Thread by @khurramn1

#1 Many raised concerns reg racial disparities in face of recent COVID-19 pandemic
@eff_ve leading efforts @HMethodistMD to systematically examine inequalities reg susceptibility to SARS-CoV-2 infection in nation’s most diverse metropolitan area: Houston
medrxiv.org/content/10.110…

#2 @eff_ve building a novel data platform form to automatize ingestion, organization & analytics serving @HMethodistMD entire research community data needs via COVID-19 Surveillance and Outcomes Registry (CURATOR)

Operational details of this registry/platform coming soon.

#3 @eff_ve showed high probability of testing positive

-African American vs White; OR:1.84, 95% 1.49–2.27
-Hispanic vs non-Hispanic; OR, 1.70, 95% CI 1.35–2.14

explored 3 mechanism of disparities: SES, residence in higher population dense areas, & higher level of comorbidities

#4 Appears all high population density likely contributing more to high infection rates as compared to SES/ in the vulnerable populations.

Interesting insights that will need to replicated in other metropolitan areas and national cohorts.

#5

"Based on marginal probabilities obtained from fully adjusted model, the probability of SARS-CoV-2 infection in a 40-year- old African American is 18.8%...12.9% in a 40-year-old White individual. A similar differential relationship observed for Hispanic vs. non-Hispanic"

#6

Where do go from here...

need more exploratory work in understanding mechanisms if we truly aspire to overcome these disparities and ensure equitable health and outcomes