1. mpox: human monkeypox virus (hMPXV) doesn't enter the nucleus. Genetic recombination with SARS-CoV-2 in the cytoplasm is possible in co-infected patients, eg people living with uncontrolled HIV-1 (PLH). It's the real threat of Covid Denial or Let 'er RIP policy.
5. Attractive electrostatic forces between the electronegative raft (red) and the electropositive virus protein (blue) control the reaction. The raft adapts its shape to the viral protein surface (see HIV-1 gp120 V3 loop and SARS-CoV-2 BA.5 spike protein).
@RealCheckMarker 7. Omicron is evolving exceptionally fast, as BA.5, BQ.1.1, XBB.1.5, XBF, DS.1, DN.1.1.1 show. Community transmission in China is driven by BA.5 and BF.7 to date.
@RealCheckMarker@RajlabN 8. Today is Good News Monday. Something that I think no one else shared, Idk why: the mpox PHEIC was extended for ten years until 2032. (Last year already)
For all poxviruses, so we're good.
Explicit focus on international cooperation and eradication. 👍
Some of us should probably work it out.
We'll just need minimal resources, sustained attention by the highest levels of government (who really just need to get out of the way; this is science, not politics, after all!).
And we need to start ASAP.
Live shot of public health officials right now, in what is arguably the nadir of the SARS pandemic:
The good news is, it's upwards from here!
On the teenage Alzheimer’s case: neurodegenerative disease used to be rare in children and adults - once modern hygiene and pasteurization of milk started in the early 1900s.
Eliminating constant BCoV outbreaks and secondary disease coincided with doubling human life expectancy.
Every time someone says “COVID-19 is novel”, the sorry souls who lost their bodies in the OC43-1889 pandemic or in SARS-2003 turn over in their graves (or do a flip-flop in heaven—take what you believe):
The name for ‘brain fog’ is SARS-associated neurocognitive disorder (SAND).
@MaastrichtU Entirely worth posting this beautiful animation.
You need to watch the video to the end, where the error is: 2/3
@MaastrichtU I'm curious what explains this western hubris and lack of systems thinking.
A question not just virologists who collectively failed to inform policymakers and the public, but all of us who are potential hosts to the lifecycle of a virus declared 'endemic' and 'to be lived with'.
@MaastrichtU Millions were told they cleared the virus upon seroconversion. Millions of (future) patients, too, will be told LongCOVID is 'in their head'. The latter claim is true, just not in the soothing sense intended.
The video suggests it takes over the ribosome, to produce only viral RNA, not the cell's mRNA anymore. @SGinossarLab: this is not for me to explain, but such details matter. cell.com/cell-reports/f…
@MaastrichtU@michaelzlin@SGinossarLab * I'll add or rewrite if more accurate explanation appears. It is important to know whether hundreds of millions of people live with persistent and/or replicating virus. The malpractice in virology and public health has gone too far.
Scientists who know should not remain silent.
Why are virologists fatally wrong on SARS?
Pathogenesis is immune-mediated. Their software packages don’t ‘see’ many of the subtler tricks this virus has up its sleeve, and clearly they’re not humble enough to work with patients.
@fitterhappierAJ 16. @BagaiDr kindly introduces this paper on convergent evolution in the SARS-CoV-2 spike. I add the Fantini papers I for more powerful analysis building on 40 years of HIV science.
The authors use 'saltation,' an influenza term. SARS is NOT influenza! 🙏
Hybrid immunity was invented in 2021 to sell the idea of SARS-CoV-2 infections as a good. There is no literature pre 2021. The idea to infect the global population with a SARS virus, including all 2 billion children aged 14 yo and younger, didn't exist. scholar.google.com/scholar?q=%22h…
You can repeat the same with "immune debt" or "immunity debt", the original flawed idea invented by French pediatrician Cohen in 2021, setting off the whole strain of argument. An incredibly effective PR campaign, less good science. scholar.google.com/scholar?hl=en&…
1. Europe imports all its bamboo. Plantations on fallow land are one good option to slow climate breakdown and create sustainable jobs. Bamboo is incredibly fast and, unlike timber, active management improves climate and ecological outcomes. Merits focus, baustoff-partner.de/d/moso-reiche-…
SARS-CoV-2 wasn't the last disruption to import based businesses. Our basic climate policy warning for seven years now. One of the reasons I'd encourage everyone to look into starting to grow Moso bamboo (phyllostachys edulis) or other suitable species in Southern Europe as well.
3. Terrestrial mammals and C4 grasses evolved and adapted below a threshold of 550 ppm. Earth will cross it within the lifetime of kids born today. - Bamboo is our most efficient C3 plant. Cenozoic CO2 proxy (CENCO2PIP) Consortium☝️ science.org/doi/10.1126/sc…
You need a scale for the collapse of 'doomsday' glacier Thwaites. Compare the past two years: iceberg B22a broke off the glacier in 2002 and gained legs in 2023, freeing Thwaites to flow into the sea over the coming years: here it is today—that's 3,000 km2 worldview.earthdata.nasa.gov/?v=-2442135.48…
3600 square kilometers, for the mathematicians here
The real problem: you cannot analyze SARS-CoV-2 OR compare it to HIV-1 without accounting for reinfections, current policy worldwide because no one bothers to plan for stopping them, ie #ZeroCovid, just as we have #ZeroHIV policy. Absurd.
SARS-CoV should be compared to HIV. They are the two best researched viruses in history. "Compare and contrast X and Y" is about the most common essay question in middle school language classes worldwide; people who want to prevent this have ill (no dad joke intended) intentions.
As AJ says, different opinions are perfectly valid here as long as people read carefully. It will get very complex. This is why as political scientist, to me learning from the policy & social parallels to the HIV/AIDS pandemic is paramount. Compare away,
The pre-ART HIV era is before me, so I learn from books and experiences. The central lesson of #UUU (#UequalsU) is: Empower the public. Help them make informed decisions.
It REQUIRES clear language as we speak, and public debate.
Don’t use Covid/LC. The real term in the literature since 2003 has been SARS survivors. It’s a SARS virus, so this require no rocket scientist, a Google search suffices. Wild how you minimize your own condition out of ignorance, friends. Worst social movement strategy I’ve seen.
Why bad? If you define LongCovid narrowly as the most extreme forms of ME/CFS or whatever, you minimize the 200+ symptoms recognized by WHO, marginalize all the hundreds of millions living with chronic infection, and slow public recognition, R&D & prevention. All around failing.
Just attended a toddler's birthday party: EVERY family reports kids constantly sick this winter, some severe/hospitalized, plus parents out, some month-long Covid + X infections. - As expected. - None of them understand this virus, thanks to ☝️ failing Covid advocacy and policy.