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H. Moses Murdock Profile picture
@haematognomist
Dec 30, 2019 • 1 tweets • 2 min read • Read on X
@sargsyanz @hdx @NEJM Thank you, this is amazing! Updated version: gray shaded area represents the space of unstructured thinking, thanks @gradydoctor @HannahRAbrams @Anand_88_Patel for chiming in, your edits been so helpful in thinking about the nuanced ways we approach cases 🙏🏾 Image

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More from @haematognomist

H. Moses Murdock Profile picture
Apr 21, 2023
#MedTwitter

Wanted to share something special: what brought me to twitter in the first place.

As a clerkship student, I was in awe of residents/attendings, and hoped to imitate not only their knowledge base but also their organized way of thinking.

pubmed.ncbi.nlm.nih.gov/37081721/
My co-med student & friend Dr. Jarrod Ehrie and I started working on frameworks. We had support and mentorship from @NadiaBennettMD and Dr. Kogan. We spent years making the frameworks and having fellows then faculty review.
We asked medical students how they learn frameworks. Most said attending clinicians

An academic computing/web services core hosted the digital frameworks

Over the years that we worked on it, I realized others were/had been doing the same:
@CPSolvers
@AndreMansoor
@adamcifu
Read 7 tweets
H. Moses Murdock Profile picture
Jul 2, 2022
#Medtwitter friends: I've been having a blast on the BMT service with @c_j_gibson and planning next week's #bmtsm #leusm teaching theme:

📰 Why we do what we do in allogeneic transplantation for myeloid malignancies: Classic/Pivotal trials/papers.

Any you'd add/swap out?
1⃣ Chemo vs. Auto vs. Allo in AML

Cassileth PA et al. Chemotherapy compared with autologous or allogeneic bone marrow transplantation in the management of acute myeloid leukemia in first remission. NEJM 1998

nejm.org/doi/full/10.10…
2⃣ Donors - Related vs. Unrelated

Gupta V et al. Comparable survival after HLA-well-matched unrelated or matched sibling donor transplantation for acute myeloid leukemia in first remission with unfavorable cytogenetics at diagnosis. Blood. 2010

ashpublications.org/blood/article/…
Read 10 tweets
H. Moses Murdock Profile picture
Jun 17, 2022
🧵Our latest in @BloodJournal
@coleman_lindsley @c_j_gibson @DanaFarberNews

Older patients with AML undergoing HCT have high rates of relapse & non-relapse mortality

We investigated how outcomes relate to both baseline characteristics and molecular MRD

tinyurl.com/4bn76ham
2. @DrChrisHourigan and others have shown that AML pts with mutations at remission (molecular MRD) have more relapse➡️ inferior survival after HCT, especially if receiving reduced intensity conditioning.
tinyurl.com/23rrbjte Image
3. We wondered:

1⃣ Is prognostic impact of MRD the same for patients age ≥ 60 (underrepresented in RCTs)?

2⃣ Is mutation persistence related to features present at diagnosis?
Read 12 tweets
H. Moses Murdock Profile picture
Mar 6, 2021
🩸Roundup of Myeloid Malignancies/BMT papers, starting w/ something I care a lot about:

1/ Poor Survival & Differential Impact of Genetic Features of Black Patients w/ #AML #leusm

Bhatnagar et al, Cancer Discovery
pubmed.ncbi.nlm.nih.gov/33277314/

We got work to do ya'll 😰 ✊🏾
2/ pubmed.ncbi.nlm.nih.gov/33664234/

Salvage use of venetoclax-based therapy for relapsed AML post allogeneic hematopoietic cell transplantation

Joshi et. al, Blood Cancer Journal
3/
Post-Transplant Cyclophosphamide (PTCy) is Associated with Increased Cytomegalovirus Infection: A CIBMTR Analysis

Goldsmith et al, Blood
pubmed.ncbi.nlm.nih.gov/33657221/
Read 9 tweets
H. Moses Murdock Profile picture
Jun 15, 2020
1/8 Day 1 of intern year orientation. The nerves & excitement are real

A tweetorial of tweetorials - resources that may be helpful for our first days on the job! We are all in this together 👊🏾

First up:
Calling consults like a pro: @VarunPhadke2
2/ Describing a rash like a pro @UCSFIMChiefs

3/

Procedures advice from @RossCSchumacher

Starting an IV from @AbbyRenkoMD2020
Read 8 tweets
H. Moses Murdock Profile picture
May 18, 2020
1/n Inspired by RLR: @rabihmgeha & @DxRxEdu...
HLH - @haematognomist & @HannahRAbrams

Two rising interns interested in🩸Heme-Onc & 📚MedEd

Teaching pearls from @NEJM CPC published 6/6/13
Dx spoilers below! @MedTweetorials
2/n First a PR:

Middle age man w/ PMHx HBV infection p/w chronic fevers and progressive weakness, found to have painful asymmetric mixed motor & sensory distal multiple mononeuropathy and nerve biopsy showing active vasculitis diagnosed with...
3/n DDx for mixed motor & sensory multiple mononeuropathy is broad!
▪️Hereditary
▪️Diabetes
▪️Vasculitis
▪️Infections (leprosy, lyme, syphilis, CMV, HIV)
▪️Neoplastic infiltration: (most commonly lymphomatous)
▪️Sarcoid, amyloid

Pt had S4...infiltration of heart & nerves?
Read 9 tweets

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