Thread by @priti899

🌍Earth's temp🌡️ has ⬆️ 0.8°C in the past decades🤨

Is this changing pattern of climate threatening 👀 kidney health❓

Let's find out why this global rise in temp concerns nephrologists so much❓

🌍🔥🌍🔥🌍🔥

💥Tweetorial alert 💥

#NephMadness #NephTweetorial #NSMC

What makes the kidneys more susceptible to acute injury from climate change?

Kidney is an amazing organ🙃🙂

⚡️It excretes concentrated waste ( To minimize fluid loss)
⚡️It is highly metabolic work🥵🥶

During heatwaves🌞🔥🌪️

💥⬆️ Incidence of heat exhaustion and stroke"
💥⬆️30 % Hospital admission due to kidney impairment
💥⬆️10% Mortality

📌revistanefrologia.com/en-relaccionad…

Now let’s try to establish some hypothesis to the mechanism of AKI due to heat

⭐️ECF depletion → ⬇️GFR
⭐️Rhabdomyolysis🦾
⭐️Hypovolemia and Hyperosmolarity → ⬆️fructokinase (polyol pathway activation)
⭐️⬆️Uric acid
⭐️Nephrolithiasis

mdpi.com/2072-6643/11/9…

Commonly associated electrolyte abnormalities seen during heat waves🌪️🔥 are

💥Hyponatremia/hypernatremia
💥Hypokalemia
💥Hypophosphatemia
💥Hypocalcemia
💥Hypomagnesemia

journals.plos.org/plosone/articl…

Prognosis of climate-related AKI is not always benign; there may be🤨👀

☄️Dialysis requirement (10–30%)
☄️ Progression to CKD (chronic tubulointerstitial nephritis)

Other concerns are
📢💬

1⃣ Urinary tract infections
2⃣ ↑Temp also brings the ⬆️ risk of kidney stone formation (up to 30% ↑)

As a result of

☀️↓Urine volume
☀️↑ Urinary supersaturation with calcium and uric acid crystals

pnas.org/content/105/28…

At finally, although not a direct effect, in a warmer temp🌅
Mosquitoes🦟– FEED more, REPRODUCE 🦟more

And with them the diseases they carry
☄️Malaria
☄️Dengue
☄️ZIKA virus

💥Mortality ⬆️rate of malaria with AKI: may ⬆️up to 45%💥

📢📢By the end of this century, average temp is expected to ⬆️ by 1 to 4.5 C 🔥🌎

So, nephrologists must acknowledge climatic change and be prepared

kidney-international.org/article/S0085-…

Read more about this
👉ajkdblog.org/2020/03/13/nep…

Excellent blog by @amyaimei

#greenNephrology
@NSMCInternship
@AJKDonline