@OhhiyoGarmen @kevinnbass I agree ApoB-containing lipoproteins have a "role in atherosclerosis". This often gets conflated with serum levels of LDL-C (dose-dependent), but the distinction is important because they are not identical. One isn't a matching proxy for the other, even where correlative...
@OhhiyoGarmen @kevinnbass ... If high LDL-C were always atherogenic, then there'd be no metabolic or lipid profile at a population level with high LDL-C, yet low atherosclerosis. This is why I initiated the #LCCholesterolChallenge to help find any studies with high LDL, high HDL, low TG = high CVD.
@OhhiyoGarmen @kevinnbass To date, I haven't had anyone submit a study that meets this criteria. All studies I've been able to locate that stratify high LDL-C + high HDL-C + low TG show low CVD.
