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📢 #Pathology #tweetorial alert!
⚕️ Dx: Plexiform #Schwannoma (aka neurilemmoma)
🔬 Multiple (2-50) nodules or foci of fascicular expansion.
🔬Biphasic: dense hypercellular areas (Antoni A) + loose hypocellular areas (Antoni B)
Scroll down ⬇️ #dermpath #BSTPath
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A plexiform multinodularity is typical of plexiform schwannoma on gross examination.
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Usually sporadic (90%)
NF2 associated (5%)
NF2 gene on 22q12 ➡️ merlin.
🆚
Plexiform neurofibroma is associated with germline mutation of NF1 (17q11.2 ➡️neurofibromin)
sciencedirect.com/science/articl…
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🧪 IHC
S100 diffusely (➕)
SOX10 (➕)
Reticulin (➕) around individual cells
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Differential Diagnoses
⭕️ Plexiform neurofibroma:
- Smaller cell
- Abundant stromal mucin
- S100 partially (+)
⭕️ Palisaded encapsulated neuroma (PEN)
- Abundant axons
⭕️ Cutaneous leiomyoma
- S100(-), SOX10(-)
- SMA and desmin (+)
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Locations:
Dermal/subcutaneous (90%)
Extremity, trunk, head and neck
Mucosal sites
Visceral rare
link.springer.com/article/10.100…
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