Amy Proal, PhD Profile picture
May 10, 2019 5 tweets 11 min read Read on X
@sickanddamned @erikmoldwarrior @MBVanElzakker @paintingsbysam @courtneylgunter @FrontPediatrics Yes:) The “successive #infection” process could start in the #womb 👉 Maternal infection during pregnancy is associated w/ higher risk of developing several chronic conditions☝️Or the mother can pass “chronic” organisms to her child even if she doesn’t have “acute” symptoms
@sickanddamned @erikmoldwarrior @MBVanElzakker @paintingsbysam @courtneylgunter @FrontPediatrics Studies on the bacterial #pathogen h. pylori are a good example of that trend 👉 #Mother’s frequently pass h.pylori to their children (via womb or close contact)☝️but even infected fathers + siblings can be a source of the inherited pathogen: ncbi.nlm.nih.gov/m/pubmed/19098… ImageImage
@sickanddamned @erikmoldwarrior @MBVanElzakker @paintingsbysam @courtneylgunter @FrontPediatrics This study found the same trend 👉 “Mother-to-child transmission of H. pylori was demonstrated in four out of five #families, whilst transmission from father-to-child and sibling-to-sibling were demonstrated in two families and one family, respectively”: microbiologyresearch.org/docserver/full… Image
@sickanddamned @erikmoldwarrior @MBVanElzakker @paintingsbysam @courtneylgunter @FrontPediatrics This study found that “not only mother-to-child transmission but also #grandmother-to-child transmission is an important mechanism for the spread of H. pylori in a three-generation household”: ncbi.nlm.nih.gov/m/pubmed/23560… ImageImage
@sickanddamned @erikmoldwarrior @MBVanElzakker @paintingsbysam @courtneylgunter @FrontPediatrics There is also growing evidence that H. pylori might be #sexually transmitted 👉 For example, “It is possible that H. pylori may be transmitted via the act of fellatio in the urethra”: ncbi.nlm.nih.gov/pmc/articles/P… Image

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More from @microbeminded2

Jan 17
Tell @ChrisCuomo that 33 scientists from 14 institutions joined forces to write this paper documenting evidence for #SARS-CoV-2 persistence as a potential driver of #LongCOVID. We call for more clinical trials of drugs capable of clearing persistent virus: pubmed.ncbi.nlm.nih.gov/37667052/
2/ We have formed a global #Consortium to study SARS-CoV-2 persistence: to determine if reservoirs of the #virus in LongCOVID tissue can drive widespread dysfunction including clotting, #microbiome, and neuroimmune abnormalities: polybio.org/longcovid
3/ Thus far, members our Consortium or our colleagues (including at NIH) have found persistent #SARS-CoV-2 RNA or proteins in tissue/nerve samples collected from dozens of human body & brain locations: pubmed.ncbi.nlm.nih.gov/36517603/
Read 18 tweets
Dec 1, 2023
I want to add that I see #SARS-CoV-2 persistence as part of a larger picture in which other latent pathogens and/or #microbiome organisms also harbored by a patient play an important role in the ultimate set up symptoms they develop
2/ Pathogens harbored by a patient at the time of SARS-CoV-2 #infection may serve as a predisposing factor to either persistence of the virus or increased disease in the acute phase
3/ E.g. Bartonella is a persistent #bacteria that drives blood vessel dysfunction by infecting #vascular endothelial cells. So someone with Bartonella may be more susceptible to SARS-CoV-2’s detrimental impact on blood vessels, and have more trouble clearing virus from such sites
Read 12 tweets
Nov 28, 2023
Incredible to see the technology being developed openly here - not just to mitigate #COVID-19 but to create an innovative global infrastructure that positions humanity in excellent shape to combat the next airborne #virus pandemic
2/ To advance this movement in which novel tools to study & contain airborne #pathogens are actively being built, one must reject the narrative that there are only two paths forward 1) To 'care' abt airborne #infection means lockdowns 2) Freedom means ignoring airborne infection
3/ It's 2023 and many intermediate solutions are possible. We can install UV light and filter #technologies in schools, airports, even homes - to remove viruses from the air. With enough of these tools in a room, people may be able to interact freely without getting infected
Read 13 tweets
Nov 3, 2023
Incredible new paper demonstrating #SARS-CoV-2 persistence + associated immune modulation in macaque monkeys. The team found replication competent SARS-CoV-2 virus in macaque lung alveolar #macrophages beyond 6 months postinfection: nature.com/articles/s4159…
2/ IFN-γ production was impaired in NK cells from macaques with persisting virus. Moreover, IFN-γ also enhanced the expression of major histocompatibility complex (MHC)-E on lung alveolar macrophages, possibly inhibiting NK cell-mediated killing
3/ In the lab, increasing SARS-CoV-2 levels during culture corresponded to ongoing viral replication and were accompanied by #virus-induced morphological changes including filiform extensions that connected multiple macrophages, with viral proteins detected in these extensions.
Read 6 tweets
Oct 14, 2023
This new preprint found that exposure + antibody responses to previous Coronaviruses may modulate the NeuroPASC (#LongCovid) immune response in a manner that could make such patients less likely to clear the SARS-CoV-2 virus: medrxiv.org/content/10.110…
Image
2/ Specifically, they found that neuroPASC patients exhibited attenuated systemic antibody responses against #SARS-CoV-2, characterized by decreased capacity to activate antibody-dependent complement deposition, NK cell activation + to bind Fcγ receptors
3/ The neuroPASC patients also showed significantly expanded antibody responses to other common #Coronaviruses including 229E, HKU1, NL63 and OC43
Read 4 tweets
Sep 4, 2023
I am excited to share our new position paper on #SARS-CoV-2 reservoir (viral persistence) in Long COVID or post-acute sequelae of COVID (PASC): nature.com/articles/s4159…
2/ We review evidence showing that some Long COVID patients may not fully clear the SARS-CoV-2 #virus after acute infection. Instead, replicating virus and/or viral RNA - potentially capable of being translated to produce viral proteins - persist in tissue as a "reservoir" Image
3/ Evidence for SARS-CoV-2 reservoir in Long COVID includes studies that have found SARS-CoV-2 RNA or protein in Long COVID tissue samples collected months after acute #COVID-19. Immune responses indicative of a SARS-CoV-2 reservoir have also been documented in #LongCovid
Read 12 tweets

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