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/1 Last week, I had a few minutes before a Mind Meld with Ian Bremmer to chat about why COVID-19 affects the elderly and why boosting your immune system matters so much.

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/2 I wanted to add a little more context on remdesivir. The effectiveness of its treatment is debated. One study, run under the auspices of the US NIH, seemed to show remdesivir reduces time in hospital (11 days vs 15 days to recovery with no statistical reduction in deaths).
/3 Meanwhile, a Chinese study of similar quality said there was no benefit of the drug. While we wait on larger study results that are underway, remdesivir is now the new standard against which others will be compared.

Source: france24.com/en/20200501-co…
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David Sinclair, PhD
@davidasinclair
One third of homes have a cat. There are 600M globally. A study @NEJM confirms cats spread #coronavirus to each other & may spread it between family members. I’m concerned it could mix with a fatal cat coronavirus... 1/n
Some say “Well, the virus has not been proven to spread from cat to human.” As @StevenAustad has pointed out, this hasn’t been tested or disproven either. It is like saying in December 2019 that a virus in China hasn’t been proven to spread to the US. 2/n
Is no one but me concerned about viral genetic mixing & a new strain emerging from cats? Cats have their own #coronaviruses. They can cause one of the most fatal cat diseases known by destroying white blood cells (HIV-like). 3/n
Read 10 tweets
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David Sinclair, PhD
@davidasinclair
1/ Let me start by saying that this was a fantastic piece on vaccine development by @stuartathompson at @NYTimes.
2/ Having started a now public company that makes vaccines (thanks to my cofounder Darren Higgins and to @gatesfoundation), I can tell you many people don't appreciate just how long it takes to develop a drug.
3/ Vaccines often take longer. Of every drug that is picked to go into humans, less than 5% will ultimately be approved. Luckily, the outbreaks of SARS and MERS in 2004 and 2012 have given us a head start (SARS and SARS-CoV-2 are ~80 percent identical).
Read 7 tweets
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David Sinclair, PhD
@davidasinclair
Outlook for this decade: POOR
1. 85% of economic impact is caused by fear of the virus not by stay-at-home. 2. WHO says the virus may never leave, like HIV. If true, we are in serious trouble. 1/n
Let’s not ignore the likelihood that survivors “will be left with chronic kidney & heart problems”, something the pro-herd immunity folks don’t consider. If you think spending 17% of US GDP on healthcare is bad now...2/n
We have also seen that leadership matters. NZ & Australia stopped movement, enforced it & tested and traced asymptomatics. They couldn’t even buy a coffee & are now essentially covid-free. US & Britain waited, let people travel & didn’t test & trace. We see the consequences. 3/n
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