Edgar V. Lerma ๐Ÿ‡ต๐Ÿ‡ญ Profile picture
Chicago Sports Fan... Nephrologist by day. My tweets are not medical advice. The views expressed here are my own and not those of my employer.

Apr 15, 2020, 37 tweets

Renal histopathological analysis of 26 postmortem findings of patients with #COVID19 in China ca. 2020 from @Kidney_Int @AgnesFogo
#CoronaKidney #NephJC
๐Ÿ‘‰๐Ÿผ kidney-international.org/article/S0085-โ€ฆ

The Novel Coronavirus 2019 Epidemic and Kidneys ca. 2020

โ€œPostulatedโ€ mechanisms:
๐Ÿ‘‰๐Ÿผ Sepsis leading to cytokine storm syndrome
๐Ÿ‘‰๐Ÿผ Direct cellular injury due to the virus
#COVID19 #CoronaKidney #NephJC
๐Ÿ‘‰๐Ÿผ kidney-international.org/article/S0085-โ€ฆ

Renal histopathological analysis of 26 postmortem findings of #COVID19 patients
๐Ÿ”ฌ RBC aggregates in proximal tubule cells & glomeruli
๐Ÿ”ฌ No fibrin or platelets
๐Ÿ”ฌ #COVID19 in podocytes and tubules
๐Ÿ”ฌ Severe endothelial injury
#CoronaKidney #NephJC
๐Ÿ‘‰๐Ÿผ kidney-international.org/article/S0085-โ€ฆ

Collapsing Glomerulopathy in a Patient with #COVID19 ca. 2020 from @KIReports @renalpathdoc #CoronaKidney #NephJC
๐Ÿ‘‰๐Ÿผ kireports.org/article/S2468-โ€ฆ

Collapsing glomerulopathy in a #COVID19 patient ca. 2020 from @Kidney_Int

Possible underlying mechanisms:
๐Ÿ“Œ Direct viral toxicity on tubular cells that also harbour ACE2
๐Ÿ“Œ Cytokine-mediated tubular damage
#CoronaKidney #Nephpearls

๐Ÿ‘‰๐Ÿผ kidney-international.org/article/S0085-โ€ฆ

Endothelial cell infection and endotheliitis in #COVID19 ca. 2020 from @TheLancet #CoronaKidney
๐Ÿ‘‰๐Ÿผ marlin-prod.literatumonline.com/pb-assets/Lancโ€ฆ

Tubuloreticular inclusions in #COVID19 related collapsing glomerulopathy ca. 2020 from @Kidney_Int #CoronaKidney
๐Ÿ‘‰๐Ÿผ kidney-international.org/article/S0085-โ€ฆ

AKI Due to Collapsing Glomerulopathy Following #COVID19 Infection ca. 2020 from @KIReports #CoronaKidney
๐Ÿ‘‰๐Ÿผ kireports.org/article/S2468-โ€ฆ

Collapsing glomerulopathy and #COVID19 ca. 2020 from @KIReports #CoronaKidney
๐Ÿ‘‰๐Ÿผ kireports.org/article/S2468-โ€ฆ

Ultrastructural Evidence for Direct Renal Infection with #COVID19 ca. 2020 from @JASN_News #Nephpearls
๐Ÿ‘‰๐Ÿผ jasn.asnjournals.org/content/jnephrโ€ฆ

Newly Diagnosed Glomerulonephritis During #COVID19 Infection Undergoing Immunosuppression Therapy, a Case Report ca. 2020 #CoronaKidney
๐Ÿ‘‰๐Ÿผ pubmed.ncbi.nlm.nih.gov/32361703/?fromโ€ฆ

Visualization ๐Ÿ”ฌof putative #COVID19 in kidney (Letter): Definite proof for presence of viral inclusions in cells requires an immunostaining w/ specific antibodies, whether in cultured cells or in tissue samples (ca. 2020) from @Kidney_Int #CoronaKidney
๐Ÿ‘‰kidney-international.org/article/S0085-โ€ฆ

Electron microscopic image of an isolate of #COVID19 seen here inside vacuoles (arrows). Note the dense membrane coat around the viral particles (ca. 2020) #CoronaKidney
๐Ÿ‘‰๐Ÿผ kidney-international.org/article/S0085-โ€ฆ

Multivesicular bodies mimicking SARS-CoV-2 in patients without #COVID19 #CoronaKidney
๐Ÿ‘‰๐Ÿผ kidney-international.org/article/S0085-โ€ฆ

Multivesicular bodies mimicking SARS-CoV-2 in patients without #COVID19 #CoronaKidney
๐Ÿ‘‰๐Ÿผ kidney-international.org/article/S0085-โ€ฆ

Multiorgan and Renal Tropism of #COVID19 ca. 2020 from @NEJM
#CoronaKidney

H/T @VelezNephHepato

๐Ÿ‘‰๐Ÿผ nejm.org/doi/pdf/10.105โ€ฆ

Electron Microscopic Investigations in #COVID19: Not all Crowns Are Coronas ca. 2020 from @Kidney_Int #CoronaKidney

H/T @kdjhaveri

๐Ÿ‘‰๐Ÿผ kidney-international.org/article/S0085-โ€ฆ

Am I a Coronavirusโ‰๏ธ
#COVID19 #CoronaKidney
๐Ÿ‘‰kidney-international.org/article/S0085-โ€ฆ

Thrombotic Microangiopathy (TMA) in a patient with #COVID19 ca. 2020 from @Kidney_Int #CoronaKidney
๐Ÿ‘‰๐Ÿผ kidney-international.org/article/S0085-โ€ฆ

Collapsing glomerulopathy following #COVID19 infection; possible relationship with APOL1 kidney risk alleles in African-Americans ca. 2020 #CoronaKidney
๐Ÿ‘‰๐Ÿผ immunopathol.com/PDF/ipp-6-e18.โ€ฆ

Anti-GBM disease during the #COVID19 pandemic ca. 2020 from @Kidney_Int @Profcpusey @stephenmcadoo #Nephpearls

Thanks to @valerie_luyckx for sharing

๐Ÿ‘‰๐Ÿผ kidney-international.org/article/S0085-โ€ฆ

Kidney Biopsy Findings in a Critically Ill #COVID19 Patient With Dialysis Dependent AKI: A Case Against โ€œSARS-CoV-2 Nephropathyโ€ ca. 2020 from @KIReports #Nephpearls

Thanks to @valerie_luyckx for sharing

kireports.org/article/S2468-โ€ฆ

#COVID19 Related Collapsing Glomerulopathy in a Kidney Transplant Recipient ca. 2020 from @AJKDonline #Nephpearls

Thanks to @kdjhaveri for sharing

ajkd.org/action/showPdfโ€ฆ

#COVID19 Associated Kidney Injury: A Case Series of Kidney Biopsy Findings ca. 2020 from @JASN_News @renalmyeloma @kdjhaveri @VBijol @renalpathdoc #Nephpearls
๐Ÿ‘‰๐Ÿผ jasn.asnjournals.org/content/early/โ€ฆ

SARS-Cov-2 virions or ubiquitous cell structures? Actual dilemma in #COVID19 era ca. 2020from @KIReports #CoronaKidney
๐Ÿ‘‰๐Ÿผ kireports.org/action/showPdfโ€ฆ

Caution in Identifying Coronaviruses by Electron Microscopy ๐Ÿ”ฌ ca. 2020 from @JASN_News #Nephpearls #COVID19 #CoronaKidney
๐Ÿ‘‰๐Ÿผ jasn.asnjournals.org/content/jnephrโ€ฆ

Histopathologic and Ultrastructural Findings in Postmortem Kidney Biopsy Material in 12 Patients with AKI and #COVID19 ca. 2020 from @JASN_News @renalpathdoc @VBijol #Nephpearls #CoronaKidney
๐Ÿ‘‰๐Ÿผ jasn.asnjournals.org/content/jnephrโ€ฆ

Kidney Biopsy ๐Ÿ”ฌ findings in patients with #COVID19 ca. 2020 from @JASN_News @ColumbiaKidney #CoronaKidney #Nephpearls
๐Ÿ‘‰๐Ÿผ jasn.asnjournals.org/content/jnephrโ€ฆ

Kidney Biopsy ๐Ÿ”ฌ findings in patients with #COVID19 ca. 2020 from @JASN_News @ColumbiaKidney #CoronaKidney #Nephpearls #VisualAbstract
๐Ÿ‘‰๐Ÿผ jasn.asnjournals.org/content/jnephrโ€ฆ

Histopathologic and Ultrastructural Findings in Postmortem Kidney Biopsy Material in 12 Patients with AKI and #COVID19 ca. 2020 from @JASN_News #CoronaKidney #Nephpearls
๐Ÿ‘‰๐Ÿผ jasn.asnjournals.org/content/jnephrโ€ฆ

Postmortem Kidney Pathology Findings in Patients with #COVID19 ca. 2020 from @JASN_News #Nephpearls #CoronaKidney
๐Ÿ‘‰๐Ÿผ jasn.asnjournals.org/content/jnephrโ€ฆ

Histopathology and ultrastructural findings of fatal #COVID19 infections in Washington State: a case series ca. 2020 from @TheLancet #CoronaKidney

H/T @valerie_luyckx

๐Ÿ‘‰๐Ÿผ thelancet.com/journals/lanceโ€ฆ

AKI and Collapsing Glomerulopathy Associated with #COVID19 and APOL1 High-Risk Genotype ca. 2020 from @JASN_News @Tiff_Caza @VelezNephHepato #CoronaKidney
๐Ÿ‘‰๐Ÿผ jasn.asnjournals.org/content/jnephrโ€ฆ

Ultrastructural ๐Ÿ”ฌ Evidence for Direct Renal Infection with #COVID19 ca. 2020 from @JASN_News #CoronaKidney
๐Ÿ‘‰๐Ÿผ jasn.asnjournals.org/content/jnephrโ€ฆ

COVAN is the new HIVAN:
the re-emergence of collapsing
glomerulopathy with #COVID19 ca. 2020 from @NatRevNeph @VelezNephHepato @Tiff_Caza @renalpathdoc #Nephpearls #CoronaKidney
๐Ÿ‘‰๐Ÿผ nature.com/articles/s4158โ€ฆ

#COVID19 Causes a Specific Dysfunction of the Kidney Proximal Tubule ca. 2020 from @Kidney_Int #CoronaKidney #Nephpearls
๐Ÿ‘‰๐Ÿผ kidney-international.org/article/S0085-โ€ฆ

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