Vectors or Vulnerable?
#Covid_19…the more you know…🤦♀️🤷♂️
What we know about MIS-C in children so far : Evidence, CDC alert and more…
🧵 1/
#Covid_19…the more you know…🤦♀️🤷♂️
What we know about MIS-C in children so far : Evidence, CDC alert and more…
🧵 1/
Minimal medical burden
Low incidence: 1.7-2%
Asymptomatic or mild symptoms, however can pass this virus onto high risk population (vectors)
Severe illness: rare, can occur with pre-existing medical conditions, but have better outcomes (compared to adults)
2/
Low incidence: 1.7-2%
Asymptomatic or mild symptoms, however can pass this virus onto high risk population (vectors)
Severe illness: rare, can occur with pre-existing medical conditions, but have better outcomes (compared to adults)
2/
Late April
UK reports 8 children “Hyperinflammatory syndrome, multiorgan involvement-Kawasaki-like disease(KLD) and Shock”
Previously asymptomatic,healthy
Older ~ 7.5 yr
All Shock, 1 coronary art aneurysm,1 dies of cerebral infarct
NO cough/significant respiratory issue
3/
UK reports 8 children “Hyperinflammatory syndrome, multiorgan involvement-Kawasaki-like disease(KLD) and Shock”
Previously asymptomatic,healthy
Older ~ 7.5 yr
All Shock, 1 coronary art aneurysm,1 dies of cerebral infarct
NO cough/significant respiratory issue
3/
Superb infographic from Dr Rob Parker @redwings54 with excellent comparison between KD/KD like syndrome and COVID inflammatory syndrome
4/
4/
So, is this KD/KLD-like-disease related to #COVID_19 at all?
A @TheLancet publication from Bergamo, Italy, an epicenter for COVID in Italy reports a 'cluster' of cases, 30 x increased incidence and severity of KLD suggesting a temporal association
5/
A @TheLancet publication from Bergamo, Italy, an epicenter for COVID in Italy reports a 'cluster' of cases, 30 x increased incidence and severity of KLD suggesting a temporal association
5/
-Starting point few weeks after 1st case of COVID
-2/10 +ve PCR (low viral replication), BUT 8/10 +ve antibody test
Recognition of this, late in the pandemic might reflect a mechanism for MIS-C - a post-infectious inflammatory syndrome, antibody or immune-complex mediated
6/
-2/10 +ve PCR (low viral replication), BUT 8/10 +ve antibody test
Recognition of this, late in the pandemic might reflect a mechanism for MIS-C - a post-infectious inflammatory syndrome, antibody or immune-complex mediated
6/
Understanding the inflammatory phenomenon in children with MIS-C may provide valuable information about immune protection for adults and children and if this is an antibody-mediated phenomenon, there might be implications for vaccine studies
7/
7/
Where are we now with MIS-C?
🇺🇸~100 cases in NY besides 19 others states (3 deaths)
Children: ages of 5 -9 (29%) and between 10-14 (28%) years old
🇮🇹🇫🇷🏴~ 50 cases reported in Europe (~ 1 death)
8/
🇺🇸~100 cases in NY besides 19 others states (3 deaths)
Children: ages of 5 -9 (29%) and between 10-14 (28%) years old
🇮🇹🇫🇷🏴~ 50 cases reported in Europe (~ 1 death)
8/
What to expect?
An 📈 in 4-6 wks from peak in your area
Parents:
Don’t panic, Be vigilant
Good news:
MIS-C is rare, most kids are responsive to intensive care
Prevention is the best cure (Face covering >2,hand hygiene and distancing)
Report to your doctor if you see 👇
9/
An 📈 in 4-6 wks from peak in your area
Parents:
Don’t panic, Be vigilant
Good news:
MIS-C is rare, most kids are responsive to intensive care
Prevention is the best cure (Face covering >2,hand hygiene and distancing)
Report to your doctor if you see 👇
9/
References
10/ End
10/ End
