Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19, bit.ly/3teIlId, our latest team effort in #COVID19 research lead by Jacob Natterman @LabSchultze and @AschenbrennerAC out now @ImmunityCP. [1/n] We performed a detailed characterization of natural killer cells in 205 patients from four independent cohorts using #scRNAseq, #MCFC and #CyTOF together with functional studies. [2/n]

Suppressive myeloid cells are a hallmark of severe COVID-19 bit.ly/3hbrGyN. Our latest preprint provides insights into systemic immune responses to SARS-CoV-2 infection incl. profound alterations of the myeloid compartment associated with severe COVID-19. (1/n) #COVID19 We combined two scRNA-seq techniques and sc-proteomics in PBMC and whole blood in two independent dual-center patient cohorts (n=46 + n=54 samples) to determine changes in immune cell composition and activation in mild and severe cases of COVID-19.(2/n) #scRNAseq #CyToF