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SalivaDirect has been issued an EUA by the FDA - as a protocol that we can share widely.

💪 @awyllie13, @VogelsChantal, @robbysikka & team.

More info on how to implement to follow.

fda.gov/news-events/pr…
See here for more info:
covidtrackerct.com/about-salivadi…
And will add @ASlavitt’s thread here:
https://t.co/CKIx0vo7Zj
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Nathan Grubaugh
@NathanGrubaugh
Now that our SalivaDirect FDA EUA application for #SARS_CoV_2 diagnostics has been submitted, here is a sneak-peak at our validation results. medRxiv pre-print is forthcoming, but twitter is faster 😉

Overview: saliva w/o special tubes > no RNA extraction > dualplex PCR

1/n
2/n
 About SalivaDirect ➡️ covidtrackerct.com/about-salivadi…

Papers & Protocols ➡️ covidtrackerct.com/saliva-related…

SalivaDirect Results ➡️ covidtrackerct.com/salivadirect-r…

NBA validation study "Swish" ➡️ covidtrackerct.com/swish/
3/n
 We validated SalivaDirect with multiple reagents & platforms to:
-make it available to more labs
-avoid specific supply chain bottlenecks
-keep costs down.

We'll provide specific information on how to conduct bridging studies to validate additional reagents/equipement
Read 10 tweets
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Nathan Grubaugh
@NathanGrubaugh
Excited to announce our new study to develop and validate an inexpensive and sensitive saliva-based method for #SARS_CoV_2 testing in partnership with the @NBA.

Will be led by @awyllie13, @hmkyale, & myself from the @YaleSPH side.

usatoday.com/story/sports/n…
We'll be using our new #SalivaDirect protocol developed by @VogelsChantal + @DougBrackney. We'll have sensitivity data and a study design overview available on our website soon.

protocols.io/view/salivadir…
Our study has 2 aims:

On the lab side, we are preparing #SalivaDirect for FDA EUA, and are validating with many different vendor reagents to drive down costs and not add supply chain bottlenecks. We are not seeking to commercialize any aspect. Our goal is to get this to $1/test
Read 9 tweets
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Nathan Grubaugh
@NathanGrubaugh
I was misquoted in the NYT for having said that "infections spreading from New York account for 60 to 65 percent of the cases across the country."

I DID NOT SAY THAT

It's now causing these spinoff stories with this in the headlines.

businessinsider.com/travel-from-ne…
The interview was initially about my teams work finding that our sequenced #SARSCoV2 genomes from Connecticut fit into mostly 2 clades - one related to genomes from WA and one related to NY. To better visualize this data, I took them to Nextstrain.
From there I showed the reporters that most of the sequenced viruses from the US were related to those sequenced from NY, suggesting that a lot of domestic spread has happened from there. Which is true, and probably not surprising given the travel in and out of NY.
Read 8 tweets

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