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Paul Maidowski Profile picture
@_ppmv
Feb 6, 2023 • 28 tweets • 21 min read • Read on X
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1. mpox: human monkeypox virus (hMPXV) doesn't enter the nucleus. Genetic recombination with SARS-CoV-2 in the cytoplasm is possible in co-infected patients, eg people living with uncontrolled HIV-1 (PLH). It's the real threat of Covid Denial or Let 'er RIP policy.

#SIDU 230206
2. Covid can have the same effect, causing lymphopenia in perhaps 1 in 3 patients (severe #LongCOVID (#LongSARS) can be compared to HIV/AIDS).

Influenza, SARS, HIV, mpox Protein E8L follow shared evolutionary dynamics for electrostatic surface potential & co-receptor switching.
3. Practical implication for clinicians: Test patients presenting with mpox symptoms for all three diseases.

Practical implications for all else: read science.
sciencedirect.com/science/articl…
mdpi.com/1999-4915/15/2…
mdpi.com/1420-3049/27/1…
mdpi.com/1999-4915/14/1…
Is there a link to Alzheimer's disease?

You bet!
mdpi.com/1422-0067/24/2…
5. Attractive electrostatic forces between the electronegative raft (red) and the electropositive virus protein (blue) control the reaction. The raft adapts its shape to the viral protein surface (see HIV-1 gp120 V3 loop and SARS-CoV-2 BA.5 spike protein).
6. @RealCheckMarker warned we should be more concerned about the origina of Omicron.

I solve:

Delta had perfected its transmissibility (T) index. To outcompete Delta, Omicron "needed outside help".

After getting it, it is now going up the T index again.
@RealCheckMarker 7. Omicron is evolving exceptionally fast, as BA.5, BQ.1.1, XBB.1.5, XBF, DS.1, DN.1.1.1 show. Community transmission in China is driven by BA.5 and BF.7 to date.
@RealCheckMarker All the awards for @RajlabN (here China plus HK, for good measure).
@RealCheckMarker @RajlabN 8. Today is Good News Monday. Something that I think no one else shared, Idk why: the mpox PHEIC was extended for ten years until 2032. (Last year already)

For all poxviruses, so we're good.

Explicit focus on international cooperation and eradication. 👍
@RealCheckMarker @RajlabN 9. Say hi to the new endemic countries for poxviruses, according to our novel SARS-CoV-2 philosophy. 🤡

Why fight viruses if you can just live with them?

The HIV community shows the way (undetectable = untransmittable U=U, or U=U=U for universal access). unaids.org/en/resources/d…
10. Share with all who think we can play stupid games with SARS but NOT win stupid prizes.

Alzheimer's Disease in a teenager. A world first!

This can go incredibly wrong within years. We won't know until years AFTER the transmission event.

Hence: N95+😷
11. Good News Monday: we can stop the madness tomorrow, Tuesday, by the same measures that stopped SARS 2003.

Unmitigated aviation - without quarantine - spreads new VoC around the globe all the time. Greed sustain this pandemic. We can end this any time.
12. How?

Some of us should probably work it out.
We'll just need minimal resources, sustained attention by the highest levels of government (who really just need to get out of the way; this is science, not politics, after all!).
And we need to start ASAP.
Live shot of public health officials right now, in what is arguably the nadir of the SARS pandemic:

The good news is, it's upwards from here!
On the teenage Alzheimer’s case: neurodegenerative disease used to be rare in children and adults - once modern hygiene and pasteurization of milk started in the early 1900s.

Eliminating constant BCoV outbreaks and secondary disease coincided with doubling human life expectancy.
Don’t halve the human lifespan!

This message works even in a society of individuals. Global health is in every country’s national interest.

We all save for retirement (unless you’re millennial or younger lol, then the climate wars are our retirement plan). So do states.

1889:
Every time someone says “COVID-19 is novel”, the sorry souls who lost their bodies in the OC43-1889 pandemic or in SARS-2003 turn over in their graves (or do a flip-flop in heaven—take what you believe):

The name for ‘brain fog’ is SARS-associated neurocognitive disorder (SAND).
14. Why explains the western academic hubris?

Watch this animated SARS-CoV-2 life cycle. This high-quality production by Profs Ravelli/Knoops @maastrichtu was widely shared.

No one noticed it's wrong.

Scissors Reality Check Mark I you spot the error. 😂
@MaastrichtU Entirely worth posting this beautiful animation.

You need to watch the video to the end, where the error is: 2/3
@MaastrichtU I'm curious what explains this western hubris and lack of systems thinking.

A question not just virologists who collectively failed to inform policymakers and the public, but all of us who are potential hosts to the lifecycle of a virus declared 'endemic' and 'to be lived with'.
@MaastrichtU Millions were told they cleared the virus upon seroconversion. Millions of (future) patients, too, will be told LongCOVID is 'in their head'. The latter claim is true, just not in the soothing sense intended.

SARS isn't influenza.

@michaelzlin Damn and this on Good News Monday!
@MaastrichtU @michaelzlin Just so we're clear, here the error I point out: SARS does not kill the host cell.
@MaastrichtU @michaelzlin Does Nsp1 fully take over the epithelial cell's function?

The video suggests it takes over the ribosome, to produce only viral RNA, not the cell's mRNA anymore. @SGinossarLab: this is not for me to explain, but such details matter.
cell.com/cell-reports/f…
@MaastrichtU @michaelzlin @SGinossarLab * I'll add or rewrite if more accurate explanation appears. It is important to know whether hundreds of millions of people live with persistent and/or replicating virus. The malpractice in virology and public health has gone too far.

Scientists who know should not remain silent.
Why are virologists fatally wrong on SARS?

Pathogenesis is immune-mediated. Their software packages don’t ‘see’ many of the subtler tricks this virus has up its sleeve, and clearly they’re not humble enough to work with patients.

It was classified as autoimmune disease already.
15. Why is genetic recombination the real threat of 'Live with Covid' policy?

(1) SARS-CoV-2 reinfections can create recombinants (XBB, XAY, XBF etc.)

(2) It can make *other* viruses more immune evasive.

The #LeonardiEffect @fitterhappierAJ facilitates.
@fitterhappierAJ 16. @BagaiDr kindly introduces this paper on convergent evolution in the SARS-CoV-2 spike. I add the Fantini papers I for more powerful analysis building on 40 years of HIV science.

The authors use 'saltation,' an influenza term. SARS is NOT influenza! 🙏
@fitterhappierAJ @BagaiDr Direct links:

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More from @_ppmv

Paul Maidowski Profile picture
Nov 19, 2024
1. May do SARS-CoV-2 science threads when I find time. "While association between ABO blood group and infection is well known for many years, lower susceptibility of O blood group to coronaviruses had already been reported nearly 20 years ago for SARS-CoV" degruyter.com/document/doi/1…
2. Transplacental SARS-CoV-2 protein Orf8 binds to complement C1q to trigger fetal inflammation - Yes, as we've been saying for years. Orf8 makes SARS (CoV-1/-2) unique among coronaviruses. Let's infect all the kids so we are really, really sure that's bad embopress.org/doi/full/10.10…Image
3. SARS-CoV-2 can trigger a devastating, destructive placental pathology causing placental dysfunction and fetal hypoxia, yet stillbirth is rare. The fetal hypoxia is acute/subacute, apparent as reduced fetal movements. 20% of participants in this study(!) sciencedirect.com/science/articl…Image
Read 8 tweets
Paul Maidowski Profile picture
Sep 20, 2024
1. The structural parallels of SARS-CoV-2 and HIV-1 were known already 20 years ago, from SARS-CoV-1. Yet COVID-19 policy and even most scientists ignore these parallels, failing to learn key lessons. Fundamentally, genetic recombination drives both pandemics—two typical articles

Image
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2. Don't worry about the specific article—there are hundreds more, and more relevant ones. The lesson here is we face syndemics, overlapping epidemics that cluster with inequity, not just distinct pandemics. All reinforce each other
link.springer.com/article/10.118…
frontiersin.org/journals/micro…
3. Background. There are literally thousands such articles; no one integrates them. That's why as political scientist, for years already, I've been arguing that only institutionalization can help with such complexity. We need a @UNAIDS for SARS-CoV, sorry
Read 29 tweets
Paul Maidowski Profile picture
Sep 12, 2024
Is bamboo our best chance to sustain modern civilization and slow climate change? No one systematically studies its global potential in food, paper, energy, & construction yet. To build resilient economic and ecosystems, we need to grow bamboo where it is needed, incl Europe 👇☕️ Moso bamboo shoot (phyllostachys edulis)
“Self made” 80 liter air pot design and 12 liter air pot propagation set. Coffee for scale
40 year old moso bamboo in southwestern France grown from seed. Photo Lihua Jiang, www.yunnan-bamboo.com
1. It is no new idea to replace plastic, steel, concrete etc. with bamboo, just as these materials originally replaced timber, clay, and bamboo. When indigenous people in Taiwan move, they plant bamboo before all else, “because it does everything timber does and is much lighter.” Taiwan mountains 台灣新竹
2. Every mountaintop here has its own name in the local - non written - language, to be found on no map. By force or virtue, indigenous people know how to sustain themselves and live within their ecological limit (“habitat”), unlike industrial civilization. Mixed bamboo forest 👇 Image
Image
Read 32 tweets
Paul Maidowski Profile picture
Aug 30, 2024
1. Growing bamboo is our best chance to avert climate breakdown: the plants build soil, help biodiversity, avoid GHG emissions, provide food & construction material, sequester carbon 30 times (!) faster than mixed temperate forest. Yet stunningly, no one coordinates this work yet 40 year old moso bamboo in southwestern France grown from seed. Photo Lihua Jiang, www.yunnan-bamboo.com
2. After 40 years of climate science - first AGGG, now IPCC -, everyone feels they know climate. Yet experts only really know their own field. Generalists and practitioners can implement solutions but need experts to develop them. Bamboo as climate solution is entirely unexplored
Two bamboo stands in Zhongshan Expo Park, Taipei
Bamboo species in Tapei botanical garden
3. Last time atmospheric carbon content was as high as today, 16 million years ago, Earth was >3°C warmer than today, the Arctic was ice free, and Iceland had a subtropical climate. People think they know what climate change means, but most really don't. mdpi.com/2673-4834/5/2/…
Read 47 tweets
Paul Maidowski Profile picture
Aug 21, 2024
We’ve shared this for years, it was known or suspected even before the pandemic from SARS-CoV-1. Friends of we’re going to learn at this rate, ignoring prepandemic science, populations worldwide will get into serious trouble
Background. Thanks for outstanding science communications @vipintukur
I'd like to delete my account, but then a sizable fraction of the early Covid twitter scicomm documentation - to show what was known when - would be gone. As far as I know, no one else with even a moderately sized account (>10k followers) shares the same readily available science
Read 5 tweets
Paul Maidowski Profile picture
Jun 13, 2024
“Bamboo is our best chance to slow climate breakdown. It can replace drivers of GHG emissions and biodiversity loss (food, construction, concrete, plastic), build soil & allow regrowing rainforest." - Let's test it. Grow bamboo as blueprint for a future ecological civilization 🧵
Moso bamboo (phyllostachys edulis) seedling grown from seed with tap root
Moso bamboo forest in China, stock photo
2. Giant bamboo dwarfs trees. As grass, it grows 30 times (!) faster and can be harvested every year. Timber takes decades; too slow. Stunningly, no one in the west described the unique climate mitigation potential of bamboo yet. - Note the rhizome system:

Image
Image
3. Climate relevant will be the use in millions of ha of plantations, just like other economically important crops. After two months on this, some significant progress: air pot kindly donated 1 m of their professional U system, so I can test it for bamboo.
Image
Read 39 tweets

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