Thread by @RajivSarin5

Why politicians or others can promote HCQ/Other stuff as GameChanger while we just watch. They know MDs/Academics haven't yet made public understand the meaning/relevance of
#StandardOfCare
#AcceptableAlternative
#ClinicalBenefit
#ExperimentalTreatment
#ClinicalTrial
#Preclinial

Though its a public health crisis, we can't expect the public to understand the critical importance of these terms as we do in Medicine/Regulatory Agencies. COVID is not the 1st or last public health crisis. Let's try to make people know & ask about these as their rights & safety

We can engage and educate the public using examples they can relate to or remember. If they get it right they will be less gullible, esp during public health crisis
#StandardOfCare
#AcceptableAlternative
#ClinicalBenefit
#ExperimentalTreatment
#ClinicalTrial Phase 1-3
#Preclinial

#Studypopulation Many men take 1Hr summer sun walk challenge. Midway many have sweating+++, thirst++ listless+ cramps++
#StandardOfCare Drink water ad libitum+salt&sugar #SupportiveCare Sit in shade & Wait till Sun is kinder
#ClinicalBenefit: Feels better Click Selfies Calls Mom

#AcceptableAlternative in absence of #StandardOfCare: Have the free 350ml water+ salted biscuits/candies provided at the start to men without own supplies
#SupportiveCare as above. Try Hitch-Hiking & water from passerby
#ClinicalBenefit Feel bit better No cramps. Text friend SOS

#ExperimentalTreatment Phase I of Prof. Fruiterix
Chew 5 seeds of rare forest berries that gathers dew with 350 ml Water/Biscuits/Lozenges. Fruiterix lab published seeds are V. Hygroscopic
#Results: Tongue discoloration in 4/5 men 2/5 men could find a ride. Stopped after Phase II

#ExperimentalTreatment of Prof Fasterix: 4 salty biscuits & 2 lozenges with 350ml water in 20 second; Lie in shade for 59 min 40 sec
#WeakComparatorArm: Take same amt of Water/ Biscuits/ Lozenges but slowly over 30 min
#Results Fasterix regime Urine colour 1 shade lighter p<0.029

#CLinicalTrial Phase3 Leading pharma asks Prof. Waterix to compare MintoGene (Mineral water+Genetically modified mint) with plain water
#Results No clinical benefit with Mintogene Surprisingly some men couldn't stand GM Mint
Prof. Waterix now global health expert on plain water

Use this or better template to make scenarios/study populations/interventions/endpoints. If the public, patients, politicians & community doctors understood the terms used in clinical trials/drug promotion, they may not be conned as often #medtwitter @oncologician @NIH @EricTopol

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