Discover and read the best of Twitter Threads about #obesity

Most recents (24)

GLP-1-based therapies are slowly approaching #bariatricsurgery level #weightloss and more exciting science to come. There is the impressive SURMOUNT-1 trial for tirzepatide #obesity nejm.org/doi/full/10.10…
Among the compelling findings, 63% of subjects achieved > 20% #weightloss with 15 mg once weekly Tirzepatide over 72 weeks #obesity nejm.org/doi/full/10.10…
The results obtained with semaglutide and now tirzepatide provide compelling examples of how investments in science over time enable new more effective therapies for metabolic disorders #T2D #Obesity perhaps #NASH. These results also raise the bar for new mechanisms in the space
Read 4 tweets
1) Welcome to an #accredited #tweetorial on optimizing the use of #SGLT2i in the management of #T2D. This program is accredited for 0.50 🆓credits for #physicians #nurses #physicianassociates #nursepratcitioners #pharmacists by @academiccme! I am @tmodarressi of @HeartDoctorNJ.
2) This program is intended for healthcare professionals and is supported by an educational grant from Boehringer Ingelheim Pharmaceuticals Inc. and Eli Lilly Company. See archived programs, all by expert authors, still available for credit at cardiometabolic-ce.com.
Read 47 tweets
Thread on #Magnesium and why it is fundamental for our #health. #micronutrients
..many people debate the various ratios of #macronutrients like #protein, #fat, and #carbohydrates in their diet to find their optimal health. Which is great as we are #bioindividuals but most miss out on #micronutrients like #vitamins and #minerals.
The way our bodies are able to use the #macronutrients is fully dependent on how our #enzymatic pathways are influenced by various #micronutrients. One of the most important amongst is #magnesium.
Read 19 tweets
1) Welcome to a new #accredited #tweetorial on Clinical and Laboratory Manifestations of #DKD in #T2D: From Early Identification to Monitoring Management. Your expert author is @edgarvlermamd.
2a) This activity is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers. It is accredited for #physicians #physicianassistants #nurses #NPs #pharmacists. Check out @cardiomet_ce for more🆓CE/#CME.
Read 45 tweets
There have been rumours this week that Government is considering a delay or U-turn on banning multi-buy deals on #junkfood.

This would be a #FalseEconomy.

🧵A short thread👇 [1/6]
These regs were brought in to tackle #obesity. During Covid-19 obesity rates have risen dramatically & the NHS is under more pressure than ever. There's an urgent need for Govt to introduce evidence-based policies to help.
Source: our #data dashboard foodfoundation.org.uk/childrens-righ… [2/6]
Junk food multi-buys are well-known to encourage unnecessary unplanned purchases & therefore ⬆️spending.

The Govt’s own figures show they increase the amount of food purchased by 22%. Allowing retailers to continue to use them won’t help with the cost of living crisis [3/6]
Read 6 tweets
Gut hormone axis. Learning from one of the best Dr. Garvey @TheAACE #aace2022 Image
Here are the players #AACE2022 #Endotwitter Image
Food intake is not a cognitive function #aace2022 #Endotwitter Image
Read 12 tweets
1) Welcome to a new #accredited #tweetorial, Prevention and Management of Heart Failure in T2 Diabetes: The Diabetologist’s Perspective! Our expert author is Melanie J Davies CBE FMedSci @profmjdavies, Prof of Diabetes Medicine, U Leicester, Leicester Diabetes Unit @LDC_Tweets
2) This program is intended for #healthcare professionals and is accredited by @academiccme for 0.75h CE/#CME credit for #physicians #physicianassistants #nurses #nursepractitioners #pharmacists 🇺🇸🇨🇦🇬🇧🇪🇺. FOLLOW US for #cardiometabolic education from expert authors!
3) @cardiomet_CE is supported by educational grants from AstraZeneca, Bayer, Boehringer Ingelheim Pharmaceuticals Inc. and Eli Lilly Company, and Chiesi. See archived programs still available for credit at cardiometabolic-ce.com. Disclosures at cardiometabolic-ce.com/disclosures/
Read 43 tweets
Today is #WorldObesityDay!

More than 1⃣ billion people worldwide are obese:
👉 650 million adults
👉 340 million adolescents
👉 39 million children.

Act now to prevent #Obesity ➡️ bit.ly/3CaS7iQ Image
#Obesity is a disease impacting most body systems.
It affects:
🔸 the heart
🔸 the liver
🔸 the kidneys
🔸 the joints
🔸 the reproductive system.

More info
👉bit.ly/3CaS7iQ

#WorldObesityDay Image
Overweight & #obesity are major risk factors for a number of chronic diseases, including:
🚨 type 2 diabetes
🚨 cardiovascular diseases
🚨 cancer
🚨 hypertension
🚨 stroke
🚨 mental health issues

More info
👉bit.ly/3CaS7iQ

#WorldObesityDay Image
Read 6 tweets
This Mendelian randomization analysis suggests that VAT mass is associated with a wide range of CVD outcomes including coronary heart disease, cardiac arrhythmia, vascular diseases, and stroke, with some circulating proteins being potential mediators of this association. Image
- Among these proteins, genetically estimated VAT mass had the highest OR value for the expression of leptin.
- Excessive VAT increased the level of leptin and further increased the incidence of all-cause heart failure, atrial fibrillation and flutter, DVT of lower extremities, pulmonary embolism, and DVT of lower extremities and pulmonary embolism.
Read 4 tweets
This one aimed to assess whether inflammation mediates the Black-White incident diabetes disparity.
- In this prospective cohort study of Black and White adults, Black adults had higher CRP and higher rates of incident diabetes than White adults.
- Inflammation as measured by CRP was found to be a risk factor for diabetes regardless of race.
Read 7 tweets
This one tried to investigate the incidence and characteristics of metabolic-associated fatty liver disease (MAFLD) in individuals living in Liaoning Province, China.
- In all subjects, BMI, systolic and diastolic blood pressure, fasting blood sugar, TG, TC, LDL-C, HDL-C, liver enzymes (ALT, AST, GGT, alkaline phosphatase), blood urea nitrogen, serum creatinine, serum uric acid, haematocrit, mean corpuscular volume and urine protein...
...were associated with MAFLD.
Read 7 tweets
This is a retrospective analysis of the data from CALERIE, that tries to characterize the contributions of the loss of energy-expending tissues and metabolic adaptations to the reduction in resting metabolic rate following weight loss.
- CALERIE, or Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy, was a large-scale, randomized clinical trial in humans that involved a 25% reduction in energy intake over the course of a 2-year period.
Findings:
Read 14 tweets
This one found an association between the implementation of restrictions on high fat, salt, and sugar advertising and relative reductions in energy, sugar, and fat purchased from such products.
- In November 2018, restrictions on the outdoor advertising of HFSS foods and drinks across the Transport for London (TfL) network were announced by the Mayor of London, UK.
- The TfL advertising estate includes the London Underground (rapid transit) network, the TfL Rail network, transport vehicles run by TfL (including some buses, trains, and taxis), and outdoor spaces owned by TfL (e.g., bus stops and land outside train stations).
Read 11 tweets
This one found greater adiposity measures to be associated with CVD risk factors even after adjustments for covariates and physical fitness in Swedish 9-year-old children.
- Body composition and physical fitness were strongly associated.
- Fat mass and fat mass index were strongly and positively associated with CVD risk factors also after adjustments for covariates including physical fitness.
Read 9 tweets
In this middle-to-older-aged active general population sample living in Lausanne, Switzerland, differential associations between permanent night work and the risk of metabolic syndrome for men and women were found.
- Permanent night work was only associated with a higher risk of metabolic syndrome in men but not in women, an that may be mediated by a higher risk of visceral obesity.
- Contrary to other studies, no association between permanent night work or night-shift work and metabolic syndrome in women was found.
Read 5 tweets
1/ Shortish thread about FGF21, a hormone secreted by the liver, muscles and other tissues that is profoundly interesting.

👉 Regulates lipids (HDL, LDL, LPL, ApoCIII and more)

👉 FGF21 analogs are being explored as a treatment for obesity, type II diabetes, NAFLD
2/ FGF21 really caught my attention when I read this paper, which provides compelling evidence that FGF21 is essential for in ketosis and lipid oxidation in mice on a ketogenic diet.
cell.com/cell-metabolis…
3/ Ketogenic diet increased GF21 levels ~20-fold and knockdown of FGF21 created severe metabolic impairments including decreased ketones, hypertriglyceridemia, fatty liver, and decreased expression of ton of genes involved in lipid and ketone metabolism
Read 9 tweets
This study evaluated the association between nutrient patterns with body fat and regional adiposity in middle-aged black South African men and women.
- "the plant-driven nutrient pattern is the most commonly consumed in South Africa. It is characterised by high factor loadings of magnesium, phosphorus, plant protein, carbohydrates, iron, B-vitamins and fibre...
"...Although the plant driven nutrient pattern was not significantly associated with total or regional fatness in the combined sample of men and women, we show for the first time that this nutrient pattern was associated with higher abdominal SAT in women but not men."
Read 10 tweets
Might be time to question your proposed solutions... ? Why getting the thinking of the High-Income Country's nutrition establishment sorted out on metabolic health and non-communicable diseases matters to the 85% of humanity living in Low- & Middle-Income countries.
Previous graphic from globalnutritionreport.org/reports/2021-g…
Read it to understand their mindset & world view.
How can the knowledge of human nutrition and metabolic health be incorporated into the global efforts? Imagine the possible impacts...
Following graphics from document cited previously.
Various authorities cite a lack of animal source foods as causal in these conditions.
Read 8 tweets
Time for a shit in gear as the @GoggleDocs continue their £takeover of the @cardiomet_CE account.

From treatments that are still in the development stage now back to basics.

In this mini-thread today we are going to cover a couple of sessions from #EASD2021 that caught our 👁️
First up led by Prof. Roy Taylor of @UniofNewcastle in collaboration with the @UniofOxford Diabetes Trial Unit.

You may remember Prof. Taylor from the seminal DiRECT Study 👉directclinicaltrial.org.uk

Today I will be going through some of the preliminary data from the ReTune Study Image
📍Twin Cycle Hypothesis (R. Tayor 2008) of #type2diabetes
📍Once an individual' subcutaneous fat reserves are full
▶️ Fat is stored in the liver
▶️ Liver derived VLDL in turn, among other things, ⤴️ pancreatic fat
▶️⤴️pancreatic fat leads onto ⤵️ insulin secretion to food Image
Read 11 tweets
#idweek2021 @IDSAInfo Implications of #COVID19 in African-American & Latinx communities by Dr Hewlett Jr #idtwitter #medEd
#idweek2021 @IDSAInfo #disparities
Implications of #COVID19 in #BLM African-American & #Latinx communities by Dr Hewlett Jr #idtwitter #medEd #pregnancy #obgyntwitter
#idweek2021 @IDSAInfo #disparities Implications of #COVID19 in #BLM African-American & #Latinx communities by Dr Hewlett Jr #idtwitter #medEd #diabetes #obesity #race #FrontlineWorkers vascular disease
Read 6 tweets
As requested by @TamarHaspel here is a brief tweetorial on my latest @NatureRevGenet review on the #genetics 🧬 of #obesity rdcu.be/cyjVV 🧵👇 1/7
While changes in the environment have driven its increased prevalence, obesity results from interaction between environmental & biological factors. Crucially, there is a strong genetic component underlying the large variation in body-weight in today’s ‘obesogenic’ environment 2/7
Classically, we’ve considered obesity in two broad categories; obesity resulting from mutations in single genes, typically rare, starting in childhood & severe; & ‘common’ obesity, a result of hundreds of genetic variants that each have a small effect 3/7
Read 7 tweets
Our new study on genetic determinants of dietary intake is out in @NatureHumBehav

Paper: nature.com/articles/s4156…

Press release: massgeneral.org/news/press-rel…

Summary stats will be available soon at @AMP_CMDKP

A short summary below:
Diet is an extremely complex exposure. In addition to measurement error, noise, correlation with other traits, reverse causation, or variation across life course, diet is based on substitutions. That is, a higher intake of A necessarily implies lower intakes from B and C.
To accommodate the substitution nature of diet, we used multivariate GWAS to factor the correlation between dietary carbohydrate, fat, and protein in 282,271 participants of European ancestry from @uk_biobank and CHARGE Consortium @chargetiger
Read 10 tweets

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