Thread by @1derfultype

🧵#diabetes prevention : are we on the right track?
Here are the players in the development of #T1D 👇
-M. Knip

#ISPAD #ISPAD2022 #dedoc°voices #NothingAboutUsWithoutUs #patientvoice #payitforward @dedocORG @ispad_org 1/n

#diabetes prevention : are we on the right track?
The different stages of #betaCells autoimmunity:
1⃣ Normoglycemia
2⃣ Presymptomatic dysglycemia
3⃣ Symptomatic dysglycemia
Primary prevention shld start during pregnancy.
-M. Knip

#ISPAD2022 #dedoc°voices @dedocORG @ispad_org 2/n

#diabetes prevention : are we on the right track?
Early life infection may be the initiator of the endotype. There is a step autoantibodies decline among those diagnosed before 7yo.
-M. Knip

#ISPAD2022 #dedoc°voices #payitforward @dedocORG @ispad_org 3/n

#diabetes prevention : are we on the right track?
Systemic #enterovirusinfection before diagnosis for sero conversion to autoantibodies.
An antidiabetogenic #CBV vaccine could be the answer.
-M. Knip

#ISPAD2022 #dedoc°voices @dedocORG @ispad_org 4/n

#diabetes prevention : are we on the right track?
Prevention must start at birth among kids with high genetic risks of #T1D.
-M. Knip

#ISPAD #ISPAD2022 #dedoc°voices #NothingAboutUsWithoutUs #diabetesadvocacy #patientvoice #payitforward @dedocORG @ispad_org 4/n

#diabetes prevention : are we on the right track?
Secondary prevention ongoing trials 👇
#Teplizumab can delay the beta cells destruction and #T1D progression.
-M. Knip

#ISPAD #ISPAD2022 #dedoc°voices #NothingAboutUsWithoutUs #payitforward @dedocORG @ispad_org 5/n

#diabetes prevention : are we on the right track?
Why must understand how and why #T1D occurs.
Still a lot to learn.
-M. Knip

#ISPAD #ISPAD2022 #dedoc°voices #NothingAboutUsWithoutUs #payitforward @dedocORG @ispad_org 6/n