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New work from our team and collaborators: The Immunology of Multisystem Inflammatory Syndrome in Children with #COVID19 (MIS-C) medrxiv.org/content/10.110… 1) we contrast MIS-C with Kawasaki disease and mild SARS-CoV2 in kids
2) MIS-C differ from hyperinflammation in severe COVID-19 disease
3) Unique cytokine profiles in MIS-C that differ from Kawasaki disease (pre-SARS-CoV2)
4) In particular IL-17A is elevated in Kawasaki but not in MIS-C
5) We also perform auto-ab screening and reveal cadidate autoantigens in MIS-C and KD, most notably Endoglin a protein important for the integrity of arterial walls and most abundantly expressed in the heart muscle
Fantastic collaborative effort together with colleagues in Rome @bambinogesu headed by Paolo Palma as well as NIls Landegren lab @karolinskainst Great effort by the talented @consiglio_cr @pou_christian @LucieSTRod Ziyang Tan, Jun Wang and more in our team @scilifelab
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