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What really is remdesivir? It’s chemical delivery vehicle for the active form: a variant of the letter A in the RNA code. Remdesivir interferes with the viral RNA copying enzyme, like a bit of plastic caught in a zipper. 1/n
Here’s a scientific paper on remdesivir if you’re curious m.jbc.org/content/early/… 2/n
The mechanism of action is called “delayed RNA chain termination”. Here’s what the natural A in the RNA code normally looks like. Remdesivir’s extra arm sticking out of the hip with the nitrogen atom at its end (N) is what gums up the zipper. 3/n
This recent trial found that “intravenous remdesivir did not significantly improve the time to clinical improvement, mortality, or time to clearance of virus in patients with serious COVID-19 compared with placebo.” ncbi.nlm.nih.gov/pmc/articles/P…
No lives were seemingly saved in any remdesivir trial, so the total lives lost won’t change because of this @US_FDA approval. It isn’t going to be a solution. We must keep doing clinical trials of new drugs. Doctors, this is just a beginning. Don’t let up.
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