Suppressive myeloid cells are a hallmark of severe COVID-19 bit.ly/3hbrGyN. Our latest preprint provides insights into systemic immune responses to SARS-CoV-2 infection incl. profound alterations of the myeloid compartment associated with severe COVID-19. (1/n) #COVID19 
Our study reports 1) time- and severity-dependent deviations of the monocyte compartment, particularly the identification of immunosuppressive monocytes at late stages in severe COVID-19, 2) the apprearance of immature and dysfunctional granulocyte subsets in severe disease.(3/n)
In detail, we report a specific increase of HLA-DRhiCD11chi inflammatory monocytes that displayed a strong interferon (IFN)-stimulated gene signature in patients with mild COVID-19, which was absent in severe disease.(4/n)
Instead, we found evidence of emergency myelopoiesis, marked by the occurrence of immunosuppressive pre- and immature neutrophils and populations of dysfunctional and suppressive mature neutrophils, as well as suppressive HLA-DRlo monocytes in severe COVID-19.(5/n)
This was a very intense and fruitful collaboration with the groups of @Sander_Lab, @AE_Saliba, @YangLi_NL, Birgit Sawitzki, Jacob Nattermann and @AschenbrennerAC within the Deutsche COVID-19 OMICs Initiative decoi.eu ... (6/n)
... spearheaded by @jsschrepping, @reusch_nico, Daniela Paclik, @kevin_bassler, Stephan Schlickeiser, Bowen Zhang, Benjamin Krämer, Tobias Krammer, Sophia Brumhard, @LorenzoBonaguro and Elena De Domenico.(7/n)
