1. mpox: human monkeypox virus (hMPXV) doesn't enter the nucleus. Genetic recombination with SARS-CoV-2 in the cytoplasm is possible in co-infected patients, eg people living with uncontrolled HIV-1 (PLH). It's the real threat of Covid Denial or Let 'er RIP policy.
#SIDU 230206
2. Covid can have the same effect, causing lymphopenia in perhaps 1 in 3 patients (severe #LongCOVID (#LongSARS) can be compared to HIV/AIDS).
Influenza, SARS, HIV, mpox Protein E8L follow shared evolutionary dynamics for electrostatic surface potential & co-receptor switching.
3. Practical implication for clinicians: Test patients presenting with mpox symptoms for all three diseases.
Practical implications for all else: read science.
sciencedirect.com/science/articl…
mdpi.com/1999-4915/15/2…
mdpi.com/1420-3049/27/1…
mdpi.com/1999-4915/14/1…
Is there a link to Alzheimer's disease?
You bet!
mdpi.com/1422-0067/24/2…
5. Attractive electrostatic forces between the electronegative raft (red) and the electropositive virus protein (blue) control the reaction. The raft adapts its shape to the viral protein surface (see HIV-1 gp120 V3 loop and SARS-CoV-2 BA.5 spike protein).
6. @RealCheckMarker warned we should be more concerned about the origina of Omicron.
I solve:
Delta had perfected its transmissibility (T) index. To outcompete Delta, Omicron "needed outside help".
After getting it, it is now going up the T index again.
@RealCheckMarker 7. Omicron is evolving exceptionally fast, as BA.5, BQ.1.1, XBB.1.5, XBF, DS.1, DN.1.1.1 show. Community transmission in China is driven by BA.5 and BF.7 to date.
@RealCheckMarker All the awards for @RajlabN (here China plus HK, for good measure).
@RealCheckMarker @RajlabN 8. Today is Good News Monday. Something that I think no one else shared, Idk why: the mpox PHEIC was extended for ten years until 2032. (Last year already)
For all poxviruses, so we're good.
Explicit focus on international cooperation and eradication. 👍
@RealCheckMarker @RajlabN 9. Say hi to the new endemic countries for poxviruses, according to our novel SARS-CoV-2 philosophy. 🤡
Why fight viruses if you can just live with them?
The HIV community shows the way (undetectable = untransmittable U=U, or U=U=U for universal access). unaids.org/en/resources/d…
10. Share with all who think we can play stupid games with SARS but NOT win stupid prizes.
Alzheimer's Disease in a teenager. A world first!
This can go incredibly wrong within years. We won't know until years AFTER the transmission event.
Hence: N95+😷
11. Good News Monday: we can stop the madness tomorrow, Tuesday, by the same measures that stopped SARS 2003.
Unmitigated aviation - without quarantine - spreads new VoC around the globe all the time. Greed sustain this pandemic. We can end this any time.
12. How?
Some of us should probably work it out.
We'll just need minimal resources, sustained attention by the highest levels of government (who really just need to get out of the way; this is science, not politics, after all!).
And we need to start ASAP.
Live shot of public health officials right now, in what is arguably the nadir of the SARS pandemic:
The good news is, it's upwards from here!
On the teenage Alzheimer’s case: neurodegenerative disease used to be rare in children and adults - once modern hygiene and pasteurization of milk started in the early 1900s.
Eliminating constant BCoV outbreaks and secondary disease coincided with doubling human life expectancy.
Don’t halve the human lifespan!
This message works even in a society of individuals. Global health is in every country’s national interest.
We all save for retirement (unless you’re millennial or younger lol, then the climate wars are our retirement plan). So do states.
1889:
Every time someone says “COVID-19 is novel”, the sorry souls who lost their bodies in the OC43-1889 pandemic or in SARS-2003 turn over in their graves (or do a flip-flop in heaven—take what you believe):
The name for ‘brain fog’ is SARS-associated neurocognitive disorder (SAND).
14. Why explains the western academic hubris?
Watch this animated SARS-CoV-2 life cycle. This high-quality production by Profs Ravelli/Knoops @maastrichtu was widely shared.
No one noticed it's wrong.
Scissors Reality Check Mark I you spot the error. 😂
@MaastrichtU Entirely worth posting this beautiful animation.
You need to watch the video to the end, where the error is: 2/3
@MaastrichtU I'm curious what explains this western hubris and lack of systems thinking.
A question not just virologists who collectively failed to inform policymakers and the public, but all of us who are potential hosts to the lifecycle of a virus declared 'endemic' and 'to be lived with'.
@MaastrichtU Millions were told they cleared the virus upon seroconversion. Millions of (future) patients, too, will be told LongCOVID is 'in their head'. The latter claim is true, just not in the soothing sense intended.
SARS isn't influenza.
@michaelzlin Damn and this on Good News Monday!
@MaastrichtU @michaelzlin Just so we're clear, here the error I point out: SARS does not kill the host cell.
@MaastrichtU @michaelzlin Does Nsp1 fully take over the epithelial cell's function?
The video suggests it takes over the ribosome, to produce only viral RNA, not the cell's mRNA anymore. @SGinossarLab: this is not for me to explain, but such details matter.
cell.com/cell-reports/f…
@MaastrichtU @michaelzlin @SGinossarLab * I'll add or rewrite if more accurate explanation appears. It is important to know whether hundreds of millions of people live with persistent and/or replicating virus. The malpractice in virology and public health has gone too far.
Scientists who know should not remain silent.
Why are virologists fatally wrong on SARS?
Pathogenesis is immune-mediated. Their software packages don’t ‘see’ many of the subtler tricks this virus has up its sleeve, and clearly they’re not humble enough to work with patients.
It was classified as autoimmune disease already.
15. Why is genetic recombination the real threat of 'Live with Covid' policy?
(1) SARS-CoV-2 reinfections can create recombinants (XBB, XAY, XBF etc.)
(2) It can make *other* viruses more immune evasive.
The #LeonardiEffect @fitterhappierAJ facilitates.
@fitterhappierAJ 16. @BagaiDr kindly introduces this paper on convergent evolution in the SARS-CoV-2 spike. I add the Fantini papers I for more powerful analysis building on 40 years of HIV science.
The authors use 'saltation,' an influenza term. SARS is NOT influenza! 🙏
@fitterhappierAJ @BagaiDr Direct links:
Share this Scrolly Tale with your friends.
A Scrolly Tale is a new way to read Twitter threads with a more visually immersive experience.
Discover more beautiful Scrolly Tales like this.