First session this morning at #ISHPSSB19: an interesting discussion, moderated by Karen Kastenhofer & @nikivermeulen on engagement of (social) scientists with systems biology and the interplay between funding and research priorities.
Recent waves of scientific fashions have driven funding priorities from systems biology to synthetic biology and now to AI-based approaches. This trend points away from understanding living systems to control and prediction without understanding. /1
There is also a recent trend to integrate responsible research and innovation #RRI research into scientific projects. Is this a good thing? /2
On the one hand, #RRI allows social scientists and philosophers to have a real impact on research ethics. On the other hand, they can be misused as a “lubrication approach to research ethics.” Rationalisation instead of true engagement with underlying motifs and practices. /3
It seems cynical to me to engage philosophers and social scientists in justifying the completely idiotic priorities of research funders (and those scientists that profit from that system). What would be a better model for a truly meaningful interaction of #RRI and research? /4

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More from @yoginho

Jan 22
I traveled to Paris to give my philosophy crash course for scientists () to a wonderful group of @lpiparis_ @FIREPhD students, as I do every year.

Contact me if you want to bring this course to your own institute! It's not only fun, but also useful...johannesjaeger.eu/philosophy.html
... allowing you to become a better researcher through philosophy. The course has an interactive, discussion-based format that is based on an online series of lecture which are freely available: .
It helps you reflect on your own scientific practice and world view using a (1) process-based, (2) perspectival-realist, and (3) deliberative approach to the philosophy of science. The course heavily focuses on students' own experiences, practices, and questions.
Read 4 tweets
Oct 10, 2023
New blog post just dropped!

"Assembly theory is cool... but doesn't quite do what its inventors say it does."



reviewing this recent Nature paper:



TL:DR: potentially interesting model, wrapped in utterly misleading packaging.johannesjaeger.eu/blog/assembly-…
nature.com/articles/s4158…
"I think assembly theory has lots of merit and potential, but this particular paper frames its argument in a way which is unfortunate and, frankly, more than just a bit misleading. My personal suspicion is that this has two reasons: (1) the authors hyped up their claims ...
... to get the paper published in a glam journal, plus (2) they also overestimate the reach and power of their model in ways which may be detrimental to its proper application and interpretation."
Read 6 tweets
Sep 9, 2023
Just received my expected rejection from @elife (after appeal).

The way I was rejected reflects the atrocious attitude of the journal & the whole field of biology towards conceptual work.

It also showcases a lack of intellectual integrity on behalf of the journal editors. 🧵
I submitted the paper knowing full well that @eLife usually restricts its scope to empirical work. The idea was to challenge that restriction, since (in my opinion) biology urgently needs a revival of serious conceptual efforts to prevent the descent of the field into pointless..
@eLife ... construction of large data sets that are increasingly costly to produce but yield diminishing returns in terms of insight and understanding into the workings and organization of living systems. Hence, no surprise when my work was deemed "out of scope." That's fair enough.
Read 21 tweets
Jan 19, 2022
The current #COVID19 media coverage around me seems to agree on three things: (1) there is nothing we can do against #omicron, (2) this variant is mild & the wave will be over soon, (3) we're soon going "endemic," to "live with the virus," & back to normality. /1
There seems to be very little push-back against this narrative, which is something that really surprises me. But worse than that: it does *not* bode well for the next pandemic (whether the next #COVID19 variant or something altogether more worrisome). /2
Re (1): we can't do anything & #ZeroCovid was never an option.

Well, we never really tried. Those few countries that did were isolated (either geographically or surrounded by countries who didn't implement any low-incidence measures). /3
Read 23 tweets
Feb 19, 2021
Our second paper on dynamical modularity, "Dynamical Modules in Metabolism, Cell and Developmental Biology" by @NickMonk14 & myself is now available as a preprint: osf.io/rydbn via @OSFramework /1
It complements our earlier evolutionary perspective on the subject (osf.io/vfz4t) with its more regulation-based approach and a long list of practical examples that illustrate our novel conceptual framework for the dynamical decomposition of complex systems. /2
Just like our earlier paper, the argument starts with the following observation: modular phenotypic traits imply that the underlying regulatory processes—the epigenotype of the organism—must be dissociable as well. How to decompose them, however, is not a trivial task. /3
Read 16 tweets
Dec 13, 2020
Darwinian Gaia: the persister perspective on evolution. aeon.co/essays/the-gai… via @aeonmag
@aeonmag I think this an amazingly refreshing and interesting new view on evolution. For several reasons. What’s even more amazing is that one of the best evolutionary biologists today has completely transformed his view of evolution in light of new evidence. How rarely does this happen?
@aeonmag I have huge respect for W. Ford Doolittle to come forth with this revolutionary change of mind. So much of our field is mired in dogmatic talking past each other. This new approach is a much needed fresh breath of air!
Read 5 tweets

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