Thread by @dianaberrent

Let's talk about breakthrough symptomatic infections in fully vaxxed adults...

Today @SurvivorCorps will meet with the @CDCgov to present our data and ask for changes in policy to reflect real world evidence.

@CDCgov is only tracking hospitalized cases so we did it instead.
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We ran a poll of our 170K member group and had 1949 fully vaxxed adults participate.

Our Key Takeaways:

-Vaccines Work (but not all the time)

-Of 1949 fully vaxxed adults there were 44 breakthrough symptomatic cases (we couldn't measure asymptomatics for obvious reasons)
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-Vaccines will likely keep you from acute symptomatic Covid needing hospitalization

-*HOWEVER* 55% of breakthrough symptomatic cases led to Long Covid (this is staggering)

-(Narrator Voice: If I had J&J I would want a booster)
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Tl/dr: Breakthrough symptomatic cases of Covid in fully vaccinated adults lead to #LongCovid. Full Stop.
#LongTermCovid
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Based on this data the CDC should revise its guidance:
-Vaxxed ppl should remain masked indoors
-Vaxxed ppl should get tested when symptomatic
-CDC should mandate reporting of All breakthrough cases
-CDC should mandate reporting of ALL vaccine injuries (VAERS is a bust)
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We cannot track what we aren’t counting.

Have we not learned that simple lesson from a mere year and a half ago?

Low testing doesn’t mean low numbers; it means bad science.
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We are also creating a new cohort of untested individuals who will struggle with diagnoses of Long-Term Covid, a devastating multi-organ condition that can ravage the body of the youngest and healthiest among us.
This is also the backbone of our economy. #LongCovid
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Our data is somewhat skewed b/c it was done within Survivor Corps. While this is not data you are going to take to the bank, it offers a tremendously compelling clue that our policies are not in line with what’s really happening on the ground.

And it's the only data we have.
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And, remember, even a really small percentage of a really big number is still a really big number.
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This is Citizen Science 2.0... Citizen Scientist Collaboration.

We are honored to collaborate with @DaisySMassey and @hmkyale @Yale @YaleMed on this and other projects.

Stay tuned for our imminent publication on MedRxiv
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Full breakdown by vaccine below:

Total – Of 1949 fully vaxxed adults there were
- 44 symptomatic breakthrough cases (2.3%)
- 24 of which led to Long Covid (55%)

3 Hospitalizations (only one of which led to Long Covid).
(These would be only 3 counted under current rules)
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Pfizer:
Of 1024 adults fully vaxxed with Pfizer there were
- 19 breakthrough symptomatic cases (1.8%);
- 12 of which led to LC (63%);
- Zero hospitalizations
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Moderna:
Of 775 adults fully vaxxed with Moderna there were
- 17 breakthrough symptomatic cases (2.2%);
- 6 of which led to LC (35%)
- 1 hospitalization (no Long Covid)
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J&J:
Of 150 adults fully vaxxed with J&J there were
- 8 breakthrough symptomatic cases (5.3%);
- 6 of which led to Long Covid (75%);
- 2 hospitalizations (one of whom developed Long Covid)
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Please r/t and thanks for following along. Please stay safe!
/end

@kavitapmd @VirusesImmunity @VinGuptaMD @DanielGriffinMD @hmkyale @drsanjaygupta @Surgeon_General @CDCDirector @RWalensky @NIHDirector @XavierBecerra @HHS_ASH @DrMJoyner @ACasadevall1 @OliviaTroye @DrEricDing

And yes I tagged the wrong Survivor Corps… 🤷‍♀️ @Survivor_Corps

Let me clarify for those in the last row… this is data based off of a biased sample. No one is suggesting that 55% of breakthrough symptomatic infections lead to Long Covid in the general population.

The fact that some cases do, though, means we should be tracking it.
@hmkyale

Our paper on Breakthrough Symptomatic cases leading to #LongCovid has been published. With @DaisySMassey and @hmkyale

@YaleMed @Survivor_Corps

THIS is Citizen Scientist Collaboration at work.

medrxiv.org/content/10.110… #medtwitter