Now this a good ongoing study in South African, #SisonkeStudy .. published in @NEJM .. studying safety data of vaccinated health care workers (HCW), with breakdown of reported adverse effects thus far.. 1/n
nejm.org/doi/full/10.10…
Sample size of HCWs receiving the Ad26. COV2. S #vaccine or the #johnsonandjohnson is very significant !! n = 288,368 .. 2/n
nejm.org/doi/full/10.10…
Results: out of total 288,368 HCWs who received the #johnsonandjohnson #vaccine fr 17th Feb 2021 till 12th Apr 2021.. ONLY 5,898 (2%) reported adverse events.. And even from these 5,898, 4,777 (or 81%) only reported mild to moderate reactogenecity.. 3/n
nejm.org/doi/full/10.10…
So out of the 5,898 that reported adverse events; 19% that were "not" mild to moderate.. 1,120 of the HCWs.. 50 were considered serious or of special interest with their diverse conditions as listed in Table 1 below.. 4/n
nejm.org/doi/full/10.10…
And looking at the 50 HCWs with serious or of special interest..
12 (24%) had #COVID19 within 28d post-vaccination,
12 (24%) had allergic rxn BUT of which ONLY 1 qualify as #anaphylaxis ..
6 (12%) had neurological condition
5 (10%) had CVS Sx .. 5/n
nejm.org/doi/full/10.10…
Other details reported adverse reactions as below.
But this interim report also notes that Rate of Adverse Effects fr Vaccination is LOW & Thromboembolic Events occured mainly in persons with risk factors like
1) obesity
2) HPT
3) DM
4) Pulmonary embolism
5) RHD
6) CVA etc
Another good article.. giving overview of #SARSCoV2 #variants & #vaccine ..
pharmaceutical-technology.com/features/covid…
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