Happy our review on the lateral plate mesoderm is out @Dev_journal, with @karin_prummel & @Susan81643382 (open access).
Our first attempt at reviewing the fascinating, wacky, complex biology as Development at a Glance with poster!
#devbio #evodevo
dev.biologists.org/content/147/12…
The LPM forms several central cell fates and organ systems, including the heart, endothelium, blood, limb connective tissue, and much more.
This seemingly weird combo of downstream fates seems unrelated the adult body - but they all share a common LPM origin!
Our review now attempts to summarize how LPM's development (and possible evolution) ties these diverse downstream fates together.
We also discuss that not all "mesoderm" is equal:
the LPM forms as dedicated mesendoderm lineage early on, both in development and evolution.🧬🧬🧬
We further summarize key points of how the LPM's individual downstream fates form - far from complete, hope you find your favorite LPM lineage(s)!
Kudos to @karin_prummel & @Susan81643382 for their detective work...
...and apologies for not being able to include ALL THE COOL SCIENCE out there on LPM cell and organ fates & disease modeling!
Speaking of disease:
considering a joint fate origin in the LPM provides a framework to think about several syndromic congenital diseases (definitely helps me!).
Case in point, heart dev & cardiopharyneal field (feat. a correct Ciona heart schematic, thx @lionlchristiaen❤️)!
Many thanks to @Dev_journal & @amjeve for this opportunity and the engaging, efficient, and enjoyable editorial process - including three constructive reviewers.
Our lab's first pub with @CUAnschutz affiliation! 🥳🎏
Importantly, @amjeve also coined the color "LPM Green" that we will try to stick to in our lab for consistency :)!
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