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Eric Topol Profile picture
@EricTopol
Jun 28, 2020 • 7 tweets • 7 min read • Read on X
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Switching gears from covid-centric to #cancer, where there have been a flurry of important papers in the past week
1. "Our discovery of #lesionsegregation challenges longstanding assumptions of cancer evolution"
nature.com/articles/s4158… @nature
media.nature.com/original/magaz… @NatureNews Image
2. 2 new papers on clonal hematopoiesis, which is associated with increased risk of cancer and heart disease
nature.com/articles/s4158…
nature.com/articles/s4158… ImageImage
3. 2 reports on using methylomes to detect or track cancer, one using plasma tDNA for brain tumors, the other urine and plasma for kidney cancer
@NatureMedicine
nature.com/articles/s4159…
nature.com/articles/s4159… ImageImage
4. The use of patient-derived tumor cell clusters to understand the biology of an individual's cancer and rapidly test drug therapies @ScienceTM
stm.sciencemag.org/content/12/549… Image
5. Patient-specific genomic variant monitoring of cancer via plasma circulating tDNA
stm.sciencemag.org/content/12/548… @ScienceTM
6. The potential for fasting to favorably modulate the course of cancer in a randomized trial of 131 patients with breast cancer
nature.com/articles/s4146… ImageImage
A nice update on use of extracellular RNA as a diagnostic for cancer and beyond
by @ElieDolgin @NatureOutlook
nature.com/articles/d4158… Image

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More from @EricTopol

Eric Topol Profile picture
Apr 13
Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is favorably affected by exercise and likely many other lifestyle factors.
Here’s (almost) everything we know about it. In Ground Truths (link in my profile d/t X-suppression)Image
Here's the response to exercise Image
The most sensitive and accurate biomarker to date Image
Read 5 tweets
Eric Topol Profile picture
Apr 5
A major @Nature paper this week found a significant decline in dementia after an outdated Shingles vaccine.
I've reviewed the study and many other relevant ones in a new Ground Truths (link in profile) Image
A Table from the post Image
The effect in the 2 natural experiments differed substantially by sex with the benefit predominant in women Image
Read 5 tweets
Eric Topol Profile picture
Apr 2
The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence
"implications are profound"
New @Nature
nature.com/articles/s4158…
nature.com/articles/d4158…
Accompanying @NatureNV nature.com/articles/d4158…
Read 4 tweets
Eric Topol Profile picture
Mar 24
Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome🧵 @NatureMedicine Image
These are the specific foods that were linked with healthy aging and other outcomes. Green-favorable; Red-unfavorable Image
Adherence to these diets (most to least in quintiles) linked to healthy aging Image
Read 4 tweets
Eric Topol Profile picture
Feb 3
A paper on microplastics accumulating in the brain was just published @NatureMedicine, open-access
I review the background and major implications in a new Ground Truths edition (link in my profile)nature.com/articles/s4159…Image
Image
The human brain:
—had 7-30 times more accumulation of microparticles (MPs) than the liver or kidney (organs with previously documented high propensity)
—from people with dementia had 5X accumulation of MPs compared with non-dementia
—there was a marked increase of accumulation over recent years
Your Health Alert washingtonpost.com/climate-enviro…Image
Read 4 tweets
Eric Topol Profile picture
Dec 31, 2024
Three new @NEJM reports on #H5N1 today
1. An overview by @MichaelGIsonMD and @DrJeanneM
"urgent need for vigilant surveillance of emerging mutations and assessment of the threat of human-to-human transmission" Image
Image
2. Report of the 13-year-old Canadian girl who developed acute respiratory failure. Sequence of her H5N1 revealed 3 mutations that may be linked to higher virulence and adaptation to human cell binding Image
Image
3. Review of 46 cases of mild H5N1 illness by CDC in 2024 Image
Read 6 tweets

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