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Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
@edgarvlermamd
Apr 15, 2020 β€’ 37 tweets β€’ 58 min read β€’ Read on X
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#COVID19 #CoronaKidney #NephJC Image
Renal histopathological analysis of 26 postmortem findings of patients with #COVID19 in China ca. 2020 from @Kidney_Int @AgnesFogo
#CoronaKidney #NephJC
πŸ‘‰πŸΌ kidney-international.org/article/S0085-… ImageImage
The Novel Coronavirus 2019 Epidemic and Kidneys ca. 2020

β€œPostulated” mechanisms:
πŸ‘‰πŸΌ Sepsis leading to cytokine storm syndrome
πŸ‘‰πŸΌ Direct cellular injury due to the virus
#COVID19 #CoronaKidney #NephJC
πŸ‘‰πŸΌ kidney-international.org/article/S0085-… ImageImage
Renal histopathological analysis of 26 postmortem findings of #COVID19 patients
πŸ”¬ RBC aggregates in proximal tubule cells & glomeruli
πŸ”¬ No fibrin or platelets
πŸ”¬ #COVID19 in podocytes and tubules
πŸ”¬ Severe endothelial injury
#CoronaKidney #NephJC
πŸ‘‰πŸΌ kidney-international.org/article/S0085-… ImageImageImageImage
Collapsing Glomerulopathy in a Patient with #COVID19 ca. 2020 from @KIReports @renalpathdoc #CoronaKidney #NephJC
πŸ‘‰πŸΌ kireports.org/article/S2468-… ImageImageImageImage
Collapsing glomerulopathy in a #COVID19 patient ca. 2020 from @Kidney_Int

Possible underlying mechanisms:
πŸ“Œ Direct viral toxicity on tubular cells that also harbour ACE2
πŸ“Œ Cytokine-mediated tubular damage
#CoronaKidney #Nephpearls

πŸ‘‰πŸΌ kidney-international.org/article/S0085-… ImageImageImageImage
Endothelial cell infection and endotheliitis in #COVID19 ca. 2020 from @TheLancet #CoronaKidney
πŸ‘‰πŸΌ marlin-prod.literatumonline.com/pb-assets/Lanc… ImageImage
Tubuloreticular inclusions in #COVID19 related collapsing glomerulopathy ca. 2020 from @Kidney_Int #CoronaKidney
πŸ‘‰πŸΌ kidney-international.org/article/S0085-… ImageImageImage
AKI Due to Collapsing Glomerulopathy Following #COVID19 Infection ca. 2020 from @KIReports #CoronaKidney
πŸ‘‰πŸΌ kireports.org/article/S2468-… ImageImageImage
Collapsing glomerulopathy and #COVID19 ca. 2020 from @KIReports #CoronaKidney
πŸ‘‰πŸΌ kireports.org/article/S2468-… ImageImage
Ultrastructural Evidence for Direct Renal Infection with #COVID19 ca. 2020 from @JASN_News #Nephpearls
πŸ‘‰πŸΌ jasn.asnjournals.org/content/jnephr… ImageImageImageImage
Newly Diagnosed Glomerulonephritis During #COVID19 Infection Undergoing Immunosuppression Therapy, a Case Report ca. 2020 #CoronaKidney
πŸ‘‰πŸΌ pubmed.ncbi.nlm.nih.gov/32361703/?from… ImageImage
Visualization πŸ”¬of putative #COVID19 in kidney (Letter): Definite proof for presence of viral inclusions in cells requires an immunostaining w/ specific antibodies, whether in cultured cells or in tissue samples (ca. 2020) from @Kidney_Int #CoronaKidney
πŸ‘‰kidney-international.org/article/S0085-… Image
Electron microscopic image of an isolate of #COVID19 seen here inside vacuoles (arrows). Note the dense membrane coat around the viral particles (ca. 2020) #CoronaKidney
πŸ‘‰πŸΌ kidney-international.org/article/S0085-… ImageImage
Multivesicular bodies mimicking SARS-CoV-2 in patients without #COVID19 #CoronaKidney
πŸ‘‰πŸΌ kidney-international.org/article/S0085-… ImageImage
Multivesicular bodies mimicking SARS-CoV-2 in patients without #COVID19 #CoronaKidney
πŸ‘‰πŸΌ kidney-international.org/article/S0085-… ImageImage
Multiorgan and Renal Tropism of #COVID19 ca. 2020 from @NEJM
#CoronaKidney

H/T @VelezNephHepato

πŸ‘‰πŸΌ nejm.org/doi/pdf/10.105… ImageImage
Electron Microscopic Investigations in #COVID19: Not all Crowns Are Coronas ca. 2020 from @Kidney_Int #CoronaKidney

H/T @kdjhaveri

πŸ‘‰πŸΌ kidney-international.org/article/S0085-… ImageImage
Am I a Coronavirus⁉️
#COVID19 #CoronaKidney
πŸ‘‰kidney-international.org/article/S0085-… Image
Thrombotic Microangiopathy (TMA) in a patient with #COVID19 ca. 2020 from @Kidney_Int #CoronaKidney
πŸ‘‰πŸΌ kidney-international.org/article/S0085-… ImageImage
Collapsing glomerulopathy following #COVID19 infection; possible relationship with APOL1 kidney risk alleles in African-Americans ca. 2020 #CoronaKidney
πŸ‘‰πŸΌ immunopathol.com/PDF/ipp-6-e18.… Image
Anti-GBM disease during the #COVID19 pandemic ca. 2020 from @Kidney_Int @Profcpusey @stephenmcadoo #Nephpearls

Thanks to @valerie_luyckx for sharing

πŸ‘‰πŸΌ kidney-international.org/article/S0085-… ImageImageImage
Kidney Biopsy Findings in a Critically Ill #COVID19 Patient With Dialysis Dependent AKI: A Case Against β€œSARS-CoV-2 Nephropathy” ca. 2020 from @KIReports #Nephpearls

Thanks to @valerie_luyckx for sharing

kireports.org/article/S2468-… ImageImageImageImage
#COVID19 Related Collapsing Glomerulopathy in a Kidney Transplant Recipient ca. 2020 from @AJKDonline #Nephpearls

Thanks to @kdjhaveri for sharing

ajkd.org/action/showPdf… ImageImageImage
#COVID19 Associated Kidney Injury: A Case Series of Kidney Biopsy Findings ca. 2020 from @JASN_News @renalmyeloma @kdjhaveri @VBijol @renalpathdoc #Nephpearls
πŸ‘‰πŸΌ jasn.asnjournals.org/content/early/… ImageImageImageImage
SARS-Cov-2 virions or ubiquitous cell structures? Actual dilemma in #COVID19 era ca. 2020from @KIReports #CoronaKidney
πŸ‘‰πŸΌ kireports.org/action/showPdf… ImageImage
Caution in Identifying Coronaviruses by Electron Microscopy πŸ”¬ ca. 2020 from @JASN_News #Nephpearls #COVID19 #CoronaKidney
πŸ‘‰πŸΌ jasn.asnjournals.org/content/jnephr… ImageImage
Histopathologic and Ultrastructural Findings in Postmortem Kidney Biopsy Material in 12 Patients with AKI and #COVID19 ca. 2020 from @JASN_News @renalpathdoc @VBijol #Nephpearls #CoronaKidney
πŸ‘‰πŸΌ jasn.asnjournals.org/content/jnephr… ImageImage
Kidney Biopsy πŸ”¬ findings in patients with #COVID19 ca. 2020 from @JASN_News @ColumbiaKidney #CoronaKidney #Nephpearls
πŸ‘‰πŸΌ jasn.asnjournals.org/content/jnephr… ImageImageImage
Kidney Biopsy πŸ”¬ findings in patients with #COVID19 ca. 2020 from @JASN_News @ColumbiaKidney #CoronaKidney #Nephpearls #VisualAbstract
πŸ‘‰πŸΌ jasn.asnjournals.org/content/jnephr… ImageImageImageImage
Histopathologic and Ultrastructural Findings in Postmortem Kidney Biopsy Material in 12 Patients with AKI and #COVID19 ca. 2020 from @JASN_News #CoronaKidney #Nephpearls
πŸ‘‰πŸΌ jasn.asnjournals.org/content/jnephr… ImageImage
Postmortem Kidney Pathology Findings in Patients with #COVID19 ca. 2020 from @JASN_News #Nephpearls #CoronaKidney
πŸ‘‰πŸΌ jasn.asnjournals.org/content/jnephr… ImageImageImageImage
Histopathology and ultrastructural findings of fatal #COVID19 infections in Washington State: a case series ca. 2020 from @TheLancet #CoronaKidney

H/T @valerie_luyckx

πŸ‘‰πŸΌ thelancet.com/journals/lance… ImageImageImageImage
AKI and Collapsing Glomerulopathy Associated with #COVID19 and APOL1 High-Risk Genotype ca. 2020 from @JASN_News @Tiff_Caza @VelezNephHepato #CoronaKidney
πŸ‘‰πŸΌ jasn.asnjournals.org/content/jnephr… ImageImageImageImage
Ultrastructural πŸ”¬ Evidence for Direct Renal Infection with #COVID19 ca. 2020 from @JASN_News #CoronaKidney
πŸ‘‰πŸΌ jasn.asnjournals.org/content/jnephr… ImageImageImageImage
COVAN is the new HIVAN:
the re-emergence of collapsing
glomerulopathy with #COVID19 ca. 2020 from @NatRevNeph @VelezNephHepato @Tiff_Caza @renalpathdoc #Nephpearls #CoronaKidney
πŸ‘‰πŸΌ nature.com/articles/s4158… ImageImage
#COVID19 Causes a Specific Dysfunction of the Kidney Proximal Tubule ca. 2020 from @Kidney_Int #CoronaKidney #Nephpearls
πŸ‘‰πŸΌ kidney-international.org/article/S0085-… ImageImage

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Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Feb 26, 2022
Advancing Evidence-Based Care in Diabetes and CKD
#ISNWCN πŸ‡²πŸ‡Ύ #Nephpearls

πŸ‘‰ kdigo.org/wp-content/upl…
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πŸ‘‰ kdigo.org/wp-content/upl…
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@goKDIGO suggest using the "prediction tool" that was derived from the largest & most geographically diverse cohort to date

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IgA Nephropathy: The @goKDIGO treatment algorithm recommends consideration of use of corticosteroids in patients with "persistent proteinuria >1g/day" if the risk/benefit profile is favorable

πŸ“Œ A GFR of 30 is considered a threshold for treatment

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Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Feb 23, 2022
First clinical-grade porcine πŸ– kidney xenotransplant using a human decedent model ca. 2022 from @amjtransplant #NephJC #Nephpearls

#VisualAbstract by @NamrataYParikh

πŸ‘‰πŸΌ pubmed.ncbi.nlm.nih.gov/35049121/ Image
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Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Jan 30, 2022
Nephrolithiasis 101: When to order a 24-hour urine collection #Nephpearls

Multiple or metabolically active stones (stones that increase in size/ number w/in a year)

Children

Demographic groups not typically prone to stone formation

Stones other than those containing calcium ImageImage
Interpretation of urine chemistries to identify lithogenic risk factors and assess the contribution of diet to the formation of kidney stones ca. 2016 from @ravineja #Nephpearls

sciencedirect.com/science/articl… Image
Neglected analytes in the 24 hour urine: ammonium and sulfate ca. 2021 from @CO_Neph_Hype @ravineja #Nephpearls

πŸ‘‰ pubmed.ncbi.nlm.nih.gov/34798636/ ImageImageImageImage
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Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture
Jan 26, 2022
PREDNOS 2: Evaluation of Daily Low-Dose Prednisolone During URTI to Prevent Relapse in Children w/ Relapsing Steroid-Sensitive Nephrotic Syndrome ca, 2022 from @JAMAPediatrics #NephJC #IPNAJC #Nephpearls

#VisualAbstract by @drM_sudha

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link.springer.com/article/10.100…
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#VisualAbstract by @jbda19

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Clinical Practice Guideline for the Management of Glomerular Diseases ca. 2021 from @goKDIGO #NephJC #Nephpearls
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πŸ‘‰ global.oup.com/academic/produ…
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πŸ‘‰ pubmed.ncbi.nlm.nih.gov/34556256/
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