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The #COVD19 antibody test has serious accuracy issues; there's a "medical free-for-all"
nytimes.com/2020/04/19/us/…
@SteveEder @mega2e @apoorva_nyc
Germany taking the lead with it @rki_de, Munich studies
nytimes.com/2020/04/18/wor… @kbennhold
Best 3 pieces I've seen to summarize the serology test assay challenges (besides other key issues as to whether IgG protects vs spread and its duration of protection)
Getting the antibody testing accurate is paramount to navigate re-entry. Here's what I learned about some aspects of testing from a pretty comprehensive, rapid immunoassay panel last month
Very good on this today from @leHotz @WSJscience
wsj.com/articles/does-……
w/ @florian_krammer and @LSHTM's Martin Hibberd (<-like the range cited😉)
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Eric Topol
@EricTopol
What is the mortality rate for #COVID19 patients put on a mechanical ventilator? A new @JAMA_current
jamanetwork.com/journals/jama/… provided substantial data, adding to the UK registry, and 4 other published papers w/ small patient numbers
Overall death rate ~70%, weighted by top 2👇
Fixed link for @JAMA_current @NorthwellHealth paper jamanetwork.com/journals/jama/…
by @SafiyaMD and colleagues
The use of mechanical ventilators may be contributing to the high mortality rate:
Mechanism, review, recommendations
ajtmh.org/content/journa…
propublica.org/article/ventil… @propublica
@CarolineYLChen
statnews.com/2020/04/21/cor… @statnews @sxbegle
Read 3 tweets
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Eric Topol
@EricTopol
For April 21/22, you get to pick
Ascending @TheEconomist
Plateau @OurWorldInData
Long plateau @FT
No matter which log, semi-log plot, none look good for US fatality curves
To predict ~60,000 deaths for the US through August, the @WhiteHouse uses the most optimistic, @IHME_UW model.
If you look at the curves above and other models reviwed @UpshotNYT, you get the sense of the different scenarios
nytimes.com/interactive/20…
The @FT April 22 update for the US #dataviz
The long plateau (~2,000 deaths/day) gets longer
That plateau is paralleled in the case curve, w/ little reduction
Soon to exceed 50,000 lost American lives, 1 million confirmed cases
Read 3 tweets
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Eric Topol
@EricTopol
More info on the Feb 6th California #COVID19 death from @HealthySCC likely community spread washingtonpost.com/nation/2020/04…
Await contact tracing and would like to see patients w/ pneumonia diagnosis in Jan/Feb have their stored blood samples analyzed, virus sequenced, dig deep into this
The problem is this may not have been the "First US foothold"
nytimes.com/2020/04/22/us/…
Santa Clara County "flu" season Jan-Mar 2020 looks a little different than prior years
Read 3 tweets

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