Discover and read the best of Twitter Threads about #pathogen

Most recents (5)

"The live SARS-like coronavirus SL-CoV-WIV1 has been isolated for the first time from bat droppings; and such virus has been confirmed to invade the host cells through the ACE2 of human beings..." ImageImageImage
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964 ImageImageImageImage
In this study, we have developed a fast and cost-effective method
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily. ImageImageImageImage
Read 66 tweets
Hey! I have some thoughts on the paper below that attempts to position #ME/CFS as an “autoimmune disease” by associating 2 SNPs with very small odds ratios to differences b/t infectious & noninfectious disease onset (OR=0.54 & OR=0.64): frontiersin.org/articles/10.33…
2/ The team didn’t study the #ME/CFS immune response itself, but instead measured several common #SNPs associated w/ certain “autoimmune” conditions in their ME/CFS subjects. For example SNPs in the gene PTPN22 (connected to #Crohn’s, type 1 #diabetes etc)
3/ PTPN22 is a gene that, in simple terms, plays a role in regulating B and T cell activity. It’s actually just a gene that impacts the immune response (there doesn’t HAVE to be anything “autoimmune”-inducing about PTPN22 activity)
Read 10 tweets
1/ Big thanks all of you on @Twitter for the interest in my thread regarding current literature on #microthrombi and #COVID19!

It’s late, so of course, more thinking and more questions about #SARSCoV2

THREAD

@ASH_hematology @EricTopol @tmprowell @kari_jerge #medtwitter
2/ Conclusion 1: I am convinced the primary driver of #SARSCOV2 infection is in asymptomatic individuals #medtwitter #nursetwitter #epitwitter

SARS-CoV-2 titers in wastewater are higher than expected from clinically confirmed cases
medrxiv.org/content/10.110…
3/ Conclusion 2: #SARSCOV2 does not discriminate. It literally infects EVERYONE.

Newborns, kids, young adults, elderly you name it…it’s infected it. Everyone has #Ace2 receptors.

Children ARE getting it (see #China data and reports of acro-ischemia and
petechiae)
Read 20 tweets
I study the illness #ME/CFS - a neuroinflammatory condition that usually begins w/ a #viral infection (sometimes a #respiratory infection!). I have argued for years that infecting #pathogens tied to the illness might persist in the central nervous system (CNS) of such patients
2/ While I realize this article is talking about acute #infection and #COVID19 - it explains that #SARS-CoV-2 “might infect neurons, raising questions about whether there could be effects on the brain that play a role in patients’ deaths:”
the-scientist.com/news-opinion/l…
3/ Matt Anderson, (one of my favorite Beth Israel pathologists!) states, “Some of the purely respiratory symptoms that you might attribute to the #disease, the inability to get air into the #lungs, might actually be defects in #respiration controlled by the #nervous system.”
Read 8 tweets
Wow! 👉 This team found that 84% of patients w/ acute ischemic #stroke had bacterial DNA in their blood clots removed from the #brain ☝️oral #pathogen viridans streptococci (already connected to #endocarditis) was the most common organism identified in the #blood clots
Here is the paper itself which states 👉 “We found DNA of viridans streptococci in most aspired thrombi of patients with acute ischemic #stroke, which suggests that oral bacteria may have a role in the cause of #cerebrovascular disease.”
Also 👉 “Repeated transient bacteremia, caused by poor dental care or bacterial #infections, may trap pathogens in atherosclerotic plaques and promote rupture of the plaques”: ahajournals.org/doi/10.1161/JA…
Read 3 tweets

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