So #ISCHEMIA#AHA19 will take time to digest; lots presented and no peer-review pub or @medrxivpreprint yet. There is often drift from the big presentation to the publication. We should resist a rush to judgment. Yet…
@medrxivpreprint A couple of things occur to me from the presentations…reinforces the prior evidence that patients w/stable ischemic heart disease have little to lose by deferring procedures. The medical therapy strategy seems safe. The procedural strategy is not saving lives or events, to date.
@medrxivpreprint It seems to question value of myocardial perfusion imaging in patients w/stable ischemic heart disease. In aggregate large costs…and not clear, in many cases, what it is adding if the procedures are not saving lives or events. Combine that w/STICH, and the question gets bigger.
@medrxivpreprint The quality of life benefit in #ISCHEMIA will likely be debated for some time. @jspertus gave an impassioned defense of the finding, but many will be concerned about it in an open label study. Not clear that they will have the data to clarify this. #ORBITA is key here. #AHA19
@medrxivpreprint@jspertus But we need time to reflect on the findings - & the ability to really review everything. Team #ISCHEMIA, why not post #preprint on @medrxivpreprint and let us read your studies while you prepare for peer review. You have already presented. Community can give you comments. #AHA19
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1/🧵 @SubodhVermaMD @MkosiborodMD and colleagues have published important findings @JACCJournals on inflammation in obesity-related HFpEF from the STEP-HFpEF Program. Let's break it down! #CardioTwitter #HFpEF #ESCCongress jacc.org/doi/10.1016/j.…
2/ The study analyzed data from 1,145 patients with obesity-related HFpEF, looking at the prevalence of inflammation (measured by CRP levels) and its relationship with patient characteristics and outcomes. #ESCCongress @JACCJournals
@JACCJournals 3/ Key finding #1: Inflammation is highly prevalent in obesity-related HFpEF. 71% of patients had CRP levels ≥2 mg/L, with 19% having very high levels (≥10 mg/L). #Inflammation #ObesityHF #ESCCongress @JACCJournals
What we do now is write a paper...& then preprint @medrxivpreprint ...then we take reviews from the journal & the world & work to make the research better. So, Internal tremors & vibrations in long COVID: a cross-sectional study is open for public comment. https://t.co/xh7dXqPcSGmedrxiv.org/content/10.110…
@medrxivpreprint Our objective: 'We compared demographics, socioeconomic characteristics, pre-pandemic comorbidities, & new-onset conditions between people with internal tremors and vibrations as part of their #LongCovid symptoms & people with long COVID but without these symptoms.' #LISTENstudy
@medrxivpreprint Our finding: Among people with long COVID, those with internal tremors and vibrations have more associated symptoms and worse health status, suggesting it may be associated with a severe phenotype of the condition. @YaleCII @YaleMed @YaleCardiology
We have been doing a series of studies, led by @jeb1426, on sex differences in symptom complexity & phenotypes in acute myocardial infarction (AMI) and their impact on diagnosis & treatment. Some imp findings. #Cardiology#MedTwitter@YaleMed@YaleCardiology@yuan_lu1
One of most important articles I’ve done… showing the noise in clinic BP measurement is large & makes it impossible to track Rx effects; almost useless in evaluating change from 2 clinic visits. Let me explain… ahajournals.org/doi/abs/10.116…@YaleMed@YaleCardiology@CircOutcomes
@yuan_lu1@CircOutcomes@SpatzErica@YaleMed@YaleCardiology@AHAScience@amjmed We wrote that persistent hypertension was a condition of repetitive measures of above-goal elevated blood pressure over a period of time (eg, 6 mos), and drug resistance was just one of many causes. And many causes were related to missed opportunities in the care pathways.
Sleep as medicine... On behalf of hospitalized patients, what is we simply stopped ordering routine lab draws before 7am. What is we wrote an order, do not disturb before 7am except for an urgent need. Or an order for 7 hrs of peace and quiet. @FutureDocsnam12.safelinks.protection.outlook.com/?url=https%3A%…
@FutureDocs I strongly believe that rest and sleep are essential to recovery from acute illness...and yet everything we do in the hospital seems to ignore the role of sleep in treatment. We need to put people in a position to help their bodies heal and recovery... not make it more difficult.
@FutureDocs In our study we found it was normal operating procedures to draw bloods from 4-6am on hospitalized patients...the unintended effect, in my view, is to slow recovery and add stress... and impede healing. Shouldn't the hospital be where people can be treated, healed and recover?