BEST BOOSTER? Mix it up — but depends which you had first. Switching vaccine for the booster seems to be the best—Pfizer to Moderna booster, Moderna to Pfizer for booster, and J&J should switch to Moderna / Pfizer booster. HT to @ScientistSwanda. #COVID19 #BoosterShots #vaccinate
2) Vaccine efficacy and booster eligibility summarized here by @MedicalLetter. secure.medicalletter.org/downloads/1621…
4) Here are the official eligibility criteria for boosters. Note that Moderna as a booster is a modified 50 mcg. Normal first 2 shots of Moderna is 100 mcg.
5) that said, if you have a cancer or immunocompromised like #MultipleMyeloma, then you should go with the Moderna full dose 100 mcg two shots. Ask your doctor if still possible.
6) Moderna 2 shots (2x 100 mcg) yielded 6x greater antibody response than 2 shots of Pfizer. Might be too late to change; but just FYI for those not vaccinated yet.
7) This booster study (top post) is funded by the NIH. Though keep in mind the Moderna “booster” they tested was the 100 mcg full dose, and not the 50 mcg currently FDA authorized Moderna booster. So while Moderna looks strongest, keep in mind it’s 2x the current booster dose.
8) The study hold a wealth of data on boosters. Really key is that J&J seems to lag all the other boosters in terms of antibody response. medrxiv.org/content/10.110…
9) What does booster offer) more than 90% risk reduction in SEVERE DISEASE in Israel 🇮🇱 for those who got 3 Pfizer doses versus 2 doses after 6 months!!! And it benefits both elderly and younger adults!!! Middle age should definitely take booster!
10) This is what happens when nationwide boosters were rolled out in Israel 🇮🇱. Its Delta variant wave stopped soon after.
11) good morning - 100 million at risk Americans can likely get boosters starting today.
12) Forgot to mention - it seems having initial Pfizer doses then switching to Moderna has slightly less severe headache, fatigue, nausea, and myalgia than a 3rd Pfizer dose.
medrxiv.org/content/10.110…
13) Unpopular thing to utter aloud — but many scientists think 1 dose J&J is way too weak. It should never have been a one dose vaccine in the first place. 2 dose should have been minimum.
14) Even 2 doses of J&J is much weaker for T cell stimulation versus 2 Pfizers.
15) What is better than figuring out which booster to get? GOING OUT TO GET ONE! see thread 🧵 of evidence 👇
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