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「神々の血脈」8巻まで書いたところで、自分が出資したゲームが発売されなくなり、他のローンも合わせて、8500万円ほど借金ができました。
僕は「神々の血脈」を書くために作家になったので、こんな状態では、作品を完成させられないと、2DKのアパートに引っ越しました。
僕は「神々の血脈」を書くために作家になったので、こんな状態では、作品を完成させられないと、2DKのアパートに引っ越しました。
突然、貧乏になったので、家族はたいへんだったと思います。女房もキッチンドランカーになりましたし、子供達も、縁の切れる友達ができて、たいへんでしたが、僕は耳をさふいで「神々の血脈」を書き続けました。1990年頃のことです
いちばん困ったのは、資料です。それまで思うように購入してきたのですが、お金がないので買うことができず、近隣の図書館に通いました。特に、国立市の図書館の地質・地球物理の本は、開架の本は全部読んだと思います。
A man sat at his desk, cursor hovering over "Delete Account" — prepared to permanently erase 15 years of contacts, correspondence, and digital history.
He was receiving over 400 unsolicited emails daily.
Fabricated invoices. Credential phishing attempts disguised as Netflix or Best Buy. Extortion threats that referenced his real password.
His colleague — a former email deliverability engineer — glanced at his screen.
"Don't do that. Your account isn't compromised. It's been systematically exploited through 22 vulnerabilities you didn't know existed. Google won't surface this information because your behavioral data is the foundation of their advertising infrastructure. Give me 14 minutes."
What followed was a masterclass in digital self-defense.
He was receiving over 400 unsolicited emails daily.
Fabricated invoices. Credential phishing attempts disguised as Netflix or Best Buy. Extortion threats that referenced his real password.
His colleague — a former email deliverability engineer — glanced at his screen.
"Don't do that. Your account isn't compromised. It's been systematically exploited through 22 vulnerabilities you didn't know existed. Google won't surface this information because your behavioral data is the foundation of their advertising infrastructure. Give me 14 minutes."
What followed was a masterclass in digital self-defense.
1. The Newsletter Data Pipeline
In 2019, you entered your email for a 15% discount. What you didn't read in the privacy policy was the clause permitting the company to "share data with trusted third-party partners." That single transaction legally authorized your email address to be sold to 47 data brokers — who redistributed it to hundreds of affiliate marketers.
Every dormant newsletter subscription actively refreshes your profile in their CRM, confirming your address as deliverable and engaged.
The fix: Open Gmail and search "unsubscribe." You will likely surface 200+ active subscriptions. Do not simply delete the emails — open each one and unsubscribe at the source. Every severed subscription closes a live pipeline feeding your identity to data aggregators.
In 2019, you entered your email for a 15% discount. What you didn't read in the privacy policy was the clause permitting the company to "share data with trusted third-party partners." That single transaction legally authorized your email address to be sold to 47 data brokers — who redistributed it to hundreds of affiliate marketers.
Every dormant newsletter subscription actively refreshes your profile in their CRM, confirming your address as deliverable and engaged.
The fix: Open Gmail and search "unsubscribe." You will likely surface 200+ active subscriptions. Do not simply delete the emails — open each one and unsubscribe at the source. Every severed subscription closes a live pipeline feeding your identity to data aggregators.
2. The Fraudulent Unsubscribe Link
You scroll to the bottom of a suspicious email and click "Unsubscribe," expecting relief. You have made a consequential error.
Spam operators and phishing networks do not honor opt-out requests. That link contains a unique tracking token. The moment you click it, their server receives a confirmed signal: this is a real, active address. Your email is immediately upgraded to a "Premium Verified" list — significantly increasing its market value on secondary data exchanges.
The fix: Never click unsubscribe on any email you did not deliberately and consciously sign up for. Instead, select the email and click Report Spam. This trains Google's machine-learning infrastructure to identify and penalize the sender's IP address and domain at scale.
You scroll to the bottom of a suspicious email and click "Unsubscribe," expecting relief. You have made a consequential error.
Spam operators and phishing networks do not honor opt-out requests. That link contains a unique tracking token. The moment you click it, their server receives a confirmed signal: this is a real, active address. Your email is immediately upgraded to a "Premium Verified" list — significantly increasing its market value on secondary data exchanges.
The fix: Never click unsubscribe on any email you did not deliberately and consciously sign up for. Instead, select the email and click Report Spam. This trains Google's machine-learning infrastructure to identify and penalize the sender's IP address and domain at scale.
Today, we are releasing Rampart: a 14.7MB machine learning model designed to protect citizens’ privacy by redacting personal information directly in your browser before it gets sent to any server
The raw text you enter into a chatbot might include names, addresses, or financial details. Rampart detects and replaces sensitive terms with stable placeholders like [NAME_1], and sends the cleaned version instead. This way, the model still understands your request but your data doesn't have to leave the device
Rampart is trained on synthetic data, open source datasets, and government FOIA releases, including OCR-processed documents to improve performance on noisy data
Just use your eyes to see what Harpole did to Charlie’s neck.
The blast from Charlie's Sennheiser G4
transmitter on his torso was never meant to kill him, just incapacitate him while Harpole finished the dirty work.
The blast at chest level gave the appearance of a gunshot to the chest. They never accounted for shrapnel from his RODE mic to hit his carotid.
The blast from Charlie's Sennheiser G4
transmitter on his torso was never meant to kill him, just incapacitate him while Harpole finished the dirty work.
The blast at chest level gave the appearance of a gunshot to the chest. They never accounted for shrapnel from his RODE mic to hit his carotid.
"A "neck snap" typically refers to a sudden, forceful twisting (rotation/torsion), hyperextension, or distraction of the head relative to the torso. The cervical spine (C1-C7 vertebrae in the neck) is mobile but protected by strong muscles, ligaments, and discs, making it very hard for a human to manually fracture it without exceptional leverage, surprise, or the victim being INCAPACITATED."
En 1844, los caminos de España eran una trampa dominada por violentas bandas de ladrones. Para erradicar esta insoportable plaga, un noble militar diseñó una estrategia invencible: jamás patrullar en solitario. Así nació la pareja de la Guardia Civil. Tira del hilo 🧵👇🏽👇🏽👇🏽
Tras finalizar la sangrienta Guerra de la Independencia, el territorio español había quedado sumido en el caos absoluto. Miles de excombatientes y desertores desesperados se echaron a los montes para sobrevivir dedicándose al bandolerismo.
Viajar de una ciudad a otra era prácticamente una sentencia de muerte asegurada. Las diligencias que transportaban mercancías valiosas y viajeros eran brutalmente asaltadas cada día, destrozando por completo la economía comercial y aterrorizando a toda la población civil.
BREAKING: Claude can now help you earn your FIRST MONEY FROM YOUTUBE in 30+ days without needing 1000 subscribers or 4000 watch hours using income streams nobody teaches beginners
Here are 8 prompts to earn from YouTube as a beginner:
Here are 8 prompts to earn from YouTube as a beginner:
1. The "Zero-Threshold" Monetization Scout
"Act as an Elite YouTube Growth and Revenue Strategist. I have zero subscribers and zero watch hours. Conduct a 24-hour diagnostic audit to identify 3 non-traditional monetization vectors (e.g., micro-sponsorships, direct asset backend sales, or specialized consulting) tailored to [Niche]. Map these streams against acute audience pain points to build an immediate 30-day cash flow strategy layout."
"Act as an Elite YouTube Growth and Revenue Strategist. I have zero subscribers and zero watch hours. Conduct a 24-hour diagnostic audit to identify 3 non-traditional monetization vectors (e.g., micro-sponsorships, direct asset backend sales, or specialized consulting) tailored to [Niche]. Map these streams against acute audience pain points to build an immediate 30-day cash flow strategy layout."
2. The "Problem-to-Premium" Offer Builder
"Act as an Expert Direct-Response Copywriter. My target audience is [Persona] struggling with [Problem]. Help me build a low-overhead, high-value $100 backend digital offer or workshop that I can plug directly into my video descriptions. Format the value proposition using the 'Immediate Operational Win + Zero Tech Complexity + 48-Hour Execution Blueprint' framework to capture buyer trust fast."
"Act as an Expert Direct-Response Copywriter. My target audience is [Persona] struggling with [Problem]. Help me build a low-overhead, high-value $100 backend digital offer or workshop that I can plug directly into my video descriptions. Format the value proposition using the 'Immediate Operational Win + Zero Tech Complexity + 48-Hour Execution Blueprint' framework to capture buyer trust fast."
Hay follón entre estadounidenses y europeos con que si usamos mucho o poco o nada el aire acondicionado.
Pues mirad lo que os digo, hace 2400 años, en Persia, ya inventaron una manera de refrescarse: fabricaban hielo EN EL DESIERTO.
Esta es la historia:
Imaginad los desiertos de el Dasht-e Kavir y el Dasht-e Lut, en la actual Irán. Son extensiones donde el día castiga con cuarenta grados largos y la tierra parece el recuerdo de un mar que se evaporó de pura desesperación. Imaginad ahora, brotando de la arena parda, una colina de barro con forma de colmena gigante o de teta apuntando al cielo, una cosa con pinta de cosa-que-no-debería-estar-ahí y sin embargo está, lleva siglos estando. Es un yakhchāl, palabra que significa, literalmente, pozo de hielo.
Y dentro de la cúpula, que es de adobe, en mitad del horno, los persas fabricaban hielo. Lo hacían nacer de la noche y de una elegantísima comprensión de la física. Insisto, hace dos mil cuatrocientos años.
El truco era no luchar contra el desierto sino aliarse con su peor enemigo secreto, que es el propio desierto. Porque el desierto es como el matón de una peli americana de institutos, esto es, tiene una debilidad: de noche, cuando el sol se pone, el cielo seco y despejado se convierte en un sumidero. El calor del suelo se escapa hacia arriba, hacia el espacio negro, sin vapor de agua que lo retenga, y la temperatura se desploma. Enfriamiento radiativo, lo llaman los manuales. Venganza nocturna, lo llamaría yo.
El agua se vertía en pozas poco profundas, resguardada por muros orientados de este a oeste que la mantenía en sombra durante el día asesino, y perdía calor hacia el cielo nocturno hasta congelarse. A veces ayudaban sembrando un bloque de hielo traído de las montañas, una semilla de frío, para que el resto cuajara antes. Y al amanecer cortaban las láminas heladas y las bajaban a una cámara subterránea, una suerte de vientre del yakhchāl, donde aguantaban el verano entero.
Porque el vientre era la otra mitad del prodigio. Muros de hasta dos metros de grosor en la base, levantados con sarooj, un mortero de arena, arcilla, clara de huevo, cal, ceniza y pelo de cabra mezclados en proporciones precisas, impermeable y reacio al calor como un monje al pecado.
Bajo tierra, un hueco que en los pozos grandes podía alcanzar miles de metros cúbicos. Arriba, la cúpula con un orificio en lo alto para que el aire caliente se escapara por arriba y arrastrara consigo el bochorno, dejando el fondo frío y quieto.
Porque aquellos persas no conocían la termodinámica pero no tenían la palabra termodinámica, no tenían la palabra albedo, no tenían a Carnot ni a Clausius ni los gráficos del programa Copernicus que hoy nos dicen que Europa se calienta al doble de velocidad que hace cien años. Pero tenían barro, sombra, agua, paciencia y una observación feroz del cielo. Y con eso fabricaban hielo en el infierno.
Nosotros, que sí tenemos la termodinámica entera, que sabemos exactamente por qué la noche del desierto enfría y por qué la dorsal atmosférica nos asa, respondemos a la canícula encendiendo aparatos que devuelven al aire más calor del que extraen de la habitación, exportando el problema al pasillo, a la calle, a la atmósfera, al año que viene, a nuestros hijos y a los hijos de nuestros hijos. Compramos frío a plazos y no somos conscientes de lo que pagamos a cambio.
Mientras, los yakhchāl siguen en pie, pero ya no se usan. Algunos se conservan por su evidente valor antropológico pero fueron jubilados con la invención del frigorífico—que en persa, por cierto, también se llama yakhchāl, ironía perfecta—. Cuando los miras en fotos, ahí en medio de los desiertos de Irán, nos recuerdan que hubo una vez una manera de combatir el calor que no consistía en fabricar más calor, a veces solo era necesario mirar arriba para entender el cielo nocturno.
Pues mirad lo que os digo, hace 2400 años, en Persia, ya inventaron una manera de refrescarse: fabricaban hielo EN EL DESIERTO.
Esta es la historia:
Imaginad los desiertos de el Dasht-e Kavir y el Dasht-e Lut, en la actual Irán. Son extensiones donde el día castiga con cuarenta grados largos y la tierra parece el recuerdo de un mar que se evaporó de pura desesperación. Imaginad ahora, brotando de la arena parda, una colina de barro con forma de colmena gigante o de teta apuntando al cielo, una cosa con pinta de cosa-que-no-debería-estar-ahí y sin embargo está, lleva siglos estando. Es un yakhchāl, palabra que significa, literalmente, pozo de hielo.
Y dentro de la cúpula, que es de adobe, en mitad del horno, los persas fabricaban hielo. Lo hacían nacer de la noche y de una elegantísima comprensión de la física. Insisto, hace dos mil cuatrocientos años.
El truco era no luchar contra el desierto sino aliarse con su peor enemigo secreto, que es el propio desierto. Porque el desierto es como el matón de una peli americana de institutos, esto es, tiene una debilidad: de noche, cuando el sol se pone, el cielo seco y despejado se convierte en un sumidero. El calor del suelo se escapa hacia arriba, hacia el espacio negro, sin vapor de agua que lo retenga, y la temperatura se desploma. Enfriamiento radiativo, lo llaman los manuales. Venganza nocturna, lo llamaría yo.
El agua se vertía en pozas poco profundas, resguardada por muros orientados de este a oeste que la mantenía en sombra durante el día asesino, y perdía calor hacia el cielo nocturno hasta congelarse. A veces ayudaban sembrando un bloque de hielo traído de las montañas, una semilla de frío, para que el resto cuajara antes. Y al amanecer cortaban las láminas heladas y las bajaban a una cámara subterránea, una suerte de vientre del yakhchāl, donde aguantaban el verano entero.
Porque el vientre era la otra mitad del prodigio. Muros de hasta dos metros de grosor en la base, levantados con sarooj, un mortero de arena, arcilla, clara de huevo, cal, ceniza y pelo de cabra mezclados en proporciones precisas, impermeable y reacio al calor como un monje al pecado.
Bajo tierra, un hueco que en los pozos grandes podía alcanzar miles de metros cúbicos. Arriba, la cúpula con un orificio en lo alto para que el aire caliente se escapara por arriba y arrastrara consigo el bochorno, dejando el fondo frío y quieto.
Porque aquellos persas no conocían la termodinámica pero no tenían la palabra termodinámica, no tenían la palabra albedo, no tenían a Carnot ni a Clausius ni los gráficos del programa Copernicus que hoy nos dicen que Europa se calienta al doble de velocidad que hace cien años. Pero tenían barro, sombra, agua, paciencia y una observación feroz del cielo. Y con eso fabricaban hielo en el infierno.
Nosotros, que sí tenemos la termodinámica entera, que sabemos exactamente por qué la noche del desierto enfría y por qué la dorsal atmosférica nos asa, respondemos a la canícula encendiendo aparatos que devuelven al aire más calor del que extraen de la habitación, exportando el problema al pasillo, a la calle, a la atmósfera, al año que viene, a nuestros hijos y a los hijos de nuestros hijos. Compramos frío a plazos y no somos conscientes de lo que pagamos a cambio.
Mientras, los yakhchāl siguen en pie, pero ya no se usan. Algunos se conservan por su evidente valor antropológico pero fueron jubilados con la invención del frigorífico—que en persa, por cierto, también se llama yakhchāl, ironía perfecta—. Cuando los miras en fotos, ahí en medio de los desiertos de Irán, nos recuerdan que hubo una vez una manera de combatir el calor que no consistía en fabricar más calor, a veces solo era necesario mirar arriba para entender el cielo nocturno.
Aquí un esquema del enfriamiento radiativo de las pozas y del yakhchal usado como nevera para el hielo.
(Por cierto, hay una errata evidente en mi texto. Sobra un no y el párrafo debería quedar así: "Porque aquellos persas conocían la termodinámica pero no tenían la palabra termodinámica...")
My brother has paid for Amazon Prime for 6 years.
He had no idea it already included 7 things he was
paying for separately — Kindle Unlimited, Spotify, cloud photo storage, a Twitch sub, and more.
I showed him. He froze. Then cancelled $39/month in subscriptions in 10 minutes.
Here's everything he didn't know:
He had no idea it already included 7 things he was
paying for separately — Kindle Unlimited, Spotify, cloud photo storage, a Twitch sub, and more.
I showed him. He froze. Then cancelled $39/month in subscriptions in 10 minutes.
Here's everything he didn't know:
Amazon Photos — unlimited, full-resolution photo backup. Not compressed, not capped.
Google Photos: $2.99/mo for 200GB
iCloud: $9.99/mo for 2TB
Prime: unlimited, forever, free
Most people never open the app. Quietly worth $100+/year.
Google Photos: $2.99/mo for 200GB
iCloud: $9.99/mo for 2TB
Prime: unlimited, forever, free
Most people never open the app. Quietly worth $100+/year.
Prime Reading — free ebooks, magazines, and comics through the Kindle app. No Kindle required. New titles drop monthly.
He was paying $11.99/mo for Kindle Unlimited. Prime Reading covers most of what a casual reader needs.
That's $144/year, gone.
He was paying $11.99/mo for Kindle Unlimited. Prime Reading covers most of what a casual reader needs.
That's $144/year, gone.
High cortisol is aging you faster than smoking and tanning beds.
Low libido, achy joints, dark circles, weak muscles.
Here are 9 natural ways to slow the clock (without medication):
1. Cold water on your face.
Low libido, achy joints, dark circles, weak muscles.
Here are 9 natural ways to slow the clock (without medication):
1. Cold water on your face.
Cold water can activate the vagus nerve and help shift the body out of panic physiology.
It triggers the mammalian diving reflex, increases parasympathetic activity, and slows heart rate.
This can help interrupt the stress spiral before it takes hold.
It triggers the mammalian diving reflex, increases parasympathetic activity, and slows heart rate.
This can help interrupt the stress spiral before it takes hold.
If your mind won't switch off, it's often high cortisol keeping you stuck.
Research links ashwagandha to lower cortisol, steadier mood, and better stress recovery.
Physician's CHOICE KSM-66 Ashwagandha is the best-absorbing one I've tried:
Aff link:
lvnta.com/lv_kTIN2HF0Xc3…
Research links ashwagandha to lower cortisol, steadier mood, and better stress recovery.
Physician's CHOICE KSM-66 Ashwagandha is the best-absorbing one I've tried:
Aff link:
lvnta.com/lv_kTIN2HF0Xc3…
I'm a cardiologist. Let me tell you about the most extraordinary act of patient agency I've ever encountered.
In 2024, a tech founder named Sid Sijbrandij was told by his oncologists that they had nothing left. His osteosarcoma — an aggressive bone cancer in his spine — had returned after surgery, radiation, and chemotherapy so brutal he needed four blood transfusions to survive it. He'd exhausted every standard treatment. He wouldn't qualify for clinical trials. The implicit message: good luck.
Most people accept that verdict. Sijbrandij — co-founder of GitLab, a company worth $6.4 billion built on the principle that information should be open and transparent — decided to treat his cancer the way he'd built his company.
He went founder mode.
He quit his day job. Assembled a dream team. Hired a geneticist named Jacob Stern, formerly of 10x Genomics. And then he did something no cancer patient has ever done at this scale.
He generated 25 terabytes of his own medical data.
Whole genome sequencing. Whole exome sequencing. Bulk RNA-seq. Single-cell RNA-seq across multiple timepoints. Full-body PET/CT scans. Organoid models grown from his own tumor tissue. Immunohistochemistry. Spatial transcriptomics. Every diagnostic modality that exists — run on his specific cancer, at his specific stage, from his specific body.
Then Jacob Stern fed it all to ChatGPT
In 2024, a tech founder named Sid Sijbrandij was told by his oncologists that they had nothing left. His osteosarcoma — an aggressive bone cancer in his spine — had returned after surgery, radiation, and chemotherapy so brutal he needed four blood transfusions to survive it. He'd exhausted every standard treatment. He wouldn't qualify for clinical trials. The implicit message: good luck.
Most people accept that verdict. Sijbrandij — co-founder of GitLab, a company worth $6.4 billion built on the principle that information should be open and transparent — decided to treat his cancer the way he'd built his company.
He went founder mode.
He quit his day job. Assembled a dream team. Hired a geneticist named Jacob Stern, formerly of 10x Genomics. And then he did something no cancer patient has ever done at this scale.
He generated 25 terabytes of his own medical data.
Whole genome sequencing. Whole exome sequencing. Bulk RNA-seq. Single-cell RNA-seq across multiple timepoints. Full-body PET/CT scans. Organoid models grown from his own tumor tissue. Immunohistochemistry. Spatial transcriptomics. Every diagnostic modality that exists — run on his specific cancer, at his specific stage, from his specific body.
Then Jacob Stern fed it all to ChatGPT
Not as a doctor. As what he called an "Iron Man suit" — an AI research partner that could synthesize 25 terabytes of genomic, imaging, and clinical data faster than any team of bioinformaticians. The AI identified patterns, surfaced relevant literature, generated hypotheses, and helped design therapeutic strategies that Sijbrandij's oncology team hadn't considered.
It identified a target called PANX3 — a protein highly expressed in his tumor but nearly absent in normal tissue. Exactly the kind of molecular fingerprint that makes precision therapy possible.
Then came the treatment cascade that reads like a medical thriller.
Sijbrandij filed five individual patient Investigational New Drug applications with the FDA. All five were approved within 48 hours. He flew to Germany for FAP radioligand therapy — a targeted radiation treatment that seeks out fibroblast markers his single-cell analysis had confirmed were dominant in his tumor. He received a checkpoint inhibitor to unleash his immune system. A personalized neoantigen peptide vaccine designed from his tumor's specific mutations. An oncolytic virus — a modified virus that infects and destroys cancer cells.
All of this — simultaneously — guided by AI-assisted analysis of his own data.
It identified a target called PANX3 — a protein highly expressed in his tumor but nearly absent in normal tissue. Exactly the kind of molecular fingerprint that makes precision therapy possible.
Then came the treatment cascade that reads like a medical thriller.
Sijbrandij filed five individual patient Investigational New Drug applications with the FDA. All five were approved within 48 hours. He flew to Germany for FAP radioligand therapy — a targeted radiation treatment that seeks out fibroblast markers his single-cell analysis had confirmed were dominant in his tumor. He received a checkpoint inhibitor to unleash his immune system. A personalized neoantigen peptide vaccine designed from his tumor's specific mutations. An oncolytic virus — a modified virus that infects and destroys cancer cells.
All of this — simultaneously — guided by AI-assisted analysis of his own data.
Before the combination therapy, only 19% of immune cells infiltrating his tumor site were T cells. After treatment: 89%. His immune system, long suppressed by the cancer, had come roaring back.
The tumor shrank enough for surgery at Memorial Sloan Kettering in April 2025. Surgeons removed what remained.
By June 2025: no evidence of disease. As of early 2026: still no evidence of disease.
He is now receiving a personalized mRNA neoantigen vaccine — custom-built from his tumor's unique mutations — to sustain the immune response. As backup, his team is developing personalized cell-based therapies equipped with genetic logic gates that trigger killing only when multiple cancer-specific signals are detected simultaneously.
His motto: "Stay paranoid."
And then he did the thing that transforms this from an extraordinary individual story into something that could change medicine.
He published everything.
The entire 25-terabyte dataset — genomic data, imaging, treatment protocols, outcomes — is publicly available at osteosarc.com. Free. Open access. So that any patient, any researcher, any physician facing a similar situation can build on what he learned.
True to the radical transparency that built GitLab. Applied to cancer.
He founded Even One Ventures to help scale personalized cancer treatment for patients who don't have a billion-dollar net worth. Because the uncomfortable truth in this story is also the most important: Sijbrandij is a billionaire. He could afford the experts, the flights to Germany, the experimental therapies, the FDA applications, the manufacturing.
He puts it bluntly: "It costs $1 billion to get a drug approved. It costs $1 million to dose one person with a personalized therapy."
The question isn't whether this works. It clearly can. The question is whether it becomes accessible — or remains the privilege of founders who can fund their own R&D.
The tumor shrank enough for surgery at Memorial Sloan Kettering in April 2025. Surgeons removed what remained.
By June 2025: no evidence of disease. As of early 2026: still no evidence of disease.
He is now receiving a personalized mRNA neoantigen vaccine — custom-built from his tumor's unique mutations — to sustain the immune response. As backup, his team is developing personalized cell-based therapies equipped with genetic logic gates that trigger killing only when multiple cancer-specific signals are detected simultaneously.
His motto: "Stay paranoid."
And then he did the thing that transforms this from an extraordinary individual story into something that could change medicine.
He published everything.
The entire 25-terabyte dataset — genomic data, imaging, treatment protocols, outcomes — is publicly available at osteosarc.com. Free. Open access. So that any patient, any researcher, any physician facing a similar situation can build on what he learned.
True to the radical transparency that built GitLab. Applied to cancer.
He founded Even One Ventures to help scale personalized cancer treatment for patients who don't have a billion-dollar net worth. Because the uncomfortable truth in this story is also the most important: Sijbrandij is a billionaire. He could afford the experts, the flights to Germany, the experimental therapies, the FDA applications, the manufacturing.
He puts it bluntly: "It costs $1 billion to get a drug approved. It costs $1 million to dose one person with a personalized therapy."
The question isn't whether this works. It clearly can. The question is whether it becomes accessible — or remains the privilege of founders who can fund their own R&D.
Hodges: This fairy tale about Russians being able to suffer better than anybody, I think that's an absolute fairy tale.
None of the oligarchs are suffering. Nobody in the upper class in Moscow and St. Petersburg is going to suffer. These are people as spoiled as anybody else. 1/
None of the oligarchs are suffering. Nobody in the upper class in Moscow and St. Petersburg is going to suffer. These are people as spoiled as anybody else. 1/
Hodges: The 90% that are not upper class — they're good at suffering because they've never had it any better.
People counting on Russians being able to just endure more and more are misreading the actual situation. People are starting to wonder what the hell's going on. 2/
People counting on Russians being able to just endure more and more are misreading the actual situation. People are starting to wonder what the hell's going on. 2/
Hodges: What will really be interesting is whether the Kremlin has to mobilize the population of Moscow or St. Petersburg.
If all the privileged young people suddenly find themselves putting on that green uniform of the Russian army, enthusiasm for this war will really drop. 3X
If all the privileged young people suddenly find themselves putting on that green uniform of the Russian army, enthusiasm for this war will really drop. 3X
If you thought COVID was built on a web of lies, wait till you hear what they did with Alzheimer’s disease.
While Big Pharma poured billions into failed drugs and fake plaque theories, one neurologist quietly proved the decline could be reversed.
And he did it without a single pharmaceutical.
Dr. Dale Bredesen discovered Alzheimer’s has five root causes, not one.
And when you treat those root causes, patients recover. 🧵
While Big Pharma poured billions into failed drugs and fake plaque theories, one neurologist quietly proved the decline could be reversed.
And he did it without a single pharmaceutical.
Dr. Dale Bredesen discovered Alzheimer’s has five root causes, not one.
And when you treat those root causes, patients recover. 🧵
This information comes from the work of medical researcher @MidwesternDoc. For all the sources and details, read the full report below.
midwesterndoctor.com/p/the-great-al…
midwesterndoctor.com/p/the-great-al…
In 1906, plaques in the brain were identified as the cause of Alzheimer’s disease.
By the 1980s, scientists discovered that those plaques were primarily composed of amyloid proteins.
And then in 1991, genetic mutations in a protein that gives rise to amyloid beta were linked to inherited forms of Alzheimer’s disease.
By the 1980s, scientists discovered that those plaques were primarily composed of amyloid proteins.
And then in 1991, genetic mutations in a protein that gives rise to amyloid beta were linked to inherited forms of Alzheimer’s disease.
You owe the IRS $100,000
They'll take $5,000 and close your file. Permanently. Balance goes to $0
It's called an Offer in Compromise. Form 656. The IRS approved 42% of them last year. Application fee: $205
Here's the exact formula they use to decide your number and how to reverse-engineer the lowest possible offer
The IRS doesn't want to chase you for 10 years. Collection employs 78,000 people. Each agent costs the agency $89,000/year in salary and overhead. Liens require court filings. Levies require processing. Garnishments require administration. They'd rather take your $5,000 check today than spend $120,000 in administrative costs over a decade trying to squeeze $100,000 out of someone who will never have it
They literally built a math formula to calculate the minimum they'll accept. Here it is:
RCP = (monthly disposable income x remaining collection months) + (net realizable equity in assets)
Monthly disposable income: your gross monthly income minus IRS-allowed living expenses. They don't use YOUR actual expenses. They use standardized tables published at the irs website standards. These tables set exact allowances by county for housing, food, transportation, healthcare, and out-of-pocket expenses
If you earn $4,200/month and the IRS allowable expense table for your county totals $3,900, your disposable income is $300/month. If you earn $3,800/month and the table allows $3,900, your disposable income is negative and the IRS considers it $0
Remaining collection months: for a lump sum offer (paid in 5 months or less), multiply disposable income by 12. For a periodic payment offer (paid over 6-24 months), multiply by 24. The lump sum multiplier is lower, which means a lump sum offer will always be cheaper than a payment plan offer. Always choose lump sum if you can
Net realizable equity in assets: bank accounts, investments, vehicles, real property. BUT they subtract allowances. Your primary car: exempt up to the IRS local standard (roughly $6,000-$10,000 in equity depending on area). Household furnishings: fully exempt. Retirement accounts: partially exempt and heavily discounted (the IRS applies a "quick sale value" of 60-80% of actual value because they know selling retirement accounts triggers penalties)
Real calculation:
Income: $4,200/month
IRS allowed expenses: $3,900/month
Disposable income: $300/month
Lump sum multiplier: 12 months
$300 x 12 = $3,600
Assets:
Bank account: $2,100
Car equity: $4,800 (below IRS exemption, counts as $0)
401k: $18,000 (quick sale value at 60% = $10,800, minus 10% early withdrawal penalty = $9,720, minus taxes at 22% = $7,582)
Household goods: exempt
But here's the part most people don't know: you can CHOOSE to exclude retirement accounts from the RCP calculation by checking a specific box on Form 433-A (OIC). The IRS has an internal policy (IRM 5.8.5.24) that allows exclusion of retirement assets for taxpayers under age 65 if liquidating those assets would cause economic hardship. Your tax preparer should know this. Most don't
Revised RCP without retirement: $3,600 + $2,100 = $5,700
Your offer: $5,700 on $100,000 in tax debt. 5.7 cents on the dollar
The nuclear part:
While the OIC is being reviewed (6-24 months), ALL collection activity legally stops. No levies. No new liens. No wage garnishment. The IRS cannot collect a single dollar from you while your offer is pending. This is codified in IRC Section 6331(k)(1)
And if the IRS fails to make a determination within 24 months of receiving your application, your offer is AUTOMATICALLY ACCEPTED. Two years of silence = you win by default. IRC Section 7122(f). They built an auto-accept clause into the law that most taxpayers never invoke because most taxpayers never file an OIC
The forms you need:
Form 433-A (OIC): complete financial disclosure for individuals. Every bank account, every asset, every income source, every expense. 8 pages. Fill it out accurately because they cross-reference against IRS records, DMV records, and financial institution reports. Lying on this form is a federal crime under 18 U.S.C. 1001
Form 656: the actual offer. Your amount, your payment terms, your signature
$205 application fee (waived if income is below 250% of federal poverty level, which is $38,100 for a single person in 2026)
Initial payment with the application: 20% of your offer for lump sum. On a $5,700 offer that's $1,140
A woman owed $213,000 across 4 tax years (2019-2022). Hadn't filed 2020 or 2021. Hadn't paid any of them. Receiving CP504 notices (intent to levy) every month. We filed the delinquent returns first (required before OIC submission), then calculated her RCP at $8,400. Submitted OIC with $1,680 initial payment
IRS accepted 9 months later. $213,000 settled for $8,400. 3.9 cents on the dollar
She went from getting levy notices every month to a $0 IRS balance. Then we fixed her credit (the tax lien had destroyed it). Then we stacked $120K in 0% business funding. She opened a cleaning company 4 months later. The same IRS that was garnishing her wages is now processing her quarterly estimated tax payments from a profitable business
the IRS is the scariest creditor in America. they can garnish without a court order. seize your bank account with 30 days notice. lien every asset you own. but they also built a form where they calculate the minimum they'll accept using a formula you can reverse-engineer, and if they don't respond in 2 years your offer is automatically approved. the math is public. the formula is published. the form costs $205. the difference between paying $100K and paying $5K is knowing it exists lol
(we fix credit and build capital stacks. if you owe back taxes, handle that first. then we get you funded. link in bio)
They'll take $5,000 and close your file. Permanently. Balance goes to $0
It's called an Offer in Compromise. Form 656. The IRS approved 42% of them last year. Application fee: $205
Here's the exact formula they use to decide your number and how to reverse-engineer the lowest possible offer
The IRS doesn't want to chase you for 10 years. Collection employs 78,000 people. Each agent costs the agency $89,000/year in salary and overhead. Liens require court filings. Levies require processing. Garnishments require administration. They'd rather take your $5,000 check today than spend $120,000 in administrative costs over a decade trying to squeeze $100,000 out of someone who will never have it
They literally built a math formula to calculate the minimum they'll accept. Here it is:
RCP = (monthly disposable income x remaining collection months) + (net realizable equity in assets)
Monthly disposable income: your gross monthly income minus IRS-allowed living expenses. They don't use YOUR actual expenses. They use standardized tables published at the irs website standards. These tables set exact allowances by county for housing, food, transportation, healthcare, and out-of-pocket expenses
If you earn $4,200/month and the IRS allowable expense table for your county totals $3,900, your disposable income is $300/month. If you earn $3,800/month and the table allows $3,900, your disposable income is negative and the IRS considers it $0
Remaining collection months: for a lump sum offer (paid in 5 months or less), multiply disposable income by 12. For a periodic payment offer (paid over 6-24 months), multiply by 24. The lump sum multiplier is lower, which means a lump sum offer will always be cheaper than a payment plan offer. Always choose lump sum if you can
Net realizable equity in assets: bank accounts, investments, vehicles, real property. BUT they subtract allowances. Your primary car: exempt up to the IRS local standard (roughly $6,000-$10,000 in equity depending on area). Household furnishings: fully exempt. Retirement accounts: partially exempt and heavily discounted (the IRS applies a "quick sale value" of 60-80% of actual value because they know selling retirement accounts triggers penalties)
Real calculation:
Income: $4,200/month
IRS allowed expenses: $3,900/month
Disposable income: $300/month
Lump sum multiplier: 12 months
$300 x 12 = $3,600
Assets:
Bank account: $2,100
Car equity: $4,800 (below IRS exemption, counts as $0)
401k: $18,000 (quick sale value at 60% = $10,800, minus 10% early withdrawal penalty = $9,720, minus taxes at 22% = $7,582)
Household goods: exempt
But here's the part most people don't know: you can CHOOSE to exclude retirement accounts from the RCP calculation by checking a specific box on Form 433-A (OIC). The IRS has an internal policy (IRM 5.8.5.24) that allows exclusion of retirement assets for taxpayers under age 65 if liquidating those assets would cause economic hardship. Your tax preparer should know this. Most don't
Revised RCP without retirement: $3,600 + $2,100 = $5,700
Your offer: $5,700 on $100,000 in tax debt. 5.7 cents on the dollar
The nuclear part:
While the OIC is being reviewed (6-24 months), ALL collection activity legally stops. No levies. No new liens. No wage garnishment. The IRS cannot collect a single dollar from you while your offer is pending. This is codified in IRC Section 6331(k)(1)
And if the IRS fails to make a determination within 24 months of receiving your application, your offer is AUTOMATICALLY ACCEPTED. Two years of silence = you win by default. IRC Section 7122(f). They built an auto-accept clause into the law that most taxpayers never invoke because most taxpayers never file an OIC
The forms you need:
Form 433-A (OIC): complete financial disclosure for individuals. Every bank account, every asset, every income source, every expense. 8 pages. Fill it out accurately because they cross-reference against IRS records, DMV records, and financial institution reports. Lying on this form is a federal crime under 18 U.S.C. 1001
Form 656: the actual offer. Your amount, your payment terms, your signature
$205 application fee (waived if income is below 250% of federal poverty level, which is $38,100 for a single person in 2026)
Initial payment with the application: 20% of your offer for lump sum. On a $5,700 offer that's $1,140
A woman owed $213,000 across 4 tax years (2019-2022). Hadn't filed 2020 or 2021. Hadn't paid any of them. Receiving CP504 notices (intent to levy) every month. We filed the delinquent returns first (required before OIC submission), then calculated her RCP at $8,400. Submitted OIC with $1,680 initial payment
IRS accepted 9 months later. $213,000 settled for $8,400. 3.9 cents on the dollar
She went from getting levy notices every month to a $0 IRS balance. Then we fixed her credit (the tax lien had destroyed it). Then we stacked $120K in 0% business funding. She opened a cleaning company 4 months later. The same IRS that was garnishing her wages is now processing her quarterly estimated tax payments from a profitable business
the IRS is the scariest creditor in America. they can garnish without a court order. seize your bank account with 30 days notice. lien every asset you own. but they also built a form where they calculate the minimum they'll accept using a formula you can reverse-engineer, and if they don't respond in 2 years your offer is automatically approved. the math is public. the formula is published. the form costs $205. the difference between paying $100K and paying $5K is knowing it exists lol
(we fix credit and build capital stacks. if you owe back taxes, handle that first. then we get you funded. link in bio)
In 1825, a rich Welsh industrialist bought an entire American town to prove that socialism could work.
He had the money, the buildings, the theory, and hundreds of eager followers waiting to move in.
Two years later, it was over. 🧵
He had the money, the buildings, the theory, and hundreds of eager followers waiting to move in.
Two years later, it was over. 🧵
Robert Owen paid around $150,000 for the town of Harmonie, Indiana. He got 20,000 acres, more than 160 buildings, working mills, and farms already producing food.
He renamed it New Harmony. Close to a thousand people arrived in the first year.
He renamed it New Harmony. Close to a thousand people arrived in the first year.
Owen already ran successful textile mills in New Lanark, Scotland, where he was famous for treating workers well and running a profitable business at the same time.
He believed that if you removed private property and paid everyone equally, cooperation would naturally replace competition.
He believed that if you removed private property and paid everyone equally, cooperation would naturally replace competition.
Gedanken zur Tageslosung für Donnerstag, den 02.07.2026
Losungswort
HERR, verdirb dein Volk und dein Erbe nicht, das du durch deine große Kraft erlöst hast!
5. Mose 9,26
Lehrtext
Der Engel sprach zu Josef: Maria wird einen Sohn
Losungswort
HERR, verdirb dein Volk und dein Erbe nicht, das du durch deine große Kraft erlöst hast!
5. Mose 9,26
Lehrtext
Der Engel sprach zu Josef: Maria wird einen Sohn
gebären, dem sollst du den Namen Jesus geben, denn er wird sein Volk retten von ihren Sünden.
Matthäus 1,21
Die Losungen der Herrnhuter Brüdergemeine
Gottes Gnade
Im heutigen Losungswort berichtet Mose dem Volk Israel, dass er Gott darum gebeten hatte, das Volk nicht
Matthäus 1,21
Die Losungen der Herrnhuter Brüdergemeine
Gottes Gnade
Im heutigen Losungswort berichtet Mose dem Volk Israel, dass er Gott darum gebeten hatte, das Volk nicht
zu verderben. Hatte Mose denn Angst vor Gott, weil dieser allmächtig ist und sowohl erhalten als auch verderben kann? Versuchte er also, Gott gnädig zu stimmen, weil er sich vor dessen Willkür fürchtete? Nein, Mose wusste, dass Gott gerecht ist. Jedoch hatte sich