Professor of Pediatric Immunology • Pediatrician • Systems Immunology • Experiments • Computation • @imperialcollege • @karolinskainst
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May 13 • 7 tweets • 4 min read
Acute hepatitis in kids. We urge colleagues with access to samples (blood/liver tissue) to consider SARS-CoV-2 superantigen-mediated disease, potentiated by a second virus (AdV) 🧵1/ thelancet.com/journals/langa…2/ @ArditiMd and colleagues first described a superantigen motif in SARS-CoV-2 and several groups have independently found T-cell skewing (TRBV11-2 expanded) in kids w #MISC, indicative of a superantigen-mediated inflammation.
Jan 19 • 7 tweets • 4 min read
How come #COVID19 is mostly mild in children? and at the same time, why do the rare hyperinflammatory syndrome #MISC affect mostly young people, and not the elderly? thread🧵and a hypothesis: cell.com/immunity/fullt…
2/In other infections, ex mononucleosis, symptomatic disease in teenagers differs from mild/asymptomatic infection in young children by stronger bystander T-cell activation and systemic inflammation.
Oct 24, 2020 • 7 tweets • 5 min read
Bifidobacteria-mediated immune system imprinting early in life biorxiv.org/content/10.110…1) Risk of asthma/allergies/autoimmunity etc associated with perturbed immune-microbe interactions early in life, but mechanisms are elusive
Sep 6, 2020 • 6 tweets • 5 min read
New from us: The immunology of MIS-C v.s Kawasaki disease and acute COVID-19. Online now in Cell: cell.com/cell/fulltext/…1/ Hyperinflammation in MIS-C differs from that of acute, severe COVID-19. Important info for therapeutic decisions.
Jul 10, 2020 • 6 tweets • 4 min read
New work from our team and collaborators: The Immunology of Multisystem Inflammatory Syndrome in Children with #COVID19 (MIS-C) medrxiv.org/content/10.110… 1) we contrast MIS-C with Kawasaki disease and mild SARS-CoV2 in kids 2) MIS-C differ from hyperinflammation in severe COVID-19 disease