Note that our most recent genealogical common ancestor was one of the millions of people alive at that time, and was no one special.
I can claim that the last genealogical common ancestor of humanity lived in Africa or East Asia, and have a similar chance of being right. 2/n
On a personal level, I find the hypothesis strange. There's nothing special about being descended from this common ancestor. Millions of people were born before this (mostly meaningless) genealogical common ancestor and were just as wonderfully human.
Millions of people were born after a genealogical common ancestor but were not descended from them. These people built amazing buildings, civilizations, and art and lived incredible lives all over the world. They are just as much part of humanity. 4/n
It's a neat parlour mathematical trick and a mathematical true that genealogical CAs exist. However, saying that this reconciles science w. the idea of Adam and Eve, sweeps a lot of stuff under a very patchy, ugly carpet. 5/n
Note that most recent genealogical CA changes over the generations. The genealogical CA of people 2k years ago can be much further back in time than the genealogical CA of everyone alive today. 6/n
This older CA is also an older (not most recent) CA to all modern humans. But there is no uniqueness to this individual, just a chain of many such genealogical ancestors tracing all the way back till eukaryotes started having sex (and further back still).
In a few thousand years someone else will be the most recent genealogical CA of all living individuals. Perhaps it'll be you #LifeGoals, but probably not. ht @jashapiro xkcd.com/1545/
@jashapiro Looking at my mentions following this thread fatherted.gifglobe.com/scene/?id=mR86…
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More from @Graham_Coop

24 Dec 19
You and I are related to each other, but the question of how closely we are related has two very different answers. One genealogical, one genetic. 1/n
To see why, consider a simulation of my family tree back over the generations, my number of genealogical ancestors doubles every generation. I soon have a lot of genealogical ancestors 2/n
An overlapping simulation of your (blue) and my (red) family trees. Because of the doubling each generation back, we soon have many overlapping ancestors (circles) just short while back. We're close genealogical cousins. In fact we're distant cousins many times. 3/n
Read 12 tweets
18 Dec 19
Updated version of @DocEdge85’s preprint on the potential for upload attacks on genetic genealogy databases, detailing various hacks. Big addition, we did a proof-of-concept demo of a simple method for obtaining peoples’ genotypes from GEDmatch 1/n
biorxiv.org/content/10.110…
@DocEdge85 GEDmatch seems to use long runs of compatible genotypes between individuals (kits) to call genetic relatedness, identity by state (phase-unaware IBS calling). These runs of IBS can broken by a single opposite-homozygous genotype, e.g see user videos 2/n
@DocEdge85 On this basis we knew that GEDmatch was likely open to an `IBS baiting’ attack, uploading 2 fake kits with opposite-homozygote genotypes at target SNP surrounded by regions of heterozygous SNPs (which will at least half-match all other genotypes). See 3/n
Read 18 tweets
5 Nov 19
I've come to the view that genetic-genealogy databases that allow uploads are a substantial risk to genetic privacy & privacy more generally. It's not just law enforcement who might be using these databases to snoop on us.
There are companies that offer private citizens access to law enforcement-style tools for collecting genetic data. See article by @sarahzhang . There's no real way of knowing these may have already been used on people w.o. their permission. theatlantic.com/science/archiv…
@sarahzhang One fair comment is that Facebook/Google etc already have far more info. on us all than genetics currently reveals. But you don't have to buy into genetic exceptionalism, or some dystopian view, to be concerned about new sources of data about ourselves moving into public realm.
Read 15 tweets
8 Aug 19
A hundred years of artificial selection (red & blue indicating up & down selection respectively).
Original datasets from ideals.illinois.edu/handle/2142/35… (incredible that they have individual-level data from back to 1896). My code here: github.com/cooplab/popgen…
Based on ggridges egs from @ClausWilke cran.r-project.org/web/packages/g…
@ClausWilke My first ever use of ggplot. Thanks to @ErinCalfee for guidance. Think I'll retire from ggplot as I doubt I'll make a nicer graph.
Read 7 tweets
28 May 19
So beyond speculating wildly about eugenic selection of embryos for high IQ, it's worth worrying about what Hsu's company is doing today (genomicprediction.com). They’re providing polygenic scores aimed at embryo selection for the following traits 1/n
From the papers they reference (biorxiv.org/content/10.110…) they’re constructing these polygenic scores based on LASSO. A standard way to choose a sparse set of SNPs in human genetics
They seem to use Lasso without any control for population stratification in their disease predictions. That's really poor if you are going to apply these predictions to choose among potential embryos from same parents, as this structure is absent in such comparisons 3/n
Read 14 tweets

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