Beverly G. Tchang, MD Profile picture
#Endocrinologist. Passionate about #obesity as a medical disease and a social misunderstanding. Tweets are my own. | #health #medtwitter #weightloss #medicine |

May 3, 2023, 6 tweets

SO EXCITED FOR THIS

Dr. Rudy Leibel of @ColumbiaMed, everyone

Key quote:
"The RISK of developing obesity comes from genes."

Note that he doesn't say obesity itself is caused by genes. This would be an oversimplification!

2/

You've seen this graph in several versions. This is what happens when genes set a risk level and the environment selects for it, resulting in a specific phenotype

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The usual (known) monogene culprits. If you're studying for obesity boards, know these.

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An excellent explanation of the genome wide polygenic risk score (GPRS). Using data of 2.1 million SNPs as markers for ↑weight or ↓weight, we can predict with SOME accuracy what the #weight differential will be at middle age, comparing highest and lowest risk cohorts

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We're not just studying obesogenic genes but also those that protect against #obesity

science.org/doi/10.1126/sc…

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