Discover and read the best of Twitter Threads about #coronaviruses

Most recents (24)

Our latest study to understand the dynamic regulation of #interferon (#IFN) and #SARSCoV2 infection.

🧵summarizing what we found and what needs to be done to understand the dynamic interplay of infection and #IFN regulation. @iScience_CP #COVID19

cell.com/iscience/fullt…
We infected human airway cells (Calu3) with #SARSCoV2, and performed a time-series #RNAseq analysis to discover global transcriptional responses. We saw expression of #IFN (beta and lambda) and IFN stimulated genes in these cells.
Here is what #SARSCoV2 infection looks like in #Calu3 (human lung epithelial cells) cells.
Read 17 tweets
For everybody looking for a break from #coronaviruses check out our @virusfusion007 recent results on a #herpesvirus known as #HHV8 or #KSHV.

The preprint is available at @biorxivpreprint bit.ly/39mvx9I.

The main findings are discussed in the 🧵 that follows (1/n) Image
KSHV and its cousin EBV use an envelope glycoprotein complex called gH/gL to bind to #EphA2 receptor tyrosine kinase to gain access to host cells. We set to determine the structure of the KSHV gH/gL-EphA2 complex and perform functional studies to understand the mechanism (2/n)
While we were gathering the functional data Su et al. published the 3.2 A structure and provided some interesting insights few months ago.
But under our 'no scoop good enough' mantra we kept working and obtained some cool data that we can now share (3/n)

go.nature.com/3sIbQRL
Read 18 tweets
Do you wonder if #SARSCoV2 came from an animal or a lab?

I finally had the time to read this paper. I shall discuss in this thread observations relevant for virus emergence and why this work further discredits the lab origin theory. #COVID

nature.com/articles/s4146…
1. Bats were collected from an irrigation pipe in Thailand. So, if you think that bats with SARS-related #coronaviruses only exist in remote caves, then you are wrong. Like most wildlife, bats can also cover long distances.
2. Coronavirus detected in Rhinolophus acuminatus in this study are evolutionary closely related to #SARSCoV2 and other SARS2-related coronaviruses detected in bats.
Read 5 tweets
1/: Spring is about to kick in. ☀️🌷 COVID-cases are naturally starting to drop, and there will be no longer grounds to maintain #restrictions. So the crisis protagonists are currently digging very deep in their bag of #tricks to find 'reasons' to conserve the status quo. ⬇️
2/: #Seasonality of viral infections is a known mechanism. It has been described in thousands of research articles like the following one: sciencedirect.com/science/articl…

However, that knowledge is currently being ignored, because it obviously does not fit into the agenda.
3/: The following graph shows that #seasonality also applies to #coronaviruses. Cases usually start dropping between January and March and start rising between November and December. Key factors for this phenomenon are, among others, #humidity and #vitaminD blood serum levels.
Read 12 tweets
When were the first human #coronaviruses (CoVs) discovered and studied?

How were these viruses associated with human #disease?

It's time to learn our history about human CoVs, and the scientists and volunteers that allowed us to identify this new group of viruses.

A THREAD.
Mid-sixties: HCoV-229E and HCoV-OC43 were identified.
1. Hamre et al. (1966)
2. McIntosh et al. (1967)
3. Tyrrell et al. (1965).

Image: Tyrrell et al. (1965).
Healthy HUMAN volunteers were infected to demonstrate that 229E and OC43 resulted in a common cold.

1. Bradburne et al. (1967, 1972)
2. Hamre et al. (1966)

Image: Bradburne et al. (1967)
Read 7 tweets
🚨#COVID19 PAPER ALERT🚨
F@h simulations of the #coronavirus Nsp16 protein (1) reveal the structural mechanism of its activation, which ultimately enables the virus to escape our immune system, & (2) detect a ‘cryptic’ pocket to block Nsp16’s action.
biorxiv.org/content/10.110…
For successful infection, #coronaviruses use a protein called Nsp16 that modifies the viral genome so that the virus avoids an immune response. Nsp16 works by binding 2 substrates: RNA (green) and SAM (pink). Viruses and humans contain similar (homologous) proteins.
Unlike other viruses and humans, #coronavirus Nsp16 requires a binding partner (Nsp10) to activate its enzymatic activity. This difference is interesting from a basic science standpoint, and because it could present a way to target the coronavirus selectively with a drug.
Read 9 tweets
Do you trust the ethics of an unethical #harmaceutical industry that went as far as getting legal protection so you can't sue them when your or your child get ruined by #vaccines? Don't be sheep is right.
Flu #vaccines are concocted in chic embryos,which are known to be laced with #coronaviruses.You get the flu shot - you inject these viruses into you body. Now go get tested for #COVID19.They love compliant idiots who question nothing.
When you inject disease-there is only one place it can go.
Read 3 tweets
Thanks for sharing my perspective in this piece @MeganEDoherty! As I mention, in these #longcovid cases, it’s very important to take the potential persistence of #COVID-19 in certain tissues and/or the central nervous system (CNS) seriously!
2/ That’s b/c #Coronaviruses have been shown capable of persisting in human #tissue or certain “anotomical sanctuaries” - for example, this team found Coronavirus RNA + antigen in the Multiple Sclerosis brain: ncbi.nlm.nih.gov/pmc/articles/P…
3/ Also in other “post-viral” syndromes like “Post-#Ebola Syndrome, viral RNA has been found in unexpected body sites like sperm, or the eyes, years after initial infection: nejm.org/doi/full/10.10…
Read 6 tweets
@Know_More_News A randomized placebo-controlled trial in children showed that #flushots increased fivefold the risk of acute respiratory infections caused by a group of noninfluenza viruses, including #coronaviruses. (Cowling et al, Clin Infect Dis 2012;54:1778)😂

bmj.com/content/368/bm…
@Know_More_News It is possible that #influenza vaccines alter our immune systems non-specifically to increase susceptibility to other infections; this has been observed with DTP and other vaccines. (Benn et al, Trends in Immunology, May 2013). #covidhoax #vaccines

bmj.com/content/368/bm…
@Know_More_News #influenza & #ARDS (#COVID19 trick 😉🤓)
"...consequences of severe respiratory failure and multiple organ dysfunction. Death is usually due to sepsis and #MODS (multi organ dysfunction).." pag 3 ncbi.nlm.nih.gov/pmc/articles/P…
Influenza has the same scenario as #COVID19
Read 5 tweets
#FactsNotFear

MUST WATCH: @FatEmperor's interview with Professor Emeritus of #Immunology Dr. Stadler of University of Bern in Switzerland.

Dr. Stadler exposes #COVID19 fear-mongering and estimates ~70-80% of us already have T-cell immunity to #SARSCoV2.
2/Dr Stadler says #HerdImmunity already achieved. Echoed by many scientists incl Oxford Univ researchers—HI Threshold required to prevent #SARSCoV2 resurgence greatly reduced d/t "innate resistance &cross-protection from exposure to seasonal coronaviruses"
3/Read interview of above #HerdImmunity threshold study co-author—Professor Sunetra Gupta of Oxford Univ

"The pre-existing antibodies & T-cell responses against #coronaviruses seem to protect against #SARSCoV2 infection, not just the outcome of infection"
reaction.life/we-may-already…
Read 3 tweets
BREAKING: Multinational team uses 3 different methods to determine where #SARSCoV2 came from: each leads to horseshoe bats found widely in Asia. The virus now causing a human #pandemic has been in bats "for decades," only now reaching people.
MORE
nature.com/articles/s4156…
2/
Big implications from this peer-reviewed paper.
First, #COVID19 is not caused by a "China virus" that was "made in a Chinese lab," as some in the #Trump admin have claimed.
2nd, it may have jumped directly from a bat to a person, without intermediary animals.
MORE Image
3/
3rd, The 2003 SARS has also been connected to Asian horseshoe bats, and these mammals may carry many types of #coronaviruses.
4th, this shows "how difficult it will be to identify viruses with potential to cause major human outbreaks before they emerge." Image
Read 6 tweets
#WWI fostered influenza in the crowded conditions of military camps in the U.S. & in the trenches of the Western Front in Europe.
The virus traveled with military personnel from camp to camp and across the Atlantic.
ncbi.nlm.nih.gov/pmc/articles/P…
#SpanishFlu #COVID19 #SARSCoV2
The 1918 #H1N1 influenza pandemic caused 500,000-700,000 deaths in the U.S.— almost 200,000 of them in Oct. 1918 alone— & an estimated 30-40 million deaths worldwide, mostly among people aged 15-35 years.
World-wide transporting of #WW1 military troops was the reason.
#SpanishFlu
The 1918 influenza pandemic was caused by an #H1N1 virus with genes of avian origin. It was first identified in U.S. military personnel in spring 1918.
500 million people or one-third of the world’s population became infected with this virus.
cdc.gov/flu/pandemic-r… #SpanishFlu
Read 28 tweets
Ryan I take issue with your rash conclusion that #COVID-19 cannot survive in a persistent form in certain #LongCovid patients, and it's unfair to say that people studying the topic or discussing the possibility of COVID-19 chronic persistence are spreading rumors or causing harm!
2/ First, there is no way for you to *know* that #COVID-19 cannot persist in a latent/chronic form in certain patients. The #virus has only existed for a short time, meaning few studies on persistence have even been able to be conducted
3/ Second, have you noted all the cell types/body sites #COVID-19 can infect? (below). Have you obtained samples from all such sites in #LongCovid cases + searched for the #virus in a persistent form? (studies of cerebrospinal fluid, tissue biopsy etc?) nature.com/articles/s4159…
Read 6 tweets
🚨#COVID19 PAPER ALERT🚨
With your help, F@h became the first #exascale computer, collected 100,000X more data than a normal paper, learned how the #Demogorgon evades our immune system, and discovered drug targets called ‘cryptic’ pockets (#FAHPockets)!
biorxiv.org/content/10.110…
With over a million people downloading F@h, we reached #exascale computing speed within weeks. This made us >5X faster than the IBM Summit supercomputer, the fastest traditional supercomputer in the world!
This newfound power enabled us to simulate every possible protein from the #SARSCoV2 virus in parallel. Together, we generated the largest dataset of protein dynamics in history. We’ve highlighted some of our exciting findings in this thread:
Read 14 tweets
Super Thread:

#COVID19 Research.
#Pandemic

Pre Planning & The Events Timeline Leading to #lockdown

#Plandemic Image
Can We Create A #pandemic Free World? Dr. Tedros Ghebreyesus - WGS 2018

m.youtube.com/watch?v=3SbRgY… Image
The @WHO Warns We're Officially on The Path to a Global #pandemic

At any moment, a life-threatening global #pandemic could spring up and wipe out a significant amount of human life on this planet.

sciencealert.com/world-health-o…
Read 58 tweets
Where do #SARSCoV2 & other #coronaviruses come from?
Big survey of SE Asian bats, bat guano, field rats & other wildlife:
- 2,164 samples collected, Jan2013 to Mar2014 from rodents & bats
- 70 sites tested, coronavirus found at 58
- 100% test+ at live rodent trade sites
MORE Image
2/
Overall
- 34.0% of field rats were positive
- 60.7% + rodent wildlife farm sites
- 94.1% of bat guano farm sites test +
- human wildlife traders 20.7% +
- large market sellers 32.0% +
- restaurant workers 55.6% +
MORE Image
3/
"We detected avian & bat #coronaviruses in wildlife farm rodents, including Malayan porcupines & bamboo rats, but we did not detect rodent-associated coronaviruses," in those animals.
No samples specifically + for #SARSCoV2 . But points to high risk sites & species.
MORE Image
Read 4 tweets
Imp Thread: public health fallacy to claim popn #SARSCoV2 IgG serology tests capture all pts recovered from #COVID19: grossly UNDERestimates % popn that was asymptomatic & recovered. Key arms of immune response to #SARSCoV2: humoral with antibodies & cell-mediated with T-cells
2/ Current public health method to estimate population immunity to #SARSCoV2 from recovered asymptomatic #COVID19 ppl uses serology tests to detect IgG antibodies: this only captures humoral immunity. Currently no widely available testing kit for T-cell immunity to #SARSCoV2
3/ Pts mount strong T-cell immune responses to #coronaviruses. Published Cell research & studies on recovered #COVID19 pts w/immunodeficiency disorders w/inability to mount B-cell responses to #SARSCoV2 reveal B-cell antibody responses not strictly required to overcome COVID-19
Read 6 tweets
1/ Q: Can people get re-infected with SARS-CoV-2?

A: While some individuals test positive again after recovering from #COVID19, a new study suggests that these #infections are NOT active.

More about how the findings below
2/ Tests used to determine if someone has #COVIDー19 detect the presence of the virus' genetic material.

However, they do not indicate whether a person has an active infection: i.e. actively shedding virus capable of infecting cells.
3/ In the study, researchers tried to isolate INFECTIOUS #coronaviruses from samples taken from 108 people who retested positive. All of those samples tested negative.

Nearly all of them had neutralizing antibodies that prevent reinfection in at least the short term.💪
Read 4 tweets
IMP @CellCellPress study of recovered non-hospitalized #COVID19 pts: #SARSCoV2 consistent w/normal antiviral immunity

100% made antibodies. 100% made CD4+ Tcells. 70% made CD8+ Tcells. CD4+ Tcell responses to spike robust: IgG & IgA Ab prodn #medtwitter
▶️cell.com/cell/fulltext/… Image
2/ Detection of #SARSCoV2-reactive CD4+ Tcells in ~50% of *unexposed* pts: suggesting cross-reactive Tcell recognition btwn circulating “common cold” #coronaviruses & #SARSCoV2—may be of value in protective #immunity based on prev SARS & influenza data

#COVID19Canada #medtwitter Image
3/ This is all very positive news:
aids in our understanding of #SARSCoV2 immune responses & will help to model future course of #COVID19—any degree of crossprotective #coronavirus immunity in pop’n could have a very substantial/positive impact on overall #COVID19Canada pandemic.
Read 3 tweets
One third of homes have a cat. There are 600M globally. A study @NEJM confirms cats spread #coronavirus to each other & may spread it between family members. I’m concerned it could mix with a fatal cat coronavirus... 1/n
Some say “Well, the virus has not been proven to spread from cat to human.” As @StevenAustad has pointed out, this hasn’t been tested or disproven either. It is like saying in December 2019 that a virus in China hasn’t been proven to spread to the US. 2/n
Is no one but me concerned about viral genetic mixing & a new strain emerging from cats? Cats have their own #coronaviruses. They can cause one of the most fatal cat diseases known by destroying white blood cells (HIV-like). 3/n
Read 10 tweets
"The live SARS-like coronavirus SL-CoV-WIV1 has been isolated for the first time from bat droppings; and such virus has been confirmed to invade the host cells through the ACE2 of human beings..." ImageImageImage
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964 ImageImageImageImage
In this study, we have developed a fast and cost-effective method
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily. ImageImageImageImage
Read 68 tweets
#Reviews on the use of #war metaphors for health workers amidst #coronaviruses & #CoViD19, explain why using #hashtags such as #CoronaSaviours and #CoronaWarriors can fuel the coexistent #infodemic, graver than the #pandemic itself!

@UN @deespeak @fayedsouza @iHrithik

#Thread👇
"Of course, we all want to contain the virus, posthaste, and to treat as many as patients as we possibly can. But to do so under the banner of war implies the necessity of a heedless approach that leaves both doctors and patients open to an indefensible level of risk."
Read 16 tweets
You’ve probably seen or heard about the #PlandemicDocumentary video. It reaches many conclusions that have zero scientific support and are dangerous because they could harm your health. Here are rebuttals and references to just a few of the false claims. A thread. (1/x)
False claim #1: The novel #coronavirus was lab-made.

Truth: Genetic science allows us to understand how and when viruses emerge. Analyses by trusted scientists clearly demonstrates that the virus occurred naturally. (2/x)
You can read the scientific paper@K_G_Andersen @scrippsresearch; @arambaut; W. Ian Lipkin; @ColumbiaMSPH; @edwardcholmes; & Robert F. Garry @Tulane here (3/x)
nature.com/articles/s4159…,
Read 20 tweets
Yes, @RudyGiuliani What An excellent Question

Timeline

* July '14 CDC lab accidents involving highly pathogenic microbes are mishandled by federal laboratories.
* Oct. '14 Moratorium placed on gain-of-function (GOF) research & funding paused (no mention of coronavirus)
2/

@RudyGiuliani the ban has seemingly grey areas built-in (shocker). It doesn't mention coronaviruses.

*'15 #NIH reportedly outsources GOF research to Wuhan Institute of Virology on coronaviruses, using a $3.7 million grant. Documents? What's #Fauci's role?

#FireFauci
* Nov.'17 Study published:"Discovery of a rich gene pool of bat SARS-related #coronaviruses provides new insights."
* Dec. 2019 #NIH lifts GOF research
ncbi.nlm.nih.gov/pmc/articles/P…
@RepMattGaetz
@SecPompeo
@RudyGiuliani
@POTUS
@ViKu1111
@WhiteCoatWaste
@RealJamesWoods
@BusyDrT
Read 5 tweets

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