Discover and read the best of Twitter Threads about #preprint

Most recents (24)

Jan Bonte “Neuroloog” @the_stinging heeft een column: Vraag het Marion. De inhoud toont dat je idd 1000 x beter bij @MarionKoopmans te rade kunt gaan dan bij Jan. Zijn laatste bijdrage is gewauwel over de #Lableak theorie. Tijd om dit eens onderuit te halen… #debunk 🧵. 1/19
Hij begint met de claim dat aanhangers van de #zoönose en #lableak theorie recht tegenover elkaar staan. Dat kan zo zijn maar dan staan er 1000 mensen links en 2 mensen rechts (Jan telt tenslotte voor 2 #cholesterolbol) 2/19
Daarbij dropt hij direct een verdachtmaking. De wetenschap zou bang zijn dat Gain of Function (GoF) onderzoeken worden gestaakt als het toch een #lableak was en daarom zijn ze zo fel. Ik zeg verdachtmaking want er is hiervoor geen enkel bewijs. 3/19
Read 21 tweets
Do you spend time inside? OF COURSE YOU DO! You should check out our paper that looks at the amount of #coronavirus #sarscov2 #COVID19 in rooms with COVID+ individuals…

🧵🧵🧵🧵 (1/18)
We had the opportunity to track individuals as they occupied the isolation dormitory on the
@uoregon campus for testing positive for #COVID19 (2/18)
We collected environmental surface swabs, petri settling plates, and active air samples using the
@thermofisher #AerosolSense… (3/18)
Read 19 tweets
Over the moon to share @danzhanghappy et al’s #preprint “Opposite polarity programs regulate asymmetric subsidiary cell divisions in grasses” - we identified a novel, distal polarity domain formed by the POLAR homolog in #Brachypodium @biorxiv_plants…🧵/1
We transcriptionally profiled the unique bdmute phenotype–viable but no stomatal subsidiary cells (SCs)–to identify genes associated with SC formation -> 4th most downregulated gene = BdPOLAR!! /2
CRISPRed bdpolar mutants showed defective SC divisions, much like classical polarity mutants that affect subsidiary mother cell (SMC) polarity factors like PANGLOSS1 homologs. Indeed, also bdpan1 mutants show this defect and double (polar;pan1) has 80% (!) defective SCs /3
Read 12 tweets
Hey #ACC22 presenters, especially late breaking studies of consequence. If you don't have simultaneous peer-reviewed pub, consider #preprint what you presented so it's archived & accessible. Let’s make it normative. @medrxivpreprint @yaleHFdoc #LBCT @EricTopol @CMichaelGibson
@medrxivpreprint @yaleHFdoc @EricTopol @CMichaelGibson For all #ACC22 presenters, preprinting is easy; we accept scientific studies, screen rapidly, post quickly. Non-profit. It is of the community-available throughout the world, understood as pre-peer reviewed, and citable. Almost all reputable journals are fine with it, incl @NEJM.
@medrxivpreprint @yaleHFdoc @EricTopol @CMichaelGibson @NEJM In the pandemic @medrxivpreprint stimulated discussions about research in progress, & many examples of advancing research. Cardiology has not yet fully embraced it, yet is this work any less important? All fields should accelerate public scientific communication & #openscience.
Read 6 tweets
Information on the public’s health should be available to the public. I’m proud to announce @nycHealthy’s new Ensuring Transparency in Health Through Open Scholarship (ETHOS) policy, which ensures our published articles are available without a paywall.
Making research and data accessible is a top priority for @nycHealthy. We strive to make info about the public’s health – your health – available in many ways.
Our commitment to providing best-available COVID-19 data in useful ways throughout the pandemic is another example. #OpenDataWeek
Read 7 tweets
Parece que si hay interés así que ahí les va:


Estos tips están basados en el concepto de #BetterPoster de Mike Morrison @mikemorrison

Lo primero que hay que tomar en cuenta es que una sesión de pósters en un #congreso es un espacio donde hay 50, 100 o más personas presentando su trabajo 👩🏻‍🏫 y, de entrada, es imposible que alguien los vea todos con detenimiento y cache de qué van 🥴


Por lo tanto, el póster tradicional (una mini versión de un artículo con introducción, métodos, etc📃) no es la mejor idea ya que requiere demasiada atención para poder comprender toooodo el contexto de la #investigación y las implicaciones de nuestros resultados

Read 16 tweets
📣#Preprint #COVID19 #ConvalescentPlasma
📌RCT (N=1.2K)
📌Outpatients age 18+
📌High-titer CCP (>1:320) vs placebo plasma w/in 9d of symptoms
📌Primary endpt: Hosp/death by d28
📌CCP 🏆: 54% ⬇️, driven by non-ICU hospitalizations (NNT=29); HR 0.46, p<.01…
2/ A few important points about this #COVID19 #convalescentplasma trial
📌High-titer CCP was much higher than that used in some other studies (median titer of >1:14,580 & 95% had >1:4820)
📌Median days to plasma: 6d
📌53 of 54 hospitalizations were in unvaxxed (#GetVaccinated!)
3/ 📌 Only 3 deaths in post-hosp period, all in controls
📌 Few #COVID19nCancer or #immunocompromised
📌 Study used #convalescent plasma mostly from Apr-Dec 2020 (ie pre-#vaccine availability)
📌Would *predict* CCP from #vaccinated to perform well vs #Omicron & #covidvariants
Read 9 tweets
Do you want a cheap (<$5) but highly accurate #aging biomarker that can be used in large experiments? Read our #preprint on TIME-Seq, a new method for inexpensive and scalable epigenetic age predictions. #clocks #longevity @davidasinclair…
Epigenetic “clocks” based on DNA methylation are the most robust and widely used aging biomarker. However, conventional approaches (methylation chip or RRBS) are hundreds of $$ per sample and low throughput.
We wanted to routinely use epigenetic clocks in large studies for low cost. So, we developed Tagmentation-based Indexing for Methylation Sequencing (TIME-Seq) for scalable and inexpensive targeted methylation sequencing of DNA methylation biomarkers.
Read 13 tweets
Nos complace presentar en versión #preprint del impacto de la variante delta en Bogotá

Trabajo colaborativo entre @NotreDame, @ZulmaCucunuba y Juliana Cuervo de @MedicinaPUJ @MRC_outbreak @hdodiazm de @UNColombia y Manuel González de @SectorSalud y @jdramirez24 de @URosario.
Este modelo es la actualización del modelo que usamos previamente para analizar escenarios de apertura escolar en Bogotá. Esta versión incluye variantes circulantes predominantemente en Bogotá y esquemas de vacunación y su eficacia conocida para variantes delta y no delta.
Para estimar la introducción de variantes en Bogotá, usamos datos de casos detectados de viajeros y la prevalencia de diferentes variantes en los países de origen. Esto fue contrastado con la dominancia de variantes en la ciudad como es reportado en @GISAID
Read 19 tweets
Pulmonary #embolism (lung blood clot) was >10 times more common after #SARSCoV2 infection (COVID19; ~15x over background rate), vs after getting #Pfizer's or #AstraZeneca's vaccine (~1.2x> background)

Similar greater risks with COVID-19 for #DVT & #VTE
2) First of all – as the authors note – in those #vaccinated against COVID-19, "thrombosis, thrombocytopenia, and thrombosis with thrombocytopenia were very rare events."
3) Data from 1.9 Million (M) recipients of AstraZeneca, ~1.7 M of Pfizer, and ~300k COVID-19 cases (few old) – compared with ~2.3 M in the general population.

These cohorts were used to calculate the observed incidence vs. background (SIR) or observed vs. expected # of cases.
Read 8 tweets
New #preprint out on mapping effects of DBS for cervical vs. generalized dystonia to the connectome. A brief thread.…
Based on N = 80 patients from five DBS centers, we mapped deep brain stimulation sites and looked at whether their structural and functional connectivity profiles could inform clinical outcomes in cervical vs. generalized dystonia.
To derive at a testable hypothesis, we looked at microstructure of the internal pallidum (stimulation site) which is made up from two large processing streams that traverse *orthoginally* from each other. i) the pallidofugal bundle and ii) the pallidothalamic tracts.
Read 10 tweets
We are extremely happy to present our lab’s first #preprint! Together with @teamstembryo we identify #hypoxia as a major microenvironmental factor that governs ES cell lineage commitment.…

Short summary 👇🏼👇🏼 (1/11)
Have you ever wondered how environmental factors such as #hypoxia together with intrinsic cellular regulators shape stem cell identity and differentiation capacity? We have (a lot!). But wait a minute you say, isn’t oxygen essential for mammalian life? (2/11)
Of course it is! But… before placentation, the embryo develops in an increasingly hypoxic environment where oxygen tension is as low as 1.5%. But what’s the physiological relevance? @odedrechavi
Read 11 tweets
🤗🇫🇷Honored to share our work on 💉💉💉for patients with
lymphoid malignancies

A thread will follow☺️

Read this #preprint on @researchsquare: Humoral and cellular responses after a third dose of BNT162b2 vaccine in patients with lymphoid malignancies…
Read 4 tweets
Estoy leyendo el artículo (#preprint) que acaba de publicarse sobre el origen del #SARSCoV2. Es una excelente recopilación de la evidencia disponible sobre el caso 👉🏻…
Voy a comentar los aspectos más relevantes en un 🧵
1/n Tenemos en primer lugar un análisis espacio-temporal de los primeros casos y un análisis filogenético de las primeras secuencias disponibles 👇🏻
Read 20 tweets
*Political Corruption & Organised Crime*

Monday 28 June, 2021
(Washington DC; London; Pretoria)

Read this #preprint on @researchsquare: Violent Crime & Extremism in #SouthSudan: The Modus Operandi of Organised Criminal Groups & Political Corruption…
#SouthSudan #Sudan #SSOT

As South Sudan approaches the ten-year anniversary of its independence from Sudan on 9 July, 2021, today we share an important preliminary briefing of a novel & groundbreaking seven-year forensic investigation into state-supported criminal activity &…
…its financing of terrorism.

This introductory-overview document is compiled from award-winning research undertaken by Dr.@DauCol.

Our investigation team shall publish complimentary technical analyses of this research’s invaluable data & unique insights over the coming months.
Read 23 tweets
We have an exciting new #preprint on @medrxivpreprint ! A novel class of #primaryimmunodeficiency, with the discovery of ITPR3 mutations in two families with combined immunodeficiency. As always, studying #PID teaches us so much about biology! 1/8…
The work is based on patients identified @UZLeuven by Rik Schrijvers and @IsabelleMeyts. Both patients had a combined #immunodeficiency with sensitivity to infections, one complicated by peripheral #neuropathy and one by #autoimmune hemolytic anemia. Over to the gene hunters! 2/8
Mutations in ITPR3 were identified by Erika Van Nieuwenhove and Frederik Staels. ITPR3 is part of a #Calcium channel, so we turned to the Serysheva lab @Irina52948708 to predict the impact on structure. Clear as day, the mutations change the charge of the channel. 3/8
Read 8 tweets
Poslechl jsem si včerejší #StudioN a jen pár poznámek k zodpovědnosti vědců, diskutovanému experimentu a k zodpovědnosti novinářů. 1/n

@FilipTitlbach @petrkou @enkocz @Simindr…
V první řadě, potenciál zneužití vědecké práce není nic nového. Jen se to nyní dostalo do hledáčku mainstreamových novinářů. Jakožto někdo, kdo se pohybuje v oblasti biotechnologií a GMO se s podobnýma věcma setkávám "denně". Různé studie byly znásilněny a jejich závěry 2/n
znásilněny, aby potvrdily něčí hypotézu. Jenže s takovou bychom nemohli publikovat nic. Protože takto znásilnit lze i dobře míněné (a třeba původně úplně nesouvisející) práce.
Read 32 tweets
Now as everyone is talking about #2DG that is made by @DRDO_India, some people are also claiming that the hypothesis was first put forward by #Patanjali. Here is my take on the paper by #Patanjali (1/6)

@Neurophysik @GorwayGlobal @drabbyphilips @ForBetterSci
In this work, #2DG is docked with key viral proteins such as viral spike glycoprotein S2, viral NSP15 endoribonuclease, and protease 3CLpro. Other in-silico parameters like drug likeliness, bioactivity indices, and ADMETox have also been studied to generate supportive data. (2/6)
First of all, this is an in-silico paper and not an in-vitro paper or a RCT. That itself means that everything written in it is plain speculation. Secondly, the paper is still on a #Preprint server @authorea which means that it has not been peer-reviewed. (3/6)
Read 6 tweets
"#AstraZeneca, we have a problem"

New #preprint from Lena Krutzke and Stefan Kochanek et. al. @uni_ulm and @UniklinikUlm on @researchsquare

"Process-related impurities in the ChAdOx1 nCov-19 vaccine"

Why is this a problem? A short thread (1/8) 👇…
"The intramuscular injection of proteins that are not part of the active principle of the #vaccine itself might have effects at different levels"

That`s why removal of impurities (e.g. host-cell proteins) is critical for #therapeutics and strictly regulated
Unfortunately, removal of process-related #impurities from viral vector-based #therapeutics (e.g. host-cell proteins) is imperfect and low levels - orders of magnitude lower than the actual active therapeutic - are usually accepted if they are classified as non-problematic
Read 9 tweets
Check out our #preprint describing a broadly neutralizing RBD antibody, which protects against SARS-CoV, bat pre-emergent CoVs, and SARS-CoV-2 B.1.351 challenge in mice. This work was led by me, @aschaefe29 @sophie_gobeil @Dapeng_LI
From >1700 antibodies, we focused in on 50 cross-reactive antibodies that cross-reacted with SARS-CoV and SARS-CoV-2 spike. We then tested the neutralization activity of these mAbs against bat CoVs SHC014 and WIV-1, SARS-CoV, and SARS-CoV-2, and found 4 pan neutralizing mAbs.
We then tested the in vivo activity of these four mAbs against SARS-CoV in mice and found that only one mAb (DH1047) protected against challenge) so we focused on this mAb for more in vivo studies.
Read 6 tweets
Recibí esta excelente pregunta de @vacl58 y quisiera contestarla con un hilo apoyado por un pre-print (artículo en espera de revisión por pares)

Lo haré lo más ameno que se pueda aún siendo un chirris técnica 🤏🏼

Va! 🧵👇🏼


Es perfectamente razonable preguntarnos si recibir la 2a dosis de las #vacunas 💉 en el tiempo establecido en los ensayos clínicos es igual de efectivo que hacerlo unos días, o incluso semanas después

La respuesta más prudente es: de manera general no es menos efectivo

¿Por qué lo digo de esa manera?

Porque ha habido casos, como el de la vacuna ChAdOx1 nCov-19 (@AstraZeneca) en donde la eficacia aumentó cuando las dosis estuvieron más espaciadas, sin embargo, estos son datos que no conocemos para todas las formulaciones


Read 18 tweets
A blockbuster #preprint of #LongCovid from UK; 1077 patients discharged in 2020; at median 5 mos only 29% fully recovered, 20% had new disability.… @medrxivpreprint @REvans_Breathe @uol3i @HamishMcAuley @LouiseVwain @Survivor_Corps @patientled @dianaberrent Image
@medrxivpreprint @REvans_Breathe @uol3i @HamishMcAuley @LouiseVwain @Survivor_Corps @patientled @dianaberrent And another indicator of the impact of #COVID19… at a median of 5 months after hospital discharge, 19% experienced a health-related change in occupation. @medrxivpreprint Image
@medrxivpreprint @REvans_Breathe @uol3i @HamishMcAuley @LouiseVwain @Survivor_Corps @patientled @dianaberrent "Factors associated with failure to recover were female, middle-age, white ethnicity, two or more co-morbidities, and more severe acute illness.” Image
Read 7 tweets
And here is another important #longCOVID #preprint by the amazing @NatalieJLambert and team. "most common symptoms were fatigue, headache, shortness breath, difficulty concentrating, cough, changed sense taste, diarrhea, & muscle aches."… @medrxivpreprint
@NatalieJLambert @medrxivpreprint "Symptoms causing greatest distress (scale 1 “none” to 5 “great deal”) were extreme pressure at base of head (4.4), syncope (4.3), sharp or sudden chest pain (4.2), brain pressure (4.2), headache (4.2), persistent chest pain or pressure (4.1), and bone pain in extremities (4.1)."
@NatalieJLambert @medrxivpreprint Again, we see a remarkable range of downstream symptoms from COVID; this illness has devastating consequences for so many that extends far beyond the acute illness. Much to learn. Need to move quickly. @Survivor_Corps @dianaberrent
Read 5 tweets
Striking #preprint on #LongCovid: 'high rates of long-term symptoms and poor long-term outcomes, present several months after hospitalisation for #Covid19’ Over 50% with symptoms months later. A quarter w/new or worse disability.… @medrxivpreprint
@medrxivpreprint So useful: ‘>half of patients reported not being fully recovered 7 mos after onset Covid-19 symptoms.’ 'Younger women &those w/more severe acute disease in-hospital had worst long-term outcomes.’ @dianaberrent @ahandvanish @louise_sigfrid @JTSglobalhealth @Tom_Drake1 @tweediechap
@medrxivpreprint @dianaberrent @ahandvanish @louise_sigfrid @JTSglobalhealth @Tom_Drake1 @tweediechap They conclude: 'Policymakers need ensure there is long-term support for people experiencing #LongCovid & plan for lasting long-term population morbidity. Funding to understand mechanisms and identify potential interventions for testing in randomised trials is urgently required.'
Read 6 tweets

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