Recent well liked threads
En honor al 26 de mayo, intentaré deconstruir el más grande lamento de Diomedes Díaz: «VOLVER A VIVIR». 
Este álbum fue lanzado, como era lo usual, el 26 de mayo de 1998. Diomedes recién salía de la cárcel por libertad condicional, mientras avanzaba el proceso penal, y estaba enfermo de lo que después sería el Guillain-Barre que le afectó los nervios hasta el final de su vida.
Su acordeonero era Iván Zuleta, el pollito que defendió en «Manguito Biche», pero al que no se le recuerda con la misma gloria de Colacho Mendoza o Juancho Rois. No era una época ni de cerca dorada y comenzaba el ocaso de la carrera del artista más importante de nuestra historia.
People keep talking about Democrats like they’ve never materially improved America.
But let’s look at the scoreboard.
• The last president to deliver multiple consecutive budget surpluses? Bill Clinton.
• Social Security? FDR.
• Medicare & Medicaid? LBJ.
• Civil Rights Act & Voting Rights Act? LBJ.
• Minimum wage, overtime protections, major child labor restrictions? FDR-era Democrats.
• FMLA protections? Clinton.
• Lilly Ledbetter Fair Pay Act? Obama.
Even the modern middle class was heavily built through Democratic-backed programs like the GI Bill, labor protections, federal home loans, and expanded access to college.
And when people talk about “fiscal responsibility,” it’s worth remembering:
The only modern presidents to move the federal budget into sustained surplus were Democrats. [1][2]
A lot of what Americans now consider “normal civilization” came from policies Republicans originally fought, mocked, or called socialism.
People inherited the benefits so completely they forgot who built them.
But let’s look at the scoreboard.
• The last president to deliver multiple consecutive budget surpluses? Bill Clinton.
• Social Security? FDR.
• Medicare & Medicaid? LBJ.
• Civil Rights Act & Voting Rights Act? LBJ.
• Minimum wage, overtime protections, major child labor restrictions? FDR-era Democrats.
• FMLA protections? Clinton.
• Lilly Ledbetter Fair Pay Act? Obama.
Even the modern middle class was heavily built through Democratic-backed programs like the GI Bill, labor protections, federal home loans, and expanded access to college.
And when people talk about “fiscal responsibility,” it’s worth remembering:
The only modern presidents to move the federal budget into sustained surplus were Democrats. [1][2]
A lot of what Americans now consider “normal civilization” came from policies Republicans originally fought, mocked, or called socialism.
People inherited the benefits so completely they forgot who built them.
Receipts:
[1] Harvard Kennedy School — “What would it take to balance the federal budget?”
hks.harvard.edu/centers/mrcbg/…
• Notes that 1969 and the Clinton-era surpluses were the only modern periods where revenues met or exceeded federal spending.
[2] Clinton White House Archives (Sept. 30, 1998)
clintonwhitehouse4.archives.gov/WH/Work/093098…
• Confirms the 1998 federal budget surplus and projected long-term debt reduction under Clinton.
[3] Reuters Fact Check — “Which U.S. presidents led the nation into new wars?”
reuters.com/article/world/…
• Reviews modern presidential war escalations and which administrations initiated major conflicts.
[4] Social Security Administration History
ssa.gov/history/35act.…
• Social Security established under Franklin D. Roosevelt in 1935.
[5] U.S. Senate Historical Office — Medicare & Medicaid
senate.gov/artandhistory/…
• Medicare and Medicaid signed into law by Lyndon B. Johnson in 1965.
[6] National Archives — Civil Rights Act of 1964
archives.gov/milestone-docu…
[7] National Archives — Voting Rights Act of 1965
archives.gov/milestone-docu…
• Landmark anti-segregation and voting protections signed under LBJ.
[8] U.S. Department of Labor — Fair Labor Standards Act
dol.gov/general/aboutd…
• Federal minimum wage, overtime protections, and child labor restrictions established during the FDR era.
[9] U.S. Department of Veterans Affairs — GI Bill History
va.gov/education/abou…
• GI Bill expanded mass college access and homeownership for returning veterans.
[10] U.S. Department of Labor — Family and Medical Leave Act
dol.gov/general/topic/…
• FMLA signed into law under Bill Clinton in 1993.
[1] Harvard Kennedy School — “What would it take to balance the federal budget?”
hks.harvard.edu/centers/mrcbg/…
• Notes that 1969 and the Clinton-era surpluses were the only modern periods where revenues met or exceeded federal spending.
[2] Clinton White House Archives (Sept. 30, 1998)
clintonwhitehouse4.archives.gov/WH/Work/093098…
• Confirms the 1998 federal budget surplus and projected long-term debt reduction under Clinton.
[3] Reuters Fact Check — “Which U.S. presidents led the nation into new wars?”
reuters.com/article/world/…
• Reviews modern presidential war escalations and which administrations initiated major conflicts.
[4] Social Security Administration History
ssa.gov/history/35act.…
• Social Security established under Franklin D. Roosevelt in 1935.
[5] U.S. Senate Historical Office — Medicare & Medicaid
senate.gov/artandhistory/…
• Medicare and Medicaid signed into law by Lyndon B. Johnson in 1965.
[6] National Archives — Civil Rights Act of 1964
archives.gov/milestone-docu…
[7] National Archives — Voting Rights Act of 1965
archives.gov/milestone-docu…
• Landmark anti-segregation and voting protections signed under LBJ.
[8] U.S. Department of Labor — Fair Labor Standards Act
dol.gov/general/aboutd…
• Federal minimum wage, overtime protections, and child labor restrictions established during the FDR era.
[9] U.S. Department of Veterans Affairs — GI Bill History
va.gov/education/abou…
• GI Bill expanded mass college access and homeownership for returning veterans.
[10] U.S. Department of Labor — Family and Medical Leave Act
dol.gov/general/topic/…
• FMLA signed into law under Bill Clinton in 1993.
Funny how some people in the replies to this post suddenly understand political realignment perfectly when claiming Lincoln, abolition, and the Civil Rights Act…
…but then pretend party history is frozen in amber when segregation, voter suppression, or attacks on voting protections come up.
You can’t simultaneously:
• condemn Dixiecrats
• claim the Civil Rights Act as moral inheritance
• praise the Voting Rights Act
• then defend gutting federal voting oversight and restricting access to the ballot
At some point the question stops being:
“What was the party label?”
…and becomes:
“What behavior are you actually defending?”
Because if the behavior survived under a different banner, then maybe the lesson absorbed wasn’t moral.
Maybe it was just branding.
…but then pretend party history is frozen in amber when segregation, voter suppression, or attacks on voting protections come up.
You can’t simultaneously:
• condemn Dixiecrats
• claim the Civil Rights Act as moral inheritance
• praise the Voting Rights Act
• then defend gutting federal voting oversight and restricting access to the ballot
At some point the question stops being:
“What was the party label?”
…and becomes:
“What behavior are you actually defending?”
Because if the behavior survived under a different banner, then maybe the lesson absorbed wasn’t moral.
Maybe it was just branding.
״סיפורו של מחדל״ - פרק 2:
היום במיזם המיוחד שלנו - איך צלצלו הפעמונים באוגדת עזה ובפיקוד הדרום שוב ושוב, ושוב, ואיש לא הבחין? איך זרמו לצה״ל במשך שנתיים (2019-2020) ידיעות רבות - שהעניקו חיזוק לתוכנית המתקפה של חמאס שכבר הייתה בידי אנשי המודיעין (מ-2018) - ואיש לא חיבר בין הנקודות?
וגם: גילויים חדשים על מבצע ״שומר החומות״ - אחת הנקודות הדרמטיות בדרך לטבח 7 באוקטובר.
הפרק המלא זמין להאזנה בכל אפליקציות הפודקאסטים, מוזמנים גם לשרשור כאן עם העיקרים >>
היום במיזם המיוחד שלנו - איך צלצלו הפעמונים באוגדת עזה ובפיקוד הדרום שוב ושוב, ושוב, ואיש לא הבחין? איך זרמו לצה״ל במשך שנתיים (2019-2020) ידיעות רבות - שהעניקו חיזוק לתוכנית המתקפה של חמאס שכבר הייתה בידי אנשי המודיעין (מ-2018) - ואיש לא חיבר בין הנקודות?
וגם: גילויים חדשים על מבצע ״שומר החומות״ - אחת הנקודות הדרמטיות בדרך לטבח 7 באוקטובר.
הפרק המלא זמין להאזנה בכל אפליקציות הפודקאסטים, מוזמנים גם לשרשור כאן עם העיקרים >>
1/ במהלך 2018 מספר בעלי תפקידים חשובים מתחלפים: הרצי הלוי מחליף את אייל זמיר כאלוף פיקוד הדרום; אליעזר טולדנו מחליף את יהודה פוקס באוגדת עזה; וגם הקמ״נים של אוגדת עזה מתחלפים. הלוי, שמגיע לחפיפה בפיקוד - לא שומע שם דבר על תוכנית המתקפה של חמאס שהגיעה לפיקוד כמה חודשים קודם >>
2/ גם במרחב דרום של שב״כ, לשם מגיע אלוף הפיקוד הטרי לחפיפה, לא מזכירים דבר בנושא.
קמ״ן אוגדת עזה החדש, סא״ל ר׳ (כיום - קמ״ן פיקוד דרום המכהן) - מחליף את סא״ל נתנאל קולה - שכתב מסמך מודיעיני מפורט על תוכנית חמאס, ועד היום יש ויכוח האם הנושא הועבר בחפיפה. כל אחד מהם טוען אחרת >>
קמ״ן אוגדת עזה החדש, סא״ל ר׳ (כיום - קמ״ן פיקוד דרום המכהן) - מחליף את סא״ל נתנאל קולה - שכתב מסמך מודיעיני מפורט על תוכנית חמאס, ועד היום יש ויכוח האם הנושא הועבר בחפיפה. כל אחד מהם טוען אחרת >>
geçen hafta claude ile bir youtube kanalının tüm içerik sistemini kurdum.
aylık planı 1 GÜNDE, tek çekimden 30 parça içerik, haftada 10 saatlik işi 2 saate indirdim.
tek kişi, sıfır ekip. tüm sistemi adım adım anlatıyorum.
aylık planı 1 GÜNDE, tek çekimden 30 parça içerik, haftada 10 saatlik işi 2 saate indirdim.
tek kişi, sıfır ekip. tüm sistemi adım adım anlatıyorum.
önce yanlışı temizleyelim: "youtube otomasyonu" robotun video basıp para yağdırması değil. öyle bir şey yok, olsa çöp çıkar.
asıl otomasyon, seni yavaşlatan tekrar eden işi claude'a vermek.
sen yönetmen kalıyorsun, işçi değil.
asıl otomasyon, seni yavaşlatan tekrar eden işi claude'a vermek.
sen yönetmen kalıyorsun, işçi değil.
katman 1, araştırma.
claude'a nişimi ve 10 rakip kanalı verdim. hangi konu patlamış, hangi başlık kalıbı çalışıyor, nerede boşluk var.
2 saatlik işi 10 dakikaya indirdi. tahminle değil, veriyle çekiyorum artık.
claude'a nişimi ve 10 rakip kanalı verdim. hangi konu patlamış, hangi başlık kalıbı çalışıyor, nerede boşluk var.
2 saatlik işi 10 dakikaya indirdi. tahminle değil, veriyle çekiyorum artık.
1/ First time I watched Fight Club, I was a teenager. I thought it was the coolest thing ever put on film.
I watched it again recently in my forties. I finally understood what it was actually about. And almost everyone I know who loves it is still watching it the way I did at 17. 🧵👇
I watched it again recently in my forties. I finally understood what it was actually about. And almost everyone I know who loves it is still watching it the way I did at 17. 🧵👇
2/ If you only know it by reputation, here’s the shape of it. Chuck Palahniuk wrote the novel in 1996, and it was adapted into a film by David Fincher in 1999. The film is famously faithful to the book with a few changes, the biggest being the ending, which Palahniuk has said he prefers to his own.
3/ The narrator has no name. He’s a recall coordinator for a car company. This guy flies around inspecting car wrecks and working out whether it’s cheaper for his employer to recall the faulty model or pay out the wrongful death settlements. That’s what he does for a living.
1/5
I'm a cardiologist. I have spent twenty years watching cholesterol destroy arteries, trigger heart attacks, and kill people I care about.
Today, Eli Lilly presented data that may begin to end that era.
VERVE-102. A single infusion. One dose. It uses base editing to permanently turn off the PCSK9 gene in your liver.
Presented today at the European Atherosclerosis Society Congress:
88% reduction in PCSK9.
62% reduction in LDL cholesterol.
Sustained up to 18 months.
No treatment-related serious adverse events.
One infusion. Not daily pills you forget to take. Not monthly injections. One dose — and your cholesterol may stay low for the rest of your life.
I'm a cardiologist. I have spent twenty years watching cholesterol destroy arteries, trigger heart attacks, and kill people I care about.
Today, Eli Lilly presented data that may begin to end that era.
VERVE-102. A single infusion. One dose. It uses base editing to permanently turn off the PCSK9 gene in your liver.
Presented today at the European Atherosclerosis Society Congress:
88% reduction in PCSK9.
62% reduction in LDL cholesterol.
Sustained up to 18 months.
No treatment-related serious adverse events.
One infusion. Not daily pills you forget to take. Not monthly injections. One dose — and your cholesterol may stay low for the rest of your life.
2/5
Let me explain why this is so profound.
There are rare people born with naturally occurring loss-of-function variants in the PCSK9 gene. Their bodies produce very little PCSK9 protein. Their LDL cholesterol stays naturally low throughout their entire lives. They almost never develop coronary heart disease.
VERVE-102 is designed to give that same genetic protection to anyone who needs it. One infusion. Permanently edits the gene. Mimics what nature already does in the luckiest among us.
Lilly acquired the technology for roughly $1 billion and is preparing to launch Phase 2 trials by the end of this year.
Heart disease remains the number one killer on earth. Every moment of LDL exposure matters for your lifetime cardiovascular risk. A one-time treatment that durably eliminates excess LDL could prevent millions of heart attacks that haven't happened yet.
This is not incremental. This is a paradigm shift.
Let me explain why this is so profound.
There are rare people born with naturally occurring loss-of-function variants in the PCSK9 gene. Their bodies produce very little PCSK9 protein. Their LDL cholesterol stays naturally low throughout their entire lives. They almost never develop coronary heart disease.
VERVE-102 is designed to give that same genetic protection to anyone who needs it. One infusion. Permanently edits the gene. Mimics what nature already does in the luckiest among us.
Lilly acquired the technology for roughly $1 billion and is preparing to launch Phase 2 trials by the end of this year.
Heart disease remains the number one killer on earth. Every moment of LDL exposure matters for your lifetime cardiovascular risk. A one-time treatment that durably eliminates excess LDL could prevent millions of heart attacks that haven't happened yet.
This is not incremental. This is a paradigm shift.
3/5
But cholesterol is only the beginning. Look at what's converging right now across medicine.
Personalized mRNA cancer vaccines. Moderna and Merck's personalized neoantigen vaccine showed a 49% reduction in cancer recurrence or death at five years in melanoma patients. They sequence your individual tumor, identify up to 34 unique mutations, and engineer a vaccine that teaches your immune system to hunt your specific cancer cells. Phase 3 trials are fully enrolled. They're expanding into lung cancer, kidney cancer, and bladder cancer.
In pancreatic cancer — one of the deadliest — patients who mounted an immune response to a personalized mRNA vaccine achieved 100% recurrence-free survival at 18 months.
A vaccine. For cancer. Personalized to your tumor. We said this was impossible ten years ago.
But cholesterol is only the beginning. Look at what's converging right now across medicine.
Personalized mRNA cancer vaccines. Moderna and Merck's personalized neoantigen vaccine showed a 49% reduction in cancer recurrence or death at five years in melanoma patients. They sequence your individual tumor, identify up to 34 unique mutations, and engineer a vaccine that teaches your immune system to hunt your specific cancer cells. Phase 3 trials are fully enrolled. They're expanding into lung cancer, kidney cancer, and bladder cancer.
In pancreatic cancer — one of the deadliest — patients who mounted an immune response to a personalized mRNA vaccine achieved 100% recurrence-free survival at 18 months.
A vaccine. For cancer. Personalized to your tumor. We said this was impossible ten years ago.
99% of people delete the wrong things when Gmail storage gets full.
They remove emails.
But Google hides the biggest storage hog somewhere else.
I freed 18GB without touching a single important email.
Here’s the first place you should check 👇
They remove emails.
But Google hides the biggest storage hog somewhere else.
I freed 18GB without touching a single important email.
Here’s the first place you should check 👇
1. THE PROMOTIONS TAB BLACK HOLE
Years of:
• shopping emails
• coupons
• newsletters
• OTPs
• marketing blasts
…are quietly eating storage.
Most people never clean them.
Search this in Gmail:
category:promotions older_than:1y
Then mass delete thousands instantly.
Years of:
• shopping emails
• coupons
• newsletters
• OTPs
• marketing blasts
…are quietly eating storage.
Most people never clean them.
Search this in Gmail:
category:promotions older_than:1y
Then mass delete thousands instantly.
2. THE HIDDEN ATTACHMENT MONSTER
Large PDFs.
Videos.
ZIP files.
Screenshots.
Old attachments silently pile up for YEARS.
Search:
has:attachment larger:10M
You’ll probably find gigabytes immediately.
Large PDFs.
Videos.
ZIP files.
Screenshots.
Old attachments silently pile up for YEARS.
Search:
has:attachment larger:10M
You’ll probably find gigabytes immediately.
🚨NotebookLM can now turn Articles, PDFs, and YouTube Videos into Structured Insights — like having an MIT researcher working alongside you.
Here are 10 prompts that will completely change how you analyze information 👇
Here are 10 prompts that will completely change how you analyze information 👇
1. Executive Summary (like a senior MIT researcher)
“Analyze all sources and generate an executive summary including:
→ Main findings.
→ Key insights.
→ Conclusions.
→ Practical implications.
→ Actionable recommendations.
Present the output in clear, professional language for an executive audience.”
“Analyze all sources and generate an executive summary including:
→ Main findings.
→ Key insights.
→ Conclusions.
→ Practical implications.
→ Actionable recommendations.
Present the output in clear, professional language for an executive audience.”
2. Critical Insight Extraction (the ideas that change the game)
“Identify the 10 most important findings from the sources. For each one, explain:
→ Why it matters.
→ What evidence supports it.
→ How it can be applied in the real world.
→ What impact it could create”
“Identify the 10 most important findings from the sources. For each one, explain:
→ Why it matters.
→ What evidence supports it.
→ How it can be applied in the real world.
→ What impact it could create”
The truth is slowly coming out about J6!
Tom Fitton had to file a case just to get the Fanone Body Cams released so the Truth could be revealed! Judicial Watch v. District of Columbia.
Judge Veronica Sanchez, ruled that Fanone’s Body Cam footage from Jan 6 had to be released to the Public!
All this because Tom Fitton filed a case to have the body camera footage released in Judicial Watch vs District of Columbia.
I bet the judge believed all of Fanone’s lies from his testimony before Congress, that’s why she agreed to release it.
We now see the lies and fake Testimony he gave under oath! Also the Judge is a Biden appointee.
NEVER FORGET that Fanone has called for the Shooting of ICE Officers, he Physically Confronted Nancy Mace at the Capitol, he flipped out on a Reporter about his pretending to be dead, and threatened President Trump.
Continued … Thread 🧵
Tom Fitton had to file a case just to get the Fanone Body Cams released so the Truth could be revealed! Judicial Watch v. District of Columbia.
Judge Veronica Sanchez, ruled that Fanone’s Body Cam footage from Jan 6 had to be released to the Public!
All this because Tom Fitton filed a case to have the body camera footage released in Judicial Watch vs District of Columbia.
I bet the judge believed all of Fanone’s lies from his testimony before Congress, that’s why she agreed to release it.
We now see the lies and fake Testimony he gave under oath! Also the Judge is a Biden appointee.
NEVER FORGET that Fanone has called for the Shooting of ICE Officers, he Physically Confronted Nancy Mace at the Capitol, he flipped out on a Reporter about his pretending to be dead, and threatened President Trump.
Continued … Thread 🧵
Thread 🧵continued 2 of 4
Part 1 Footage:
The released footage PLAINLY showed that Michael Fanone attempted many times to turn off his body camera on January 6th, while he was faking a heart attack AND faking that he was unconscious.
Part 1 Footage:
The released footage PLAINLY showed that Michael Fanone attempted many times to turn off his body camera on January 6th, while he was faking a heart attack AND faking that he was unconscious.
Thread 🧵continued 3 of 4
Part 2 Footage:
The released footage PLAINLY showed that Michael Fanone was up and walking around the White House AFTER he faked his heart attack and being unconscious.
The footage also shows MANY other officers walking with him and going along with the rouse.
Part 2 Footage:
The released footage PLAINLY showed that Michael Fanone was up and walking around the White House AFTER he faked his heart attack and being unconscious.
The footage also shows MANY other officers walking with him and going along with the rouse.
Famous Insta Hottie Simran Kaur’s app-exclusive collections 👀 I promise you haven’t seen these before 🔥😱
A Thread 🧵
A Thread 🧵
Sur base du post de @CommanderTorenn, j'ai refait (avec l'IA) les graphiques. cc @NicolasQuiPaie
Budget des actifs de 1956 à 2026 :
1/n
Budget des actifs de 1956 à 2026 :
1/n
Coût total employeur :
2/n
2/n
Pourvoir d'achat d'un cadre Français moyen :
3/n
3/n
AG1 has 550+ active Meta ads right now.
But they aren't brainstorming 550 different ideas.
They just run these 5 proven formats on repeat.
[bookmark this]
But they aren't brainstorming 550 different ideas.
They just run these 5 proven formats on repeat.
[bookmark this]
1/ The High-Stress Professional
Simple. Relatable. Exhausted.
A nurse getting home from a long shift, talking about how cortisol keeps her from unwinding.
It’s not a generic "I can't sleep" ad. It targets a very specific, high-stress career. That’s the hook.
Simple. Relatable. Exhausted.
A nurse getting home from a long shift, talking about how cortisol keeps her from unwinding.
It’s not a generic "I can't sleep" ad. It targets a very specific, high-stress career. That’s the hook.
2/ The Authority Endorsement
Dr. Andrew Huberman sitting in a dark room, breaking down the exact science and formulation of the supplement.
Instant credibility.
(If you can't afford a $100M podcaster, that's fine. Hire a local doctor, a nutritionist, or a certified expert in your niche. The psychology is the exact same).
Dr. Andrew Huberman sitting in a dark room, breaking down the exact science and formulation of the supplement.
Instant credibility.
(If you can't afford a $100M podcaster, that's fine. Hire a local doctor, a nutritionist, or a certified expert in your niche. The psychology is the exact same).
The Telegraph: Macron tore up 65 years of doctrine to defend Europe with French nukes, with or without the US.
Poland, Germany, the Netherlands, Belgium, Greece, Sweden, Denmark, and now the Czech Republic will host French nuclear-armed Rafales. 1/
Poland, Germany, the Netherlands, Belgium, Greece, Sweden, Denmark, and now the Czech Republic will host French nuclear-armed Rafales. 1/
France holds 290 warheads, Britain 225. Their combined arsenal totals 515 weapons against Russia's 5,580 and America's 5,225.
Without Washington, Russia alone outguns Europe 11-to-1 in warheads. Macron's plan makes those 515 European weapons unpredictable enough to matter. 2/
Without Washington, Russia alone outguns Europe 11-to-1 in warheads. Macron's plan makes those 515 European weapons unpredictable enough to matter. 2/
Under Macron's "forward deterrence" plan, French Rafale jets carrying tactical nukes will rotate secretly through allied bases across Europe.
Britain's four Trident submarines and France's four ballistic-missile subs will maintain a continuous at-sea deterrent. 3/
Britain's four Trident submarines and France's four ballistic-missile subs will maintain a continuous at-sea deterrent. 3/
🚨 A federal court has blocked Alabama from using its new congressional map, ordering the state to use a court-imposed map with 2 majority-black seats for the 2026 elections.
The three-judge panel finds that Plaintiffs are likely to succeed on their Section 2 claims even after Callais.
It also finds that Alabama intentionally discriminated against black voters in violation of the 14th Amendment.
It also finds that Alabama intentionally discriminated against black voters in violation of the 14th Amendment.
The Court finds that Purcell does not bar relief because the court-imposed map is the operational status quo.
At the height of COVID, a “crazy” doctor was treating patients with a 99.96% survival rate.
Dr. Zelenko’s protocol was so effective, it sparked a war against HCQ.
They mocked his claims, but they kept coming true. Here’s what he said:
#1 - “Not everyone got the same thing.”
Dr. Zelenko’s protocol was so effective, it sparked a war against HCQ.
They mocked his claims, but they kept coming true. Here’s what he said:
#1 - “Not everyone got the same thing.”
In an interview with Mel K, Dr. Zelenko said, “Some of the lots were 5,000% more lethal than others — or think of it as 50x. So, let’s say one vial killed one person. Another vial killed 50 people.”
“If everyone would have gotten the same thing, it would be a clear correlation that you’re being poisoned, and no one would take it,” Dr. Zelenko concluded. Thus, the answer to why some people took the shot and turned out okay is because “not everyone got the same thing.”
“If everyone would have gotten the same thing, it would be a clear correlation that you’re being poisoned, and no one would take it,” Dr. Zelenko concluded. Thus, the answer to why some people took the shot and turned out okay is because “not everyone got the same thing.”
Dr. Zelenko’s bold claim was confirmed in March 2023, when a study performed by Schmeling and colleagues found that 4.2% of the batches accounted for a staggering 71% of adverse events.
1/5
I'm a cardiologist. Here's why I recommend men take 5 mg of tadalafil — Cialis — every single day.
Not for ED. Not for performance.
I take it for the same reason every serious longevity physician I respect does: to protect my cardiovascular system, my brain perfusion, and my endothelial health at the most fundamental level.
This drug — famous for all the wrong reasons — has quietly become one of the most powerful tools in preventive cardiology. And the data is now too strong for me to keep quiet about it.
I'm a cardiologist. Here's why I recommend men take 5 mg of tadalafil — Cialis — every single day.
Not for ED. Not for performance.
I take it for the same reason every serious longevity physician I respect does: to protect my cardiovascular system, my brain perfusion, and my endothelial health at the most fundamental level.
This drug — famous for all the wrong reasons — has quietly become one of the most powerful tools in preventive cardiology. And the data is now too strong for me to keep quiet about it.
2/5
Here's what tadalafil actually does.
PDE5 is the enzyme that breaks down cGMP — the molecule that tells your smooth muscle to relax and your blood vessels to dilate. By blocking PDE5, tadalafil produces system-wide vasodilation: better blood flow to the heart, brain, lungs, kidneys, muscles — every organ downstream of your vascular tree.
Unlike Viagra, which lasts 4-6 hours, tadalafil's effects last up to 36 hours. A low daily dose keeps plasma levels stable around the clock.
Now here's why this matters for your heart.
Endothelial dysfunction — the failure of that thin layer of cells lining 60,000 miles of your blood vessels — is the earliest, most predictive marker of cardiovascular disease. It precedes plaque, heart attacks, and strokes by years. By the time most patients reach my office, the damage is done.
Tadalafil directly improves endothelial function. It reduces arterial stiffness. It shows anti-fibrotic effects on the heart muscle in preclinical models. It's already FDA-approved for pulmonary arterial hypertension.
Most patients come to me when something has already broken. I'm treating the pipes before they clog.
Here's what tadalafil actually does.
PDE5 is the enzyme that breaks down cGMP — the molecule that tells your smooth muscle to relax and your blood vessels to dilate. By blocking PDE5, tadalafil produces system-wide vasodilation: better blood flow to the heart, brain, lungs, kidneys, muscles — every organ downstream of your vascular tree.
Unlike Viagra, which lasts 4-6 hours, tadalafil's effects last up to 36 hours. A low daily dose keeps plasma levels stable around the clock.
Now here's why this matters for your heart.
Endothelial dysfunction — the failure of that thin layer of cells lining 60,000 miles of your blood vessels — is the earliest, most predictive marker of cardiovascular disease. It precedes plaque, heart attacks, and strokes by years. By the time most patients reach my office, the damage is done.
Tadalafil directly improves endothelial function. It reduces arterial stiffness. It shows anti-fibrotic effects on the heart muscle in preclinical models. It's already FDA-approved for pulmonary arterial hypertension.
Most patients come to me when something has already broken. I'm treating the pipes before they clog.
3/5
The population-level data made this decision easy for me.
A longitudinal study analyzing over 500,000 men from the TriNetX database — one of the largest real-world datasets in medicine — found tadalafil was associated with:
34% reduced all-cause mortality. 27% reduced heart attacks. 34% reduced stroke. 21% reduced venous thromboembolism. 32% reduced dementia.
Half a million men. Three-year follow-up. Propensity-matched for demographics and eight pre-existing conditions.
A separate meta-analysis pooling data from over 8 million individuals found PDE5 inhibitor use associated with a 47% reduction in Alzheimer's risk.
A UK study of nearly 270,000 men found that those with 20 or more tadalafil prescriptions had a 44% reduction in dementia risk.
I want to be transparent: these are observational studies, not randomized controlled trials. But the consistency of the signal across multiple large databases, the biological plausibility, and the established safety profile make this a compelling addition to a longevity protocol.
The population-level data made this decision easy for me.
A longitudinal study analyzing over 500,000 men from the TriNetX database — one of the largest real-world datasets in medicine — found tadalafil was associated with:
34% reduced all-cause mortality. 27% reduced heart attacks. 34% reduced stroke. 21% reduced venous thromboembolism. 32% reduced dementia.
Half a million men. Three-year follow-up. Propensity-matched for demographics and eight pre-existing conditions.
A separate meta-analysis pooling data from over 8 million individuals found PDE5 inhibitor use associated with a 47% reduction in Alzheimer's risk.
A UK study of nearly 270,000 men found that those with 20 or more tadalafil prescriptions had a 44% reduction in dementia risk.
I want to be transparent: these are observational studies, not randomized controlled trials. But the consistency of the signal across multiple large databases, the biological plausibility, and the established safety profile make this a compelling addition to a longevity protocol.
Snyder: Trump is very much on Putin’s side. He keeps saying Russia has to win, will win, or has already won — but none of that is true.
Trump moved a lot of American power onto Russia’s side, and still Russia has not won. Russia is losing the war. 1/
Trump moved a lot of American power onto Russia’s side, and still Russia has not won. Russia is losing the war. 1/
Snyder: America has two negotiators, and neither is a diplomat: the president’s son-in-law and the president’s friend.
In any other country, that would look corrupt and impossible to work. It has already failed with Ukraine and Iran. 2/
In any other country, that would look corrupt and impossible to work. It has already failed with Ukraine and Iran. 2/
Snyder: Trump took the United States and made it much less powerful. China was never going to catch up unless Trump became president.
Now America has losses in science, education, and a war it should never have fought — so Trump goes to Beijing to beg. 3/
Now America has losses in science, education, and a war it should never have fought — so Trump goes to Beijing to beg. 3/
Aprovechando esta crítica de Roemer, vamos a hablar en un hilo divulgativo sobre la importancia de la modelización de las expectativas en economía, sus implicaciones y la manera "adecuada" de concebir qué dicen y qué no dice la famosa hipótesis de "expectativas racionales".
Creo que entender bien la cuestión es mucho más interesante que la versión caricaturesca de "los economistas creen que la gente se comporta como robots y nunca se equivocan". Aunque es un gran economista, creo que Roemer simplifica demasiado cuando dice que se trata de "una mera conveniencia matemática para cerrar el modelo"....🧵
Creo que entender bien la cuestión es mucho más interesante que la versión caricaturesca de "los economistas creen que la gente se comporta como robots y nunca se equivocan". Aunque es un gran economista, creo que Roemer simplifica demasiado cuando dice que se trata de "una mera conveniencia matemática para cerrar el modelo"....🧵
2) Empecemos por una diferencia clave entre la física y la economía. Cuando se lanza un cohete a la Luna, su trayectoria no cambia porque exista una teoría que la describa. Sin embargo con las personas ocurre algo más complicado. La gente cambia su comportamiento en función de lo que cree que va a pasar. Por ejemplo, si el Banco Central anuncia hoy que subirá los tipos de interés durante los próximos cinco años, las empresas y los mercados reaccionan hoy mismo tomando posiciones para intentar beneficiarse de la situación. Y no toman las mismas posiciones si se creen el anuncio que si no.
Tom Sargent explica la complejidad añadida del comportamiento humano con un ejemplo de fútbol americano (JFV lo cuenta en el video que enlazo, aproximadamente en el 1:27). Un quarterback no juega igual en el primer cuarto que en el último. Al comienzo del partido puede ser más conservador, ocultar ciertas jugadas o no enseñar todas sus armas demasiado pronto. En el último cuarto, en cambio, quizá arriesga más, acelera el ritmo o busca pases largos porque el tiempo se acaba y el rival ya conoce parte de su estrategia. Cada decisión depende, por tanto, no solo de las reglas del juego, sino de lo que cada jugador cree que harán los demás. Todos observan, aprenden y reaccionan a lo que hace el resto.
Creo que podemos afirmar ya en este punto que hacer macro sin modelar expectativas es como analizar un partido de fútbol americano olvidando que los jugadores piensan estratégicamente...
youtu.be/awGnC17aCxs?si…
Tom Sargent explica la complejidad añadida del comportamiento humano con un ejemplo de fútbol americano (JFV lo cuenta en el video que enlazo, aproximadamente en el 1:27). Un quarterback no juega igual en el primer cuarto que en el último. Al comienzo del partido puede ser más conservador, ocultar ciertas jugadas o no enseñar todas sus armas demasiado pronto. En el último cuarto, en cambio, quizá arriesga más, acelera el ritmo o busca pases largos porque el tiempo se acaba y el rival ya conoce parte de su estrategia. Cada decisión depende, por tanto, no solo de las reglas del juego, sino de lo que cada jugador cree que harán los demás. Todos observan, aprenden y reaccionan a lo que hace el resto.
Creo que podemos afirmar ya en este punto que hacer macro sin modelar expectativas es como analizar un partido de fútbol americano olvidando que los jugadores piensan estratégicamente...
youtu.be/awGnC17aCxs?si…
3) La manera de tratar esto no se entendió de golpe. En los 50 y 60, la macro de la denominada sìntésis neoclásica construía modelos cada vez mayores, con decenas de ecuaciones para modernizar las relaciones entre los agregados de las economías (consumo, inventarios, inversión, exportaciónes...).
A medida que la dinámica (entendida como el paso del tiempo) se volvía más y más protagonista, asomaba un problema importante la inversión de hoy depende de la producción que se espera mañana. ¿Y cómo podríamos modelizar lo que la gente cree que pasará mañana?
Propongamos, por ejemplo, quizá las dos dos opciones más obvias.
1⃣ Previsión perfecta, que consistiría en asumir que los agentes aciertan exactamente lo que ocurrirá. El problema es evidente. Si eliminamos el error, también desaparece la incertidumbre.
2⃣ Expectativas adaptativas, que parten de una idea intuitiva: la gente forma sus expectativas mirando el pasado. Si la inflación lleva años subiendo, espera que siga subiendo. Es, en cierto modo, conducir mirando el retrovisor. Aunque de hecho explica ciertas dinámicas nada triviales por sus consecuencias (el error trágico de "prepararse para la guerra pasada", por ejemplo), el problema es doble. Por un lado, el enfoque podía ser miope. Por otro, dejaba demasiado margen al economista, porque pequeños cambios en los pesos dados al pasado alteraban mucho los resultados. Ajustando esos parámetros, el modelo podía acabar diciendo casi cualquier cosa.
Se necesita, posiblemente, UNA TERCERA, que tardaría veinte años en formalizarse...
A medida que la dinámica (entendida como el paso del tiempo) se volvía más y más protagonista, asomaba un problema importante la inversión de hoy depende de la producción que se espera mañana. ¿Y cómo podríamos modelizar lo que la gente cree que pasará mañana?
Propongamos, por ejemplo, quizá las dos dos opciones más obvias.
1⃣ Previsión perfecta, que consistiría en asumir que los agentes aciertan exactamente lo que ocurrirá. El problema es evidente. Si eliminamos el error, también desaparece la incertidumbre.
2⃣ Expectativas adaptativas, que parten de una idea intuitiva: la gente forma sus expectativas mirando el pasado. Si la inflación lleva años subiendo, espera que siga subiendo. Es, en cierto modo, conducir mirando el retrovisor. Aunque de hecho explica ciertas dinámicas nada triviales por sus consecuencias (el error trágico de "prepararse para la guerra pasada", por ejemplo), el problema es doble. Por un lado, el enfoque podía ser miope. Por otro, dejaba demasiado margen al economista, porque pequeños cambios en los pesos dados al pasado alteraban mucho los resultados. Ajustando esos parámetros, el modelo podía acabar diciendo casi cualquier cosa.
Se necesita, posiblemente, UNA TERCERA, que tardaría veinte años en formalizarse...
