Discover and read the best of Twitter Threads about #preprint

Most recents (24)

We have an exciting new #preprint on @medrxivpreprint ! A novel class of #primaryimmunodeficiency, with the discovery of ITPR3 mutations in two families with combined immunodeficiency. As always, studying #PID teaches us so much about biology! 1/8

medrxiv.org/content/10.110…
The work is based on patients identified @UZLeuven by Rik Schrijvers and @IsabelleMeyts. Both patients had a combined #immunodeficiency with sensitivity to infections, one complicated by peripheral #neuropathy and one by #autoimmune hemolytic anemia. Over to the gene hunters! 2/8
Mutations in ITPR3 were identified by Erika Van Nieuwenhove and Frederik Staels. ITPR3 is part of a #Calcium channel, so we turned to the Serysheva lab @Irina52948708 to predict the impact on structure. Clear as day, the mutations change the charge of the channel. 3/8
Read 8 tweets
Poslechl jsem si včerejší #StudioN a jen pár poznámek k zodpovědnosti vědců, diskutovanému experimentu a k zodpovědnosti novinářů. 1/n

@FilipTitlbach @petrkou @enkocz @Simindr

denikn.cz/625229/studio-…
V první řadě, potenciál zneužití vědecké práce není nic nového. Jen se to nyní dostalo do hledáčku mainstreamových novinářů. Jakožto někdo, kdo se pohybuje v oblasti biotechnologií a GMO se s podobnýma věcma setkávám "denně". Různé studie byly znásilněny a jejich závěry 2/n
znásilněny, aby potvrdily něčí hypotézu. Jenže s takovou bychom nemohli publikovat nic. Protože takto znásilnit lze i dobře míněné (a třeba původně úplně nesouvisející) práce.
3/n
Read 32 tweets
Now as everyone is talking about #2DG that is made by @DRDO_India, some people are also claiming that the hypothesis was first put forward by #Patanjali. Here is my take on the paper by #Patanjali (1/6)

@Neurophysik @GorwayGlobal @drabbyphilips @ForBetterSci
In this work, #2DG is docked with key viral proteins such as viral spike glycoprotein S2, viral NSP15 endoribonuclease, and protease 3CLpro. Other in-silico parameters like drug likeliness, bioactivity indices, and ADMETox have also been studied to generate supportive data. (2/6)
First of all, this is an in-silico paper and not an in-vitro paper or a RCT. That itself means that everything written in it is plain speculation. Secondly, the paper is still on a #Preprint server @authorea which means that it has not been peer-reviewed. (3/6)
Read 6 tweets
"#AstraZeneca, we have a problem"

New #preprint from Lena Krutzke and Stefan Kochanek et. al. @uni_ulm and @UniklinikUlm on @researchsquare

"Process-related impurities in the ChAdOx1 nCov-19 vaccine"

Why is this a problem? A short thread (1/8) 👇
researchsquare.com/article/rs-477…
"The intramuscular injection of proteins that are not part of the active principle of the #vaccine itself might have effects at different levels"

That`s why removal of impurities (e.g. host-cell proteins) is critical for #therapeutics and strictly regulated
(2/8)
Unfortunately, removal of process-related #impurities from viral vector-based #therapeutics (e.g. host-cell proteins) is imperfect and low levels - orders of magnitude lower than the actual active therapeutic - are usually accepted if they are classified as non-problematic
(3/8)
Read 9 tweets
Check out our #preprint describing a broadly neutralizing RBD antibody, which protects against SARS-CoV, bat pre-emergent CoVs, and SARS-CoV-2 B.1.351 challenge in mice. This work was led by me, @aschaefe29 @sophie_gobeil @Dapeng_LI
(thread)
@Baric_Lab
biorxiv.org/content/10.110…
From >1700 antibodies, we focused in on 50 cross-reactive antibodies that cross-reacted with SARS-CoV and SARS-CoV-2 spike. We then tested the neutralization activity of these mAbs against bat CoVs SHC014 and WIV-1, SARS-CoV, and SARS-CoV-2, and found 4 pan neutralizing mAbs.
We then tested the in vivo activity of these four mAbs against SARS-CoV in mice and found that only one mAb (DH1047) protected against challenge) so we focused on this mAb for more in vivo studies.
Read 6 tweets
Recibí esta excelente pregunta de @vacl58 y quisiera contestarla con un hilo apoyado por un pre-print (artículo en espera de revisión por pares)

Lo haré lo más ameno que se pueda aún siendo un chirris técnica 🤏🏼

Va! 🧵👇🏼

1/16

#VacunasCOVID19
Es perfectamente razonable preguntarnos si recibir la 2a dosis de las #vacunas 💉 en el tiempo establecido en los ensayos clínicos es igual de efectivo que hacerlo unos días, o incluso semanas después

La respuesta más prudente es: de manera general no es menos efectivo

2/16
¿Por qué lo digo de esa manera?

Porque ha habido casos, como el de la vacuna ChAdOx1 nCov-19 (@AstraZeneca) en donde la eficacia aumentó cuando las dosis estuvieron más espaciadas, sin embargo, estos son datos que no conocemos para todas las formulaciones

Peeero...

3/16
Read 18 tweets
A blockbuster #preprint of #LongCovid from UK; 1077 patients discharged in 2020; at median 5 mos only 29% fully recovered, 20% had new disability. medrxiv.org/content/10.110… @medrxivpreprint @REvans_Breathe @uol3i @HamishMcAuley @LouiseVwain @Survivor_Corps @patientled @dianaberrent Image
@medrxivpreprint @REvans_Breathe @uol3i @HamishMcAuley @LouiseVwain @Survivor_Corps @patientled @dianaberrent And another indicator of the impact of #COVID19… at a median of 5 months after hospital discharge, 19% experienced a health-related change in occupation. @medrxivpreprint Image
@medrxivpreprint @REvans_Breathe @uol3i @HamishMcAuley @LouiseVwain @Survivor_Corps @patientled @dianaberrent "Factors associated with failure to recover were female, middle-age, white ethnicity, two or more co-morbidities, and more severe acute illness.” Image
Read 7 tweets
And here is another important #longCOVID #preprint by the amazing @NatalieJLambert and team. "most common symptoms were fatigue, headache, shortness breath, difficulty concentrating, cough, changed sense taste, diarrhea, & muscle aches." medrxiv.org/content/10.110… @medrxivpreprint
@NatalieJLambert @medrxivpreprint "Symptoms causing greatest distress (scale 1 “none” to 5 “great deal”) were extreme pressure at base of head (4.4), syncope (4.3), sharp or sudden chest pain (4.2), brain pressure (4.2), headache (4.2), persistent chest pain or pressure (4.1), and bone pain in extremities (4.1)."
@NatalieJLambert @medrxivpreprint Again, we see a remarkable range of downstream symptoms from COVID; this illness has devastating consequences for so many that extends far beyond the acute illness. Much to learn. Need to move quickly. @Survivor_Corps @dianaberrent
Read 5 tweets
Striking #preprint on #LongCovid: 'high rates of long-term symptoms and poor long-term outcomes, present several months after hospitalisation for #Covid19’ Over 50% with symptoms months later. A quarter w/new or worse disability. medrxiv.org/content/10.110… @medrxivpreprint
@medrxivpreprint So useful: ‘>half of patients reported not being fully recovered 7 mos after onset Covid-19 symptoms.’ 'Younger women &those w/more severe acute disease in-hospital had worst long-term outcomes.’ @dianaberrent @ahandvanish @louise_sigfrid @JTSglobalhealth @Tom_Drake1 @tweediechap
@medrxivpreprint @dianaberrent @ahandvanish @louise_sigfrid @JTSglobalhealth @Tom_Drake1 @tweediechap They conclude: 'Policymakers need ensure there is long-term support for people experiencing #LongCovid & plan for lasting long-term population morbidity. Funding to understand mechanisms and identify potential interventions for testing in randomised trials is urgently required.'
Read 6 tweets
How to combine Virtual Laser Scanning (#VLS) and Open Government Data (#OGD) of @swisstopo? A thread on how the #OpenSource HELIOS++ laser scanning simulator can be used to scan #Säntis 🇨🇭(2502m) and test different scan strategies or generate training data for #MachineLearning. Digital terrain model coloured by elevation (left), real poi
With the #OGD step, @swisstopo is making large volumes of high quality geodata freely accessible. We are most excited about the 3D data, which includes digital surface models (DSM), digital terrain models (DTM) and classified 3D laser point clouds!
As believe that the combination of #OpenData and #OpenSource software is a key element to promote more transparent, inclusive and effective research, we thought to ourselves: Let’s combine @swisstopo #OpenData and our own #OpenSource software HELIOS++.
Read 12 tweets
Le saviez-vous ? #LeSaviezVousCOVID

Décryptage du communiqué de presse de l’@HAS_sante publié ce jour et détaillant les données scientifiques ayant conduit aux modifications des recommandations sur la vaccination #AstraZeneca
Thread⤵️ en 7️⃣ tweets à lire jusqu’au bout❗️
1️⃣ Étude du @bmj_latest non encore publiée et en attente de relecture
#preprint:
👉🏼«Les données d’une étude écossaise en vie réelle, soumise au British Medical Journal et EN ATTENTE de revue par les pairs»
👉🏼«Résultats très encourageants»🤔
👉🏼«Sur les bénéfices à court terme»😳
2️⃣ 👉🏼 »Quelle que soit la tranche d’âge, la vaccination par un des 2 vaccins étudiés réduit significativement le nombre D’HOSPITALISATIONS »
👉🏼 »Les effets les + marqués sont observés de 28 à 34 jours après la première injection #Pfizer ou #AstraZeneca »
Read 8 tweets
Le saviez-vous? #LeSaviezVousCOVID
1️⃣Maintien des mesures barrières pour protéger les non vaccinés⚠️
😔Certes l’immunité collective induite par le vaccin est insuffisante car ns sommes très peu à être vaccinés
🔆MAIS les vaccinés peuvent reprendre la vie NORMALE entre EUX #espoir Image
2️⃣La baisse de la contagiosité induite par les vaccins est en cours d’étude dans les cohortes de vie réelle.
L’étude israélienne @NEJM est très encourageante sur ce point avec une efficacité de 92% contre la possibilité d'être infecté et de développer des symptômes. Image
3️⃣Une autre étude (#preprint)de Cambridge annonce la même tendance «A single dose of the Pfizer vaccine can reduce asymptomatic infections by 75%, according to research that suggests the jab could substantially curtail transmission of the disease»
Merci @MahmoudZureik pour la réf ImageImage
Read 5 tweets
This #preprint on Vitamin D treatment for #COVID19 has now been retracted and an investigation has been initiated into this study due to concerns about the description of the research

papers.ssrn.com/sol3/papers.cf…
Please read instead this Randomized control trial study (240 participants) on high dose vitamin D vs placebo for #COVID19 demonstrating that Vitamin D3 has no effect on hospital length stay in moderate to severe #COVID19

jamanetwork.com/journals/jama/…
Claim on the effectiveness of vitamin D for #COVID19 has been circulated for quite a while, starting from Facebook post. I was asked multiple times and with others I have debunked it as a possible treatment for #COVID19 back in June for the AAP fact check
aap.com.au/vitamin-d-clai…
Read 3 tweets
Eigentlich wollte ich zum Thema #VitaminD und #COVID19 nichts mehr schreiben. Zu nervig. Jetzt macht ein neuer #Preprint die Runde. Die Pressemeldungen überschlagen sich schon, ohne die erheblichen Schwachpunkte zu nennen. Ein kleiner Servicetweet. 1/x papers.ssrn.com/sol3/papers.cf…
Es handelt sich mal wieder um einen sog. #Preprint. Das heißt: Das wissenschaftliche Prüfverfahren des Peer Reviews wurde noch nicht durchlaufen. Peer Review nervt mich auch oft, aber ohne geht’s nicht. Deshalb: Dies sind noch nicht überprüfte Daten! 2/x
Der Titel klingt harmlos, aber das Abstract hat es in sich: 551 zufallsverteilte #COVID19-Patienten haben entweder #Calcifediol (VitaminD3-Vorstufe) oder nichts erhalten (Kontr.). Ergebnis: Aus der Vitamin D-Gruppe starben 36 Patienten (6,5%), aus der Kontrollgruppe 57 (15%). 3/x
Read 12 tweets
🚨Exciting results from the #RECOVERY trial #preprint of #Tocalizumab (Toci) in hospitalized people w/ #COVID19
-reduced 28-day mortality (29 vs 33%; NNT)
-decreased likelihood of requiring MV (33% vs 38%)
-shorter hospital stay (median 20 vs >28 days)
medrxiv.org/content/10.110…
1/
They randomized 4116 pts to weight-based Toci vs usual care (UC):
-groups were balanced: mostly male (>65%), older (>60 yo), & w/ comorbidities (>55%)
-most patients (82%) also received dexamethasone
-they received Toci early in hospitalization but were 7-14 days after onset
2/
Notably, only 83% of patients in the Toci group actually received Toci (plus 2.6% randomized to the UC group got Toci); this would decrease the effect size and bias the towards null.

This means their ITT analysis is probably *underestimating* the true effect size somewhat.

3/
Read 13 tweets
Un hilo con los efectos de pandemia en niños
Prepárense para reportes/noticias devastadoras

La situación de los niños es LA catástrofe omitida y LA AMENAZA para humanidad

Hemos transformado la pandemia en el evento más disruptivo para una generación de niños entera

Coronnials Image
2/
"Mi hijo murió de Coronavirus pero no de la forma que lo piensas" (Un padre)

Aumento de SUICIDIOS en adolescentes forzó a reabrir escuelas en Las Vegas

"Efectos adversos" del cierre de escuelas son la punta del iceberg de una catástrofe prevenible

nytimes.com/2021/01/24/us/…
3/
Si cierras escuelas, pierdes banderas rojas para detectar maltrato infantil doméstico

En 🇬🇧 hubo caída del 10% en derivaciones a servicios pediátricos entre abril-Nov 2020 pero aumentaron 27% notificaciones de accidentes graves

theguardian.com/society/2021/j…
Read 26 tweets
Very excited to share our new #PrePrint where we report a virus closely related to SARS-CoV-2 found in bats from Cambodia! @PasteurCambodia @institutpasteur biorxiv.org/cgi/content/sh… short 🧵1/7
The virology team @PasteurCambodia has screened 400+ archived samples of wild animals incl. different bat species, and found a positive SARS-like signal in rectal swabs of 2 Rhinolophus shameli bats from 2010. 2/7
mNGS & phylogenetic analysis revealed a virus closely related to SARS-CoV-2. It consistently branches with SARS-CoV-2 and RaTG13 in most of the genome, aside of a small portion corresponding to the spike N terminal domain (more divergent). 3/7
Read 7 tweets
A thread on pandemic effects on children
Be prepared for devastating news/reports

Children´s situation is THE neglected catastrophe and THE THREAT for humanity

We have transformed a pandemic in the most disrupting event for an entire generation of children: Coronnials Image
2/
"My child died from Coronavirus, not the way you think" (A father)

A rise in SUICIDE among children/adolescents have forced Las Vegas to reopen its schools

Schools closure "side effects" is just the tip of the iceberg of a preventable catastrophe

nytimes.com/2021/01/24/us/…
3/
If you close schools, you loose red flags to detect domestic child abuse.

In 🇬🇧 a 10% fall in referrals to children's services between April and Nov 2020 but a 27% rise in serious incident notifications

theguardian.com/society/2021/j…
Read 29 tweets
Esta semana generamos 89 genomas SARS-CoV-2 de casos en Lima del 10-13 de diciembre 2020. Identificamos 16 linajes y NO encontramos las variantes de interés B.1.1.7 (UK), B.1.351 (Sudáfrica) o P.1 (Brasil). Las secuencias ya se encuentran en @GISAID.
1/15
Con esto sumamos 440 genomas peruanos publicados. Pueden explorar los datos en este build de @nextstrain creado por @quipupe.
2/
nextstrain.org/community/quip…
Las variantes de interés comparten la mutación N501Y en la proteina spike. Las de SA y Brasil comparten K417N y E484K. Estas mutaciones han aparecido de forma independiente en distintas partes del mundo y parecen asociadas a una mayor transmisibilidad.
3/
sciencemag.org/news/2021/01/n…
Read 16 tweets
🚨n.b. #postprint 🚨

v10 of our #LivingReview is live on @qeios

We have reviewed 345 studies. 52 of sufficient quality for #MetaAnalysis to explore the association of #Smoking and #COVID19 #infection, #hospitalisation, #severity and #mortality.

qeios.com/read/UJR2AW.11
No dramatic changes from v9 posted in November.

Most studies from 🇺🇸, 🇨🇳 & 🇬🇧 but from 39 countries. 65% hospital based, 8% purely community. Median of 461 individuals per study.

Smoking remains poorly recorded, only 29% of studies categorise as current 🚬, former and never 🚭
6 studies report on alternative nicotine products.

Large amounts of missing data in many studies on 🚬 status introducing bias.

Huge reliance on #ElectronicHealthRecords and all the limitations that brings. See our recent #PrePrint if interested (doi.org/10.1101/2020.1…)
Read 16 tweets
Behold, my latest #preprint with @KonopkaLab on imaging genomics and autism spectrum disorder.

Association between resting-state functional brain connectivity and gene expression is altered in autism spectrum disorder medrxiv.org/content/10.110…
Based on our previous study and many others, we hypothesized that the relationship between gene expression and rs-fMRI might be disrupted in neuropsychiatric disorders, such as autism spectrum disorder (ASD) (2/n).
sciencedirect.com/science/articl…
To test this hypotehsis, we coupled gene expression with functional measurements (fALFF and ReHo) from the very same brain regions. We used 11 Brodmann areas from healthy and ASD patients (3/n).
Read 9 tweets
Today I read:
In Search of Shifting and Emergent Librarian Identities: A Philosophical Approach to the Librarian Identity Problem, doi.org/10.21083/partn…

Librarian Identity is something I think about a lot and this paper helped add some critical perspective and insight.
Today I read
Feminist Co-Mentoring: A Model for Academic Professional Development, jstor.org/stable/4316944
A good approach to mentoring, I hope to work this way w peers
"Thus, the goal of co-mentoring is the development of the whole person, not simply [their] intellectual side"
Today I read:
Why your anxiety might also be a superpower, via @thesiswhisperer.
As a professional staff member in research support who does a lot of cross-bound work, I deeply feel Role Ambiguity.
Read 18 tweets
Highlights from our #preprint on #transcription activation domains (ADs)!

-found all ADs in yeast TFs
-predicted yeast & human ADs
-tested binding of all ADs to #Mediator & #TFIID
-explained mechanism with structural modeling & kinetic experiments

(1/16)
biorxiv.org/content/10.110… Image
We tested ~7500 53aa tiles covering all 164 yeast transcription factors (TFs) in an activation screen in vivo.

By controlling for fragment expression & sorting GFP activation into 8 bins, we get quantitative measurements with super high signal-to-noise. We found 150 ADs. (2/16) Image
Tiles with lots of acidic & hydrophobic residues activated most.

But there are conflicting reports on whether acidic residues are important, so we mutated all the acidic residues in each AD. Besides one interesting case, no mutants activated.

So all yeast ADs are acidic! (3/16) Image
Read 17 tweets
Hi friends at @ASAPbio_ and fans or preprints, I really need your help. I'm a bit fan of #preprints, but there is new development that if it finds copycats, will totally kill preprints at @biorxiv and @medrxiv. There is a journal at @mitpress, called 'Rapid REviews COVID19'. It..
downloads #preprints from @biorxiv and @medrxiv, and starts a formal peer review process, against the wishes of the authors, and then puts the reviews online. Our paper is already under peer review, and I really believe it should not be peer reviewed by @mitpress against our wish
Why is it a problem? 1) Imagine you have a controversial paper. It may become unpublishable, and in this way Rapid Reviews will have severely compromised the career chances of the postdocs and PhD students participating
Read 7 tweets

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