Even if 1% of population gets infected & we have as much as CFR as in #southkorea, our efforts are averting between 0.5-2.3 million deaths. In terms of mitigation, we are the first country in the world to do a #Lockdown21 on a national scale #covidinindia#LockdownLessons 1ofn
How to move forward? First, some ground realities 1. Testing everyone is going to take time. 2. Treatment is going to available only later. 3. Vaccine development is far
Next, once lockdown is lifted, most of India is susceptible to new infections.
How to stop future infections?
If there are active transmissions going on, it will spread like wildfire later. So catch these foci of transmission and contain them to these local areas.
So, the focus is NOT on the states/areas that are detecting, testing and controlling well.
High focus should be on two areas to prevent spread later.
1. Identify states/areas which are silent or reporting poorly. If a state has not reported cases earlier (due to many reasons), hotspots or deaths will start getting reported (as no one can hide it) sooner or later
2. The NCDC has identified hotspots. The states should ensure transmission would not spread from these areas.
Both these (silent and hotspots) require heightened surveillance, regular review and strict containment.
Focus of action has shifted from national to state and sub-state level for effective mitigation and containment. If a state is not reporting enough cases, now is the time to make sure we are not missing a transmission. Otherwise, they can be hotspots once the lockdown is lifted.
Ask the right question, you will find the answer.
Where is virus? Who are at risk?
Why are states not reporting?
Why deaths are reported (now) when cases weren't reported earlier?
How to identify cases without testing?
How to isolate all cases?
How to effectively trace contacts?
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However mild #Omicron is, it is not a vaccine. There are deaths and hospitalizations due to this variant.
Stay away from misinformation.
Compared to Vaccination, natural infection could not protect population (against death or hospitalization) against any variant (Alpha, Beta, Gamma or Delta).
Proponents of Herd immunity are saying it again; #Omicron would provide herd immunity.
Evidence matters, not opinions
During delta wave, this is what we knew based on #Epidemiology of infectious diseases.
-This is not the last variant.
-There will be another wave.
More actions points can be following :- 1. Since day of 1st case of #Omicron#B.1.1.529, establish travel history & identify secondary transmission throughout world. If primary case was in early November, not difficult to miss areas of circulation.
1ofn who.int/news/item/26-1…
2. Botswana, South Africa & Hong Kong cannot be the only areas where #Omicron has travelled. These areas are the ones that have probably better surveillance and genomic sequencing and hence have reported in timely manner. Absence of reporting is not absence of circulation.
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3. Imposing travel restrictions, restricting entry from few countries is NOT going to help either prevent or control the spread of #Omicron. It’s akin to closing stable door after horse has bolted. Instead, identify cluster of cases of recent origin & do genomic sequencing.
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Brilliant study done in China, If scaled up, blood pressure reduction (-26.3 mmHg) achieved by training lay health workers can reduce significant mortality in LMICs.
-Globally, >17.9 million people die each year CVDs.
-Hypertension related CVDs contribute a significant proportion
-Chinese study shows some of these deaths & disability are preventable.
-Train lay village workers in BP measurement, counseling & provide affordable drugs.
Sudden cardiac arrest & Sudden cardiac death (SCD) refer to the sudden cessation of cardiac activity with hemodynamic collapse, typically due to sustained ventricular tachycardia/ventricular fibrillation; mostly occur in patients with previously undiagnosed diseaes.
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Results from Framingham heart study suggests that more men are affected with increasing age.
Not rare, 15 percent of the total mortality in the United States & other developed nations is due to SCD. (pubmed.ncbi.nlm.nih.gov/11684624/)
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-It is the initial clinical manifestation of 15% of coronary heart diseases (CHD).
-SCD is the mechanism of death in over 60% of patients with known CHD.
-Risk increases by a number of factors: Age, underlying cardiac diseases, post-menopausal women, CHD risk factors
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This tweet thread is about the results from the second serosurvey done in the #Karnataka state. Ahead of sharing the link, some caveats first. 1. The @DHFWKA has used the data from this round of serosurvey in late March to update testing and surveillance strategies.
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2. The study found Lower levels of IgG seroprevalence, mostly due to antibody waning. 3. A substudy was done to confirm the antibody waning. This study was delayed due to rapid surge of cases in April. 4. We found near 0 prevalence of active cases during mid-February 2021.
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5. There was a subsequent surge seen in Karnataka state due to a mix of alpha, delta which was picking up speed in April, and a large susceptible population were infected. 6. Results from the substudy on antibody waning was necessary for releasing the final report & paper.
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Polio anywhere could be a threat to countries that had eradicated it. It took decades to eradicate polio in most parts while some are yet to eradicate. Not just this necessity, it was possible mostly due to a collaborative approach & strong leadership at the global level. 1/N
Lessons from Polio Eradiation, Cochi S et al
-Strong political & social support in each country
-Strategic planning & policy development
-Partnership management & donor coordination
-Program operations & tactics
-Oversight and independent monitoring.
If there was high polio circulation in one region, other countries could prevent the possibilities of its import by vaccinating the children in their countreis. Therefore, all countries are continuing polio vaccination till other regions accomplish eradication.
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