ideas, they have the energy. It’s just about unlocking their firepower to make change.”
“Organizing” to get folks the clot shot. 😏
“If we had had 10,000 Change Collective members when the pandemic hit, we would have had a network of 10,000 people who could jump in their communities and immediately organize to make sure folks were getting vaccinated,” Lierman said.
“Civic Nation, founded in 2015, has adopted or reimagined projects from the Obama White House over the years. The Change Collective echoes an Obama-era White House award series called “Champions of Change” that sought to highlight stories of people improving their communities. That initiative was conceived as a way to show local progress amid partisan gridlock and dysfunction at the national level.”
archive.is/JVBhK
♦️Obama launches leadership network (Change Collective)
“Jackson will be among the first sites of a new leadership program Obama will soon launch to build a national network of young leaders from a range of regions, identities, backgrounds and political persuasions who are intent on improving their local communities at a time of intense polarization.
Named the Change Collective, the program intends to create a network of local leaders who will gain resources and share strategies to improve communities across the country. The program’s inaugural class will include 25 participants in each of three pilot cities: Chicago, Detroit and Jackson. The network aims to quickly expand to a variety of different communities of varying sizes across the country.”
“The program will be overseen by several Obama administration alumni who hope to equip people with training and mentorship from a politically and professionally diverse set of advisers. It will be housed within Civic Nation, a nonprofit founded by Obama administration alumni that coordinates campaigns a variety of issues including voting rights, combating sexual assault and legal activism.”
Firepower 😏
“Change happens from the ground up,” said Kyle Lierman, chief executive of Civic Nation. “How can we elevate, connect and develop changemakers? They have the best ideas, they have the energy. It’s just about unlocking their firepower to make change.”
“Organizing” to get folks the clot shot. 😏
“If we had had 10,000 Change Collective members when the pandemic hit, we would have had a network of 10,000 people who could jump in their communities and immediately organize to make sure folks were getting vaccinated,” Lierman said.
“Civic Nation, founded in 2015, has adopted or reimagined projects from the Obama White House over the years. The Change Collective echoes an Obama-era White House award series called “Champions of Change” that sought to highlight stories of people improving their communities. That initiative was conceived as a way to show local progress amid partisan gridlock and dysfunction at the national level.”
archive.is/JVBhK
$ABXX.TO Ok a live thread of the call. They're reading from a script!! Abaxx can't silence critics. @JoshCrumb reminds me of another 'CEO' that was in a similar position, body language says it all. @viceroyresearch 1/
$ABXX.TO Apparently they've more than enough explanation and documentation to lead an honest researcher to reconsider their view.
that's why they cancelled our invite. 2/
that's why they cancelled our invite. 2/
Instead, they simply ignore the many thoughtful and valid criticisms of their report, and the evidence and documents contradicting their claims. but they fail to point out that $ABXX.TO haven't responded, & where they have it's drivel. 3/
Sobre el tema Messi y su papá, solamente voy a decir: hacer periodismo es una cosa y otra cosa es "comunicar". Lo repito en cada oportunidad que tengo. Chequear una noticia, investigar un dato o desarrollar una idea periodística lleva tiempo. Y el tiempo es dinero para un medio.
Es más fácil, rápido y barato recurrir al clickbait, a la nota chabacana, a tirar al aire cualquier cosa sobre cualquier persona total después pedimos perdón. El oficio del periodista es otra cosa, lo sé porque trabajé más de 15 años de eso y tuve compañeros que me enseñaron todo
También entiendo que el consumo cambió y hoy la gente no busca informarse, se topa con la información. El problema más grave de esa nueva realidad es que consumimos de forma acrítica esa información, en modo distracción.
La mayoría nunca llega a 150g de proteína al día porque complica demasiado sus comidas.
Después de analizar a personas que construyen músculo y mantienen un peso saludable hacen lo mismo: repiten 3-4 comidas simples
Aquí tienes la lista:
1. Huevos con queso fresco
Después de analizar a personas que construyen músculo y mantienen un peso saludable hacen lo mismo: repiten 3-4 comidas simples
Aquí tienes la lista:
1. Huevos con queso fresco
1. Huevos con queso fresco
* 4 huevos enteros
* 100g queso fresco
* Verduras
* Sal y especias
40g Proteína
* 4 huevos enteros
* 100g queso fresco
* Verduras
* Sal y especias
40g Proteína
2. Yogur griego proteico
* 300g yogur griego
* 1 scoop proteína whey
* Frutos rojos
* Canela
55g Proteína
* 300g yogur griego
* 1 scoop proteína whey
* Frutos rojos
* Canela
55g Proteína
ACNA legislative news: Bp Chip Edgar (South Carolina), joined by Bp Chris Warner (Mid-Atlantic), withdrew the diocese's 2 resolutions seeking the release of the Ruch trial transcripts & the eventual third-party report on the Ruch investigation. 🧵
Instead, a "third-party mediated inquiry" will be pursued into the procedures of the Ruch court, led by 4 diocesan chancellors, with a final report to be given to the standing committees and clergy who want to see it.
Bp Edgar: "I have never been much of a student of math, but when I was in high school, I had a math teacher... [who] always said to us... 'always show your work... you must always justify your answers.'
In 1942, an American shipyard built a 441-foot cargo ship in 4 days, 15 hours, and 29 minutes.
Not started. Not assembled from a kit. Built, from the laying of the keel to sliding into the water.
At the time, German U-boats were sinking Allied ships faster than Britain could replace them.
So America responded by building ships on a scale the enemy could never match.
This is the story of the Liberty ships..🧵1/6
Not started. Not assembled from a kit. Built, from the laying of the keel to sliding into the water.
At the time, German U-boats were sinking Allied ships faster than Britain could replace them.
So America responded by building ships on a scale the enemy could never match.
This is the story of the Liberty ships..🧵1/6
🧵 2/6
In 1941 Britain was being strangled.
German U-boats prowled the Atlantic in packs, sinking the merchant ships that carried the food, fuel, and weapons keeping Britain alive. By 1942 they were sinking ships at a rate that threatened to outpace Allied replacement. If the losses continued, Britain could be starved into surrender.
The United States, even before it entered the war, came up with an answer. It would mass-produce a single, simple, standardized cargo ship in numbers the enemy could never hope to match. The design, based on a British emergency cargo ship, was deliberately basic and cheap, an ungainly, slow vessel that President Roosevelt himself called a dreadful-looking object.
They named the first one the Patrick Henry, after the American revolutionary who said "give me liberty, or give me death." The whole class took its name from that. The Liberty ships.
The first one took 244 days to build. That was about to change dramatically.
In 1941 Britain was being strangled.
German U-boats prowled the Atlantic in packs, sinking the merchant ships that carried the food, fuel, and weapons keeping Britain alive. By 1942 they were sinking ships at a rate that threatened to outpace Allied replacement. If the losses continued, Britain could be starved into surrender.
The United States, even before it entered the war, came up with an answer. It would mass-produce a single, simple, standardized cargo ship in numbers the enemy could never hope to match. The design, based on a British emergency cargo ship, was deliberately basic and cheap, an ungainly, slow vessel that President Roosevelt himself called a dreadful-looking object.
They named the first one the Patrick Henry, after the American revolutionary who said "give me liberty, or give me death." The whole class took its name from that. The Liberty ships.
The first one took 244 days to build. That was about to change dramatically.
🧵 3/6
The man who transformed it was Henry Kaiser, an industrialist who had never built a ship in his life before the war.
That turned out to be his advantage. Kaiser did not build ships the way shipbuilders had done it for centuries, one at a time, piece by piece, by skilled craftsmen. He built them the way Henry Ford built cars.
Whole sections of the ship were prefabricated in factories far from the water, sometimes hundreds of miles inland, then shipped by rail to the yard and welded together rather than riveted. The work was broken down into simple steps that could be taught to brand new workers, many of them women and people who had never seen a shipyard before.
The construction time collapsed. From 244 days, to an average of around 42 days, and in some yards far less. By 1943 American yards were delivering an average of about three Liberty ships every single day.
Then they decided to see how fast they could really go.
The man who transformed it was Henry Kaiser, an industrialist who had never built a ship in his life before the war.
That turned out to be his advantage. Kaiser did not build ships the way shipbuilders had done it for centuries, one at a time, piece by piece, by skilled craftsmen. He built them the way Henry Ford built cars.
Whole sections of the ship were prefabricated in factories far from the water, sometimes hundreds of miles inland, then shipped by rail to the yard and welded together rather than riveted. The work was broken down into simple steps that could be taught to brand new workers, many of them women and people who had never seen a shipyard before.
The construction time collapsed. From 244 days, to an average of around 42 days, and in some yards far less. By 1943 American yards were delivering an average of about three Liberty ships every single day.
Then they decided to see how fast they could really go.