Dr. Marks says radiation (XRT) technique allows for both better treatment planning for treating disease area and to minimize collateral damage (heart, lung) #SABCS19
SEER data backs up the reduction of cardiac risk over time... #SABCS19
Dr Marks critical of short followup of nipple sparing mastectomy data. #SABCS19
Breast satisfaction, psych well being and sexual well being better with breast conservation + XRT #SABCS19
Now Dr Thompson takes the podium to counter the debate. #SABCS19
(He already is scoring major points for clever graphics and professional jests) #SABCS19
“This debate is really about PATIENT CHOICE” #SABCS19
Highlights both short term and long term side effect of XRT #SABCS19
Cardiac risk remains a “cause for concern” #SABCS19
Great job using Dr Marks own words in battle... #SABCS19
Important comment: Mastectomy means loss of sensation—and emphasizing sensation matters to emotional and sexual heath. Also talks about implant risks/toxicity. #SABCS19
Some persons, through absolutely no fault of their own, present with metastatic disease.
In some persons, through absolutely no fault of their own, breast cancer comes back in another part of their body. #bcsm#bcam /2
Persons with zero risk factors are diagnosed with the disease. It does not matter if you do not have a family history. It does not matter if you faithfully do your mammogram (mammos detect early, they don’t prevent). #bcsm#bcam /3
T2
KAITLIN randomized patients after adriacymycin/cyclophosphamide to either paclitaxel/trastuzumab/pertuzumab or TDM-1/pertuzumab. #bcsm
The two arms were nearly identical for primary endpoint IDFS, subsequently a “ negative “ trial. This trial raises all sorts of questions and controversies. Based on TRAIN-2, the administration of anthracycline to all patients likely could have been avoided #bcsm
Additionally, we have little data about the specific benefits of adding pertuzumab to TDM-1. #bcsm
America,
In WW1, America lost 116,516 people, with over half (63,114) of those deaths attributed to influenza/disease rather than combat. I know these figures because #KansasCity is home to the remarkable the National WW1 museum. You should visit when this is all over.
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But as I watch the numbers unfold and read the predictions, I can’t help but wonder—where will the international COVID19 memorial be located? New York? They already currently have 1552 #COVID19 deaths.
On September 11 there were 2,997 victims /2
There were indications that use of any antioxidant supplement (vitamins A, C, and E; carotenoids; coenzyme Q10) both before and during treatment was associated with an increased hazard of recurrence (adjusted hazard ratio [adjHR], 1.41; 95% CI, 0.98 to 2.04; P = .06) /2
Relationships with individual antioxidants were weaker perhaps because of small numbers. For nonantioxidants, vitamin B12 use both before and during chemotherapy was significantly associated with poorer disease-free survival (adjHR, 1.83; 95% CI, 1.15 to 2.92; P < .01)... /3