Recent well liked threads
COVID-19 is not just a story of inflammation. This review argues that it is also a story about what SARS2 does to mitochondria - and how that can turn infection into energy failure, cell injury, and worse oxygenation. This is an important mechanistic review🧵
Mitochondria are not framed here as passive bystanders damaged late in severe illness. In this model, they are active participants in disease - they shape ATP production, ROS, apoptosis, and oxygen sensing.
The review describes two main routes of damage -
very early changes in expression of mito-related genes (hours)
direct interactions between viral proteins and host mito proteins.
So not just the cell is stressed, but a more specific viral rewiring of core cell machinery.
very early changes in expression of mito-related genes (hours)
direct interactions between viral proteins and host mito proteins.
So not just the cell is stressed, but a more specific viral rewiring of core cell machinery.
thinking about omega!will who’s secretly pregnant in the epilogue. they got mated before graduation but their friends don’t know he’s already expecting after spending only one heat with mike. his alpha does, though; will broke the news to him last night, when he came over.
they know they’re going too fast but they can’t help it, it took them almost two years to start courting each other after the final battle. will kept his distance from mike for a while—he wasn’t mated to el but sometimes, an incomplete bond hurt twice as much as a fulfilled one.
he would know; he may have been just a kid when his father left but he remembers how torn up his mother had been in the aftermath. she refused to sleep in her bed—her nest—for weeks as his scent had gone sour, causing repulsion, her hand tracing the faded bite marks on her neck.
co-dependent #byler but it’s mike ruining will for anyone else because he listens to his every whim and goes the extra mile to solve the problems he faces. one time, will complains about the subway being crowded in the morning and he comes home to find a car in their driveway.
at first, it’s just a regular tuesday evening except when will places his bag on the couch and takes off his shoes, his brows furrow and his bunny teeth sink into his bottom lip for a second before he schools his expression and walks barefoot to their dining table. it’s enough.
not everyone would pick up on his distress from such a small sign of discomfort but just as his mother loves to remind him on their weekly scheduled phone calls, michael wheeler is not like everyone else. his heart seizes at the sight, desperate to fix whatever caused will pain.
🚨 Clearing your cookies does nothing.
That is not how they track you anymore.
Texas A&M and Johns Hopkins just published the first peer-reviewed proof.
It is called browser fingerprinting.
Here is what they found and what actually stops it:
That is not how they track you anymore.
Texas A&M and Johns Hopkins just published the first peer-reviewed proof.
It is called browser fingerprinting.
Here is what they found and what actually stops it:
Your browser leaks signals on every page load.
Screen resolution. Installed fonts. GPU model. Time zone. Browser version.
Alone, each one is harmless.
Combined, they form a fingerprint unique to your device.
No cookie. No login. No permission.
They see the fingerprint. They know it is you.
Screen resolution. Installed fonts. GPU model. Time zone. Browser version.
Alone, each one is harmless.
Combined, they form a fingerprint unique to your device.
No cookie. No login. No permission.
They see the fingerprint. They know it is you.
Texas A&M and Johns Hopkins built a tool called FPTrace.
Published at the ACM Web Conference 2025.
What they proved for the first time:
When your fingerprint changes, the price advertisers pay to target you changes with it. In real time.
This is not passive collection. This is active commercial targeting.
Published at the ACM Web Conference 2025.
What they proved for the first time:
When your fingerprint changes, the price advertisers pay to target you changes with it. In real time.
This is not passive collection. This is active commercial targeting.
🧵 HILO: Nadie te está contando lo que va a pasar con la comida en 2027. Yo si
1/ Ormuz lleva 2 meses efectivamente cerrado. Todo el mundo habla del petróleo. Nadie habla de lo que de verdad te va a afectar en el supermercado el año que viene.
1/ Ormuz lleva 2 meses efectivamente cerrado. Todo el mundo habla del petróleo. Nadie habla de lo que de verdad te va a afectar en el supermercado el año que viene.
2/ El Golfo Pérsico no solo exporta petróleo. Exporta el 46% del comercio mundial de urea — el fertilizante nitrogenado más usado en el planeta. Desde el 28 de febrero: cero barcos. Cero urea saliendo.
3/ ¿Por qué importa la urea? Porque el nitrógeno es el único fertilizante que no puedes saltarte ni una sola temporada. Potasio y fósforo: puedes esperar un año. Nitrógeno: si no lo aplicas esta primavera, esa cosecha no existe. Punto.
Cortisol dropped 24%. Anxiety dropped 58%.
One session.
Peer-reviewed journal.
My morning routine looks WEIRD but the BENEFITS are awesome:
One session.
Peer-reviewed journal.
My morning routine looks WEIRD but the BENEFITS are awesome:
This is how stress is stealing all the good chemicals in your brain:
It wipes out dopamine: the drive to want things.
It wipes out serotonin: the feeling of being okay.
It wipes out anandamide: the background sense of calm and satisfaction.
It wipes out oxytocin: the capacity to feel safe with people.
It wipes out GABA: the brain's natural brake on anxiety.
Five systems. At the same time.
And then it takes the thinking brain offline so you can't even reason your way out.
It wipes out dopamine: the drive to want things.
It wipes out serotonin: the feeling of being okay.
It wipes out anandamide: the background sense of calm and satisfaction.
It wipes out oxytocin: the capacity to feel safe with people.
It wipes out GABA: the brain's natural brake on anxiety.
Five systems. At the same time.
And then it takes the thinking brain offline so you can't even reason your way out.
The routine I'm talking about is based on this study:
Journal of Nervous and Mental Disease. Randomized controlled trial for EFT tapping.
One 60-minute session.
The tapping group dropped cortisol by 24%.
Anxiety dropped 58%. Depression dropped 49%. Overall symptoms dropped 50%.
Cortisol measured directly from saliva, not a questionnaire or a feeling scale.
A second study in 2020 replicated it. Their number: 43% cortisol reduction.
Journal of Nervous and Mental Disease. Randomized controlled trial for EFT tapping.
One 60-minute session.
The tapping group dropped cortisol by 24%.
Anxiety dropped 58%. Depression dropped 49%. Overall symptoms dropped 50%.
Cortisol measured directly from saliva, not a questionnaire or a feeling scale.
A second study in 2020 replicated it. Their number: 43% cortisol reduction.
🚨BREAKING: DOJ charges the Southern Poverty Law Center (SPLC) with wire fraud, false statements, and conspiracy to commit money laundering.
The SPLC secretly funneled $3M+ in donor funds to violent racist extremist groups:
-Ku Klux Klan
-American Nazi Party
-Aryan Nation
-United Klans of America
-Unite the Right
-National Alliance
-National Socialist Movement
-Sadistic Souls Motorcycle Club
-American Front
To hide the payments, SPLC allegedly opened bank accounts under fictitious entities to conceal the source and control of donor funds.
Per the indictment: an SPLC field source was a member of the online leadership chat group that planned the 2017 "Unite the Right" rally in Charlottesville — made racist postings under SPLC supervision and helped coordinate transportation to the event.
FBI Director Kash Patel: "They lied to their donors, vowing to dismantle violent extremist groups, and actually turned around and paid the leaders of these very extremist groups — even utilizing the funds to have these groups facilitate the commission of state and federal crimes."
Acting AG Todd Blanche: "The SPLC is manufacturing racism to justify its existence. Using donor money to allegedly profit off Klansmen cannot go unchecked."
Scheme allegedly ran 2014–2023.
FBI calls it an ongoing investigation.
Insane!!!
The SPLC secretly funneled $3M+ in donor funds to violent racist extremist groups:
-Ku Klux Klan
-American Nazi Party
-Aryan Nation
-United Klans of America
-Unite the Right
-National Alliance
-National Socialist Movement
-Sadistic Souls Motorcycle Club
-American Front
To hide the payments, SPLC allegedly opened bank accounts under fictitious entities to conceal the source and control of donor funds.
Per the indictment: an SPLC field source was a member of the online leadership chat group that planned the 2017 "Unite the Right" rally in Charlottesville — made racist postings under SPLC supervision and helped coordinate transportation to the event.
FBI Director Kash Patel: "They lied to their donors, vowing to dismantle violent extremist groups, and actually turned around and paid the leaders of these very extremist groups — even utilizing the funds to have these groups facilitate the commission of state and federal crimes."
Acting AG Todd Blanche: "The SPLC is manufacturing racism to justify its existence. Using donor money to allegedly profit off Klansmen cannot go unchecked."
Scheme allegedly ran 2014–2023.
FBI calls it an ongoing investigation.
Insane!!!
Federal Grand Jury Charges Southern Poverty Law Center for Wire Fraud, False Statements, and Conspiracy to Commit Money Laundering
justice.gov/usao-mdal/pr/f…
justice.gov/usao-mdal/pr/f…
2) The SPLC paid the leader of the American Nazi Party — a former KKK member and Aryan Nations director — $70,000, while listing him as an extremist on their own website, from which they solicited donations.
Any questions?
Any questions?
🚨READ IT
Today, @DAGToddBlanche & @FBIDirectorKash announced an 11-count indictment against the SPLC.
While SPLC raises money by claiming to oppose white supremacy, the indictment accuses the SPLC of paying the Ku Klux Klan😲
🧵1/12dailysignal.com/2026/04/21/spl…
Today, @DAGToddBlanche & @FBIDirectorKash announced an 11-count indictment against the SPLC.
While SPLC raises money by claiming to oppose white supremacy, the indictment accuses the SPLC of paying the Ku Klux Klan😲
🧵1/12dailysignal.com/2026/04/21/spl…
The indictment includes six counts of wire fraud, because the SPLC claimed that it aims to "dismantle white supremacy" but it actually funded a broad swath of white nationalist groups.
🧵2/12
🧵2/12
Beginning in the 1980s—the decade when SPLC's offices got firebombed—the SPLC cultivated a network of informants with violent extremist groups. It maintained those informants as recently as 2023, according to the indictment. SPLC funneled more than $3 million to them.
🧵3/12
🧵3/12
Después de 9 años en el gimnasio y de haber ayudado a más de 900 personas a bajar entre 9 y 36 kilos, aquí les dejo todos los consejos de fitness que pude recopilar:
1. Deja de beber alcohol.
1. Deja de beber alcohol.
2. Reducir una pulgada de cintura equivale a perder entre 1,5 y 2 kg de grasa. La báscula no es lo único que importa.
3. Consume al menos 50 g de proteína en tu primera comida.
4. Haz un ayuno de 24 horas a la semana.
5. ¿Pasas mucho tiempo sentado? Haz ejercicios de suspensión en barra después de cada entrenamiento para descomprimir la columna.
3. Consume al menos 50 g de proteína en tu primera comida.
4. Haz un ayuno de 24 horas a la semana.
5. ¿Pasas mucho tiempo sentado? Haz ejercicios de suspensión en barra después de cada entrenamiento para descomprimir la columna.
6. El 90% de tus comidas deben consistir en: pollo, bistec, carne de res, salmón, camarones, yogur griego, huevos, fruta, arroz, verduras y papas.
7. Levanta las piernas al menos dos veces por semana. Los músculos más grandes del cuerpo se encuentran en la parte inferior del cuerpo.
7. Levanta las piernas al menos dos veces por semana. Los músculos más grandes del cuerpo se encuentran en la parte inferior del cuerpo.
Most freelancers waste 6 hours doing work that AI can do in 6 minutes.The problem isn't the tool. It's the prompt.
Here are 5 AI prompts I use daily to run my entire workflow:👇
Here are 5 AI prompts I use daily to run my entire workflow:👇
1. The Brief Decoder
"I just received this client brief: [paste]. Identify the 3 things they actually want (vs. what they said), flag any vague requirements, and give me 5 clarifying questions I should ask before starting."
"I just received this client brief: [paste]. Identify the 3 things they actually want (vs. what they said), flag any vague requirements, and give me 5 clarifying questions I should ask before starting."
2. The Scope Protector
"Based on this project scope: [paste]. Write a professional email that sets clear deliverables, timelines, and revision limits, without sounding defensive or difficult to work with."
"Based on this project scope: [paste]. Write a professional email that sets clear deliverables, timelines, and revision limits, without sounding defensive or difficult to work with."
Olly Robbins: “It was difficult... as a leader, to explain why very talented and experienced diplomats were having to leave... and people who would be widely considered to have rather fewer credentials would be [given] these important jobs.” Really? 1/3
Robbins himself was arguably a political appointee. Yes, a career civil servant, but no FCDO experience. As for the senior appointments in his bizarre FCDO restructure, many top diplomats were "voluntarily severed", passed over for those with "rather fewer credentials". 2/3
Not to mention his "FCDO 2030" restructure that will slash ~25% of jobs, dramatically weakening FCDO's capacity to represent British citizens abroad.
So: no to ministerial scapegoating of officials. But no to the emerging cult of Saint Olly of King Charles Street, too. 3/3
So: no to ministerial scapegoating of officials. But no to the emerging cult of Saint Olly of King Charles Street, too. 3/3
I spoke with Zhang Chi, who spent the past year inside ByteDance Seed, the AI research division behind Doubao, China's most-used chatbot. His view, from the inside: the gap between Chinese and American AI iswidening. 🧵
Recent pieces have suggested Chinese AI is catching up and US export controls are a dud. Zhang, now a prof at Peking University, disagrees.
On iteration speed:
"Rumor has it that Google can do a full round of LLM training — both pre-training and post-training — in three months. One iteration every three months. But ByteDance, we can only do one iteration in half a year."
"I don't think any Chinese company can catch up soon."
"Rumor has it that Google can do a full round of LLM training — both pre-training and post-training — in three months. One iteration every three months. But ByteDance, we can only do one iteration in half a year."
"I don't think any Chinese company can catch up soon."
After years of working with top professionals, I’ve realised this:
You don’t need a perfect diet.
You need the right food categories.
These 7 improve gut health, metabolism, mitochondria & brain performance.
They’ve transformed their health & can do the same for you.
You don’t need a perfect diet.
You need the right food categories.
These 7 improve gut health, metabolism, mitochondria & brain performance.
They’ve transformed their health & can do the same for you.
Most nutrition advice is tribal.
“Keto vs vegan vs carnivore”
But your body doesn’t care about labels.
“Keto vs vegan vs carnivore”
But your body doesn’t care about labels.
It cares about:
→ nutrients
→ compounds
→ biological effects
These 7 categories deliver across ALL diets:
→ nutrients
→ compounds
→ biological effects
These 7 categories deliver across ALL diets:
🧵 Una riflessione sull'attacco della Russia nei confronti di @Giorgia Meloni: cause, obiettivi, modus operandi e possibili implicazioni.
Ed un focus sul ruolo di Vannacci, che nei piani del Cremlino potrebbe svolgere un ruolo più centrale di quello che crediamo.
1/➡️
Ed un focus sul ruolo di Vannacci, che nei piani del Cremlino potrebbe svolgere un ruolo più centrale di quello che crediamo.
1/➡️
Partiamo dalle cause. Credo che il fattore decisivo che ha portato il Cremlino ad alzare il tiro contro Giorgia Meloni non sia stato l'attacco di Trump, che pure può aver fatto da catalizzatore, facendo emergere una vulnerabilità che i russi hanno deciso di sfruttare.
2/➡️
2/➡️
Credo piuttosto siano state le parole di Meloni sul gas russo.
Dopo l'invasione dell'Ucraina, l'Europa ha deciso di togliersi dal collo il cappio di Gazprom. La chiusura dello stretto di Hormuz rappresenta, per i russi, un'occasione d'oro per rimettercelo. Forse l'ultima.
3/➡️
Dopo l'invasione dell'Ucraina, l'Europa ha deciso di togliersi dal collo il cappio di Gazprom. La chiusura dello stretto di Hormuz rappresenta, per i russi, un'occasione d'oro per rimettercelo. Forse l'ultima.
3/➡️
1 HILO IGNORANCIA Y LIBERTAD DE EXPRESIÓN
Hay una correlación entre la Ignorancia y Libertad de Expresión
Cuanto más Ignorancia, más Libertad de Expresión
Gracias al “Sistema Educativo”, tenemos mucha Libertad de Expresión
Total, digan lo que digan nadie podrá entenderlo..+
Hay una correlación entre la Ignorancia y Libertad de Expresión
Cuanto más Ignorancia, más Libertad de Expresión
Gracias al “Sistema Educativo”, tenemos mucha Libertad de Expresión
Total, digan lo que digan nadie podrá entenderlo..+
2 Así que por ejemplo el rabino David Touitou, puede decir “sus cosas” sin que nadie en Europa sea capaz de entenderlo
¿Es posible mayor Libertad de expresión?
Y todo gracias al “Sistema Educativo”
¿Es posible mayor Libertad de expresión?
Y todo gracias al “Sistema Educativo”
3 La IGNORANCIA te encierra en el mundo de los prejuicios
Por eso carece de importancia si a “los niños” les explican "su situación”
Lean lo que lean dirán "Qué bonito todo" y pasarán a hablar de la canción de moda
Por eso carece de importancia si a “los niños” les explican "su situación”
Lean lo que lean dirán "Qué bonito todo" y pasarán a hablar de la canción de moda
