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Eric Topol Profile picture
@EricTopol
Jun 28, 2020 • 7 tweets • 7 min read • Read on X
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Switching gears from covid-centric to #cancer, where there have been a flurry of important papers in the past week
1. "Our discovery of #lesionsegregation challenges longstanding assumptions of cancer evolution"
nature.com/articles/s4158… @nature
media.nature.com/original/magaz… @NatureNews Image
2. 2 new papers on clonal hematopoiesis, which is associated with increased risk of cancer and heart disease
nature.com/articles/s4158…
nature.com/articles/s4158… ImageImage
3. 2 reports on using methylomes to detect or track cancer, one using plasma tDNA for brain tumors, the other urine and plasma for kidney cancer
@NatureMedicine
nature.com/articles/s4159…
nature.com/articles/s4159… ImageImage
4. The use of patient-derived tumor cell clusters to understand the biology of an individual's cancer and rapidly test drug therapies @ScienceTM
stm.sciencemag.org/content/12/549… Image
5. Patient-specific genomic variant monitoring of cancer via plasma circulating tDNA
stm.sciencemag.org/content/12/548… @ScienceTM
6. The potential for fasting to favorably modulate the course of cancer in a randomized trial of 131 patients with breast cancer
nature.com/articles/s4146… ImageImage
A nice update on use of extracellular RNA as a diagnostic for cancer and beyond
by @ElieDolgin @NatureOutlook
nature.com/articles/d4158… Image

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More from @EricTopol

Eric Topol Profile picture
Feb 3
A paper on microplastics accumulating in the brain was just published @NatureMedicine, open-access
I review the background and major implications in a new Ground Truths edition (link in my profile)nature.com/articles/s4159…Image
Image
The human brain:
—had 7-30 times more accumulation of microparticles (MPs) than the liver or kidney (organs with previously documented high propensity)
—from people with dementia had 5X accumulation of MPs compared with non-dementia
—there was a marked increase of accumulation over recent years
Your Health Alert washingtonpost.com/climate-enviro…Image
Read 4 tweets
Eric Topol Profile picture
Dec 31, 2024
Three new @NEJM reports on #H5N1 today
1. An overview by @MichaelGIsonMD and @DrJeanneM
"urgent need for vigilant surveillance of emerging mutations and assessment of the threat of human-to-human transmission" Image
Image
2. Report of the 13-year-old Canadian girl who developed acute respiratory failure. Sequence of her H5N1 revealed 3 mutations that may be linked to higher virulence and adaptation to human cell binding Image
Image
3. Review of 46 cases of mild H5N1 illness by CDC in 2024 Image
Read 6 tweets
Eric Topol Profile picture
Dec 9, 2024
We're learning how to control the immune response, like a rheostat, even in the brain. Implications for understanding the basis and potential treatment of autoimmune conditions like multiple sclerosis, #LongCovid, #MECFS, and brain cancer.
A brief review of 6 recent, important reports
in the new Ground Truths, open-accessImage
Such as Programming T cells with brain-specific proteins and payloads
@ScienceMagazine science.org/doi/10.1126/sc…
Or peptide fragments of myelin basic protein that suppress the immune response @Nature nature.com/articles/s4158…Image
Read 4 tweets
Eric Topol Profile picture
Nov 13, 2024
New @NEJM
A whopping (~90%) reduction of progression to Type 2 diabetes with tirzepatide (GLP-1 drug, dual receptor) vs placebo in a randomized trial of >2,500 participants with obesity, absolute reduction of 10/100 treated

by @AniaJastreboff and collaboratorsnejm.org/doi/full/10.10…Image
In other GLP-1 new publications today
—Country-wide Sweden reduced hospitalizations for alcohol or substance abuse with these drugs
jamanetwork.com/journals/jamap… @JAMAPsych
—Concerns about discontinuation
jamanetwork.com/journals/jama/… @JAMA_current Image
Other new anti-obesity drugs in the pipeline, one that also increases energy expenditure
@NatureNV nature.com/articles/d4158…Image
Read 4 tweets
Eric Topol Profile picture
Nov 13, 2024
A dedicated issue of @ScienceTM on #LongCovid
—Sex-specific differences, with perspective by @VirusesImmunity and @SilvaJ_C
—Insights for therapies @AndreaCoxMDPhD
—Deconvoluting "Osler's Web" @MichaelPelusoMD @DeeksSteven @DrMaureenHanson @SaydahSharon
—+RECOVER Trial, Lyme diseaseImage
Image
Image
science.org/toc/stm/16/773
Where we have failed to date: finding an effective therapy. That has to change
science.org/doi/epdf/10.11…Image
Read 4 tweets
Eric Topol Profile picture
Oct 19, 2024
An elegant @Nature study by @AkassoglouLab has illuminated our understanding of the role of fibrin (component of blood clots), #SARSCoV2, and brain inflammation in Covid and #LongCovid.
This discovery and more in the new Ground Truths podcast, with transcript, key figures (such as as the one below) and citations. Open-access. Link in my profile.Image
Image
A clip from our conversation. Unknowingly, @AkassoglouLab was gearing up for understanding this complex pathophysiology for many years before Covid hit
For treatment, it's not just as simple as preventing fibrin clots. It's isolating the pro-inflammatory action of fibrin, targeted by the antibody
Read 4 tweets

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