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1/
A couple (55M/52F) p/w fever 39F, myalgias, dry cough, and mild diarrhea. Pt and his wife love their pet cockatiels (Charlie + Angel). You dx psittacosis!

Pts ask what should happen to their 🦜🦜, what do you say? #MedTwitter #IDTwitter #IDMedEd
2/
Let's learn about psittacosis in humans before we get to the poll answer!

🦠Chlamydia psittaci
🧫Obligate intracellular GN bacteria
🔹22 cases were reported in 2018 to CDC NNDS

🦜Birds are primary zoonotic reservoir (altho has been seen in other animals eg sheep, cattle) Image
3/
🦠C.psittaci documented in >450 spp of birds
🦜Most human inf = pet psittacine 🦜(parakeet/cockatiel/cockatoo/parrot)
🔹Also seen: 🦃,🐔,🦆 , pigeon etc
💥Outbreaks related to pet shops, aviaries, vet facilities, poultry processing (2018, 🐔plant➡️ncbi.nlm.nih.gov/pmc/articles/P…)
4/
🔃Transmit via inhalation of aerosolized dried bird droppings usually
🔹Can occur w/bird secretions/bites, transient exposures

🩺Leads to atypical pna sxs (fever, HA, myalgias, dry cough). Sometimes pharyngitis, diarrhea, LFT changes
▪️Incubation: 5-14d
5/
Severe fulminant cases are infrequent but possible (resp failure, septic shock, ARF)

Atypical pnas can be difficult to differentiate clinically. Outside of the right epi hx, a severe headache might be a noticeable difference compared to other atypicals Image
6/
🧪Dx: Serology. Cx is discouraged given risk of lab transmission

💊Tx:
▪️Preferred = Tetracyclines (Doxy x 14d)
▪️Proposed alternatives = Macrolides, FQ (mostly based on in vitro activity, limited clinical experience)
7/
🦜Psittacosis can be cured/suppressed in birds with abxs, so no need to do more to prevent recurrent human infection!
🔖Anecdotally, pet shop owners add tetracycline to drinking water of birds for sale to keep them in good health until they are relocated in less crowded cages
8/
Crowded conditions for🦜➡️⬆️shedding of orgs

For outbreaks, will need epi investigation fr source bird (esp if bought w/i past 2 mo)

Otherwise, aviaries/poultry plants/etc have cleaning guidelines/techniques to ⬇️aerosolization of infected particles
pubmed.ncbi.nlm.nih.gov/28891690/
9/
💉There's no vaccine for birds quite yet, so that is not an option.

Check out a great review and illustrative case here: pubmed.ncbi.nlm.nih.gov/20171542/ Image
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